The role of BF-7 on neuroprotection and enhancement of cognitive function

Korean Journal of Physiology and Pharmacology

Volumn 8, Issue 4, 2004, Pages 173-179

  Chae, Hee Sun ^a   Kang, Yong Koo ^a   Shin, Yong Kyu ^a   Lee, Hyun Jung ^a   Lee, Kwang Gill ^c   Yeo, Joo Hong ^c   Kim, Yong Sik ^b   Sohn, Dong Suep ^a   Kim, Kyung Yong ^a   Lee, Won Bok ^a   Lee, Sang Hyung ^b   Kim, Sung Su ^a  

^a Chung Ang University   (South Korea)

^b Seoul National University   (South Korea)

^c National Institute of Animal Science   (South Korea)

Author keywords

Amyloid; BF 7; Brain; Learning and memory; Natural product

Indexed keywords

4 [5 (4 METHYL 1 PIPERAZINYL)[2,5' BI 1H BENZIMIDAZOL] 2' YL]PHENOL; AMYLOID BETA PROTEIN; BF 7; CASPASE; DOCOSAHEXAENOIC ACID; ICOSAPENTAENOIC ACID; NATURAL PRODUCT; PLACEBO; PROTEINASE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ADOLESCENT; APOPTOSIS; ARTICLE; ATTENTION; ATTENUATION; BIOACCUMULATION; BRAIN FUNCTION; CLINICAL TRIAL; COGNITION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG ISOLATION; DRUG MECHANISM; DRUG MIXTURE; ENZYME ACTIVITY; HIGH SCHOOL; HUMAN; HUMAN CELL; INTELLIGENCE TEST; LEARNING; MEMORY; MENTAL CONCENTRATION; NERVE CELL CULTURE; NEUROBLASTOMA CELL; NEUROPROTECTION; SERICULTURE; STATISTICAL SIGNIFICANCE; STUDENT;

EID: 7444235929     PISSN: 12264512     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Behl C, Davis J, Cole GM, Schubert D. Vitamin E protects nerve cells from amyloid toxicity. Biochem. Biophys Res Commun 186: 944-950, 1992
2. Boland B, Campbell V. beta-Amyloid (1-40)-induced apoptosis of cultured cortical neurones involves calpain-mediated cleavage of poly-ADP-ribose polymerase. Neurobiol Aging 24: 179-186, 2003
3. Cutler RG, Kelly J, Storie K, Pedersen WA, Tammara A, Hatanpaa K, Troncoso JC, Mattson MP. Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease. Proc Natl Acad Sci USA 101: 2070-2075, 2004
4. Cummings JL, Kaufer D. Neuropsychiatric aspects of Alzheimer's disease: the cholinergic hypothesis revisited. Neurology 47: 876-883, 1996
5. Goodman YD, Mattson MP. Staurosporin and K-252 compounds protect hippocampal neurons against amyloid β-peptide toxicity and oxidative injury. Brain Res 650: 170-174, 1994
6. Guo ZH, Mattson MP. Neurotrophic factors protect terminals against amyloid- and oxidative stress-induced impairment of glucose transport, glutamate transport and mitochondrial function. Cereb Cortex 10: 50-57, 2000
7. Kumar U, Dunlop DM, Richardson JS. The acute neurotoxic effect of β-amyloid on mature cultures of rat hippocampal neurons is attenuated by the anti-oxidant U-78517F. Int J Neurosci 79: 185-190, 1994
8. Mattson MP. Cellular actions of β-amyloid precursor protein and its soluble and fibrillogenic derivates. Physiol Rev 77: 1081-1132, 1997
9. Min SK, Moon IW, Ko RW, Shin HS. Effects of transdermal nicotine on attention and memory in healthy elderly non-smokers. Psychopharmacology (Berl) 159: 83-88, 2001
10. Permanne B, Adessi C, Saborio GPSF, Frossard MJ. Van Dopre J, Dewachter I, Banks WA, Van Leuven F, Soto C. Reduction of amyloid load and cerebral damage in a transgenic mouse model of Alzheimer's disease by treatment with a β-sheet breaker peptide. FASEB J 16: 860-862, 2002
11. Shimoke K, Chiba H. Nerve growth factor prevents 1-methyl-4-penyl-1,2,3,6- tetrahydropyridine-induced cell death via the Akt athway by suppressing caspase-3-like activity using PC12 cells: relevance to therapeutical application for Parkinson's disease. J Neurosci Res 63: 402-409, 2001
12. Soreghan B, Thomas SN, Yang AJ. Aberrant sphingomyelin/ceramide metabolic- induced neuronal endosomal/lysosomal dysfunction: potential pathological consequences in age-related neurodegeneration. Adv Drug Deliv Rev 55: 1515-1524, 2003
13. Soto C, Sigurdsson EM, Morelli L, Kumar RA, Castano EM, Frangione B. β-Sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis: implications for Alzheimer's therapy. Nat Med 4: 822-826, 1998
14. Uauy-Dagach R, Valenzuela A. Marine oils as a source of omega-3 fatty acids in the diet: how to optimize the health benefits. Prog Food Nutr Sci 16:199-243, 1992
15. Wang JY, Shum AY, Ho YJ, Wang JY. Oxidative neurotoxicity in rat cerebral cortex neurons: synergistic effects of H2O2 and NO on apoptosis involving activation of p38 mitogen-activated protein kinase and caspase-3. J Neurosci Res 72: 508-519, 2003
16. 2+ dependant. Neurosci Lett 167: 93-96, 1994
17. Yakovlev AG, Faden AI. Caspase-dependent apoptotic pathways in CNS injury. Mol Neurobiol 24: 131-144, 2001
18. Yankner BA. Mechanisms of neuronal degeneration in Alzheimer's disease. Neuron 16: 921-932, 1996