WAVE2 protein complex coupled to membrane and microtubules

Journal of Oncology

Volumn , Issue , 2012, Pages

  Takahashi, Kazuhide ^a  

^a KANAGAWA CANCER CENTER   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CATENIN; CELL ADHESION MOLECULE; CYTOSKELETON PROTEIN; RAC1 PROTEIN; REGULATOR PROTEIN; UNCLASSIFIED DRUG; UVOMORULIN; WAVE2 PROTEIN;

ACTIN FILAMENT; CANCER CELL; CELL ADHESION; CELL INVASION; CELL MIGRATION; COMPLEX FORMATION; HUMAN; LAMELLIPODIUM; MEMBRANE BINDING; MICROTUBULE; MICROTUBULE ASSEMBLY; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION;

EID: 84863081067     PISSN: 16878450     EISSN: 16878469     Source Type: Journal    
DOI: 10.1155/2012/590531     Document Type: Review

References (139)

1. Gumbiner B., Stevenson B., Grimaldi A., The role of the cell adhesion molecule uvomorulin in the formation and maintenance of the epithelial junctional complex Journal of Cell Biology 1988 107 4 1575 1587
2. Takeichi M., The cadherins: cellcell adhesion molecules controlling animal morphogenesis Development 1988 102 4 639 655
3. Takeichi M., Cadherin cell adhesion receptors as a morphogenetic regulator Science 1991 251 5000 1451 1455 (Pubitemid 121000430)
4. Shapiro L., Fannon A. M., Kwong P. D., Thompson A., Lehmann M. S., Grubel G., Legrand J. F., Als-Nielsen J., Colman D. R., Hendrickson W. A., Structural basis of cellcell adhesion by cadherins Nature 1995 374 6520 327 337
5. Ozawa M., Barbault H., Kemler R., The cytoplasmic domain of the cell adhesion molecule uvomorulin assoicates with three independent proteins structurally related in different species EMBO Journal 1989 8 6 1711 1717 (Pubitemid 19273986)
6. Magee A. I., Buxton R. S., Transmembrane molecular assemblies regulated by the greater cadherin family Current Opinion in Cell Biology 1991 3 5 854 861 (Pubitemid 121006143)
7. Hirano S., Kimoto N., Shimoyama Y., Hirohashi S., Takeichi M., Identification of a neural -catenin as a key regulator of cadherin function and multicellular organization Cell 1992 70 2 293 301
8. Nagafuchi A., Takeichi M., Cell binding function of E-cadherin is regulated by the cytoplasmic domain EMBO Journal 1988 7 12 3679 3684
9. Knudsen K. A., Soler A. P., Johnson K. R., Wheelock M. J., Interaction of -actinin with the cadherin/catenin cellcell adhesion complex via -catenin Journal of Cell Biology 1995 130 1 67 77
10. Berx G., Cleton-Jansen A. M., Nollet F., De Leeuw W. J. F., Van De Vijver M. J., Cornelisse C., Van Roy F., E-cadherin is a tumour/invasion suppressor gene mutated in human lobular breast cancers EMBO Journal 1995 14 24 6107 6115 (Pubitemid 26007298)
11. Kadowaki T., Shiozaki H., Inoue M., Tamura S., Oka H., Doki Y., Iihara K., Matsui S., Iwazawa T., Nagafuchi A., Tsukita S., Mori T., E-cadherin and -catenin expression in human esophageal cancer Cancer Research 1994 54 1 291 296
12. Schipper J. H., Frixen U. H., Behrens J., Unger A., Jahnke K., Birchmeier W., E-cadherin expression in squamous cell carcinomas of head and neck: inverse correlation with tumor dedifferentiation and lymph node metastasis Cancer Research 1991 51 23 6328 6337
13. Shimoyama Y., Hirohashi S., Expression of E- and P-cadherin in gastric carcinomas Cancer Research 1991 51 8 2185 2192
