Discovery and optimisation of potent, selective, ethanolamine inhibitors of bacterial phenylalanyl tRNA synthetase

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 9, 2005, Pages 2305-2309

  Jarvest, Richard L ^a   Erskine, Symon G ^b   Forrest, Andrew K ^a   Fosberry, Andrew P ^a   Hibbs, Martin J ^a   Jones, Joanna J ^a   O'Hanlon, Peter J ^a   Sheppard, Robert J ^a   Worby, Angela ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

^b GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ENZYME; ETHANOLAMINE DERIVATIVE; LIGASE INHIBITOR; PHENYLALANINE TRANSFER RNA LIGASE; PHENYLALANINE TRANSFER RNA LIGASE INHIBITOR; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG SYNTHESIS; ENANTIOSELECTIVITY; ENZYME INHIBITION; HAEMOPHILUS INFLUENZAE; IC 50; MAMMAL; NONHUMAN; STAPHYLOCOCCUS AUREUS; STRUCTURE ACTIVITY RELATION;

BACTERIA (MICROORGANISMS); MAMMALIA; STAPHYLOCOCCUS AUREUS;

EID: 17144381316     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.03.003     Document Type: Article

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