Stem cells in drug screening for neurodegenerative disease

Korean Journal of Physiology and Pharmacology

Volumn 16, Issue 1, 2012, Pages 1-9

  Kim, Hyun Jung ^a   Jin, Chang Yun ^a  

^a Chung Ang University   (South Korea)

Author keywords

Drug screening; ES cells; IPS; Neurodegeneration; Stem cells

Indexed keywords

NATURAL PRODUCT;

CELL DIFFERENTIATION; CELL FATE; CELL PROLIFERATION; CELL SURVIVAL; DEGENERATIVE DISEASE; DRUG SCREENING; EMBRYONIC STEM CELL; GLIA CELL; HUMAN; MULTIPOTENT STEM CELL; NERVOUS SYSTEM DEVELOPMENT; NEURAL STEM CELL; NONHUMAN; PLURIPOTENT STEM CELL; REVIEW; STEM CELL; TOXICITY TESTING;

EID: 84863348754     PISSN: 12264512     EISSN: None     Source Type: Journal    
DOI: 10.4196/kjpp.2012.16.1.1     Document Type: Review

References (115)

1. Kim HJ. Stem cell potential in Parkinson's disease and molecular factors for the generation of dopamine neurons. Biochim Biophys Acta. 2011;1812:1-11.
2. Jones JM, Thomson JA Human embryonic stem cell technology. Semin Reprod Med. 2000;18:219-223. (Pubitemid 32183221)
3. Studer L, Tabar V, McKay RD. Transplantation of expanded mesencephalic precursors leads to recovery in parkinsonian rats. Nat Neurosci. 1998;1:290-295.
4. Sánchez-Pernaute R, Studer L, Bankiewicz KS, Major EO, McKay RD. In vitro generation and transplantation of precursor-derived human dopamine neurons. J Neurosci Res. 2001;65:284-288. (Pubitemid 32727029)
5. Levy YS, Stroomza M, Melamed E, Offen D. Embryonic and adult stem cells as a source for cell therapy in Parkinson's disease. J Mol Neurosci. 2004;24:353-386.
6. Chen LW, Kuang F, Wei LC, Ding YX, Yung KK, Chan YS. Potential application of induced pluripotent stem cells in cell replacement therapy for Parkinson's disease. CNS Neurol Disord Drug Targets. 2011;10:449-458.
7. Lindvall O, Kokaia Z. Stem cell therapy for human brain disorders. Kidney Int. 2005;68:1937-1939. (Pubitemid 43117765)
8. Germain N, Banda E, Grabel L. Embryonic stem cell neurogenesis and neural specification. J Cell Biochem. 2010;111:535-542.
9. Fraichard A, Chassande O, Bilbaut G, Dehay C, Savatier P, Samarut J. In vitro differentiation of embryonic stem cells into glial cells and functional neurons. J Cell Sci. 1995;108:3181-3188.
10. Kehat I, Kenyagin-Karsenti D, Snir M, Segev H, Amit M, Gepstein A, Livne E, Binah O, Itskovitz-Eldor J, Gepstein L. Human embryonic stem cells can differentiate into myocytes with structural and functional properties of cardiomyocytes. J Clin Invest. 2001;108:407-414. (Pubitemid 32730787)
11. Xu C, Police S, Rao N, Carpenter MK. Characterization and enrichment of cardiomyocytes derived from human embryonic stem cells. Circ Res. 2002;91:501-508.
12. Mummery C, Ward-van Oostwaard D, Doevendans P, Spijker R, van den Brink S, Hassink R, van der Heyden M, Opthof T, Pera M, de la Riviere AB, Passier R, Tertoolen L. Differentiation of human embryonic stem cells to cardiomyocytes: role of coculture with visceral endoderm-like cells. Circulation. 2003;107:2733-2740. (Pubitemid 36667249)
13. Noguchi H. Production of pancreatic beta-cells from stem cells. Curr Diabetes Rev. 2010;6:184-190.
14. Shi Y. Generation of functional insulin-producing cells from human embryonic stem cells in vitro. Methods Mol Biol. 2010;636:79-85.
15. Chen C, Zhang Y, Sheng X, Huang C, Zang YQ. Differentiation of embryonic stem cells towards pancreatic progenitor cells and their transplantation into streptozotocin-induced diabetic mice. Cell Biol Int. 2008;32:456-461.
