Targeting cancer stem cells with natural products

Current Drug Targets

Volumn 13, Issue 8, 2012, Pages 1054-1064

  Burnett, Joseph ^a   Newman, Bryan ^a   Sun, Duxin ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

AKt; Cancer stem cell; Hedgehog; HIF 1 ; Natural product; NF b; Notch; Wnt signaling

Indexed keywords

ALDEHYDE DEHYDROGENASE; BETA CATENIN; CELASTROL; CYCLOPAMINE; ECHINOMYCIN; FRIZZLED PROTEIN; HEAT SHOCK PROTEIN; LEPOURCELET; NATURAL PRODUCT; NOTCH RECEPTOR; PARTHENOLIDE; PIPERINE; RESVERATROL; SALINOMYCIN; SONIC HEDGEHOG PROTEIN; SULFORAPHANE; UNCLASSIFIED DRUG; WITHAFERIN A; WNT PROTEIN; WNT3A PROTEIN;

ACUTE GRANULOCYTIC LEUKEMIA; ARTICLE; CANCER CHEMOTHERAPY; CANCER STEM CELL; CELL PROLIFERATION; CLINICAL EFFECTIVENESS; GENE OVEREXPRESSION; HIGH THROUGHPUT SCREENING; HUMAN; MOLECULAR INTERACTION; NONHUMAN; TUMOR MICROENVIRONMENT;

BIOLOGICAL AGENTS; HUMANS; NEOPLASTIC STEM CELLS; SIGNAL TRANSDUCTION;

EID: 84863555824     PISSN: 13894501     EISSN: 18735592     Source Type: Journal    
DOI: 10.2174/138945012802009062     Document Type: Article

References (155)

1. Hanahan D, Weinberg RA. The Hallmarks of Cancer. Cell 2000; 100(1): 57-70.
2. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ. Cancer Statistics, 2009. CA Cancer J Clin 2009; 59(4): 225-49.
3. Gottesman MM. Mechanisms of cancer drug resistance. Annu Rev Med 2002; 53(1): 615-27.
4. Dick JE. Stem cell concepts renew cancer research. Blood 2008; 112(13): 4793-807.
5. Southam CM, Brunschwig A. Quantitative studies of autotransplantation of human cancer. Preliminary report. Cancer 1961; 14(5): 971-8.
6. Till JE, McCulloch EA, Siminovitch L. A stochastic model of stem cell proliferation, based on the growth of spleen colony-forming cells. Proc Natl Acad Sci USA 1964; 51(1): 29-36.
7. Gupta PB, Fillmore CM, Jiang G, et al. Stochastic State Transitions Give Rise to Phenotypic Equilibrium in Populations of Cancer Cells. Cell 2011; 146(4): 633-44.
8. Sarkar B, Dosch J, Simeone DM. Cancer Stem Cells: A New Theory Regarding a Timeless Disease. Chem Rev 2009; 109(7): 3200-8.
9. Prince ME, Sivanandan R, Kaczorowski A, et al. Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma. Proc Natl Acad Sci USA 2007; 104(3): 973-8.
10. Fong MY, Kakar SS. The role of cancer stem cells and the side population in epithelial ovarian cancer. Histol Histopathol 2010; 25(1): 113-20.
11. Al-Hajj M, Wicha MS, Benito-Hernandez A, Morrison SJ, Clarke MF. Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci USA 2003; 100(7): 3983-8.
12. Spangrude GJ, Heimfeld S, Weissman IL. Purification and characterization of mouse hematopoietic stem cells. Science 1988; 241(4861): 58-62.
13. Hillen H, Wessels T, Haanen C. Bone-marrow-proliferation patterns in acute myeloblastic leukaemia determined by pulse cytophotometry. Lancet 1975; 305(7907): 609-11.
14. Buick RN, Minden MD, McCulloch EA. Self-renewal in culture of proliferative blast progenitor cells in acute myeloblastic leukemia. Blood 1979; 54(1): 95-104.
15. Lapidot T, Sirard C, Vormoor J, et al. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature 1994; 367(6464): 645-8.
