Effects of Nelumbo nucifera rhizome extract on cell proliferation and neuroblast differentiation in the hippocampal dentate gyrus in a scopolamine-induced amnesia animal model

Phytotherapy Research

Volumn 25, Issue 6, 2011, Pages 809-815

  Yoo, Dae Young ^a   Kim, Woosuk ^a   Yoo, Ki Yeon ^b   Lee, Choong Hyun ^a,c   Choi, Jung Hoon ^c   Kang, Il Jun ^b   Yoon, Yeo Sung ^a   Kim, Dong Woo ^d   Won, Moo Ho ^c   Hwang, In Koo ^a  

^a Seoul National University   (South Korea)

^b Hallym University   (South Korea)

^c Kangwon National University   (South Korea)

^d Central Research Center   (South Korea)

Author keywords

aquatic herb; brain derived neurotrophic factor; doublecortin; Ki67; neurogenesis; subgranular zone

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; DOUBLECORTIN; GALANTAMINE; KI 67 ANTIGEN; NELUMBO NUCIFERA EXTRACT; SCOPOLAMINE;

AMNESIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL MIGRATION; CELL PROLIFERATION; CELL PROTECTION; CHOLINERGIC SYSTEM; CONTROLLED STUDY; DENDRITE; DENTATE GYRUS; DENTATE HILUS; DRUG EFFICACY; DRUG MECHANISM; GRANULE CELL; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; NERVE CELL DIFFERENTIATION; NEUROBLAST; NONHUMAN; RAT; RHIZOME;

AMNESIA; ANIMALS; CELL DIFFERENTIATION; CELL PROLIFERATION; DENTATE GYRUS; MALE; MICE; NELUMBO; NEUROGENESIS; NEURONS; PLANT EXTRACTS; RATS; RATS, WISTAR; RHIZOME; SCOPOLAMINE;

ANIMALIA; NELUMBO NUCIFERA; RATTUS;

EID: 79957845595     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.3337     Document Type: Article

References (27)