16. Yamamoto H, Quinn G, Asari A, Yamanokuchi H, Teratani T, Terada M, Ochiya T. Differentiation of embryonic stem cells into hepatocytes: biological functions and therapeutic application. Hepatology. 2003;37:983-993. (Pubitemid 36538675)
17. Teratani T, Yamamoto H, Aoyagi K, Sasaki H, Asari A, Quinn G, Sasaki H, Terada M, Ochiya T. Direct hepatic fate specification from mouse embryonic stem cells. Hepatology. 2005;41:836-846. (Pubitemid 40462947)
18. Van Haute L, De Block G, Liebaers I, Sermon K, De Rycke M. Generation of lung epithelial-like tissue from human embryonic stem cells. Respir Res. 2009;10:105.
19. Wang D, Haviland DL, Burns AR, Zsigmond E, Wetsel RA. A pure population of lung alveolar epithelial type II cells derived from human embryonic stem cells. Proc Natl Acad Sci USA. 2007;104:4449-4454. (Pubitemid 47186246)
20. Yamamoto M, Tachibana T, Hashimoto H, Ishiwata I, Ishikawa H. The differentiation of early embryonic stem cells into adipocytes-like cells. Hum Cell. 2003;16:117-122.
21. Kim HJ, Rosenfeld MG. Epigenetic control of stem cell fate to neurons and glia. Arch Pharm Res. 2010;33:1467-1473.
22. Thomson JA, Itskovitz-Eldor J, Shapiro SS, Waknitz MA, Swiergiel JJ, Marshall VS, Jones JM. Embryonic stem cell lines derived from human blastocysts. Science. 1998;282:1145-1147. (Pubitemid 28516247)
23. Suemori H. Establishment and therapeutic use of human embryonic stem cell lines. Hum Cell. 2006;19:65-70.
24. Gepstein L. Derivation and potential applications of human embryonic stem cells. Circ Res. 2002;91:866-876. (Pubitemid 35373586)
25. Reubinoff BE, Pera MF, Fong CY, Trounson A, Bongso A. Embryonic stem cell lines from human blastocysts: somatic differentiation in vitro. Nat Biotechnol. 2000;18:399-404. (Pubitemid 30217526)
26. Pera MF, Reubinoff B, Trounson A. Human embryonic stem cells. J Cell Sci. 2000;113:5-10. (Pubitemid 30066328)
27. Lim JM, Lee M, Lee EJ, Gong SP, Lee ST. Stem cell engineering: limitation, alternatives, and insight. Ann NY Acad Sci. 2011;1229:89-98.
28. Hyun I. The bioethics of stem cell research and therapy. J Clin Invest. 2010;120:71-75.
29. Tasso R, Pennesi G. When stem cells meet immunoregulation. Int Immunopharmacol. 2009;9:596-598.
30. Cabrera CM, Cobo F, Nieto A, Concha A. Strategies for preventing immunologic rejection of transplanted human embryonic stem cells. Cytotherapy. 2006;8:517-518. (Pubitemid 44597004)
31. Usas A, Mačiulaitis J, Mačiulaitis R, Jakubonienė N, Milašius A, Huard J. Skeletal muscle-derived stem cells: Implications for cell-mediated therapies. Medicina (Kaunas). 2011;47:469-479.
32. Frati C, Savi M, Graiani G, Lagrasta C, Cavalli S, Prezioso L, Rossetti P, Mangiaracina C, Ferraro F, Madeddu D, Musso E, Stilli D, Rossini A, Falco A, Angelis AD, Rossi F, Urbanek K, Leri A, Kajstura J, Anversa P, Quaini E, Quaini F. Resident cardiac stem cells. Curr Pharm Des. 2011;17:3252-3257.
33. Fun E, Brinton TJ. Bone marrow stem cells for the treatment of ischemic heart disease: a clinical trial review. J Cardiovasc Transi Res. 2009;2:202-218.
34. Chugh AR, Zuba-Surma EK, Dawn B. Bone marrow-derived mesenchymal stems cells and cardiac repair. Minerva Cardioangiol. 2009;57:185-202.