16. Dean M, Fojo T, Bates S. Tumour stem cells and drug resistance. Nat Rev Cancer 2005; 5(4): 275-84.
17. Franceschi S, Bidoli E, La Vecchia C, Talamini R, D'Avanzo B, Negri E. Tomatoes and risk of digestive-tract cancers. Int J Cancer 1994; 59(2): 181-4.
18. De Stefani E, Oreggia F, Boffetta P, Deneo-Pellegrini H, Ronco A, Mendilaharsu M. Tomatoes, tomato-rich foods, lycopene and cancer of the upper aerodigestive tract: a case-control in Uruguay. Oral Oncol 2000; 36(1): 47-53.
19. Steinmetz KA, Potter JD. Vegetables, fruit, and cancer. I. Epidemiology. Cancer Causes Control 1991; 2(5): 325-57.
20. Li Y, Wicha MS, Schwartz SJ, Sun D. Implications of cancer stem cell theory for cancer chemoprevention by natural dietary compounds. J Nutr Biochem 2011; 22(9): 799-806.
21. Jemal A, Siegel R, Xu J, Ward E. Cancer Statistics, 2010. CA Cancer J Clin 2010; 60(5): 277-300.
22. Keshtgar M, Davidson T, Pigott K, Falzon M, Jones A. Current status and advances in management of early breast cancer. Int J Surg 2010; 8(3): 199-202.
23. McDermott SP, Wicha MS. Targeting breast cancer stem cells. Mol Oncol 2010; 4(5): 404-19.
24. US Food and Drug Administration. Guidance for industry: Clinical trial endpoints for the approval of cancer drugs and biologics. Available at: http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/ucm071590.pdf [accessed 8/20/2011]
25. Therasse P, Arbuck SG, Eisenhauer EA, et al. New Guidelines to Evaluate the Response to Treatment in Solid Tumors. J Natl Cancer Inst 2000; 92(3): 205-16.
26. Eisenhauer EA, Therasse P, Bogaerts J, et al. New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1). Eur J Cancer 2009; 45(2): 228-47.
27. Reya T, Morrison SJ, Clarke MF, Weissman IL. Stem cells, cancer, and cancer stem cells. Nature 2001; 414(6859): 105-111.
28. Ginestier C, Hur MH, Charafe-Jauffret E, et al. ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. Cell Stem Cell 2007; 1(5): 555-567.
29. Zhou BB, Zhang H, Damelin M, Geles KG, Grindley JC, Dirks PB. Tumour-initiating cells: challenges and opportunities for anticancer drug discovery. Nat Rev Drug Discov 2009; 8(10): 806-823.
30. Sakariassen PØ, Immervoll H, Chekenya M. Cancer stem cells as mediators of treatment resistance in brain tumors: status and controversies. Neoplasia 2007; 9(11): 882-892.
31. Hirsch HA, Iliopoulos D, Tsichlis PN, Struhl K. Metformin Selectively Targets Cancer Stem Cells, and Acts Together with Chemotherapy to Block Tumor Growth and Prolong Remission. Cancer Res 2009; 69(19): 7507-7511.
32. Shafee N, Smith CR, Wei S, et al. Cancer Stem Cells Contribute to Cisplatin Resistance in Brca1/p53-Mediated Mouse Mammary Tumors. Cancer Res 2008; 68(9): 3243-3250.
33. Bao S, Wu Q, McLendon RE, et al. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature 2006; 444(7120): 756-760.
34. Tanei T, Morimoto K, Shimazu K, et al. Association of Breast Cancer Stem Cells Identified by Aldehyde Dehydrogenase 1 Expression with Resistance to Sequential Paclitaxel and Epirubicin-Based Chemotherapy for Breast Cancers. Clin Cancer Res 2009; 15(12): 4234-4241.
35. Gupta PB, Onder TT, Jiang G, et al. Identification of Selective Inhibitors of Cancer Stem Cells by High-Throughput Screening. Cell 2009; 138(4): 645-659.