1. Brown J, Cooper-Kuhn CM, Kempermann G, et al. 2003. Enriched environment and physical activity stimulate hippocampal but not olfactory bulb neurogenesis. Eur J Neurosci 17: 2042-2046. (Pubitemid 36713965)
2. Cooper-Kuhn CM, Winkler J, Kuhn HG., 2004. Decreased neurogenesis after cholinergic forebrain lesion in the adult rat. J Neurosci Res 77: 155-165. (Pubitemid 38859401)
3. Couillard-Despres S, Winner B, Schaubeck S, et al. 2005. Doublecortin expression levels in adult brain reflect neurogenesis. Eur J Neurosci 21: 1-14. (Pubitemid 40193870)
4. Deng W, Aimone JB, Gage FH,. 2010. New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory? Nat Rev Neurosci 11: 339-350.
5. Francis F, Koulakoff A, Boucher D, et al. 1999. Doublecortin is a developmentally regulated, microtubule-associated protein expressed in migrating and differentiating neurons. Neuron 23: 247-256. (Pubitemid 29315721)
6. Gage FH., 2000. Mammalian neural stem cells. Science 287: 1433-1438. (Pubitemid 30127128)
7. Gleeson JG, Lin PT, Flanagan LA, Walsh CA,. 1999. Doublecortin is a microtubule-associated protein and is expressed widely by migrating neurons. Neuron 23: 257-271. (Pubitemid 29315722)
8. Gustafsson E, Lindvall O, Kokaia Z,. 2003. Intraventricular infusion of TrkB-Fc fusion protein promotes ischemia-induced neurogenesis in adult rat dentate gyrus. Stroke 34: 2710-2715. (Pubitemid 37392772)
9. Jin K, Xie L, Mao XO, Greenberg DA,. 2006. Alzheimer's disease drugs promote neurogenesis. Brain Res 1085: 183-188. (Pubitemid 43728188)
10. Kotani S, Yamauchi T, Teramoto T, Ogura H,. 2006. Pharmacological evidence of cholinergic involvement in adult hippocampal neurogenesis in rats. Neuroscience 142: 505-514. (Pubitemid 44415335)
11. Kotani S, Yamauchi T, Teramoto T, Ogura H,. 2008. Donepezil, an acetylcholinesterase inhibitor, enhances adult hippocampal neurogenesis. Chem Biol Interact 175: 227-230.
12. Kuhn HG, Dickinson-Anson H, Gage FH., 1996. Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation. J Neurosci 16: 2027-2033. (Pubitemid 26144015)
13. Mukherjee PK, Kumar V, Houghton PJ,. 2007. Screening of Indian medicinal plants for acetylcholinesterase inhibitory activity. Phytother Res 21: 1142-1145.
14. Mukherjee PK, Saha K, Balashbramanian R, Pal M, Saha BP,. 1996. Studies on psychopharmacological effects of Nelumbo nucifera Gaertn. rhizome extract. J Ethnopharmacol 54: 63-67. (Pubitemid 26393471)
15. Mukherjee PK, Saha K, Saha BP,. 1997. Effect of Nelumbo nucifera rhizome extract on blood sugar level in rats. J Ethnopharmacol 58: 207-213. (Pubitemid 27503911)
16. Oh JH, Choi BJ, Chang MS, Park SK,. 2009. Nelumbo nucifera semen extract improves memory in rats with scopolamine-induced amnesia through the induction of choline acetyltransferase expression. Neurosci Lett 461: 41-44.
17. Ono Y, Hattori E, Fukaya Y, Imai S, Ohizumi Y,. 2006. Anti-obesity effect of Nelumbo nucifera leaves extract in mice and rats. J Ethnopharmacol 106: 238-244. (Pubitemid 43766196)
18. Paxinos G, Watson C,. 2007. The Rat Brain in Stereotaxic Coordinates. Elsevier Academic Press: Amsterdam.
19. Sairanen M, Lucas G, Ernfors P, Castrén M, Castrén E,. 2005. Brain-derived neurotrophic factor and antidepressant drugs have different but coordinated effects on neuronal turnover, proliferation, and survival in the adult dentate gyrus. J Neurosci 25: 1089-1094. (Pubitemid 40268949)
20. Scharfman H, Goodman J, Macleod A, Phani S, Antonelli C, Croll S,. 2005. Increased neurogenesis and the ectopic granule cells after intrahippocampal BDNF infusion in adult rats. Exp Neurol 192: 348-356. (Pubitemid 40347259)
21. Sohn DH, Kim YC, Oh SH, Park EJ, Li X, Lee BH,. 2003. Hepatoprotective and free radical scavenging effects of Nelumbo nucifera. Phytomedicine 10: 165-169. (Pubitemid 36433212)
22. Taliaz D, Stall N, Dar DE, Zangen A,. 2010. Knockdown of brain-derived neurotrophic factor in specific brain sites precipitates behaviors associated with depression and reduces neurogenesis. Mol Psychiatry 15: 80-92.
23. Tamura M, Koyama R, Ikegaya Y, Matsuki N, Yamada MK,. 2006. K252a, an inhibitor of Trk, disturbs pathfinding of hippocampal mossy fibers. Neuroreport 17: 481-486.
24. Thome J, Sakai N, Shin K, et al. 2000. cAMP response element-mediated gene transcription is upregulated by chronic antidepressant treatment. J Neurosci 20: 4030-4036. (Pubitemid 30365673)
25. van der Borght K, Mulder J, Keijser JN, Eggen BJ, Luiten PG, van der Zee EA., 2005. Input from the medial septum regulates adult hippocampal neurogenesis. Brain Res Bull 67: 117-125. (Pubitemid 41225325)
26. Walter J, Keiner S, Witte OW, Redecker C,. Age-related effects on hippocampal precursor cell subpopulations and neurogenesis. Neurobiol Aging doi:10.1016/j.neurobiolaging.2009.11.011
27. Yang WM, Shim KJ, Choi MJ, et al. 2008. Novel effects of Nelumbo nucifera rhizome extract on memory and neurogenesis in the dentate gyrus of the rat hippocampus. Neurosci Lett 443: 104-107.