Bone marrow stem cells for the treatment of ischemic heart disease: A clinical trial review

Journal of Cardiovascular Translational Research

Volumn 2, Issue 2, 2009, Pages 202-218

  Fuh, Eric ^a   Brinton, Todd J ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Bone marrow stem cell; Cell therapy; Chronic myocardial infarction; Ischemic heart disease; Refractory angina

Indexed keywords

ARTICLE; CARDIOMYOPATHY; CELL TYPE; HEART FAILURE; HEART LEFT VENTRICLE FAILURE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; ISCHEMIC HEART DISEASE; PRIORITY JOURNAL; ADULT; AGED; BONE MARROW TRANSPLANTATION; CLINICAL TRIAL (TOPIC); CONVALESCENCE; EVIDENCE BASED MEDICINE; FEMALE; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE; MALE; MIDDLE AGED; MYOCARDIAL ISCHEMIA; PATHOLOGY; PATHOPHYSIOLOGY; REGENERATION; STEM CELL TRANSPLANTATION; TIME; TREATMENT OUTCOME;

ADULT; AGED; BONE MARROW TRANSPLANTATION; CLINICAL TRIALS AS TOPIC; EVIDENCE-BASED MEDICINE; FEMALE; HUMANS; MALE; MIDDLE AGED; MYOCARDIAL ISCHEMIA; MYOCARDIUM; RECOVERY OF FUNCTION; REGENERATION; STEM CELL TRANSPLANTATION; TIME FACTORS; TREATMENT OUTCOME; VENTRICULAR FUNCTION, LEFT;

ANGINA;

EID: 67349096289     PISSN: 19375387     EISSN: 19375395     Source Type: Journal    
DOI: 10.1007/s12265-009-9095-8     Document Type: Article

References (49)