14. Morton R. A., Ewing C. M., Nagafuchi A., Tsukita S., Isaacs W. B., Reduction of E-cadherin levels and deletion of the -catenin gene in human prostate cancer cells Cancer Research 1993 53 15 3585 3590 (Pubitemid 23229641)
15. Shimoyama Y., Nagafuchi A., Fujita S., Gotoh M., Takeichi M., Tsukita S., Hirohashi S., Cadherin dysfunction in a human cancer cell line: possible involvement of loss of -catenin expression in reduced cellcell adhesiveness Cancer Research 1992 52 20 5770 5774
16. Pierceall W. E., Woodard A. S., Morrow J. S., Rimm D., Fearon E. R., Frequent alterations in E-cadherin and -and -catenin expression in human breast cancer cell lines Oncogene 1995 11 7 1319 1326
17. Fujii K., Furukawa F., Matsuyoshi N., Ligand activation of overexpressed epidermal growth factor receptor results in colony dissociation and disturbed E-cadherin function in HSC-1 human cutaneous squamous carcinoma cells Experimental Cell Research 1996 223 1 50 62 (Pubitemid 26063921)
18. Hoschuetzky H., Aberle H., Kemler R., -Catenin mediates the interaction of the cadherin-catenin complex with epidermal growth factor receptor Journal of Cell Biology 1994 127 5 1375 1380 (Pubitemid 24362569)
19. Shibamoto S., Hayakawa M., Takeuchi K., Hori T., Oku N., Miyazawa K., Kitamura N., Takeichi M., Ito F., Tyrosine phosphorylation of -catenin and plakoglobin enhanced by hepatocyte growth factor and epidermal growth factor in human carcinoma cells Cell Adhesion and Communication 1994 1 4 295 305
20. Takahashi K., Suzuki K., Density-dependent inhibition of growth involves prevention of EGF receptor activation by E-cadherin-mediated cellcell adhesion Experimental Cell Research 1996 226 1 214 222 (Pubitemid 26238945)
21. Behrens J., Vakaet L., Friis R., Winterhager E., Van Roy F., Mareel M. M., Birchmeier W., Loss of epithelial differentiation and gain of invasiveness correlates with tyrosine phosphorylation of the E-cadherin/ -catenin complex in cells transformed with a temperature-sensitive v-SRC gene Journal of Cell Biology 1993 120 3 757 766 (Pubitemid 23035144)
22. Hamaguchi M., Matsuyoshi N., Ohnishi Y., Gotoh B., Takeichi M., Nagai Y., P60(v-src) causes tyrosine phosphorylation and inactivation of the N-cadherin-catenin cell adhesion system EMBO Journal 1993 12 1 307 314 (Pubitemid 23042409)
23. Takahashi K., Suzuki K., Tsukatani Y., Induction of tyrosine phosphorylation and association of -catenin with EGF receptor upon tryptic digestion of quiescent cells at confluence Oncogene 1997 15 1 71 78 (Pubitemid 27348098)
24. Tsukatani Y., Suzuki K., Takahashi K., Loss of density-dependent growth inhibition and dissociation of -Catenin from E-cadherin Journal of Cellular Physiology 1997 173 1 54 63 (Pubitemid 27417723)
25. Gebbink M. F., Zondag G. C., Koningstein G. M., Feiken E., Wubbolts R. W., Moolenaar W. H., Cell surface expression of receptor protein tyrosine phosphatase RPTP is regulated by cellcell contact Journal of Cell Biology 1995 131 1 251 260
26. Ostman A., Yang Q., Tonks N. K., Expression of DEP-1, a receptor-like protein-tyrosine-phosphatase, is enhanced with increasing cell density Proceedings of the National Academy of Sciences of the United States of America 1994 91 21 9680 9684 (Pubitemid 24311871)