36. Katoh M, Katoh M. WNT Signaling Pathway and Stem Cell Signaling Network. Clin Cancer Res 2007; 13(14): 4042-5.
37. Liu S, Dontu G, Mantle ID, et al. Hedgehog Signaling and Bmi-1 Regulate Self-renewal of Normal and Malignant Human Mammary Stem Cells. Cancer Res 2006; 66(12): 6063-71.
38. Dontu G, Jackson KW, McNicholas E, Kawamura MJ, Abdallah W, Wicha M. Role of Notch signaling in cell-fate determination of human mammary stem/progenitor cells. Breast Cancer Res 2004; 6(6): R605-15.
39. Yamakado K, Tanaka N, Nakagawa T, Kobayashi S, Yanagawa M, Takeda K. Renal Angiomyolipoma: Relationships between Tumor Size, Aneurysm Formation, and Rupture. Radiology 2002; 225(1): 78-82.
40. Bonner WA, Hulett HR, Sweet RG, Herzenberg LA. Fluorescence Activated Cell Sorting. Rev Sci Instrum 1972; 43(3): 404-409.
41. Fillmore CM, Kuperwasser C. Human breast cancer cell lines contain stem-like cells that self-renew, give rise to phenotypically diverse progeny and survive chemotherapy. Breast Cancer Res 2008; 10(2): R25.
42. Vasiliou V, Pappa A, Petersen DR. Role of aldehyde dehydrogenases in endogenous and xenobiotic metabolism. Chem Biol Interact 2000; 129(1-2): 1-19.
43. Duester G, Mic FA, Molotkov A. Cytosolic retinoid dehydrogenases govern ubiquitous metabolism of retinol to retinaldehyde followed by tissue-specific metabolism to retinoic acid. Chem Biol Interact 2003; 143-144: 201-210.
44. Armstrong L, Stojkovic M, Dimmick I, et al. Phenotypic Characterization of Murine Primitive Hematopoietic Progenitor Cells Isolated on Basis of Aldehyde Dehydrogenase Activity. Stem Cells 2004; 22(7): 1142-51.
45. Hess DA, Meyerrose TE, Wirthlin L, et al. Functional characterization of highly purified human hematopoietic repopulating cells isolated according to aldehyde dehydrogenase activity. Blood 2004; 104(6): 1648-55.
46. Corti S, Locatelli F, Papadimitriou D, et al. Identification of a Primitive Brain-Derived Neural Stem Cell Population Based on Aldehyde Dehydrogenase Activity. Stem Cells 2006; 24(4): 975-985.
47. Clay MR, Tabor M, Owen JH, et al. Single-marker identification of head and neck squamous cell carcinoma cancer stem cells with aldehyde dehydrogenase. Head Neck 2010; 32(9): 1195-1201.
48. Kim MP, Fleming JB, Wang H, et al. ALDH Activity Selectively Defines an Enhanced Tumor-Initiating Cell Population Relative to CD133 Expression in Human Pancreatic Adenocarcinoma. PLoS ONE 2011; 6(6): e20636.
49. Silva IA, Bai S, McLean K, et al. Aldehyde Dehydrogenase in Combination with CD133 Defines Angiogenic Ovarian Cancer Stem Cells That Portend Poor Patient Survival. Cancer Res 2011; 71(11): 3991-4001.
50. Li C, Heidt DG, Dalerba P, et al. Identification of Pancreatic Cancer Stem Cells. Cancer Res 2007; 67(3): 1030-7.
51. Charafe-Jauffret E, Ginestier C, Iovino F, et al. Breast cancer cell lines contain functional cancer stem cells with metastatic capacity and a distinct molecular signature. Cancer Res 2009; 69(4): 1302-13.
52. Bez A, Corsini E, Curti D, et al. Neurosphere and neurosphereforming cells: morphological and ultrastructural characterization. Brain Res 2003; 993(1-2): 18-29.
53. Clement V, Sanchez P, de Tribolet N, Radovanovic I, Ruiz i Altaba A. HEDGEHOG-GLI1 Signaling Regulates Human Glioma Growth, Cancer Stem Cell Self-Renewal, and Tumorigenicity. Curr Biol 2007; 17(2): 165-72.
