Aberrant expression of BAFF in T cells of systemic lupus erythematosus, which is recapitulated by a human T cell line, Loucy

International Immunology

Volumn 18, Issue 7, 2006, Pages 1189-1196

  Yoshimoto, Keiko ^a,b   Takahashi, Yasue ^b   Ogasawara, Mie ^b   Setoyama, Yumiko ^a   Suzuki, Katsuya ^a   Tsuzaka, Kensei ^a   Abe, Tohru ^a   Takeuchi, Tsutomu ^a  

^a SAITAMA MEDICAL UNIVERSITY   (Japan)

^b KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Autoimmune disease; BAFF; Furin; IFN ; Systemic lupus erythematosus; T cell

Indexed keywords

B LYMPHOCYTE ACTIVATING FACTOR; CD3 ANTIBODY; CYTOKINE; FURIN; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CATALYSIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; LYMPHOCYTE FUNCTION; MOLECULAR MECHANICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN SECRETION; QUANTITATIVE ANALYSIS; SIGNAL TRANSDUCTION; SYSTEMIC LUPUS ERYTHEMATOSUS; T LYMPHOCYTE ACTIVATION;

B-CELL ACTIVATING FACTOR; CELL LINE; DENDRITIC CELLS; FURIN; GENE EXPRESSION REGULATION; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LUPUS ERYTHEMATOSUS, SYSTEMIC; MEMBRANE PROTEINS; MONOCYTES; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 33745236700     PISSN: 09538178     EISSN: 14602377     Source Type: Journal    
DOI: 10.1093/intimm/dxl053     Document Type: Article

References (45)