1. HC Kung DL Hoyert J Xu SL Murphy 2008 Deaths: final data for 2005 National Vital Statistics Reports 56 1 120
2. D Lloyd-Jones R Adams M Carnethon G De Simone TB Ferguson K Flegal 2009 Heart Disease and Stroke Statistics-2009 Update. A report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee Circulation 119 e21 e181
3. LR Elveback DC Connolly LJ Melton 3rd 1986 Coronary heart disease in residents of Rochester, Minnesota. VII. Incidence 1950 through 1982 Mayo Clinic Proceedings 61 896 900 (Pubitemid 17181743)
4. WB Kannel M Feinleib 1972 Natural history of angina pectoris in the Framingham study. Prognosis and survival American Journal of Cardiology 29 154 163
5. FD Fortuin P Vale DW Losordo J Symes GA DeLaria JJ Tyner 2003 One-year follow-up of direct myocardial gene transfer of vascular endothelial growth factor-2 using naked plasmid deoxyribonucleic acid by way of thoracotomy in no-option patients American Journal of Cardiology 92 436 439 (Pubitemid 36959880)
6. CL Grines MW Watkins G Helmer W Penny J Brinker JD Marmur 2002 Angiogenic Gene Therapy (AGENT) trial in patients with stable angina pectoris Circulation 105 1291 1297 (Pubitemid 34260418)
7. M Hedman J Hartikainen M Syvanne J Stjernvall A Hedman A Kivela 2003 Safety and feasibility of catheter-based local intracoronary vascular endothelial growth factor gene transfer in the prevention of postangioplasty and in-stent restenosis and in the treatment of chronic myocardial ischemia: phase II results of the Kuopio Angiogenesis Trial (KAT) Circulation 107 2677 2683 (Pubitemid 36667240)
8. TD Henry BH Annex GR [tmp] McKendall MA Azrin JJ Lopez FJ Giordano 2003 The VIVA trial: Vascular endothelial growth factor in Ischemia for Vascular Angiogenesis Circulation 107 1359 1365 (Pubitemid 36350732)
9. TD Henry K Rocha-Singh JM Isner DJ Kereiakes FJ Giordano M Simons 2001 Intracoronary administration of recombinant human vascular endothelial growth factor to patients with coronary artery disease American Heart Journal 142 872 880 (Pubitemid 33016208)
10. RJ Laham NA Chronos M Pike ME Leimbach JE Udelson JD Pearlman 2000 Intracoronary basic fibroblast growth factor (FGF-2) in patients with severe ischemic heart disease: results of a phase I open-label dose escalation study Journal of the American College of Cardiology 36 2132 2139
11. DW Losordo PR Vale JF Symes CH Dunnington DD Esakof M Maysky 1998 Gene therapy for myocardial angiogenesis: initial clinical results with direct myocardial injection of phVEGF165 as sole therapy for myocardial ischemia Circulation 98 2800 2804 (Pubitemid 29003959)
12. B Schumacher P Pecher BU von Specht T Stegmann 1998 Induction of neoangiogenesis in ischemic myocardium by human growth factors: first clinical results of a new treatment of coronary heart disease Circulation 97 645 650 (Pubitemid 28090957)
13. FW Sellke RJ Laham ER Edelman JD Pearlman M Simons 1998 Therapeutic angiogenesis with basic fibroblast growth factor: technique and early results Annals of Thoracic Surgery 65 1540 1544 (Pubitemid 28313604)
14. PR Vale DW Losordo CE Milliken MC [tmp] McDonald LM Gravelin CM Curry 2001 Randomized, single-blind, placebo-controlled pilot study of catheter-based myocardial gene transfer for therapeutic angiogenesis using left ventricular electromechanical mapping in patients with chronic myocardial ischemia Circulation 103 2138 2143 (Pubitemid 32458322)
15. + stem cells in patients with chronic ischemic heart disease: a 12-month follow-up International Journal of Cardiology 109 21 27
16. + stem cells for intractable angina: a phase I/IIa double-blind, randomized controlled trial Circulation 115 3165 3172 (Pubitemid 47018140)
17. + stem cells in patients with refractory ischemia: preliminary results Thoracic and Cardiovascular Surgery 56 71 76
18. HF Tse S Thambar YL Kwong P Rowlings G Bellamy J [tmp] McCrohon 2007 Prospective randomized trial of direct endomyocardial implantation of bone marrow cells for treatment of severe coronary artery diseases (PROTECT-CAD trial) European Heart Journal 28 2998 3005 (Pubitemid 350262782)
19. SL Beeres JJ Bax TA Kaandorp K Zeppenfeld HJ Lamb P Dibbets-Schneider 2006 Usefulness of intramyocardial injection of autologous bone marrow-derived mononuclear cells in patients with severe angina pectoris and stress-induced myocardial ischemia American Journal of Cardiology 97 1326 1331 (Pubitemid 44316786)
20. SL Beeres JJ Bax P Dibbets-Schneider MP Stokkel WE Fibbe EE van der Wall 2006 Sustained effect of autologous bone marrow mononuclear cell injection in patients with refractory angina pectoris and chronic myocardial ischemia: twelve-month follow-up results American Heart Journal 152 684 e611 686 (Pubitemid 44396915)
21. S Fuchs LF Satler R Kornowski P Okubagzi G Weisz R Baffour 2003 Catheter-based autologous bone marrow myocardial injection in no-option patients with advanced coronary artery disease: a feasibility study Journal of the American College of Cardiology 41 1721 1724 (Pubitemid 36584242)
22. S Fuchs R Kornowski G Weisz LF Satler PC Smits P Okubagzi 2006 Safety and feasibility of transendocardial autologous bone marrow cell transplantation in patients with advanced heart disease American Journal of Cardiology 97 823 829 (Pubitemid 43313253)
23. C Briguori B Reimers C Sarais M Napodano P Pascotto G Azzarello 2006 Direct intramyocardial percutaneous delivery of autologous bone marrow in patients with refractory myocardial angina American Heart Journal 151 674 680 (Pubitemid 43290259)
24. J Vicario C Campo J Piva F Faccio L Gerardo C Becker H Ortega 2005 One-year follow-up of transcoronary sinus administration of autologous bone marrow in patients with chronic refractory angina Cardiovascular Revascularization Medicine 6 99 107 (Pubitemid 41579078)
25. F Kuethe BM Richartz C Kasper HG Sayer K Hoeffken GS Werner 2005 Autologous intracoronary mononuclear bone marrow cell transplantation in chronic ischemic cardiomyopathy in humans International Journal of Cardiology 100 485 491 (Pubitemid 40503297)
26. BE Strauer M Brehm T Zeus T Bartsch C Schannwell C Antke 2005 Regeneration of human infarcted heart muscle by intracoronary autologous bone marrow cell transplantation in chronic coronary artery disease: the IACT Study Journal of the American College of Cardiology 46 1651 1658 (Pubitemid 41531618)
