메뉴 건너뛰기




Volumn 180, Issue 3, 2008, Pages 1903-1912

Dual roles of immunoregulatory cytokine TGF-β in the pathogenesis of autoimmunity-mediated organ damage

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; MESSENGER RNA; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA ANTIBODY; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2; TRANSFORMING GROWTH FACTOR BETA1;

EID: 40749089639     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.180.3.1903     Document Type: Article
Times cited : (111)

References (42)
  • 2
    • 28444493730 scopus 로고    scopus 로고
    • SLE: Translating lessons from model systems to human disease
    • Singh, R. R. 2005. SLE: translating lessons from model systems to human disease. Trends Immunol. 26: 572-579.
    • (2005) Trends Immunol , vol.26 , pp. 572-579
    • Singh, R.R.1
  • 3
    • 0037388451 scopus 로고    scopus 로고
    • Pathogenic T cells in murine lupus exhibit spontaneous signaling activity through phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathways
    • Niculescu, F., P. Nguyen, T. Niculescu, H. Rus, V. Rus, and C. S. Via. 2003. Pathogenic T cells in murine lupus exhibit spontaneous signaling activity through phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathways. Arthritis Rheum. 48: 1071-1079.
    • (2003) Arthritis Rheum , vol.48 , pp. 1071-1079
    • Niculescu, F.1    Nguyen, P.2    Niculescu, T.3    Rus, H.4    Rus, V.5    Via, C.S.6
  • 4
    • 0037438466 scopus 로고    scopus 로고
    • + T cells from lupus-prone mice avoid antigen-specific tolerance induction in vivo
    • + T cells from lupus-prone mice avoid antigen-specific tolerance induction in vivo. J. Immunol. 170: 741-748.
    • (2003) J. Immunol , vol.170 , pp. 741-748
    • Bouzahzah, F.1    Jung, S.2    Craft, J.3
  • 7
    • 0242584870 scopus 로고    scopus 로고
    • TGF-β 1 regulates lymphocyte homeostasis by preventing activation and subsequent apoptosis of peripheral lymphocytes
    • Bommireddy, R., V. Saxena, I. Ormsby, M. Yin, G. P. Boivin, G. F. Babcock, R. R. Singh, and T. Doetschman. 2003. TGF-β 1 regulates lymphocyte homeostasis by preventing activation and subsequent apoptosis of peripheral lymphocytes. J. Immunol. 170: 4612-4622.
    • (2003) J. Immunol , vol.170 , pp. 4612-4622
    • Bommireddy, R.1    Saxena, V.2    Ormsby, I.3    Yin, M.4    Boivin, G.P.5    Babcock, G.F.6    Singh, R.R.7    Doetschman, T.8
  • 8
    • 0028990699 scopus 로고
    • SLE-like autoantibodies and Sjogren's syndrome-like lymphoproliferation in TGF-β knockout mice
    • Dang, H., A. G. Geiser, J. J. Letterio, T. Nakabayashi, L. Kong, G. Fernandes, and N. Talal. 1995. SLE-like autoantibodies and Sjogren's syndrome-like lymphoproliferation in TGF-β knockout mice. J. Immunol. 155: 3205-3212.
    • (1995) J. Immunol , vol.155 , pp. 3205-3212
    • Dang, H.1    Geiser, A.G.2    Letterio, J.J.3    Nakabayashi, T.4    Kong, L.5    Fernandes, G.6    Talal, N.7
  • 10
    • 59949092818 scopus 로고    scopus 로고
    • Conditional TGF-β receptor II deletion in murine thymocytes results in spontaneous T cell activation and multiorgan inflammation
    • Adams, D. E., J. Q. Yang, and R. R. Singh. 2004. Conditional TGF-β receptor II deletion in murine thymocytes results in spontaneous T cell activation and multiorgan inflammation. FASEB J. 18: A1136.