35. Woo DH, Kim SK, Lim HJ, Heo J, Park HS, Kang GY, Kim SE, You HJ, Hoeppner DJ, Kim Y, Kwon H, Choi TH, Lee JH, Hong SH, Song KW, Ann EK, Chenoweth JG, Tesar PJ, McKay RD, Kim JH. Direct and indirect contribution of human embryonic stem cell-derived hepatocyte-like cells to liver repair in mice. Gastroenterology. http://dx.doi.org/10.1053/j.gastro.2011.11.030.
36. Turner R, Lozoya O, Wang Y, Cardinale V, Gaudio E, Alpini G, Mendel G, Wauthier E, Barbier C, Alvaro D, Reid LM. Human hepatic stem cell and maturational liver lineage biology. Hepatology. 2011;53:1035-1045.
37. Grisar JC, Haddad F, Gomari FA, Wu JC. Endothelial progenitor cells in cardiovascular disease and chronic inflammation: from biomarker to therapeutic agent. Biomark Med. 2011;5: 731-744.
38. Gage FH. Mammalian neural stem cells. Science. 2000;287:1433-1438. (Pubitemid 30127128)
39. Kim HJ, McMillan E, Han F, Svendsen CN. Regionally specified human neural progenitor cells derived from the mesencephalon and forebrain undergo increased neurogenesis following overexpression of ASCL1. Stem Cells. 2009;27:390-398.
40. Kim HJ, Sugimori M, Nakafuku M, Svendsen CN. Control of neurogenesis and tyrosine hydroxylase expression in neural progenitor cells through bHLH proteins and Nurr1. Exp Neurol. 2007;203:394-405. (Pubitemid 46149589)
41. Holowacz T, Huelsken J, Dufort D, van der Kooy D. Neural stem cells are increased after loss of β-catenin, but neural progenitors undergo cell death. Eur J Neurosci. 2011;33:1366-1375.
42. Hsu YC, Lee DC, Chiu IM. Neural stem cells, neural progenitors, and neurotrophic factors. Cell Transplant. 2007;16:133-150.
43. Jepsen K, Solum D, Zhou T, McEvilly RJ, Kim HJ, Glass CK, Hermanson O, Rosenfeld MG. SMRT-mediated repression of an H3K27 demethylase in progression from neural stem cell to neuron. Nature. 2007;450:415-419. (Pubitemid 350126746)
44. Abematsu M, Smith I, Nakashima K. Mechanisms of neural stem cell fate determination: extracellular cues and intracellular programs. Curr Stem Cell Res Ther. 2006;1:267-277.
45. Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006;126:663-676. (Pubitemid 44233629)
46. Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, Yamanaka S. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell. 2007;131:861-872. (Pubitemid 350138099)
47. Kim JB, Zaehres H, Wu G, Gentile L, Ko K, Sebastiano V, Arauzo-Bravo MJ, Ruau D, Han DW, Zenke M, Schöler HR Pluripotent stem cells induced from adult neural stem cells by reprogramming with two factors. Nature. 2008;454:646-650.
48. Liao J, Wu Z, Wang Y, Cheng L, Cui C, Gao Y, Chen T, Rao L, Chen S, Jia N, Dai H, Xin S, Kang J, Pei G, Xiao L. Enhanced efficiency of generating induced pluripotent stem (iPS) cells from human somatic cells by a combination of six transcription factors. Cell Res. 2008;18:600-603. (Pubitemid 351630949)
49. Durnaoglu S, Genc S, Genc K. Patient-specific pluripotent stem cells in neurological diseases. Stem Cells Int. 2011;2011:212487.
50. Soldner F, Hockemeyer D, Beard C, Gao Q, Bell GW, Cook EG, Hargus G, Blak A, Cooper O, Mitalipova M, Isacson O, Jaenisch R. Parkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factors. Cell. 2009;136:964-977.
51. Saporta MA, Grskovic M, Dimos JT. Induced pluripotent stem cells in the study of neurological diseases. Stem Cell Res Ther. 2011;2:37.
52. Dimos JT, Rodolfa KT, Niakan KK, Weisenthal LM, Mitsumoto H, Chung W, Croft GF, Saphier G, Leibel R, Goland R, Wichterle H, Henderson CE, Eggan K. Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons. Science. 2008;321:1218-1221.
53. Ebert AD, Yu J, Rose FF Jr, Mattis VB, Lorson CL, Thomson JA, Svendsen CN. Induced pluripotent stem cells from a spinal muscular atrophy patient. Nature. 2009;457:277-280.