27. Balsamo J., Arregui C., Leung T., Lilien J., The nonreceptor protein tyrosine phosphatase PTP1B binds to the cytoplasmic domain of N-cadherin and regulates the cadherinactin linkage Journal of Cell Biology 1998 143 2 523 532 (Pubitemid 28487868)
28. Balsamo J., Leung T., Ernst H., Zanin M. K., Hoffman S., Lilien J., Regulated binding of a PTP1B-like phosphatase to N-cadherin: control of cadherin-mediated adhesion by dephosphorylation of -catenin Journal of Cell Biology 1996 134 3 801 813 (Pubitemid 26271335)
29. Brady-Kalnay S. M., Mourton T., Nixon J. P., Pietz G. E., Kinch M., Chen H., Brackenbury R., Rimm D. L., Del Vecchio R. L., Tonks N. K., Dynamic interactions of PTP with multiple cadherins in vivo Journal of Cell Biology 1998 141 1 287 296 (Pubitemid 28182659)
30. Brady-Kalnay S. M., Rimm D. L., Tonks N. K., Receptor protein tyrosine phosphatase PTP associates with cadherins and catenins in vivo Journal of Cell Biology 1995 130 4 977 986
31. Kypta R. M., Su H., Reichardt L. F., Association between a transmembrane protein tyrosine phosphatase and the cadherincatenin complex Journal of Cell Biology 1996 134 6 1519 1529 (Pubitemid 26318023)
32. Weissbach L., Settleman J., Kalady M. F., Snijders A. J., Murthy A. E., Yan-Y. X., Bernards A., Identification of a human RasGAP-related protein containing calmodulin- binding motifs Journal of Biological Chemistry 1994 269 32 20517 20521
33. Bashour A. M., Fullerton A. T., Hart M. J., Bloom G. S., IQGAP1, a Rac- and Cdc42-binding protein, directly binds and cross- links microfilaments Journal of Cell Biology 1997 137 7 1555 1566 (Pubitemid 27282236)
34. Fukataf M., Kuroda S., Fujii K., Nakamura T., Shoji I., Matsuura Y., Okawa K., Iwamatsu A., Kikuchi A., Kaibuchi K., Regulation of cross-linking of actin filament by IQGAP1, a target for Cdc42 Journal of Biological Chemistry 1997 272 47 29579 29583 (Pubitemid 27508046)
35. Brown M. D., Sacks D. B., IQGAP1 in cellular signaling: bridging the GAP Trends in Cell Biology 2006 16 5 242 249 (Pubitemid 43744436)
36. Izumi G., Sakisaka T., Baba T., Tanaka S., Morimoto K., Takai Y., Endocytosis of E-cadherin regulated by Rac and Cdc42 small G proteins through IQGAP1 and actin filaments Journal of Cell Biology 2004 166 2 237 248 (Pubitemid 38988776)
37. Takahashi K., Nakajima E., Suzuki K., Involvement of protein phosphatase 2A in the maintenance of E-cadherin-mediated cellcell adhesion through recruitment of IQGAP1 Journal of Cellular Physiology 2006 206 3 814 820 (Pubitemid 43191057)
38. Suzuki K., Takahashi K., Induction of E-cadherin endocytosis by loss of protein phosphatase 2A expression in human breast cancers Biochemical and Biophysical Research Communications 2006 349 1 255 260 (Pubitemid 44331789)
39. Calin G. A., di Iasio M. G., Caprini E., Vorechovsky I., Natali P. G., Sozzi G., Croce C. M., Barbanti-Brodano G., Russo G., Negrini M., Low frequency of alterations of the (PPP2R1A) and (PPP2R1B) isoforms of the subunit A of the serine-threonine phosphatase 2A in human neoplasms Oncogene 2000 19 9 1191 1195 (Pubitemid 30157549)
40. Ruediger R., Pham H. T., Walter G., Alterations in protein phosphatase 2A subunit interaction in human carcinomas of the lung and colon with mutations in the A subunit gene Oncogene 2001 20 15 1892 1899 (Pubitemid 32458699)