1. Moore, P. A., Belvedere, O., Orr, A. et al. 1999. BLyS: Member of the tumor necrosis factor family and B lymphocyte stimulator. Science 285:260.
2. 2-terminal kinase. J. Biol. Chem. 274:15978.
3. Schneider, P., MacKay, F., Steiner, V. et al. 1999. BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth. J. Exp. Med. 189:1747.
4. Shu, H. B., Hu, W. H. and Johnson, H. 1999. TALL-1 is a novel member of the TNF family that is down-regulated by mitogens. J. Leukoc. Biol. 65:680.
5. Tribouley, C., Wallroth, M., Chan, V. et al. 1999. Characterization of a new member of the TNF family expressed on antigen presenting cells. Biol. Chem. 380:1443.
6. Batten, M., Groom, J., Cachero, T. G. et al. 2000. BAFF mediates survival of peripheral immature B lymphocytes. J. Exp. Med. 192:1453.
7. Rolink, A. G., Tschopp, J., Schneider, P. and Melchers, F. 2002. BAFF is a survival and maturation factor for mouse B cells. Eur. J. Immunol. 32:2004.
8. Schiemann, B., Gommerman, J. L., Vora, K. et al. 2001. An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway. Science 293:2111.
9. Gross, J. A., Johnston, J., Mudri, S. et al. 2000. TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease. Nature 404:995.
10. Marsters, S. A., Yan, M., Pitti, R. M., Haas, P. E., Dixit, V. M. and Ashkenazi, A. 2000. Interaction of the TNF homologues BLyS and APRIL with the TNF receptor homologues BCMA and TACI. Curr. Biol. 10:785.
11. Shu, H. B. and Johnson, H. 2000. B cell maturation protein is a receptor for the tumor necrosis factor family member TALL-1. Proc. Natl Acad. Sci. USA 97:9156.
12. Thompson, J. S., Bixler, S. A., Qian, F. et al. 2001. BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF. Science 293:2108.
13. Xia, X. Z., Treanor, J., Senaldi, G. et al. 2000. TACI is a TRAF-interacting receptor for TALL-1, a tumor necrosis factor family member involved in B cell regulation. J. Exp. Med. 192:137.
14. Yan, M., Marsters, S. A., Grewal, I. S., Wang, H., Ashkenazi, A. and Dixit, V. M. 2000. Identification of a receptor for BLyS demonstrates a crucial role in humoral immunity. Nat. Immunol. 1:37.
15. Yu, G., Boone, T., Delaney, J. et al. 2000. APRIL and TALL-I and receptors BCMA and TACI: System for regulating humoral immunity. Nat. Immunol. 1:252.
16. Hatzoglou, A., Roussel, J., Bourgeade, M. F. et al. 2000. TNF receptor family member BCMA (B cell maturation) associates with TNF receptor-associated factor (TRAF) 1, TRAF2, and TRAF3 and activates NF-kappa B, elk-1, c-Jun N-terminal kinase, and p38 mitogen-activated protein kinase. J. Immunol. 165:1322.
17. Khare, S. D., Sarosi, I., Xia, X. Z. et al. 2000. Severe B cell hyperplasia and autoimmune disease in TALL-1 transgenic mice. Proc. Natl Acad. Sci. USA 97:3370.
18. Mackay, F., Woodcock, S. A., Lawton, P. et al. 1999. Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations. J. Exp. Med. 190:1697.
19. Matsushita, T., Hasegawa, M., Yanaba, K., Kodera, M., Takehara, K. and Sato, S. 2006. Elevated serum BAFF levels in patients with systemic sclerosis: Enhanced BAFF signaling in systemic sclerosis B lymphocytes. Arthritis Rheum. 54:192.
20. Quartuccio, L., Fabris, M. and Ferraccioli, G. 2004. B lymphocyte stimulator (BLyS) and monocytes: Possible role in autoimmune diseases with a particular reference to rheumatoid arthritis. Reumatismo 56:143.
21. Stohl, W., Metyas, S., Tan, S. M. et al. 2003. B lymphocyte stimulator overexpression in patients with systemic lupus erythematosus: longitudinal observations. Arthritis Rheum. 48:3475.
22. Zhang, J., Roschke, V., Baker, K. P. et al. 2001. Cutting edge: A role for B lymphocyte stimulator in systemic lupus erythematosus. J. Immunol. 166:6.
23. Cheema, G. S., Roschke, V., Hilbert, D. M. and Stohl, W. 2001. Elevated serum B lymphocyte stimulator levels in patients with systemic immune-based rheumatic diseases. Arthritis Rheum. 44:1313.
24. Lavie, F., Miceli-Richard, C., Quillard, J., Roux, S., Leclerc, P. and Mariette, X. 2004. Expression of BAFF (BLyS) in T cells infiltrating labial salivary glands from patients with Sjogren's syndrome. J. Pathol. 202:496.
25. Gavin, A. L., Ait-Azzouzene, D., Ware, C. F. and Nemazee, D. 2003. DeltaBAFF, an alternate splice isoform that regulates receptor binding and biopresentation of the B cell survival cytokine, BAFF. J. Biol. Chem. 278:38220.
26. Kohler, G. and Milstein, C. 1975. Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 256:495.
27. Bradley, L. M., Dalton, D. K. and Croft, M. 1996. A direct role for IFN-gamma in regulation of Th1 cell development. J. Immunol. 157:1350.
28. Heeg, K., Reimann, J., Kabelitz, D., Hardt, C. and Wagner, H. 1985. A rapid colorimetric assay for the determination of IL-2-producing helper T cell frequencies. J. Immunol. Methods 77:237.
29. Hahne, M., Kataoka, T., Schroter, M. et al. 1998. APRIL, a new ligand of the tumor necrosis factor family, stimulates tumor cell growth. J. Exp. Med. 188:1185.
30. Ben-Bassat, H., Shlomai, Z., Kohn, G. and Prokocimer, M. 1990. Establishment of a human T-acute lymphoblastic leukemia cell line with a (16;20) chromosome translocation. Cancer Genet. Cytogenet. 49:241.
31. Davis, R. J. 2000. Signal transduction by the JNK group of MAP kinases. Cell 103:239.
32. Nardelli, B., Belvedere, O., Roschke, V. et al. 2001. Synthesis and release of B-lymphocyte stimulator from myeloid cells. Blood 97:198.
33. Scapini, P., Nardelli, B., Nadali, G. et al. 2003. G-CSF-stimulated neutrophils are a prominent source of functional BLyS. J. Exp. Med. 197:297.
34. Scapini, P., Carletto, A., Nardelli, B. et al. 2005. Proinflammatory mediators elicit secretion of the intracellular B-lymphocyte stimulator pool (BLyS) that is stored in activated neutrophils: Implications for inflammatory diseases. Blood 105:830.
35. Ohata, J., Zvaifler, N. J., Nishio, M. et al. 2005. Fibroblast-like synoviocytes of mesenchymal origin express functional B cell-activating factor of the TNF family in response to proinflammatory cytokines. J. Immunol. 174:864.
36. Smeekens, S. P. and Steiner, D. F. 1990. Identification of a human insulinoma cDNA encoding a novel mammalian protein structurally related to the yeast dibasic processing protease Kex2. J. Biol. Chem. 265:2997.
37. Van de Ven,W. J., Creemers, J.W. and Roebroek, A. J. 1991. Furin: The prototype mammalian subtilisin-like proprotein-processing enzyme. Endoproteolytic cleavage at paired basic residues of proproteins of the eukaryotic secretory pathway. Enzyme 45:257.
38. Nakayama, K. 1997. Furin: A mammalian subtilisin/Kex2p-like endoprotease involved in processing of a wide variety of precursor proteins. Biochem. J. 327(Pt 3):625.
39. Woodrow, M., Clipstone, N. A. and Cantrell, D. 1993. p21ras and calcineurin synergize to regulate the nuclear factor of activated T cells. J. Exp. Med. 178:1517.
40. Robak, E., Smolewski, P., Wozniacka, A., Sysa-Jedrzejowska, A., Stepien, H. and Robak, T. 2004. Relationship between peripheral blood dendritic cells and cytokines involved in the pathogenesis of systemic lupus erythematosus. Eur. Cytokine Netw. 15:222.
41. al-Janadi, M., al-Balla, S., al-Dalaan, A. and Raziuddin, S. 1993. Cytokine profile in systemic lupus erythematosus, rheumatoid arthritis, and other rheumatic diseases. J. Clin. Immunol. 13:58.
42. Gomez, D., Correa, P. A., Gomez, L. M., Cadena, J., Molina, J. F. and Anaya, J. M. 2004. Th1/Th2 cytokines in patients with systemic lupus erythematosus: Is tumor necrosis factor alpha protective? Semin. Arthritis Rheum. 33:404.
43. Kim, T., Kanayama, Y., Negoro, N., Okamura, M., Takeda, T. and Inoue, T. 1987. Serum levels of interferons in patients with systemic lupus erythematosus. Clin. Exp. Immunol. 70:562.
44. Funauchi, M., Sugishima, H., Minoda, M. and Horiuchi, A. 1991. Serum level of interferon-gamma in autoimmune diseases. Tohoku J. Exp. Med. 164:259.
45. Csiszar, A., Nagy, G., Gergely, P., Pozsonyi, T. and Pocsik, E. 2000. Increased interferon-gamma (IFN-gamma), IL-10 and decreased IL-4 mRNA expression in peripheral blood mononuclear cells (PBMC) from patients with systemic lupus erythematosus (SLE). Clin. Exp. Immunol. 122:464.