Genomics-based identification of targets in pathogenic bacteria for potential therapeutic and diagnostic use

Toxicology

Volumn 160, Issue 1-3, 2001, Pages 181-189

  Raczniak, Gregory ^a   Ibba, Michael ^b   Söll, Dieter ^a  

^a YALE UNIVERSITY   (United States)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Amidotransferase; Aminoacyl tRNA; Borrelia; Chlamydia; Evolution; Genomics; Lyme disease; Protein synthesis; Sexually transmitted disease; tRNA

Indexed keywords

AMINOACYL TRANSFER RNA; SYNTHETASE; TRANSFERASE;

ARTICLE; BACTERIAL GENETICS; BACTERIAL INFECTION; CELL VIABILITY; CHLAMYDIA; CHLAMYDIASIS; CONTROLLED STUDY; DIAGNOSTIC VALUE; ENZYME SPECIFICITY; GENE THERAPY; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; LYME DISEASE; MAMMAL; MYCOPLASMA; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RICKETTSIA; RNA SYNTHESIS; SPECIES DIFFERENCE; SPIROCHETE;

AMINO ACYL-TRNA SYNTHETASES; ANTI-BACTERIAL AGENTS; BORRELIA BURGDORFERI GROUP; CHLAMYDIA INFECTIONS; CHLAMYDIA TRACHOMATIS; ENZYME INHIBITORS; GENOME, BACTERIAL; LYME DISEASE; PROTEOME; RNA, TRANSFER;

BORRELIA; CHLAMYDIA; MAMMALIA;

EID: 0035819917     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(00)00454-6     Document Type: Article

References (39)

1. Chlamydia infections and heart disease linked through antigenic mimicry
2. Biology of Borrelia species
3. Thermus thermophilus: A link in evolution of the tRNA-dependent amino acid amidation pathways
4. Gln
5. Rational design of femtomolar inhibitors of isoleucyl tRNA synthetase from a binding model for pseudomonic acid-A
6. Complete genome sequence of the methanogenic archaeon, Methanococcus jannaschii
7. Lyme disease - A tick-borne spirochetosis?
8. Cognition, mechanism, and evolutionary relationships in aminoacyl-tRNA synthetases
9. Gln amidotransferase: A novel heterotrimeric enzyme required for correct decoding of glutamine codons during translation
10. Mechanism of action of ochratoxin A
11. Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi
12. Interaction of L cells and Chlamydia psittaci: Entry of the parasite and host responses to its development
13. Chlamydia trachomatis interrupts an exocytic pathway to acquire endogenously synthesized sphingomyelin in transit from the Golgi apparatus to the plasma membrane
14. The adaptor hypothesis revisited
15. Aminoacyl-tRNA synthesis: Divergent routes to a common goal
16. A euryarchaeal lysyl-tRNA synthetase: Resemblance to class I synthetases
17. Archaeal-type lysyl-tRNA synthetase in the Lyme disease spirochete Borrelia burgdorferi
18. Substrate recognition by class I lysyl-tRNA synthetases: A molecular basis for gene displacement
19. Aminoacyl-tRNA synthesis
20. Yeast mitochondrial DNA specifies tRNA for 19 amino acids: Deletion mapping of the tRNA genes
21. Lyme borreliosis
22. Effect of Borrelidin on the threonyl-tRNA-synthetase activity and the regulation of threonine-biosynthetic enzymes in Saccharomyces cerivisiae
23. The epidemiology of trachoma predicts more blindness in the future
24. Aminoacyl-tRNA synthetases: General features and recognition of transfer RNAs
25. Inhibitors of aminoacyl-tRNA synthetases as novel anti-infectives
26. Protein biosynthesis in organelles requires misaminoacylation of tRNA
27. Vesicular interactions of the Chlamydia trachomatis inclusion are determined by chlamydial early protein synthesis rather than route of entry
28. Trends of gonorrhea and chlamydial infection during 1985-1996 among active-duty soldiers at a United States Army installation
29. Lyme disease
30. Lyme disease: A review of aspects of its immunology and immunopathogenesis
31. Discrimination against misacylated tRNA by chloroplast elongation factor Tu
32. One polypeptide with two aminoacyl-tRNA synthetase activities
33. Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis
34. Comparative epidemiology of heterosexual gonococcal and chlamydial networks: Implications for transmission patterns
35. Indolmycin inhibits prokaryotic tryptophanyl-tRNA ligase
36. Further codon assignments in an extremely halophilic bacterium using a cell-free protein-synthesizing system and a ribosomal binding assay
37. Transfer RNA as a cofactor coupling amino acid synthesis with that of protein
38. Aminoacyl-tRNA synthetases, the genetic code, and the evolutionary process
39. tRNA on the ribosome: A Waggle theory