41. Wang S. S., Esplin E. D., Li J. L., Huang L., Gazdar A., Minna J., Evans G. A., Alterations of the PPP2R1B gene in human lung and colon cancer Science 1998 282 5387 284 287 (Pubitemid 28487198)
42. Nunbhakdi-Craig V., Machleidt T., Ogris E., Bellotto D., White C. L. III, Sontag E., Protein phosphatase 2A associates with and regulates atypical PKC and the epithelial tight junction complex Journal of Cell Biology 2002 158 5 967 978 (Pubitemid 35001086)
43. Mulrooney J., Foley K., Vineberg S., Barreuther M., Grabel L., Phosphorylation of the 1 integrin cytoplasmic domain: toward an understanding of function and mechanism Experimental Cell Research 2000 258 2 332 341 (Pubitemid 30483511)
44. Suzuki K., Takahashi K., Reduced cell adhesion during mitosis by threonine phosphorylation of 1 integrin Journal of Cellular Physiology 2003 197 2 297 305 (Pubitemid 37485258)
45. Suzuki K., Takahashi K., Reduced expression of the regulatory A subunit of serine/threonine protein phosphatase 2A in human breast cancer MCF-7 cells International Journal of Oncology 2003 23 5 1263 1268
46. Suzuki K., Chikamatsu Y., Takahashi K., Requirement of protein phosphatase 2A for recruitment of IQGAP1 to Rac-bound 1 integrin Journal of Cellular Physiology 2005 203 3 487 492 (Pubitemid 40629010)
47. Nakajima E., Suzuki K., Takahashi K., Mitotic dissociation of IQGAP1 from Rac-bound 1-integrin is mediated by protein phosphatase 2A Biochemical and Biophysical Research Communications 2004 326 1 249 253 (Pubitemid 39573226)
48. Takahashi K., Suzuki K., Regulation of protein phosphatase 2A-mediated recruitment of IQGAP1 to 1 integrin by EGF through activation of Ca 2+ /calmodulin- dependent protein kinase II Journal of Cellular Physiology 2006 208 1 213 219 (Pubitemid 43849007)
49. Kamei T., Matozaki T., Sakisaka T., Kodama A., Yokoyama S., Peng Y. F., Nakano K., Takaishi K., Takai Y., Coendocytosis of cadherin and c-Met coupled to disruption of cellcell adhesion in MDCK cellsregulation by Rho, Rac and Rab small G proteins Oncogene 1999 18 48 6776 6784
50. Fujita Y., Krause G., Scheffner M., Zechner D., Leddy H. E. M., Behrens J., Sommer T., Birchmeier W., Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex Nature Cell Biology 2002 4 3 222 231 (Pubitemid 34218196)
51. Le T. L., Yap A. S., Stow J. L., Recycling of E-cadherin: a potential mechanism for regulating cadherin dynamics Journal of Cell Biology 1999 146 1 219 232 (Pubitemid 29349976)
52. Palacios F., Schweitzer J. K., Boshans R. L., D'Souza-Schorey C., ARF6-GTP recruits Nm23H1 to facilitate dynamin-mediated endocytosis during adherens junctions disassembly Nature Cell Biology 2002 4 12 929 936 (Pubitemid 35469422)
53. Mitchison T. J., Cramer L. P., Actin-based cell motility and cell locomotion Cell 1996 84 3 371 379 (Pubitemid 26058562)
54. Svitkina T. M., Borisy G. G., Arp2/3 complex and actin depolymerizing factor/cofilin in dendritic organization and treadmilling of actin filament array in lamellipodia Journal of Cell Biology 1999 145 5 1009 1026 (Pubitemid 29270059)
55. Machesky L. M., Mullins R. D., Higgs H. N., Kaiser D. A., Blanchoin L., May R. C., Hall M. E., Pollard T. D., Scar, a WASp-related protein, activates nucleation of actin filaments by the Arp2/3 complex Proceedings of the National Academy of Sciences of the United States of America 1999 96 7 3739 3744 (Pubitemid 29168980)