54. Ebert AD, Svendsen CN. Human stem cells and drug screening: opportunities and challenges. Nat Rev Drug Discov. 2010;9:367-372.
55. Lian Q, Chow Y, Esteban MA, Pei D, Tse HF. Future perspective of induced pluripotent stem cells for diagnosis, drug screening and treatment of human diseases. Thromb Haemost. 2010;104:39-44.
56. Maury Y, Gauthier M, Peschanski M, Martinat C. Human pluripotent stem cells for disease modelling and drug screening. Bioessays. 2012;34:61-71.
57. Rowntree RK, McNeish JD. Induced pluripotent stem cells: opportunities as research and development tools in 21st century drug discovery. Regen Med. 2010;5:557-568.
58. Trosko JE, Chang CC. Factors to consider in the use of stem cells for pharmaceutic drug development and for chemical safety assessment. Toxicology. 2010;270:18-34.
59. Redmond DE Jr, Sladek JR, Spencer DD. Transplantation of embryonic dopamine neurons for severe Parkinson's disease. N Engl J Med. 2001;345:146-147. (Pubitemid 32634577)
60. Dunnett SB. Transplantation of embryonic dopamine neurons: what we know from rats. J Neurol. 1991;238:65-74.
61. Freed CR, Greene PE, Breeze RE, Tsai WY, DuMouchel W, Kao R, Dillon S, Winfield H, Culver S, Trojanowski JQ, Eidelberg D, Fahn S. Transplantation of embryonic dopamine neurons for severe Parkinson's disease. N Engl J Med. 2001;344:710-719. (Pubitemid 32204988)
62. Olanow CW, Freeman T, Kordower J. Transplantation of embryonic dopamine neurons for severe Parkinson's disease. N Engl J Med. 2001;345:146.
63. Visnyei K, Onodera H, Damoiseaux R, Saigusa K, Petrosyan S, De Vries D, Ferrari D, Saxe J, Panosyan EH, Masterman-Smith M, Mottahedeh J, Bradley KA, Huang J, Sabatti C, Nakano I, Kornblum HI. A molecular screening approach to identify and characterize inhibitors of glioblastoma stem cells. Mol Cancer Ther. 2011;10:1818-1828.
64. Inamdar AA, Moore JC, Cohen RI, Bennett JW. A model to evaluate the cytotoxicity of the fungal volatile organic compound 1-octen-3-o1 in human embryonic stem cells. Mycopathologia. 2012;173:13-20.
65. Takahashi J, Palmer TD, Gage FH. Retinoic acid and neurotrophins collaborate to regulate neurogenesis in adult-derived neural stem cell cultures. J Neurobiol. 1999;38:65-81. (Pubitemid 29016815)
66. Rohwedel J, Guan K, Wobus AM. Induction of cellular differentiation by retinoic acid in vitro. Cells Tissues Organs. 1999;165:190-202.
67. Kim HJ, Leeds P, Chuang DM. The HDAC inhibitor, sodium butyrate, stimulates neurogenesis in the ischemic brain. J Neurochem. 2009;110:1226-1240.
68. Yoo DY, Kim W, Nam SM, Kim DW, Chung JY, Choi SY, Yoon YS, Won MH, Hwang IK Synergistic effects of sodium butyrate, a histone deacetylase inhibitor, on increase of neurogenesis induced by pyridoxine and increase of neural proliferation in the mouse dentate gyrus. Neurochem Res. 2011;36:1850-1857.
69. Hsieh J, Nakashima K, Kuwabara T, Mejia E, Gage FH. Histone deacetylase inhibition-mediated neuronal differentiation of multipotent adult neural progenitor cells. Proc Natl Acad Sci USA. 2004;101:16659-16664. (Pubitemid 39557769)
70. Lennington JB, Yang Z, Conover JC. Neural stem cells and the regulation of adult neurogenesis. Reprod Biol Endocrinol. 2003;1:99.