54. Ponti D, Costa A, Zaffaroni N, et al. Isolation and In vitro Propagation of Tumorigenic Breast Cancer Cells with Stem/Progenitor Cell Properties. Cancer Res 2005; 65(13): 5506-11.
55. Li Y, Zhang T, Korkaya H, et al. Sulforaphane, a dietary component of broccoli/broccoli sprouts, inhibits breast cancer stem cells. Clin Cancer Res 2010; 16(9): 2580-90.
56. Charafe-Jauffret E, Ginestier C, Birnbaum D. Breast cancer stem cells: tools and models to rely on. BMC Cancer 2009; 9: 202.
57. Singh SK, Clarke ID, Terasaki M, et al. Identification of a cancer stem cell in human brain tumors. Cancer Res 2003; 63(18): 5821-8.
58. Singh AV, Xiao D, Lew KL, Dhir R, Singh SV. Sulforaphane induces caspase-mediated apoptosis in cultured PC-3 human prostate cancer cells and retards growth of PC-3 xenografts in vivo. Carcinogenesis 2004; 25(1): 83-90.
59. Dalerba P, Dylla SJ, Park IK, et al. Phenotypic characterization of human colorectal cancer stem cells. Proc Natl Acad Sci USA 2007; 104(24): 10158-63.
60. Clay MR, Tabor M, Owen JH, et al. Single-marker identification of head and neck squamous cell carcinoma cancer stem cells with aldehyde dehydrogenase. Head Neck 2010; 32(9): 1195-1201.
61. Prince ME, Sivanandan R, Kaczorowski A, et al. Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma. Proc Natl Acad Sci USA 2007; 104(3): 973-978.
62. Patrawala L, Calhoun T, Schneider-Broussard R, et al. Highly purified CD44+ prostate cancer cells from xenograft human tumors are enriched in tumorigenic and metastatic progenitor cells. Oncogene 2006; 25(12): 1696-1708.
63. Kryczek I, Liu S, Roh M, et al. Expression of aldehyde dehydrogenase and CD133 defines ovarian cancer stem cells. Int J Cancer 2012; 130(1): 29-39.
64. Willert K, Brown JD, Danenberg E, et al. Wnt proteins are lipidmodified and can act as stem cell growth factors. Nature 2003; 423(6938): 448-52.
65. Reya T, Duncan AW, Ailles L, et al. A role for Wnt signalling in self-renewal of haematopoietic stem cells. Nature 2003; 423(6938): 409-14.
66. Barker N, van Es JH, Kuipers J, et al. Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature 2007; 449(7165): 1003-7.
67. Barker N, Huch M, Kujala P, et al. Lgr5(+ve) Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In vitro. Cell Stem Cell 2010; 6(1): 25-36.
68. Zeng YA, Nusse R. Wnt Proteins Are Self-Renewal Factors for Mammary Stem Cells and Promote Their Long-Term Expansion in Culture. Cell Stem Cell 2010; 6(6): 568-77.
69. Miyake K, Medina KL, Hayashi S, Ono S, Hamaoka T, Kincade PW. Monoclonal antibodies to Pgp-1/CD44 block lymphohemopoiesis in long-term bone marrow cultures. J Exp Med 1990; 171(2): 477-88.
70. Wielenga VJ, Smits R, Korinek V, et al. Expression of CD44 in Apc and Tcf Mutant Mice Implies Regulation by the WNT Pathway. Am J Pathol 1999; 154(2): 515-523.
71. Sy MS, Guo YJ, Stamenkovic I. Inhibition of tumor growth in vivo with a soluble CD44-immunoglobulin fusion protein. J Exp Med 1992; 176(2): 623-627.
72. Müller-Tidow C, Steffen B, Cauvet T, et al. Translocation Products in Acute Myeloid Leukemia Activate the Wnt Signaling Pathway in Hematopoietic Cells. Mol Cell Biol 2004; 24(7): 2890-2904.
