Synthetic CpG oligodeoxynucleotides augment BAFF- and APRIL-mediated immunoglobulin secretion

European Journal of Immunology

Volumn 37, Issue 7, 2007, Pages 1785-1795

  Katsenelson, Nora ^a   Kanswal, Sunita ^a   Puig, Montserrat ^c   Mostowski, Howard ^b   Verthelyi, Daniela ^c   Akkoyunlu, Mustafa ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^b CENTER FOR BIOLOGICS EVALUATION AND RESEARCH   (United States)

^c Center for Drug Evaluation and Research   (United States)

Author keywords

A proliferation inducing ligand; BAFF; CpG; Immunoglobulin; TACI

Indexed keywords

APRIL PROTEIN; B CELL ACTIVATING FACTOR; B LYMPHOCYTE RECEPTOR; CPG OLIGODEOXYNUCLEOTIDE; IMMUNOGLOBULIN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; LIPOPOLYSACCHARIDE; NEUTRALIZING ANTIBODY; TOLL LIKE RECEPTOR 9; TRANSMEMBRANE ACTIVATOR CALCIUM MODULATOR AND CYCLOPHILIN LIGAND INTERACTOR; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; B LYMPHOCYTE ACTIVATION; CONTROLLED STUDY; FEMALE; IMMUNOGLOBULIN PRODUCTION; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SPLEEN CELL; UPREGULATION;

ANIMALS; ANTIBODY FORMATION; B-CELL ACTIVATION FACTOR RECEPTOR; B-CELL MATURATION ANTIGEN; B-LYMPHOCYTES; CPG ISLANDS; FEMALE; LIPOPOLYSACCHARIDES; LYMPHOCYTE ACTIVATION; MICE; MICE, KNOCKOUT; OLIGODEOXYRIBONUCLEOTIDES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TOLL-LIKE RECEPTOR 4; TOLL-LIKE RECEPTOR 9; TRANSMEMBRANE ACTIVATOR AND CAML INTERACTOR PROTEIN; TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 13;

EID: 34447535192     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200636800     Document Type: Article

References (39)

