Discovery and SAR of benzyl phenyl ethers as inhibitors of bacterial phenylalanyl-tRNA synthetase

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 3, 2009, Pages 665-669

  Montgomery, Justin I ^a   Toogood, Peter L ^a   Hutchings, Kim M ^a   Liu, Jia ^a   Narasimhan, Lakshmi ^a   Braden, Timothy ^a   Dermyer, Michael R ^a   Kulynych, Angela D ^a   Smith, Yvonne D ^a   Warmus, Joseph S ^a   Taylor, Clarke ^a  

^a PFIZER INC   (United States)

Author keywords

Aminoacyl tRNA synthetase; Antibacterial; Benzyl phenyl ether; FRS; Phenylalanyl tRNA synthetase; PheRS; SAR

Indexed keywords

BENZENE DERIVATIVE; BENZYL DERIVATIVE; DOFETILIDE; ETHER DERIVATIVE; PHENYLALANINE TRANSFER RNA LIGASE;

ANTIBACTERIAL ACTIVITY; ARTICLE; DRUG CLEARANCE; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; HAEMOPHILUS INFLUENZAE; HIGH THROUGHPUT SCREENING; IC 50; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; STREPTOCOCCUS PNEUMONIAE; STRUCTURE ACTIVITY RELATION;

ADENOSINE TRIPHOSPHATE; ANTI-BACTERIAL AGENTS; ANTI-INFECTIVE AGENTS; BACTERIA; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; INHIBITORY CONCENTRATION 50; MODELS, CHEMICAL; PHENYL ETHERS; PHENYLALANINE-TRNA LIGASE; STRUCTURE-ACTIVITY RELATIONSHIP;

BACTERIA (MICROORGANISMS);

EID: 58549117083     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.12.054     Document Type: Article

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