73. Lu D, Zhao Y, Tawatao R, et al. Activation of the Wnt signaling pathway in chronic lymphocytic leukemia. Proc Natl Acad Sci USA 2004; 101(9): 3118-3123.
74. Kinzler KW, Vogelstein B. Lessons from Hereditary Colorectal Cancer. Cell 1996; 87(2): 159-70.
75. Cho RW, Wang X, Diehn M, et al. Isolation and Molecular Characterization of Cancer Stem Cells in MMTV-Wnt-1 Murine Breast Tumors. Stem Cells 2008; 26(2): 364-371.
76. Reya T, Clevers H. Wnt signalling in stem cells and cancer. Nature 2005; 434(7035): 843-850.
77. Polakis P. Wnt signaling and cancer. Genes Dev 2000; 14(15): 1837-1851.
78. Klaus A, Birchmeier W. Wnt signalling and its impact on development and cancer. Nat Rev Cancer 2008; 8(5): 387-98.
79. Gao C, Chen YG. Dishevelled: The hub of Wnt signaling. Cell Signal 2010; 22(5): 717-27.
80. Bernatik O, Ganji RS, Dijksterhuis JP, et al. Sequential activation and inactivation of dishevelled in the Wnt/beta-catenin pathway by casein kinases. J Biol Chem 2011; 286(12): 10396-410.
81. Pradeep CR, Kuttan G. Effect of piperine on the inhibition of lung metastasis induced B16F-10 melanoma cells in mice. Clin Exp Metastasis 2002; 19(8): 703-8.
82. Selvendiran K, Banu SM, Sakthisekaran D. Protective effect of piperine on benzo(a)pyrene-induced lung carcinogenesis in Swiss albino mice. Clin Chim Acta 2004; 350(1-2): 73-8.
83. Kakarala M, Brenner DE, Korkaya H, et al. Targeting breast stem cells with the cancer preventive compounds curcumin and piperine. Breast Cancer Res Treat 2010; 122(3): 777-85.
84. Lepourcelet M, Chen YN, France DS, et al. Small-molecule antagonists of the oncogenic Tcf/β-catenin protein complex. Cancer Cell 2004; 5(1): 91-102.
85. Mani SA, Guo W, Liao MJ, Eaton EN, et al. The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells. Cell 2008; 133(4): 704-15.
86. Basler K, Struhl G. Compartment boundaries and the control of Drosopfiffa limb pattern by hedgehog protein. Nature 1994; 368(6468): 208-14.
87. Echelard Y, Epstein DJ, St-Jacques B, et al. Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell 1993; 75(7): 1417-30.
88. Lewis MT, Ross S, Strickland PA, et al. The Gli2 Transcription Factor Is Required for Normal Mouse Mammary Gland Development. Dev Biol 2001; 238(1): 133-44.
89. Palma V, Ruiz i Altaba A. Hedgehog-GLI signaling regulates the behavior of cells with stem cell properties in the developing neocortex. Development 2004; 131(2): 337-45.
90. Palma V, Lim DA, Dahmane N, et al. Sonic hedgehog controls stem cell behavior in the postnatal and adult brain. Development 2005; 132(2): 335-44.
91. Ramalho-Santos M, Melton DA, McMahon AP. Hedgehog signals regulate multiple aspects of gastrointestinal development. Development 2000; 127(12): 2763-72.
92. Liu S, Dontu G, Mantle ID, et al. Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells. Cancer Res 2006; 66(12): 6063-71.
93. Marini KD, Payne BJ, Watkins DN, Martelotto LG. Mechanisms of Hedgehog signalling in cancer. Growth Factors 2011; 29(6): 221-234.
94. Theunissen JW, de Sauvage FJ. Paracrine Hedgehog Signaling in Cancer. Cancer Res 2009; 69(15): 6007-6010.
95. Wang Y, McMahon AP, Allen BL. Shifting paradigms in Hedgehog signaling. Curr Opin Cell Biol 2007; 19(2): 159-165.
96. Chen JK, Taipale J, Cooper MK, Beachy PA. Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened. Genes Dev 2002; 16(21): 2743-2748.
