Characterization of isoleucyl-tRNA synthetase from Staphylococcus aureus: II. Mechanism of inhibition by reaction intermediate and pseudomonic acid analogues studied using transient and steady-state kinetics

Journal of Biological Chemistry

Volumn 273, Issue 48, 1999, Pages 31691-31701

  Pope, Andrew J ^a,b   Moore, Keith J ^a   McVey, Mary ^a   Mensah, Lucy ^a   Benson, Neil ^a   Osbourne, Neal ^a   Broom, Nigel ^a   Brown, Murray J B ^a   O'Hanlon, Peter ^a  

^a SmithKline Beecham ^*  (United Kingdom)

^b SmithKline Beecham   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE PHOSPHATE; BACTERIAL ENZYME; ENZYME INHIBITOR; ISOLEUCINE TRANSFER RNA LIGASE; PSEUDOMONIC ACID;

AMINOACYLATION; ARTICLE; ENZYME ANALYSIS; ENZYME INHIBITION; ENZYME KINETICS; FLUORESCENCE ANALYSIS; NONHUMAN; PRIORITY JOURNAL; STAPHYLOCOCCUS AUREUS; STOICHIOMETRY;

ANTI-BACTERIAL AGENTS; ISOLEUCINE; ISOLEUCINE-TRNA LIGASE; KINETICS; MODELS, CHEMICAL; MOLECULAR STRUCTURE; MUPIROCIN; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIP;

BACTERIA (MICROORGANISMS); STAPHYLOCOCCUS AUREUS;

EID: 0033610812     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.273.48.31691     Document Type: Article

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