71. Kuhn HG, Dickinson-Anson H, Gage FH. Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation. J Neurosci. 1996;16:2027-2033. (Pubitemid 26144015)
72. García-Verdugo JM, Doetsch F, Wichterle H, Lim DA, Alvarez-Buylla A. Architecture and cell types of the adult subventricular zone: in search of the stem cells. J Neurobiol. 1998;36:234-248. (Pubitemid 28363234)
73. Pencea V, Bingaman KD, Freedman LJ, Luskin MB. Neurogenesis in the subventricular zone and rostral migratory stream of the neonatal and adult primate forebrain. Exp Neurol. 2001;172:1-16. (Pubitemid 33141150)
74. Rishton GM. Small molecules that promote neurogenesis in vitro. Recent Pat CNS Drug Discov. 2008;3:200-208.
75. Taupin P. Neurogenic drugs and compounds. Recent Pat CNS Drug Discov. 2010;5:253-257.
76. Malberg JE, Duman RS. Cell proliferation in adult hippocampus is decreased by inescapable stress: reversal by fluoxetine treatment. Neuropsychopharmacology. 2003;28:1562-1571. (Pubitemid 41070856)
77. Chadwick W, Mitchell N, Caroll J, Zhou Y, Park SS, Wang L, Becker KG, Zhang Y, Lehrmann E, Wood WH 3rd, Martin B, Maudsley S. Amitriptyline-mediated cognitive enhancement in aged 3xTg Alzheimer's disease mice is associated with neurogenesis and neurotrophic activity. PLoS One. 2011;6: e21660.
78. Malberg JE, Eisch AJ, Nestler EJ, Duman RS. Chronic anti-depressant treatment increases neurogenesis in adult rat hippocampus. J Neurosci. 2000;20:9104-9110. (Pubitemid 32042912)
79. Boldrini M, Underwood MD, Hen R, Rosoklija GB, Dwork AJ, John Mann J, Arango V. Antidepressants increase neural progenitor cells in the human hippocampus. Neuropsychopharmacology. 2009;34:2376-2389.
80. Anacker C, Zunszain PA, Cattaneo A, Carvalho LA, Garabedian MJ, Thuret S, Price J, Pariante CM. Antidepressants increase human hippocampal neurogenesis by activating the glucocorticoid receptor. Mol Psychiatry. 2011;16:738-750.
81. Marcussen AB, Flagstad P, Kristjansen PE, Johansen FF, Englund U. Increase in neurogenesis and behavioural benefit after chronic fluoxetine treatment in Wistar rats. Acta Neurol Scand. 2008;117:94-100.
82. Rozzini L, Chilovi BV, Conti M, Bertoletti E, Zanetti M, Trabucchi M, Padovani A. Efficacy of SSRIs on cognition of Alzheimer's disease patients treated with Cholinesterase inhibitors. Int Psychogeriatr. 2010;22:114-119.
83. Encimas JM, Vaahtokari A, Enikolopov G. Fluoxetine targets early progenitor cells in the adult brain. Proc Natl Acad Sci USA. 2006;103:8233-8238. (Pubitemid 43801081)
84. Ohira K, Miyakawa T. Chronic treatment with fluoxetine for more than 6 weeks decreases neurogenesis in the subventricular zone of adult mice. Mol Brain. 2011;4:10.
85. Peng ZW, Xue YY, Wang HN, Wang HH, Xue F, Kuang F, Wang BR, Chen YC, Zhang LY, Tan QR. Sertraline promotes hippocampus-derived neural stem cells differentiating into neurons but not glia and attenuates LPS-induced cellular damage. Prog Neuropsychopharmacol Biol Psychiatry. 2012;36:183-188.
86. Hellweg R, Ziegenhorn A, Heuser I, Deuschle M. Serum concentrations of nerve growth factor and brain-derived neurotrophic factor in depressed patients before and after antidepressant treatment. Pharmacopsychiatry. 2008;41:66-71. (Pubitemid 351427525)
87. Boku S, Nakagawa S, Masuda T, Nishikawa H, Kato A, Toda H, Song N, Kitaichi Y, Inoue T, Koyama T. Effects of mood stabilizers on adult dentate gyrus-derived neural precursor cells. Prog Neuropsychopharmacol Biol Psychiatry. 2011;35:111-117.
88. Hanson ND, Nemeroff CB, Owens MJ. Lithium, but not fluoxetine or the corticotropin-releasing factor receptor 1 receptor antagonist R121919, increases cell proliferation in the adult dentate gyrus. J Pharmacol Exp Ther. 2011;337:180-186.
89. Fiorentini A, Rosi MC, Grossi C, Luccarini I, Casamenti F. Lithium improves hippocampal neurogenesis, neuropathology and cognitive functions in APP mutant mice. PLoS One. 2010;5:e14382.
