Mechanisms of MPTP toxicity

Movement Disorders

Volumn 13, Issue SUPPL. 1, 1998, Pages 35-38

  Przedborski, Serge ^a   Jackson Lewis, Vernice ^a  

^a Neurology Department ^*  (United States)

Author keywords

Free radicals; Mitochondria; MPTP; Parkinson's disease; Pathogenesis

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; FREE RADICAL; NITRIC OXIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; CELL DEATH; CLINICAL FEATURE; CONFERENCE PAPER; DISEASE MODEL; DISEASE PREDISPOSITION; DOPAMINERGIC NERVE CELL; EXPERIMENTAL MODEL; HUMAN; METABOLISM; MITOCHONDRIAL RESPIRATION; NERVE DEGENERATION; NITRATION; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL;

ANIMALS; CELL DEATH; DISEASE MODELS, ANIMAL; DOPAMINE; DOPAMINE AGENTS; FREE RADICALS; HUMANS; MITOCHONDRIA; MPTP POISONING; NERVE DEGENERATION; PARKINSON DISEASE, SECONDARY; SUBSTANTIA NIGRA;

EID: 0031895005     PISSN: 08853185     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (19)

1. Fahn S. Parkinsonism. In: Wyngaarden JB, Smith LH Jr, eds. Cecil's textbook of medicine, 18th ed. Philadelphia, PA: WB Saunders, 1988:2143-2147.
2. Fahn S. Adverse effects of levodopa in Parkinson's disease. In: Calne DB, ed. Handbook of experimental pharmacology, vol 8. Berlin: Springer-Verlag, 1989:386-409.
3. Langston JW. MPTP: the promise of a new neurotoxin. In: Marsden CD, Fahn S, eds. Movement disorders 2. London: Butterworths, 1987:73-90.
4. Tipton KF, Singer TP. Advances in our understanding of the mechanisms of the neurotoxicity of MPTP and related compounds. J Neurochem 1993;61:1191-1206.
5. Kostic V, Donovan D, Yokoyama R, Przedborski S, Uhl G. Transgenic mice with increased number of dopamine transporters (DAT) show greater sensitivity to MPTP. Soc Neurosci Abstr 1996;22:722.
6. Haber SN, Ryoo H, Cox C, Lu W. Subsets of midbrain dopaminergic neurons in monkeys are distinguished by different levels of mRNA for the dopamine transporter: comparison with the mRNA for the D2 receptor, tyrosine hydroxylase and calbindin immunoreactivity. J Comp Neurol 1995;362:400-410.
7. Liu Y, Roghani A, Edwards RH. Gene transfer of a reserpine-sensitive mechanism of resistance to N-methyl-4-phenylpyridinium. Proc Natl Acad Sci USA 1992;89:9074-9078.
8. Takahashi N, Miner LL, Sora I, et al. VMAT2 knockout mice: heterozygotes display reduced amphetamine-conditioned reward, enhanced amphetamine locomotion and enhanced MPTP toxicity. Proc Natl Acad Sci USA 1997;94:9938-9943.
9. Przedborski S, Jackson-Lewis V, Kostic V, et al. Superoxide dismutase, catalase, and glutathione peroxidase activities in copper/ zinc-superoxide dismutase transgenic mice. J Neurochem 1992;58: 1760-1767.
10. Przedborski S, Kostic V, Jackson-Lewis V, et al. Transgenic mice with increased Cu/Zn-superoxide dismutase activity are resistant to N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity. J Neurosci 1992;12:1658-1667.
11. Przedborski S, Jackson-Lewis V, Yokoyama R, et al. Role of neuronal nitric oxide in MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine)-induced dopaminergic neurotoxicity. Proc Natl Acad Sci USA 1996;93:4565-4571.
12. Schulz JB, Matthews RT, Muqit MMK, et al. Inhibition of neuronal nitric oxide synthase by 7-nitroindazole protects against MPTP-induced neurotoxicity in mice. J Neurochem 1995;64:936-939.
13. Hantraye P, Brouillet E, Ferrante R, et al. Inhibition of neuronal nitric oxide synthase prevents MPTP-induced parkinsonism in baboons. Nat Med 1996;2:1017-1021.
14. King MP, Attardi G. Human cells lacking mtDNA: repopulation with exogenous mitochondria by complementation. Science 1989; 246:500-503.
15. Khan U, Filiano B, King MP, Przedborski S. Is Parkinson's disease (PD) an extra-mitochondrial disorder? Neurology 1997;48:A201.
16. Turski L, Bressier K, Rettig KJ, et al. Protection of substantia nigra from MPP+ neurotoxicity by N-methyl-D-aspartate antagonists. Nature 1991;349:414-418.
17. Beal MF. Aging, energy, and oxidative stress in neurodegenerative diseases. Ann Neurol 1995;38:357-366.
18. Jackson-Lewis V, Jakowec M, Burke RE, Przedborski S. Time course and morphology of dopaminergic neuronal death caused by the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Neurodegeneration 1995;4:257-269.
19. Tatton NA, Kish SJ. In situ detection of apoptotic nuclei in the substantia nigra compacta of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice using terminal deoxynucleotidyl transferase labeling and acridine orange staining. Neuroscience 1997;77:1037-1048.