Identification of novel inhibitors of methionyl-tRNA synthetase (MetRS) by virtual screening

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 14, 2008, Pages 3932-3937

  Finn, John ^a   Stidham, Mark ^a   Hilgers, Mark ^a   G C , Kedar ^a  

^a Trius Therapeutics Inc   (United States)

Author keywords

Aminoacyl tRNA synthetase; Antibacterial; Virtual screening

Indexed keywords

ANTIINFECTIVE AGENT; DOCKING PROTEIN; ENZYME INHIBITOR; METHIONINE TRANSFER RNA LIGASE; METHIONINE TRANSFER RNA LIGASE INHIBITOR;

ARTICLE; CATALYST; DATA BASE; ENZYME INHIBITION; HYDROPHOBICITY; NONHUMAN; PHARMACOPHORE; PROTEIN STRUCTURE; STAPHYLOCOCCUS AUREUS; VIRTUAL REALITY; X RAY ANALYSIS;

AMINO ACYL-TRNA SYNTHETASES; ANTI-INFECTIVE AGENTS; BINDING SITES; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; ENZYME INHIBITORS; LIGANDS; METHIONINE-TRNA LIGASE; MODELS, CHEMICAL; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIP;

STAPHYLOCOCCUS AUREUS;

EID: 47349092284     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.06.032     Document Type: Article

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