27. B Assmus J Honold V Schachinger MB Britten U Fischer-Rasokat 2006 Transcoronary transplantation of progenitor cells after myocardial infarction New England Journal of Medicine 355 1222 1232 (Pubitemid 44427446)
28. LM de la Fuente SH Stertzer J Argentieri E Penaloza J Miano B Koziner 2007 Transendocardial autologous bone marrow in chronic myocardial infarction using a helical needle catheter: 1-year follow-up in an open-label, nonrandomized, single-center pilot study (the TABMMI study) American Heart Journal 154 79 e71 77 (Pubitemid 46920501)
29. SL Beeres JJ Bax P Dibbets-Schneider MP Stokkel WE Fibbe EE van der Wall 2007 Intramyocardial injection of autologous bone marrow mononuclear cells in patients with chronic myocardial infarction and severe left ventricular dysfunction American Journal of Cardiology 100 1094 1098 (Pubitemid 47404464)
30. LR Gao ZG Wang ZM Zhu YX Fei S He HT Tian 2006 Effect of intracoronary transplantation of autologous bone marrow-derived mononuclear cells on outcomes of patients with refractory chronic heart failure secondary to ischemic cardiomyopathy American Journal of Cardiology 98 597 602 (Pubitemid 44233453)
31. EC Perin HF Dohmann R Borojevic SA Silva AL Sousa CT Mesquita 2003 Transendocardial, autologous bone marrow cell transplantation for severe, chronic ischemic heart failure Circulation 107 2294 2302 (Pubitemid 36578498)
32. EC Perin HF Dohmann R Borojevic SA Silva AL Sousa GV Silva 2004 Improved exercise capacity and ischemia 6 and 12 months after transendocardial injection of autologous bone marrow mononuclear cells for ischemic cardiomyopathy Circulation II110 II213 218 (Pubitemid 39263725)
33. F Lebrun G Berchem C Delagardelle J Beissel D Rouy DR Wagner 2006 Improvement of exercise-induced cardiac deformation after cell therapy for severe chronic ischemic heart failure Journal of Cardiac Failure 12 108 113 (Pubitemid 43340151)
34. M Mazo V Planat-Benard G Abizanda B Pelacho B Leobon JJ Gavira 2008 Transplantation of adipose derived stromal cells is associated with functional improvement in a rat model of chronic myocardial infarction European Journal of Heart Failure 10 454 462
35. E Meliga BM Strem HJ Duckers PW Serruys 2007 Adipose-derived cells Cell Transplantation 16 963 970
36. P Menasche O Alfieri S Janssens W [tmp] McKenna H Reichenspurner L Trinquart 2008 The Myoblast Autologous Grafting in Ischemic Cardiomyopathy (MAGIC) trial: first randomized placebo-controlled study of myoblast transplantation Circulation 117 1189 1200
37. DA Taylor BZ Atkins P Hungspreugs TR Jones MC Reedy KA Hutcheson 1998 Regenerating functional myocardium: improved performance after skeletal myoblast transplantation Nature Medicine 4 929 933 (Pubitemid 28364032)
38. AJ Becker CE Mc JE Till 1963 Cytological demonstration of the clonal nature of spleen colonies derived from transplanted mouse marrow cells Nature 197 452 454
39. L Siminovitch EA [tmp] McCulloch JE Till 1963 The distribution of colony-forming cells among spleen colonies Journal of Cellular Physiology 62 327 336
40. L Dawson AS Bateman-House D Mueller Agnew H Bok DW Brock A Chakravarti 2003 Safety issues in cell-based intervention trials Fertility and Sterility 80 1077 1085 (Pubitemid 37377728)
41. TD Fraker Jr SD Fihn RJ Gibbons J Abrams K Chatterjee J Daley 2007 2007 chronic angina focused update of the ACC/AHA 2002 guidelines for the management of patients with chronic stable angina: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines Writing Group to develop the focused update of the 2002 guidelines for the management of patients with chronic stable angina Journal of the American College of Cardiology 50 2264 2274 (Pubitemid 350166813)
42. RJ Gibbons J Abrams K Chatterjee J Daley PC Deedwania JS Douglas 2003 ACC/AHA 2002 guideline update for the management of patients with chronic stable angina-summary article: a report of the American College of Cardiology/American Heart Association Task Force on practice guidelines (Committee on the Management of Patients With Chronic Stable Angina) Journal of the American College of Cardiology 41 159 168 (Pubitemid 36044419)
43. L Gepstein G Hayam SA Ben-Haim 1997 A novel method for nonfluoroscopic catheter-based electroanatomical mapping of the heart. In vitro and in vivo accuracy results Circulation 95 1611 1622 (Pubitemid 27142822)
44. SA Hunt WT Abraham MH Chin AM Feldman GS Francis TG Ganiats 2005 ACC/AHA 2005 Guideline Update for the Diagnosis and Management of Chronic Heart Failure in the Adult: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Update the 2001 Guidelines for the Evaluation and Management of Heart Failure): developed in collaboration with the American College of Chest Physicians and the International Society for Heart and Lung Transplantation: endorsed by the Heart Rhythm Society Circulation 112 e154 e235
45. AT Askari S Unzek ZB Popovic CK Goldman F Forudi M Kiedrowski 2003 Effect of stromal-cell-derived factor 1 on stem-cell homing and tissue regeneration in ischaemic cardiomyopathy Lancet 362 697 703 (Pubitemid 37101067)
46. JP Levesque J Hendy Y Takamatsu PJ Simmons LJ Bendall 2003 Disruption of the CXCR4/CXCL12 chemotactic interaction during hematopoietic stem cell mobilization induced by GCSF or cyclophosphamide Journal of Clinical Investigation 111 187 196 (Pubitemid 36105917)
47. I Petit M Szyper-Kravitz A Nagler M Lahav A Peled L Habler 2002 G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4 Nature Immunology 3 687 694 (Pubitemid 34752479)
48. J Yamaguchi KF Kusano O Masuo A Kawamoto M Silver S Murasawa 2003 Stromal cell-derived factor-1 effects on ex vivo expanded endothelial progenitor cell recruitment for ischemic neovascularization Circulation 107 1322 1328 (Pubitemid 36314418)
49. D Hou EA Youssef TJ Brinton P Zhang P Rogers ET Price 2005 Radiolabeled cell distribution after intramyocardial, intracoronary, and interstitial retrograde coronary venous delivery: implications for current clinical trials Circulation 112 I150 156 (Pubitemid 41266667)