1. Schneider, P., The role of APRIL and BAFF in lymphocyte activation. Curr. Opin. Immunol. 2005. 17: 282-289.
2. Thompson, J. S., Schneider, P., Kalled, S. L., Wang, L., Lefevre, E. A., Cachero, T. G., MacKay, F. et al., BAFF binds to the tumor necrosis factor receptor-like molecule B cell maturation antigen and is important for maintaining the peripheral B cell population. J. Exp. Med. 2000. 192: 129-135.
3. Schiemann, B., Gommerman, J. L., Vora, K., Cachero, T. G., Shulga-Morskaya, S., Dobles, M., Frew, E. and Scott, M. L., An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway. Science 2001. 293: 2111-2114.
4. Batten M., Groom, J., Cachero, T. G., Qian, F., Schneider, P., Tschopp, J., Browning, J. L. and MacKay, F., BAFF mediates survival of peripheral immature B lymphocytes. J. Exp. Med. 2000. 192: 1453-1466.
5. Khare, S. D., Sarosi, I., Xia, X. Z., McCabe, S., Miner, K., Solovyev, I., Hawkins, N. et al., Severe B cell hyperplasia and autoimmune disease in TALL-1 transgenic mice. Proc. Natl. Acad. Sci. USA 2000. 97: 3370-3375.
6. MacKay, F., Woodcock, S. A., Lawton, P., Ambrose, C., Baetscher, M., Schneider, P., Tschopp, J. and Browning, J. L., Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations. J. Exp. Med. 1999. 190: 1697-1710.
7. Gross, J. A., Johnston, J., Mudri, S., Enselman, R., Dillon, S. R., Madden, K., Xu, W. et al., TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease. Nature 2000. 404: 995-999.
8. Litinskiy, M. B., Nardelli, B., Hilbert, D. M., He, B., Schaffer, A., Casali, P. and Cerutti, A., DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL. Nat. Immunol. 2002. 3: 822-829.
9. Castigli, E., Scott, S., Dedeoglu, F., Bryce, P., Jabara, H., Bhan A. K., Mizoguchi, E. and Geha, R. S., Impaired IgA class switching in APRIL-deficient mice. Proc. Natl. Acad. Sci. USA 2004. 101: 3903-3908.
10. von Bulow, G. U., van Deursen, J. M. and Brain, R. J., Regulation of the T-independent humoral response by TACI. Immunity 2001. 14: 573-582.
11. Castigli, E., Wilson, S. A., Scott, S., Dedeoglu, F., Xu, S., Lam, K. P., Bram, R. J. et al., TACI and BAFF-R mediate isotype switching in B cells. J. Exp. Med. 2005. 201: 35-39.
12. Seshasayee, D., Valdez, P., Yan, M., Dixit, V. M., Tumas, D. and Grewal, I. S., Loss of TACI causes fatal lymphoproliferation and autoimmunity, establishing TACI as an inhibitory BLyS receptor. Immunity 2003. 18: 279-288.
13. O'Connor, B. P., Raman, V. S., Erickson, L. D., Cook, W. J., Weaver, L. K., Ahonen, C., Lin, L. L. et al., BCMA is essential for the survival of long-lived bone marrow plasma cells. J. Exp. Med. 2004. 199: 91-98.
14. Yang, M., Hase, H., Legarda-Addison, D., Varughese, L., Seed, B. and Ting, A. T., B cell maturation antigen, the receptor for a proliferation-inducing ligand and B cell-activating factor of the TNF family, induces antigen presentation in B cells. J. Immunol. 2005. 175: 2814-2824.
15. Iwasaki, A. and Medzhitov, R., Toll-like receptor control of the adaptive immune responses. Nat. Immunol. 2004. 5: 987-995.
16. Lin, L., Gerth, A. J. and Peng, S. L., CpG DNA redirects class-switching towards "Th1-like" Ig isotype production via TLR9 and MyD88. Eur. J. Immunol. 2004. 34: 1483-1487.
17. He, B., Qiao, X. and Cerutti, A., CpG DNA induces IgG class switch DNA recombination by activating human B cells through an innate pathway that requires TLR9 and cooperates with IL-10. J. Immunol. 2004. 173: 4479-4491.
18. Bernasconi, N. L., Traggiai, E. and Lanzavecchia, A., Maintenance of serological memory by polyclonal activation of human memory B cells. Science 2002. 298: 2199-2202.
19. Bernasconi, N. L., Onai, N. and Lanzavecehia, A., A role for Toll-like receptors in acquired immunity: Up-regulation of TLR9 by BCR triggering in naive B cells and constitutive expression in memory B cells. Blood 2003. 101: 4500-4504.
20. Bourke, E., Bosisio, D., Golay, J., Polentarutti, N. and Mantovani, A., The Toll-like receptor repertoire of human B lymphocytes: Inducible and selective expression of TLR9 and TLR10 in normal and transformed cells. Blood 2003. 102: 956-963.