    • (2004) FASEB J , vol.18
    • Adams, D.E.1    Yang, J.Q.2    Singh, R.R.3
  • 11
    • 33748448717 scopus 로고    scopus 로고
    • Transforming growth factor-β controls development, homeostasis, and tolerance of T cells by regulatory T cell-dependent and -independent mechanisms
    • Li, M. O., S. Sanjabi, and R. A. Flavell. 2006. Transforming growth factor-β controls development, homeostasis, and tolerance of T cells by regulatory T cell-dependent and -independent mechanisms. Immunity 25: 455-471.
    • (2006) Immunity , vol.25 , pp. 455-471
    • Li, M.O.1    Sanjabi, S.2    Flavell, R.A.3
  • 12
    • 33748465396 scopus 로고    scopus 로고
    • Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-β receptor
    • Marie, J. C., D. Liggitt, and A. Y. Rudensky. 2006. Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-β receptor. Immunity 25: 441-454.
    • (2006) Immunity , vol.25 , pp. 441-454
    • Marie, J.C.1    Liggitt, D.2    Rudensky, A.Y.3
  • 13
    • 0032030620 scopus 로고    scopus 로고
    • Decreased production of TGF-β by lymphocytes from patients with systemic lupus erythematosus
    • Ohtsuka, K., J. D. Gray, M. M. Stimmler, B. Toro, and D. A. Horwitz. 1998. Decreased production of TGF-β by lymphocytes from patients with systemic lupus erythematosus. J. Immunol. 160: 2539-2545.
    • (1998) J. Immunol , vol.160 , pp. 2539-2545
    • Ohtsuka, K.1    Gray, J.D.2    Stimmler, M.M.3    Toro, B.4    Horwitz, D.A.5
  • 14
    • 0032415984 scopus 로고    scopus 로고
    • Mechanisms of progression of renal damage in lupus nephritis: Pathogenesis of renal scarring
    • Grande, J. P. 1998. Mechanisms of progression of renal damage in lupus nephritis: pathogenesis of renal scarring. Lupus 7: 604-610.
    • (1998) Lupus , vol.7 , pp. 604-610
    • Grande, J.P.1
  • 15
    • 0038349941 scopus 로고    scopus 로고
    • New insights into mechanisms of fibrosis in immune renal injury
    • Strutz, F., and E. G. Neilson. 2003. New insights into mechanisms of fibrosis in immune renal injury. Springer Semin. Immunopathol. 24: 459-476.
    • (2003) Springer Semin. Immunopathol , vol.24 , pp. 459-476
    • Strutz, F.1    Neilson, E.G.2
  • 16
    • 0036099111 scopus 로고    scopus 로고
    • Outcome of relapse in lupus nephritis: Roles of reversal of renal fibrosis and response of inflammation to therapy
    • Hill, G. S., M. Delahousse, D. Nochy, E. Thervet, F. Vrtovsnik, P. Remy, D. Glotz, and J. Bariety. 2002. Outcome of relapse in lupus nephritis: roles of reversal of renal fibrosis and response of inflammation to therapy. Kidney Int. 61: 2176-2186.
    • (2002) Kidney Int , vol.61 , pp. 2176-2186
    • Hill, G.S.1    Delahousse, M.2    Nochy, D.3    Thervet, E.4    Vrtovsnik, F.5    Remy, P.6    Glotz, D.7    Bariety, J.8
  • 17
    • 0036206528 scopus 로고    scopus 로고
    • Classes, activity and chronicity indices, and α-smooth muscle actin expression as prognostic parameters in lupus nephritis outcome
    • Ravinal, R. C., R. S. Costa, T. M. Coimbra, M. T. Pastorello, E. B. Coelho, M. Dantas, and R. M. dos. 2002. Classes, activity and chronicity indices, and α-smooth muscle actin expression as prognostic parameters in lupus nephritis outcome. Lupus 11: 82-87.