97. Bar EE, Chaudhry A, Lin A, et al. Cyclopamine-Mediated Hedgehog Pathway Inhibition Depletes Stem-Like Cancer Cells in Glioblastoma. Stem Cells 2007; 25(10): 2524-2533.
98. Mueller MT, Hermann PC, Witthauer J, et al. Combined Targeted Treatment to Eliminate Tumorigenic Cancer Stem Cells in Human Pancreatic Cancer. Gastroenterology 2009; 137(3): 1102-1113.
99. Artavanis-Tsakonas S, Rand MD, Lake RJ. Notch signaling: cell fate control and signal integration in development. Science 1999; 284(5415): 770-806.
100. Cabrera CV. Lateral inhibition and cell fate during neurogenesis in Drosophila: the interactions between scute, Notch and Delta. Development 1990; 110(1): 733-742.
101. Lewis J. Notch signalling and the control of cell fate choices in vertebrates. Semin Cell Dev Biol 1998; 9(6): 583-589.
102. Cagan RL, Ready DF. Notch is required for successive cell decisions in the developing Drosophila retina. Genes Dev 1989; 3(8): 1099-1112.
103. Claxton S, Fruttiger M. Periodic Delta-like 4 expression in developing retinal arteries. Gene Expr Patterns 2004; 5(1): 123-127.
104. Hellström M, Phng LK, Hofmann JJ, et al. Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis. Nature 2007; 445(7129): 776-780.
105. Bray SJ. Notch signalling: a simple pathway becomes complex. Nat Rev Mol Cell Biol 2006; 7(9): 678-689.
106. Kopan R, Ilagan MX. The canonical Notch signaling pathway: unfolding the activation mechanism. Cell 2009; 137(2): 216-233.
107. Fortini ME. Notch signaling: the core pathway and its posttranslational regulation. Dev Cell 2009; 16(5): 633-647.
108. Reedijk M, Odorcic S, Chang L, et al. High-level coexpression of JAG1 and NOTCH1 is observed in human breast cancer and is associated with poor overall survival. Cancer Res 2005; 65(18): 8530-8537.
109. Dickson BC, Mulligan AM, Zhang H, et al. High-level JAG1 mRNA and protein predict poor outcome in breast cancer. Mod Pathol 2007; 20(6): 685-693.
110. Reedijk M, Pinnaduwage D, Dickson BC, et al. JAG1 expression is associated with a basal phenotype and recurrence in lymph nodenegative breast cancer. Breast Cancer Res Treat 2008; 111(3): 439-448.
111. Pece S, Serresi M, Santolini E, et al. Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis. J Cell Biol 2004; 167(2): 215-221.
112. Ellisen LW, Bird J, West DC, et al. TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. Cell 1991; 66(4): 649-661.
113. Weng AP, Ferrando AA, Lee W, et al. Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science 2004; 306(5694): 269-271.
114. Ranganathan P, Weaver KL, Capobianco AJ. Notch signalling in solid tumours: a little bit of everything but not all the time. Nat Rev Cancer 2011; 11(5): 338-351.
115. Cohen B, Shimizu M, Izrailit J, et al. Cyclin D1 is a direct target of JAG1-mediated Notch signaling in breast cancer. Breast Cancer Res Treat 2010; 123(1): 113-124.
116. Sharma VM, Calvo JA, Draheim KM, et al. Notch1 contributes to mouse T-cell leukemia by directly inducing the expression of cmyc. Mol Cell Biol 2006; 26(21): 8022-8031.
117. Weng AP, Millholland JM, Yashiro-Ohtani Y, et al. C-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/ lymphoma. Genes Dev 2006; 20(15): 2096-20109.
118. Murata J, Ohtsuka T, Tokunaga A, et al. Notch-Hes1 pathway contributes to the cochlear prosensory formation potentially through the transcriptional down-regulation of p27Kip1. J Neurosci Res 2009; 87(16): 3521-3534.
