Potent and selective inhibitors of bacterial methionyl tRNA synthetase derived from an oxazolone-dipeptide scaffold

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 8, 2004, Pages 1909-1911

  Tandon, Manish ^a   Coffen, David L ^a   Gallant, Paul ^b   Keith, Dennis ^b   Ashwell, Mark A ^a  

^a ARQULE INC   (United States)

^b CUBIST PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

METHIONINE TRANSFER RNA LIGASE; OXAZOLINE DERIVATIVE;

ARTICLE; DRUG POTENCY; DRUG SELECTIVITY; ENTEROCOCCUS FAECALIS; ENZYME INHIBITION; IC 50; NONHUMAN; PROTEIN FOLDING; STAPHYLOCOCCUS AUREUS; STRUCTURE ACTIVITY RELATION;

BACTERIA; ENTEROCOCCUS; ENZYME INHIBITORS; HUMANS; METHIONINE-TRNA LIGASE; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; OXAZOLONE; PEPTIDES; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIP;

BACTERIA (MICROORGANISMS); STAPHYLOCOCCUS; STAPHYLOCOCCUS AUREUS;

EID: 1642619403     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.01.094     Document Type: Article

References (7)

1. Bush K., Macielage M., Clancy J. Emerg. Drugs. 5:2000;347.
2. Ibba M., Söll D. Annu. Rev. Biochem. 69:2000;617.
3. Bertino J.S., Am J. Health Syst. Pharm. 54:1997;2185.
4. Parenti M.A., Hatfield S.M., Leyden J.J. Clinical Pharmacy. 6:1987;761.
5. 50 was determined by fitting the results from a 10-point dose-response curve. All results are the average of at least two measurements.
6. Behringer H., Horst T. Chem. Ber. 90:1957;1398.
7. Benoiton N.L., Hudecz F., Francis M.F., Int J. Pept. Prot. Res. 45:1995;266.