    • (2002) Lupus , vol.11 , pp. 82-87
    • Ravinal, R.C.1    Costa, R.S.2    Coimbra, T.M.3    Pastorello, M.T.4    Coelho, E.B.5    Dantas, M.6    dos, R.M.7
  • 19
    • 0025277164 scopus 로고
    • Suppression of experimental glomerulonephritis by antiserum against transforming growth factor β 1
    • Border, W. A., S. Okuda, L. R. Languino, M. B. Sporn, and E. Ruoslahti. 1990. Suppression of experimental glomerulonephritis by antiserum against transforming growth factor β 1. Nature 346: 371-374.
    • (1990) Nature , vol.346 , pp. 371-374
    • Border, W.A.1    Okuda, S.2    Languino, L.R.3    Sporn, M.B.4    Ruoslahti, E.5
  • 20
    • 0028280073 scopus 로고
    • Sustained expression of TGF-β 1 underlies development of progressive kidney fibrosis
    • Yamamoto, T., N. A. Noble, D. E. Miller, and W. A. Border. 1994. Sustained expression of TGF-β 1 underlies development of progressive kidney fibrosis. Kidney Int. 45: 916-927.
    • (1994) Kidney Int , vol.45 , pp. 916-927
    • Yamamoto, T.1    Noble, N.A.2    Miller, D.E.3    Border, W.A.4
  • 21
    • 0027450159 scopus 로고
    • Transforming growth factor-β protein and mRNA in glomeruli in normal and diseased human kidneys
    • Yoshioka, K., T. Takemura, K. Murakami, M. Okada, S. Hino, H. Miyamoto, and S. Maki. 1993. Transforming growth factor-β protein and mRNA in glomeruli in normal and diseased human kidneys. Lab. Invest. 68: 154-163.
    • (1993) Lab. Invest , vol.68 , pp. 154-163
    • Yoshioka, K.1    Takemura, T.2    Murakami, K.3    Okada, M.4    Hino, S.5    Miyamoto, H.6    Maki, S.7
  • 22
    • 0035892231 scopus 로고    scopus 로고
    • Role of TGF-β in development of spontaneous autoimmune thyroiditis in NOD.H-2h4 mice
    • Braley-Mullen, H., K. Chen, Y. Wei, and S. Yu. 2001. Role of TGF-β in development of spontaneous autoimmune thyroiditis in NOD.H-2h4 mice. J. Immunol. 167: 7111-7118.
    • (2001) J. Immunol , vol.167 , pp. 7111-7118
    • Braley-Mullen, H.1    Chen, K.2    Wei, Y.3    Yu, S.4
  • 24
    • 34247232969 scopus 로고    scopus 로고
    • Animal models of systemic lupus erythematosus
    • 7th Ed. D. J. Wallace and B. H. Hahn, eds. Lippincott Williams and Wilkins, Philadelphia, pp
    • Hahn, B. H., and R. R. Singh. 2007. Animal models of systemic lupus erythematosus. In Dubois' Lupus Erythematosus, 7th Ed. D. J. Wallace and B. H. Hahn, eds. Lippincott Williams and Wilkins, Philadelphia, pp. 299-355.
    • (2007) Dubois' Lupus Erythematosus , pp. 299-355
    • Hahn, B.H.1    Singh, R.R.2
  • 26
    • 0030002897 scopus 로고    scopus 로고
    • Neonatal peptide exposure can prime T cells and, upon subsequent immunization, induce their immune deviation: Implications for antibody vs. T cell-mediated autoimmunity
    • Singh, R. R., B. H. Hahn, and E. E. Sercarz. 1996. Neonatal peptide exposure can prime T cells and, upon subsequent immunization, induce their immune deviation: implications for antibody vs. T cell-mediated autoimmunity. J. Exp. Med. 183: 1613-1621.
    • (1996) J. Exp. Med , vol.183 , pp. 1613-1621
    • Singh, R.R.1    Hahn, B.H.2    Sercarz, E.E.3
  • 28
    • 0037087318 scopus 로고    scopus 로고
    • Murine sclerodermatous graft-versus-host disease, a model for human scleroderma: Cutaneous cytokines, chemokines, and immune cell activation
    • Zhang, Y., L. L. McCormick, S. R. Desai, C. Wu, and A. C. Gilliam. 2002. Murine sclerodermatous graft-versus-host disease, a model for human scleroderma: cutaneous cytokines, chemokines, and immune cell activation. J. Immunol. 168: 3088-3098.