119. Monahan P, Rybak S, Raetzman LT. The notch target gene HES1 regulates cell cycle inhibitor expression in the developing pituitary. Endocrinology 2009; 150(9): 4386-4394.
120. Riccio O, van Gijn ME, Bezdek AC, et al. Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2. EMBO Rep 2008; 9(4): 377-383.
121. Palomero T, Dominguez M, Ferrando AA. The role of the PTEN/AKT Pathway in NOTCH1-induced leukemia. Cell Cycle 2008; 7(8): 965-970.
122. Ristorcelli E, Beraud E, Mathieu S, Lombardo D, Verine A. Essential role of Notch signaling in apoptosis of human pancreatic tumoral cells mediated by exosomal nanoparticles. Int J Cancer 2009; 125(5): 1016-1026.
123. Wang Z, Li Y, Banerjee S, Kong D, et al. Down-regulation of Notch-1 and Jagged-1 inhibits prostate cancer cell growth, migration and invasion, and induces apoptosis via inactivation of Akt, mTOR, and NF-kappaB signaling pathways. J Cell Biochem 2010; 109(4): 726-736.
124. Dontu G, Jackson KW, McNicholas E, Kawamura MJ, Abdallah WM, Wicha MS. Role of Notch signaling in cell-fate determination of human mammary stem/progenitor cells. Breast Cancer Res 2004; 6(6): R605-R615.
125. Pistollato F, Rampazzo E, Persano L, et al. Interaction of hypoxiainducible factor-1alpha and Notch signaling regulates medulloblastoma precursor proliferation and fate. Stem Cells 2010; 28(11): 1918-1929.
126. Farnie G, Clarke RB. Mammary stem cells and breast cancer--role of Notch signalling. Stem Cell Rev 2007; 3(2): 169-175.
127. Farnie G, Clarke RB, Spence K, et al. Novel cell culture technique for primary ductal carcinoma in situ: role of Notch and epidermal growth factor receptor signaling pathways. J Natl Cancer Inst 2007; 99(8): 616-627.
128. Leong KG, Niessen K, Kulic I, et al. Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin. J Exp Med 2007; 204(12): 2935-2948.
129. Wang Z, Zhang Y, Banerjee S, Li Y, Sarkar FH. Notch-1 downregulation by curcumin is associated with the inhibition of cell growth and the induction of apoptosis in pancreatic cancer cells. Cancer 2006; 106(11): 2503-2513.
130. Wang Z, Zhang Y, Banerjee S, Li Y, Sarkar FH. Inhibition of nuclear factor kappab activity by genistein is mediated via Notch-1 signaling pathway in pancreatic cancer cells. Int J Cancer 2006; 118(8): 1930-1936.
131. Wang Z, Zhang Y, Li Y, Banerjee S, Liao J, Sarkar FH. Downregulation of Notch-1 contributes to cell growth inhibition and apoptosis in pancreatic cancer cells. Mol Cancer Ther 2006; 5(3): 483-4893.
132. Cecchinato V, Chiaramonte R, Nizzardo M, et al. Resveratrolinduced apoptosis in human T-cell acute lymphoblastic leukaemia MOLT-4 cells. Biochem Pharmacol 2007; 74(11): 1568-1574.
133. Koduru S, Kumar R, Srinivasan S, Evers MB, Damodaran C. Notch-1 inhibition by Withaferin-A: a therapeutic target against colon carcinogenesis. Mol Cancer Ther 2010; 9(1): 202-210.
134. Wang XN, Wu Q, Yang X, Zhang LS, Wu YP, Lu C. Effects of Celastrol on growth inhibition of U937 leukemia cells through the regulation of the Notch1/NF-kappaB signaling pathway in vitro. Chin J Cancer 2010; 29(4): 385-390.
135. Sansal I, Sellers WR. The Biology and Clinical Relevance of the PTEN Tumor Suppressor Pathway. J Clin Oncol 2004; 22(14): 2954-2963.
136. Cross DA, Alessi DR, Cohen P, Andjelkovich M, Hemmings BA. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 1995; 378(6559): 785-789.