90. Hao Y, Creson T, Zhang L, Li P, Du F, Yuan P, Gould TD, Manji HK, Chen G. Mood stabilizer valproate promotes ERK pathway-dependent cortical neuronal growth and neurogenesis. J Neurosci. 2004;24:6590-6599. (Pubitemid 38971708)
91. Laeng P, Pitts RL, Lemire AL, Drabik CE, Weiner A, Tang H, Thyagarajan R, Mallon BS, Altar CA. The mood stabilizer valproic acid stimulates GABA neurogenesis from rat forebrain stem cells. J Neurochem. 2004;91:238-251. (Pubitemid 39314954)
92. Jung GA, Yoon JY, Moon BS, Yang DH, Kim HY, Lee SH, Bryja V, Arenas E, Choi KY. Valproic acid induces differentiation and inhibition of proliferation in neural progenitor cells via the beta-catenin-Ras-ERK-p21Cip/WAF1 pathway. BMC Cell Biol. 2008;9:66.
93. Go HS, Seo JE, Kim KC, Han SM, Kim P, Kang YS, Han SH, Shin CY, Ko KH. Valproic acid inhibits neural progenitor cell death by activation of NF-κB signaling pathway and up-regulation of Bcl-XL. J Biomed Sci. 2011;18:48.
94. Wurdak H, Zhu S, Min KH, Aimone L, Lairson LL, Watson J, Chopiuk G, Demas J, Charette B, Haider R, Weerapana E, Cravatt BF, Cline HT, Peters EC, Zhang J, Walker JR, Wu C, Chang J, Tuntland T, Cho CY, Schultz PG. A small molecule accelerates neuronal differentiation in the adult rat. Proc Natl Acad Sci USA. 2010;107:16542-16547.
95. Chang DJ, Jeong MY, Song J, Jin CY, Suh YG, Kim HJ, Min KH. Discovery of small molecules that enhance astrocyte differentiation in rat fetal neural stem cells. Bioorg Med Chem Lett. 2011;21:7050-7053.
96. Saxe JP, Wu H, Kelly TK, Phelps ME, Sun YE, Kornblum HI, Huang J. A phenotypic small-molecule screen identifies an orphan ligand-receptor pair that regulates neural stem cell differentiation. Chem Biol. 2007;14:1019-1030. (Pubitemid 47404902)
97. Pieper AA, Xie S, Capota E, Estill SJ, Zhong J, Long JM, Becker GL, Huntington P, Goldman SE, Shen CH, Capota M, Britt JK, Kotti T, Ure K, Brat DJ, Williams NS, MacMillan KS, Naidoo J, Melito L, Hsieh J, De Brabander J, Ready JM, McKnight SL. Discovery of a proneurogenic, neuroprotective chemical. Cell. 2010;142:39-51.
98. Lu D, Qu C, Goussev A, Jiang H, Lu C, Schallert T, Mahmood A, Chen J, Li Y, Chopp M. Statins increase neurogenesis in the dentate gyrus, reduce delayed neuronal death in the hippocampal CA3 region, and improve spatial learning in rat after traumatic brain injury. J Neurotrauma. 2007;24:1132-1146. (Pubitemid 47106287)
99. Lu D, Goussev A, Chen J, Pannu P, Li Y, Mahmood A, Chopp M. Atorvastatin reduces neurological deficit and increases synaptogenesis, angiogenesis, and neuronal survival in rats subjected to traumatic brain injury. J Neurotrauma. 2004;21:21-32. (Pubitemid 38141799)
100. Kong PJ, Kim YM, Lee HJ, Kim SS, Yoo ES, Chun W. Neuroprotective effects of methanol extracts of Jeju native plants on hydrogen peroxide-induced cytotoxicity in SH-SY5Y human neuroblastoma Cells. Korean J Physiol Pharmacol. 2007;11:170-174.
101. Kwon MS, Lee JK, Park SH, Sim YB, Jung JS, Won MH, Kim SM, Suh HW. Neuroprotective effect of visnagin on kainic acid-induced neuronal cell death in the mice hippocampus. Korean J Physiol Pharmacol. 2010;14:257-263.
