Altering APP proteolysis: Increasing sAPPalpha production by targeting dimerization of the APP Ectodomain

PLoS ONE

Volumn 7, Issue 6, 2012, Pages

  Libeu, Clare A Peters ^a   Descamps, Olivier ^a   Zhang, Qiang ^a   John, Varghese ^a   Bredesen, Dale E ^a  

^a BUCK INSTITUTE FOR RESEARCH ON AGING   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; DISULFIRAM; OLIGOMER; SULFIRAM; TRYPTOPHAN;

ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DIMERIZATION; ECTODOMAIN; FLUORESCENCE; NEUROBLASTOMA CELL; PROTEIN BINDING; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN DOMAIN; X RAY CRYSTALLOGRAPHY;

AMYLOID BETA-PROTEIN PRECURSOR; ANILINO NAPHTHALENESULFONATES; ANIMALS; CHO CELLS; CRICETINAE; DISULFIRAM; FLUORESCENCE; HUMANS; MODELS, MOLECULAR; PEPTIDE FRAGMENTS; PEPTIDES; PROTEIN BINDING; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, TERTIARY; PROTEOLYSIS; RATS; RECOMBINANT FUSION PROTEINS; SCATTERING, SMALL ANGLE; TRYPTOPHAN; X-RAY DIFFRACTION;

EID: 84863111022     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0040027     Document Type: Article

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