137. Korkaya H, Paulson A, Charafe-Jauffret E, et al. Regulation of mammary stem/progenitor cells by PTEN/Akt/beta-catenin signaling. PLoS Biol 2009; 7(6): e1000121.
138. Supko JG, Hickman RL, Grever MR, Malspeis L. Preclinical pharmacologic evaluation of geldanamycin as an antitumor agent. Cancer Chemother and Pharmacol 1995; 36(4): 305-15.
139. Schulte TW, Neckers LM. The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin. Cancer Chemother Pharmacol 1998; 42(4): 273-9.
140. Sauvageot CM, Weatherbee JL, Kesari S, et al. Efficacy of the HSP90 inhibitor 17-AAG in human glioma cell lines and tumorigenic glioma stem cells. Neuro Oncol 2009; 11(2): 109-21.
141. Li Y, Zhang T, Schwartz SJ, Sun D. Sulforaphane Potentiates the Efficacy of 17-Allylamino 17-Demethoxygeldanamycin Against Pancreatic Cancer Through Enhanced Abrogation of Hsp90 Chaperone Function. Nutr Cancer 2011; 63(7): 1151-9.
142. Guzman ML, Neering SJ, Upchurch D, et al. Nuclear factorkappaB is constitutively activated in primitive human acute myelogenous leukemia cells. Blood 2001; 98(8): 2301-7.
143. Liu S, Ginestier C, Ou SJ, et al. Breast Cancer Stem Cells Are Regulated by Mesenchymal Stem Cells through Cytokine Networks. Cancer Res 2011; 71(2): 614-24.
144. Korkaya H, Liu S, Wicha MS. Regulation of Cancer Stem Cells by Cytokine Networks: Attacking Cancer's Inflammatory Roots. Clin Cancer Res 2011; 17(19): 6125-9.
145. Ginestier C, Liu S, Diebel ME, et al. CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts. J Clin Invest 2010; 120(2): 485-97.
146. Guzman ML, Rossi RM, Karnischky L, et al. The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cells. Blood 2005; 105(11): 4163-9.
147. Keith B, Simon MC. Hypoxia-Inducible Factors, Stem Cells, and Cancer. Cell 2007; 129(3): 465-72.
148. Wang Y, Liu Y, Malek SN, Zheng P, Liu Y. Targeting HIF1a Eliminates Cancer Stem Cells in Hematological Malignancies. Cell Stem Cell 2011; 8(4): 399-411.
149. Kong D, Park EJ, Stephen AG, et al. Echinomycin, a Small-Molecule Inhibitor of Hypoxia-Inducible Factor-1 DNA-Binding Activity. Cancer Res 2005; 65(19): 9047-55.
150. Muss HB, Blessing JA, Malfetano J. Echinomycin (NSC 526417) in squamous-cell carcinoma of the cervix. A phase II trial of the gynecologic oncology group. Am J Clin Oncol 1990; 13(3): 191-3.
151. Kallifatidis G, Labsch S, Rausch V, et al. Sulforaphane Increases Drug-mediated Cytotoxicity Toward Cancer Stem-like Cells of Pancreas and Prostate. Mol Ther 2011; 19(1): 188-95.
152. Feldmann G, Dhara S, Fendrich V, et al. Blockade of Hedgehog Signaling Inhibits Pancreatic Cancer Invasion and Metastases: A New Paradigm for Combination Therapy in Solid Cancers. Cancer Res 2007; 67(5): 2187-96.
153. Juge N, Mithen R, Traka M. Molecular basis for chemoprevention by sulforaphane: a comprehensive review. Cell Mol Life Sci 2007; 64(9): 1105-27.
154. Choi JS, Choi HK, Shin SC. Enhanced bioavailability of paclitaxel after oral coadministration with flavone in rats. Int J Pharm 2004; 275(1-2): 165-70.
155. Shoba G, Joy D, Joseph T, Majeed M, Rajendran R, Srinivas PS. Influence of Piperine on the Pharmacokinetics of Curcumin in Animals and Human Volunteers. Planta Med 1998; 64(4): 353-6.