Differentiation of embryonic stem cells towards pancreatic progenitor cells and their transplantation into streptozotocin-induced diabetic mice

Cell Biology International

Volumn 32, Issue 4, 2008, Pages 456-461

  Chen, Chunhua ^a   Zhang, Yuebo ^a   Sheng, Xiaoyan ^a   Huang, Cheng ^a   Zang, Ying Qin ^a  

^a Chinese Academy of Sciences   (China)

Author keywords

Differentiation; Embryonic stem cell; Pancreatic progenitor; Streptozotocin; Transplantation; Type I diabetes

Indexed keywords

AMYLIN; GLUCAGON; GLUCOSE; GLUCOSE TRANSPORTER 2; HEPATOCYTE NUCLEAR FACTOR 3BETA; INSULIN; INSULIN I; INSULIN II; MESSENGER RNA; NICOTINAMIDE; TRANSCRIPTION FACTOR GATA 4; TRANSCRIPTION FACTOR PDX 1;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DIFFERENTIATION; CELL FATE; CONTROLLED STUDY; EMBRYO; EMBRYONIC STEM CELL; ENDODERM; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; HYPERGLYCEMIA; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PANCREAS ISLET CELL; STEM CELL TRANSPLANTATION; STREPTOZOCIN DIABETES; TREATMENT OUTCOME;

ANIMALS; BLOOD GLUCOSE; CELL DIFFERENTIATION; CELL SHAPE; DIABETES MELLITUS, EXPERIMENTAL; EMBRYONIC STEM CELLS; GENE EXPRESSION REGULATION; IMMUNOHISTOCHEMISTRY; INSULIN; ISLETS OF LANGERHANS TRANSPLANTATION; MALE; MICE; MICE, INBRED C57BL; PANCREAS; STEM CELL TRANSPLANTATION; STEM CELLS; STREPTOZOCIN;

MUS;

EID: 42749088782     PISSN: 10656995     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cellbi.2007.12.017     Document Type: Article

References (26)

1. Ahlgren U., Jonsson J., Jonsson L., Simu K., and Edlund H. Beta-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes. Genes Dev 12 (1998) 1763-1768
2. Ang S.L., and Rossant J. HNF-3 beta is essential for node and notochord formation in mouse development. Cell 78 (1994) 561-574
3. Blyszczuk P., Czyz J., Kania G., Wagner M., Roll U., St-Onge L., et al. Expression of Pax4 in embryonic stem cells promotes differentiation of nestin-positive progenitor and insulin-producing cells. Proc Natl Acad Sci 100 (2003) 998-1003
4. Bradley A., Evans M., Kaufman M.H., and Robertson E. Formation of germ-line chimaeras from embryo-derived teratocarcinoma cell lines. Nature 309 (1984) 255-256
5. Di Lisa F., and Ziegler M. Pathophysiological relevance of mitochondria in NAD(+) metabolism. FEBS Lett 492 (2001) 4-8
6. Guillam M.T., Dupraz P., and Thorens B. Glucose uptake, utilization, and signaling in GLUT2-null islets. Diabetes 49 (2000) 1485-1491
7. Hanabusa T., Kubo K., Oki C., Nakano Y., Okai K., Sanke T., et al. Islet amyloid polypeptide (IAPP) secretion from islet cells and its plasma concentration in patients with non-insulin-dependent diabetes mellitus. Diabetes Res Clin Pract 15 (1992) 89-96
8. Hori Y., Rulifson I.C., Tsai B.C., Heit J.J., Cahoy J.D., and Kim S.K. Growth inhibitors promote differentiation of insulin-producing tissue from embryonic stem cells. Proc Natl Acad Sci 99 (2002) 16105-16110
9. Jonsson J., Carlsson L., Edlund T., and Edlund H. Insulin-promoter-factor 1 is required for pancreas development in mice. Nature 371 (1994) 606-609
10. Kahan B.W., Jacobson L.M., Hullett D.A., Ochoada J.M., Oberley T.D., Lang K.M., et al. Pancreatic precursors and differentiated islet cell types from murine embryonic stem cells: an in vitro model to study islet differentiation. Diabetes 52 (2003) 2016-2024
11. Keller G.M. In vitro differentiation of embryonic stem cells. Curr Opin Cell Biol 7 (1995) 862-869
12. Kubo A., Shinozaki K., Shannon J.M., Kouskoff V., Kennedy M., Woo S., et al. Development of definitive endoderm from embryonic stem cells in culture. Development 131 (2004) 1651-1662
13. Leon-Quinto T., Jones J., Skoudy A., Burcin M., and Soria B. In vitro directed differentiation of mouse embryonic stem cells into insulin-producing cells. Diabetologia 47 (2004) 1442-1451
14. Lumelsky N., Blondel O., Laeng P., Velasco I., Ravin R., and McKay R. Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets. Science 292 (2001) 1389-1394
15. Melloul D., Marshak S., and Cerasi E. Regulation of insulin gene transcription. Diabetologia 45 (2002) 309-326
16. Miyazaki S., Yamato E., and Miyazaki J. Regulated expression of pdx-1 promotes in vitro differentiation of insulin-producing cells from embryonic stem cells. Diabetes 53 (2004) 1030-1037
17. Mulder H., Myrsen-Axcrona U., Gebre-Medhin S., Ekblad E., and Sundler F. Expression of non-classical islet hormone-like peptides during the embryonic development of the pancreas. Microsc Res Tech 43 (1998) 313-321
18. Otonkoski T., Beattie G.M., Mally M.I., Ricordi C., and Hayek A. Nicotinamide is a potent inducer of endocrine differentiation in cultured human fetal pancreatic cells. J Clin Invest 92 (1993) 1459-1466
19. Shapiro A.M., Lakey J.R., Ryan E.A., Korbutt G.S., Toth E., Warnock G.L., et al. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med 343 (2000) 230-238
20. Slack J.M. Developmental biology of the pancreas. Development 121 (1995) 1569-1580
21. Soria B., Roche E., Berna G., Leon-Quinto T., Reig J.A., and Martin F. Insulin-secreting cells derived from embryonic stem cells normalize glycemia in streptozotocin-induced diabetic mice. Diabetes 49 (2000) 157-162
22. Thorens B., Guillam M.T., Beermann F., Burcelin R., and Jaquet M. Transgenic reexpression of GLUT1 or GLUT2 in pancreatic beta cells rescues GLUT2-null mice from early death and restores normal glucose-stimulated insulin secretion. J Biol Chem 275 (2000) 23751-23758
23. Vaca P., Berna G., Martin F., and Soria B. Nicotinamide induces both proliferation and differentiation of embryonic stem cells into insulin-producing cells. Transplant Proc 35 (2003) 2021-2023
24. Wilson M.E., Kalamaras J.A., and German M.S. Expression pattern of IAPP and prohormone convertase 1/3 reveals a distinctive set of endocrine cells in the embryonic pancreas. Mech Dev 115 (2002) 171-176
25. Wu K.L., Gannon M., Peshavaria M., Offield M.F., Henderson E., Ray M., et al. Hepatocyte nuclear factor 3beta is involved in pancreatic beta-cell-specific transcription of the pdx-1 gene. Mol Cell Biol 17 (1997) 6002-6013
26. Zaret K.S. Molecular genetics of early liver development. Annu Rev Physiol 58 (1996) 231-251