Mood stabilizer valproate promotes ERK pathway-dependent cortical neuronal growth and neurogenesis

Journal of Neuroscience

Volumn 24, Issue 29, 2004, Pages 6590-6599

  Hao, Yanlei ^a   Creson, Thomas ^a   Zhang, Lei ^a   Li, Pipeng ^a   Du, Fu ^b   Yuan, Peixiong ^a   Gould, Todd D ^a   Manji, Husseini K ^a   Chen, Guang ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^b FD NeuroTechnologies   (United States)

Author keywords

ERK; Mania; Mood disorders; Neurite outgrowth; Neurogenesis; Valproate

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 HYDROXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTICONVULSIVE AGENT; BASIC FIBROBLAST GROWTH FACTOR; BROXURIDINE; DIMETHYL SULFOXIDE; ENZYME INHIBITOR; GLYCOGEN SYNTHASE KINASE 3; HISTONE DEACETYLASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; NEUROTROPHIN 3; PROTEIN BCL 2; RAF PROTEIN; TRANQUILIZER; UO 126; VALPROIC ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIPOLAR DISORDER; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG EFFECT; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; IMMUNOCYTOCHEMISTRY; MALE; MANIA; MOOD DISORDER; MOUSE; NERVE CELL CULTURE; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTIMANIC AGENTS; CELL PROLIFERATION; CELLS, CULTURED; CEREBRAL CORTEX; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GLYCOGEN SYNTHASE KINASE 3; GYRUS CINGULI; HIPPOCAMPUS; HISTONE DEACETYLASES; MALE; MAP KINASE SIGNALING SYSTEM; MICE; MICE, INBRED C57BL; NEURONS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RATS; RATS, WISTAR; RIBOSOMAL PROTEIN S6 KINASES, 90-KDA; VALPROIC ACID;

EID: 3242788185     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.5747-03.2004     Document Type: Article

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