    • (2002) J. Immunol , vol.168 , pp. 3088-3098
    • Zhang, Y.1    McCormick, L.L.2    Desai, S.R.3    Wu, C.4    Gilliam, A.C.5
  • 29
    • 0037306606 scopus 로고    scopus 로고
    • Therapeutic role of TGF-β-neutralizing antibody in mouse cyclosporin A nephropathy: Morphologic improvement associated with functional preservation
    • Ling, H., X. Li, S. Jha, W. Wang, L. Karetskaya, B. Pratt, and S. Ledbetter. 2003. Therapeutic role of TGF-β-neutralizing antibody in mouse cyclosporin A nephropathy: morphologic improvement associated with functional preservation. J. Am. Soc. Nephrol. 14: 377-388.
    • (2003) J. Am. Soc. Nephrol , vol.14 , pp. 377-388
    • Ling, H.1    Li, X.2    Jha, S.3    Wang, W.4    Karetskaya, L.5    Pratt, B.6    Ledbetter, S.7
  • 30
    • 0037120006 scopus 로고    scopus 로고
    • Vaccination with minigenes encoding V(H)-derived major histocompatibility complex class I-binding epitopes activates cytotoxic T cells that ablate autoantibody-producing B cells and inhibit lupus
    • Fan, G. C., and R. R. Singh. 2002. Vaccination with minigenes encoding V(H)-derived major histocompatibility complex class I-binding epitopes activates cytotoxic T cells that ablate autoantibody-producing B cells and inhibit lupus. J. Exp. Med. 196: 731-741.
    • (2002) J. Exp. Med , vol.196 , pp. 731-741
    • Fan, G.C.1    Singh, R.R.2
  • 31
    • 0141889082 scopus 로고    scopus 로고
    • Repeated α-galactosylceramide administration results in expansion of NK T cells and alleviates inflammatory dermatitis in MRL-lpr/lpr mice
    • Yang, J. Q., V. Saxena, H. Xu, L. Van Kaer, C. R. Wang, and R. R. Singh. 2003. Repeated α-galactosylceramide administration results in expansion of NK T cells and alleviates inflammatory dermatitis in MRL-lpr/lpr mice. J. Immunol. 171: 4439-4446.
    • (2003) J. Immunol , vol.171 , pp. 4439-4446
    • Yang, J.Q.1    Saxena, V.2    Xu, H.3    Van Kaer, L.4    Wang, C.R.5    Singh, R.R.6
  • 33
    • 0038682002 scopus 로고    scopus 로고
    • Mechanisms of TGF-β signaling from cell membrane to the nucleus
    • Shi, Y., and J. Massague. 2003. Mechanisms of TGF-β signaling from cell membrane to the nucleus. Cell 113: 685-700.
    • (2003) Cell , vol.113 , pp. 685-700
    • Shi, Y.1    Massague, J.2
  • 34
    • 0032911002 scopus 로고    scopus 로고
    • Cytokine-mediated down-regulation of B cell activity in SLE: Effects of interleukin-2 and transforming growth factor-β
    • Ohtsuka, K., J. D. Gray, F. P. Quismorio, Jr., W. Lee, and D. A. Horwitz. 1999. Cytokine-mediated down-regulation of B cell activity in SLE: effects of interleukin-2 and transforming growth factor-β. Lupus 8: 95-102.
    • (1999) Lupus , vol.8 , pp. 95-102
    • Ohtsuka, K.1    Gray, J.D.2    Quismorio Jr., F.P.3    Lee, W.4    Horwitz, D.A.5
  • 35
    • 0035985790 scopus 로고    scopus 로고
    • The potential of human regulatory T cells generated ex vivo as a treatment for lupus and other chronic inflammatory diseases
    • Horwitz, D. A., J. D. Gray, and S. G. Zheng. 2002. The potential of human regulatory T cells generated ex vivo as a treatment for lupus and other chronic inflammatory diseases. Arthritis Res. 4: 241-246.