56. Pollard T. D., Borisy G. G., Cellular motility driven by assembly and disassembly of actin filaments Cell 2003 112 4 453 465 (Pubitemid 36263079)
57. Hall A., Rho GTpases and the actin cytoskeleton Science 1998 279 5350 509 514 (Pubitemid 28067271)
58. Derry J. M., Ochs H. D., Francke U., Isolation of a novel gene mutated in Wiskott-Aldrich syndrome Cell 1994 78 4 635 644 (Pubitemid 24268586)
59. Higgs H. N., Pollard T. D., Activation by Cdc42 and PIP2 of Wiskott-Aldrich Syndrome protein (WASp) stimulates actin nucleation by Arp2/3 complex Journal of Cell Biology 2000 150 6 1311 1320
60. Miki H., Miura K., Takenawa T., N-WASP, a novel actin-depolymerizing protein, regulates the cortical cytoskeletal rearrangement in a PIP2-dependent manner downstream of tyrosine kinases EMBO Journal 1996 15 19 5326 5335 (Pubitemid 26336215)
61. Suetsugu S., Miki H., Takenawa T., Identification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complex Biochemical and Biophysical Research Communications 1999 260 1 296 302 (Pubitemid 29351823)
62. Takenawa T., Suetsugu S., The WASP-WAVE protein network: connecting the membrane to the cytoskeleton Nature Reviews Molecular Cell Biology 2007 8 1 37 48 (Pubitemid 46012013)
63. Lorenz M., Yamaguchi H., Wang Y., Singer R. H., Condeelis J., Imaging sites of N-WASP activity in lamellipodia and invadopodia of carcinoma cells Current Biology 2004 14 8 697 703 (Pubitemid 38503607)
64. Takenawa T., Miki H., WASP and WAVE family proteins: key molecules for rapid rearrangement of cortical actin filaments and cell movement Journal of Cell Science 2001 114 10 1801 1809 (Pubitemid 32530035)
65. Takahashi K., Suzuki K., Requirement of kinesin-mediated membrane transport of WAVE2 along microtubules for lamellipodia formation promoted by hepatocyte growth factor Experimental Cell Research 2008 314 11-12 2313 2322
66. Takahashi K., Suzuki K., Membrane transport of WAVE2 and lamellipodia formation require Pak1 that mediates phosphorylation and recruitment of stathmin/Op18 to Pak1WAVE2kinesin complex Cellular Signalling 2009 21 5 695 703
67. Nakagawa H., Miki H., Nozumi M., Takenawa T., Miyamoto S., Wehland J., Small J. V., IRSp53 is colocalised with WAVE2 at the tips of protruding lamellipodia and filopodia independently of Mena Journal of Cell Science 2003 116 12 2577 2583 (Pubitemid 36790138)
68. Miki H., Suetsugu S., Takenawa T., WAVE, a novel WASP-family protein involved in actin reorganization induced by Rac EMBO Journal 1998 17 23 6932 6941 (Pubitemid 28550287)
69. Kurisu S., Suetsugu S., Yamazaki D., Yamaguchi H., Takenawa T., Rac-WAVE2 signaling is involved in the invasive and metastatic phenotypes of murine melanoma cells Oncogene 2005 24 8 1309 1319 (Pubitemid 40343111)
70. Pierre P., Scheel J., Rickard J. E., Kreis T. E., CLIP-170 links endocytic vesicles to microtubules Cell 1992 70 6 887 900
71. Perez F., Diamantopoulos G. S., Stalder R., Kreis T. E., CLIP-170 highlights growing microtubule ends in vivo Cell 1999 96 4 517 527 (Pubitemid 29106839)
72. Hirokawa N., Pfister K. K., Yorifuji H., Wagner M. C., Brady S. T., Bloom G. S., Submolecular domains of bovine brain kinesin identified by electron microscopy and monoclonal antibody decoration Cell 1989 56 5 867 878 (Pubitemid 19082522)