21. Gantner, F., Hermann, P., Nakashima, K., Matsukawa, S., Sakai, K. and Bacon, K. B., CD40-dependent and -independent activation of human tonsil B cells by CpG oligodeoxynucleotides. Eur. J. Immunol. 2003. 33: 1576-1585.
22. Poeck, H., Wagner, M., Battiany, J., Rothenfusser, S., Wellisch, D., Hornung, V., Jahrsdorfer, B. et al., Plasmacytoid dendritic cells, antigen, and CpG-C license human B cells for plasma cell differentiation and immunoglobulin production in the absence of T-cell help. Blood 2004. 103: 3058-3064.
23. Ng, L. G., Ng, C. H., Woehl, B., Sutherland, A. P., Huo, J., Xu, S., MacKay, F. and Lam, K. P., BAFF costimulation of Toll-like receptor-activated B-1 cells. Eur. J. Immunol. 2006. 36: 1837-1846.
24. Klinman, D. M., Currie, D., Gursel, I. and Verthelyi, D., Use of CpG oligodeoxynucleotides as immune adjuvants. Immunol. Rev. 2004. 199: 201-216.
25. Krieg, A. M., CpG motifs in bacterial DNA and their immune effects. Annu. Rev. Immunol. 2002. 20: 709-760.
26. Krieg, A. M., CpG DNA: A pathogenic factor in systemic lupus erythematosus? J. Clin. Immunol. 1995. 15: 284-292.
27. Vollmer, J., Weeratna, R., Payette, P., Jurk, M., Schetter, C., Laucht, M., Wader, T. et al., Characterization of three CpG oligodeoxynucleoticle classes with distinct immunostimulatory activities. Eur. J. Immunol. 2004. 34: 251-262.
28. Ishii, K. J., Coban, C., Kato, H., Takahashi, K., Torii, Y., Takeshita, F., Ludwig, H. et al., A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA. Nat. Immunol. 2006. 7: 40-48.
29. Castigh, E., Wilson, S. A., Garibyan, L., Rachid, R., Bonilla, F., Schneider, L. and Geha, R. S., TACI is mutant in common variable immunodeficiency and IgA deficiency. Nat. Genet. 2005. 37: 829-834.
30. Ng, L. G., Sutherland, A. P., Newton, R., Qian, F., Cachero, T. G., Scott, M. L., Thompson, J. S. et al., B cell-activating factor belonging to the TNF family (BAFF)-R is the principal BAFF receptor facilitating BAFF costimulation of circulating T and B cells. J. Immunol. 2004. 173: 807-817.
31. Shulga-Morskaya, S., Dobles, M., Walsh, M. E., Ng, L. G., MacKay, F., Rao, S. P., Kalled, S. L. and Scott, M. L., B cell-activating factor belonging to the TNF family acts through separate receptors to support B cell survival and T cell-independent antibody formation. J. Immunol. 2004. 173: 2331-2341.
32. Sasaki, Y., Casola, S., Kutok, J. L., Rajewsky, K. and Schmidt-Supprian, M., TNF family member B cell-activating factor (BAFF) receptor-dependent and -independent roles for BAFF in B cell physiology. J. Immunol. 2004. 173: 2245-2252.
33. Eastcott, J. W., Holmberg, C. J., Dewhirst, F. E., Esch, T. R., Smith, D. J. and Taubman, M. A., Oligonuclecitide containing CpG motifs enhances immune response to mucosally or systemically administered tetanus toxoid. Vaccine 2001. 19: 1636-1642.
34. Landers, C. D. and Bondada, S., CpG oligodeoxynucleotides stimulate cord blood mononuclear cells to produce immunoglobulins. Clin. Immunol. 2005. 116: 236-245.
35. Kovarik, J., Bozzotti, P., Tougne, C., Davis, H. L., Lambert, P. H., Krieg, A. M. and Siegrist, C. A., Adjuvant effects of CpG oligodeoxynucleotides on responses against T-independent type 2 antigens. Immunology 2001. 102: 67-76.
36. Weintraub, A., Immunology of bacterial polysaccharicle antigens. Carbohydr. Res. 2003. 338: 2539-2547.
37. Fagarasan, S. and Honjo, T., T-independent immune response: New aspects of B cell biology. Science 2000. 290: 89-92.
38. Chelvarajan, R. L., Raithatha, R., Venkataraman, C., Kaul, R., Han, S. S., Robertson, D. A. and Bondada, S., CpG oligodeoxynucleotides overcome the unresponsiveness of neonatal B cells to stimulation with the thymus-independent stimuli anti-IgM and TNP-Ficoll. Eur. J. Immunol. 1999. 29: 2808-2818.
39. Livak, K. J. and Schmittgen, T. D., Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T)) method. Methods 2001. 25: 402-408.