102. Chae HS, Kang YK, Shin YK, Lee HJ, Yu JI, Lee KG, Yeo JH, Kim YS, Sohn DS, Kim KY, Lee WB, Lee SH, Kim SS. The role of BF-7 on neuroprotection and enhancement of cognitive function. Korean J Physiol Pharmacol. 2004;8:173-179. (Pubitemid 39440088)
103. Park HJ, Shim HS, Kim H, Kim KS, Lee H, Hahm DH, Shim I. Effects of glycyrrhizae radix on repeated restraint stress-induced neurochemical and behavioral responses. Korean J Physiol Pharmacol. 2010;14:371-376.
104. Weng MS, Liao CH, Yu SY, Lin JK. Garcinol promotes neurogenesis in rat cortical progenitor cells through the duration of extracellular signal-regulated kinase signaling. J Agric Food Chem. 2011;59:1031-1040.
105. Liu JW, Tian SJ, de Barry J, Luu B. Panaxadiol glycosides that induce neuronal differentiation in neurosphere stem cells. J Nat Prod. 2007;70:1329-1334. (Pubitemid 47401575)
106. de Sampaio e Spohr TC, Stipursky J, Sasaki AC, Barbosa PR, Martins V, Benjamim CF, Roque NF, Costa SL, Gomes FC. Effects of the flavonoid casticin from Brazilian Croton betulaster in cerebral cortical progenitors in vitro: direct and indirect action through astrocytes. J Neurosci Res. 2010;88:530-541.
107. Cho JY, Kon PJ, Chun W, Moon YO, Park YT, Lim SY, Kim SS. Curcumin attenuates glial cell activation but cannot suppress hippocampal CA3 neuronal cell death in i.c.v. kanic acid injection model. Korean J Physiol Pharmacol. 2003;7:307-310. (Pubitemid 38219733)
108. Kim SJ, Son TG, Park HR, Park M, Kim MS, Kim HS, Chung HY, Mattson MP, Lee J. Curcumin stimulates proliferation of embryonic neural progenitor cells and neurogenesis in the adult hippocampus. J Biol Chem. 2008;283:14497-14505.
109. Yoo DY, Kim W, Yoo KY, Lee CH, Choi JH, Kang IJ, Yoon YS, Kim DW, Won MH, Hwang IK. Effects of Nelumbo nucifera rhizome extract on cell proliferation and neuroblast differentiation in the hippocampal dentate gyrus in a scopolamine-induced amnesia animal model. Phytother Res. 2011;25:809-815.
110. Yang WM, Shim KJ, Choi MJ, Park SY, Choi BJ, Chang MS, Park SK. Novel effects of Nelumbo nucifera rhizome extract on memory and neurogenesis in the dentate gyrus of the rat hippocampus. Neurosci Lett. 2008;443:104-107.
111. Park IH, Zhao R West JA, Yabuuchi A, Huo H, Ince TA, Lerou PH, Lensch MW, Daley GQ. Reprogramming of human somatic cells to pluripotency with defined factors. Nature. 2008;451:141-146.
112. Yu J, Vodyanik MA, Smuga-Otto K, Antosiewicz-Bourget J, Frane JL, Tian S, Nie J, Jonsdottir GA, Ruotti V, Stewart R, Slukvin II, Thomson JA. Induced pluripotent stem cell lines derived from human somatic cells. Science. 2007;318:1917-1920.
113. Park IH, Arora N, Huo H, Maherali N, Ahfeldt T, Shimamura A, Lensch MW, Cowan C, Hochedlinger K, Daley GQ. Disease-specific induced pluripotent stem cells. Cell. 2008; 134:877-886.
114. Soldner F, Laganière J, Cheng AW, Hockemeyer D, Gao Q, Alagappan R Khurana V, Golbe LI, Myers RH, Lindquist S, Zhang L, Guschin D, Fong LK, Vu BJ, Meng X, Urnov FD, Rebar EJ, Gregory PD, Zhang HS, Jaenisch R. Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations. Cell. 2011;146:318-331.
115. Liu GH, Suzuki K, Qu J, Sancho-Martinez I, Yi F, Li M, Kumar S, Nivet E, Kim J, Soligalla RD, Dubova I, Goebl A, Plongthongkum N, Fung HL, Zhang K, Loring JF, Laurent LC, Izpisua Belmonte JC. Targeted gene correction of laminopathy-associated LMNA mutations in patient-specific iPSCs. Cell Stem Cell. 2011;8:688-694.