73. Pfister K. K., Wagner M. C., Stenoien D. L., Brady S. T., Bloom G. S., Monoclonal antibodies to kinesin heavy and light chains stain vesicle-like structures, but not microtubules, in cultured cells Journal of Cell Biology 1989 108 4 1453 1463 (Pubitemid 19097050)
74. Suzuki K., Takahashi K., Regulation of lamellipodia formation and cell invasion by CLIP-170 in invasive human breast cancer cells Biochemical and Biophysical Research Communications 2008 368 2 199 204
75. Fukata M., Watanabe T., Noritake J., Nakagawa M., Yamaga M., Kuroda S., Matsuura Y., Iwamatsu A., Perez F., Kaibuchi K., Rac1 and Cdc42 capture microtubules through IQGAP1 and CLIP-170 Cell 2002 109 7 873 885 (Pubitemid 34786002)
76. Oikawa T., Yamaguchi H., Itoh T., Kato M., Ijuin T., Yamazaki D., Suetsugu S., Takenawa T., Ptdlns(3,4,5)P 3 binding is necessary for WAVE2-induced formation of lamellipodia Nature Cell Biology 2004 6 5 420 426 (Pubitemid 38607502)
77. Leng Y., Zhang J., Badour K., Arpaia E., Freeman S., Cheung P., Siu M., Siminovitch K., Abelson-interactor-1 promotes WAVE2 membrane translocation and Abelson-mediated tyrosine phosphory lation required for WAVE2 activation Proceedings of the National Academy of Sciences of the United States of America 2005 102 4 1098 1103 (Pubitemid 40170732)
78. Innocenti M., Frittoli E., Ponzanelli I., Falck J. R., Brachmann S. M., Di Fiore P. P., Scita G., Phosphoinositide 3-kinase activates Rac by entering in a complex with Eps8, Abi1, and Sos-1 Journal of Cell Biology 2003 160 1 17 23 (Pubitemid 36091713)
79. Kunda P., Craig G., Dominguez V., Baum B., Abi, Sra1, and kette control the stability and localization of SCAR/WAVE to regulate the formation of actin-based protrusions Current Biology 2003 13 21 1867 1875 (Pubitemid 37347929)
80. Steffen A., Rottner K., Ehinger J., Innocenti M., Scita G., Wehland J., Stradal T. E. B., Sra-1 and Nap1 link Rac to actin assembly driving lamellipodia formation EMBO Journal 2004 23 4 749 759 (Pubitemid 38418742)
81. Bokoch G. M., Biology of the p21-activated kinases Annual Review of Biochemistry 2003 72 743 781 (Pubitemid 36930459)
82. Kumar R., Gururaj A. E., Barnes C. J., p21-activated kinases in cancer Nature Reviews Cancer 2006 6 6 459 471
83. Bagrodia S., Taylor S. J., Jordon K. A., van Aelst L., Cerione R. A., A novel regulator of p21-activated kinases Journal of Biological Chemistry 1998 273 37 23633 23636 (Pubitemid 28435688)
84. Daniels R. H., Hall P. S., Bokoch G. M., Membrane targeting of p21-activated kinase 1 (PAK1) induces neurite outgrowth from PC12 cells EMBO Journal 1998 17 3 754 764 (Pubitemid 28062054)
85. Davila M., Frost A. R., Grizzle W. E., Chakrabarti R., LIM kinase 1 is essential for the invasive growth of prostate epithelial cells: implications in prostate cancer Journal of Biological Chemistry 2003 278 38 36868 36875 (Pubitemid 37140021)
86. Vadlamudi R. K., Li F., Barnes C. J., Bagheri-Yarmand R., Kumar R., p-41-Arc subunit of human Arp2/3 complex is a p21-activated kinase-1-interacting substrate EMBO Reports 2004 5 2 154 160 (Pubitemid 38401194)
87. Vadlamudi R. K., Li F., Adam L., Nguyen D., Ohta Y., Stossel T. P., Kumar R., Filamin is essential in actin cytoskeletal assembly mediated by p21-activated kinase 1 Nature Cell Biology 2002 4 9 681 690 (Pubitemid 34993704)