    • (2002) Arthritis Res , vol.4 , pp. 241-246
    • Horwitz, D.A.1    Gray, J.D.2    Zheng, S.G.3
  • 36
    • 4644236340 scopus 로고    scopus 로고
    • + T cells in lupus-prone (NZB x NZW) F1 mice and healthy (BALB/c x NZW) F1 mice may influence autoimmunity in the lupus model
    • + T cells in lupus-prone (NZB x NZW) F1 mice and healthy (BALB/c x NZW) F1 mice may influence autoimmunity in the lupus model. Eur. J. Immunol. 34: 2489-2499.
    • (2004) Eur. J. Immunol , vol.34 , pp. 2489-2499
    • Karpouzas, G.A.1    La Cava, A.2    Ebling, F.M.3    Singh, R.R.4    Hahn, B.H.5
  • 37
    • 0034608948 scopus 로고    scopus 로고
    • Long-term prevention of renal insufficiency, excess matrix gene expression, and glomerular mesangial matrix expansion by treatment with monoclonal antitransforming growth factor-β antibody in db/db diabetic mice
    • Ziyadeh, F. N., B. B. Hoffman, D. C. Han, M. C. Iglesias-De La Cruz, S. W. Hong, M. Isono, S. Chen, T. A. McGowan, and K. Sharma. 2000. Long-term prevention of renal insufficiency, excess matrix gene expression, and glomerular mesangial matrix expansion by treatment with monoclonal antitransforming growth factor-β antibody in db/db diabetic mice. Proc. Natl. Acad. Sci. USA 97: 8015-8020.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 8015-8020
    • Ziyadeh, F.N.1    Hoffman, B.B.2    Han, D.C.3    Iglesias-De La Cruz, M.C.4    Hong, S.W.5    Isono, M.6    Chen, S.7    McGowan, T.A.8    Sharma, K.9
  • 39
    • 0035132655 scopus 로고    scopus 로고
    • Effect of anti-transforming growth factor-β antibodies in cyclosporine-induced renal dysfunction
    • Islam, M., J. F. Burke, Jr., T. A. McGowan, Y. Zhu, S. R. Dunn, P. McCue, J. Kanalas, and K. Sharma. 2001. Effect of anti-transforming growth factor-β antibodies in cyclosporine-induced renal dysfunction. Kidney Int. 59: 498-506.
    • (2001) Kidney Int , vol.59 , pp. 498-506
    • Islam, M.1    Burke Jr., J.F.2    McGowan, T.A.3    Zhu, Y.4    Dunn, S.R.5    McCue, P.6    Kanalas, J.7    Sharma, K.8
  • 40
    • 0141796312 scopus 로고    scopus 로고
    • TGF-β-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes
    • Belghith, M., J. A. Bluestone, S. Barriot, J. Megret, J. F. Bach, and L. Chatenoud. 2003. TGF-β-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes. Nat. Med. 9: 1202-1208.
    • (2003) Nat. Med , vol.9 , pp. 1202-1208
    • Belghith, M.1    Bluestone, J.A.2    Barriot, S.3    Megret, J.4    Bach, J.F.5    Chatenoud, L.6
  • 42
    • 0034327176 scopus 로고    scopus 로고
    • Cutting edge: TGF-β inhibits Th type 2 development through inhibition of GATA-3 expression
    • Gorelik, L., P. E. Fields, and R. A. Flavell. 2000. Cutting edge: TGF-β inhibits Th type 2 development through inhibition of GATA-3 expression. J. Immunol. 165: 4773-4777.
    • (2000) J. Immunol , vol.165 , pp. 4773-4777
    • Gorelik, L.1    Fields, P.E.2    Flavell, R.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.