88. Horwitz S. B., Shen H. J., He L., Dittmar P., Neef R., Chen J., Schubart U. K., The microtubule-destabilizing activity of metablastin (p19) is controlled by phosphorylation Journal of Biological Chemistry 1997 272 13 8129 8132 (Pubitemid 27147759)
89. Daub H., Gevaert K., Vandekerckhove J., Sobel A., Hall A., Rac/Cdc42 and p65PAK regulate the microtubule-destabilizing protein stathmin through phosphorylation at serine 16 Journal of Biological Chemistry 2001 276 3 1677 1680 (Pubitemid 32109635)
90. Wittmann T., Bokoch G. M., Waterman-Storer C. M., Regulation of microtubule destabilizing activity of Op18/Stathmin downstream of Rac1 Journal of Biological Chemistry 2004 279 7 6196 6203 (Pubitemid 38220653)
91. Belmont L. D., Mitchison T. J., Identification of a protein that interacts with tubulin dimers and increases the catastrophe rate of microtubules Cell 1996 84 4 623 631 (Pubitemid 26071742)
92. Cassimeris L., The oncoprotein 18/stathmin family of microtubule destabilizers Current Opinion in Cell Biology 2002 14 1 18 24 (Pubitemid 34131652)
93. Manser E., Loo T. H., Koh C. G., Zhao Z. S., Chen X. Q., Tan L., Tan I., Leung T., Lim L., PAK kinases are directly coupled to the PIX family of nucleotide exchange factors Molecular Cell 1998 1 2 183 192 (Pubitemid 128378659)
94. Morimura S., Suzuki K., Takahashi K., PIX and GIT1 regulate HGF-induced lamellipodia formation and WAVE2 transport Biochemical and Biophysical Research Communications 2009 382 3 614 619
95. Jourdain L., Curmi P., Sobel A., Pantaloni D., Carlier M. F., Stathmin: a tubulin-sequestering protein which forms a ternary T2S complex with two tubulin molecules Biochemistry 1997 36 36 10817 10821 (Pubitemid 27396235)
96. Schuyler S. C., Pellman D., Microtubule "plus-end-tracking proteins": the end is just the beginning Cell 2001 105 4 421 424 (Pubitemid 32520848)
97. Galjart N., Perez F., A plus-end raft to control microtubule dynamics and function Current Opinion in Cell Biology 2002 15 1 48 53 (Pubitemid 36044714)
98. Galjart N., CLIPs and CLASPs and cellular dynamics Nature Reviews Molecular Cell Biology 2005 6 6 487 498 (Pubitemid 40780560)
99. Howard J., Hyman A. A., Dynamics and mechanics of the microtubule plus end Nature 2003 422 6933 753 758 (Pubitemid 36514118)
100. Mimori-Kiyosue Y., Tsukita S., "Search-and-Capture" of microtubules through Plus-End-Binding proteins (+TIPs) Journal of Biochemistry 2003 134 3 321 326 (Pubitemid 37288329)
101. Akhmanova A., Steinmetz M. O., Tracking the ends: a dynamic protein network controls the fate of microtubule tips Nature Reviews Molecular Cell Biology 2008 9 4 309 322 (Pubitemid 351430849)
102. Bieling P., Kandels-Lewis S., Telley I. A., van Dijk J., Janke C., Surrey T., CLIP-170 tracks growing microtubule ends by dynamically recognizing composite EB1/tubulinbinding sites Journal of Cell Biology 2008 183 7 1223 1233
103. Komarova Y., de Groot C. O., Grigoriev I., Gouveia S. M., Munteanu E. L., Schober J. M., Honnappa S., Buey R. M., Hoogenraad C. C., Dogterom M., Borisy G. G., Steinmetz M. O., Akhmanova A., Mammalian end binding proteins control persistent microtubule growth Journal of Cell Biology 2009 184 5 691 706
104. Takahashi K., Tanaka T., Suzuki K., Directional control of WAVE2 membrane targeting by EB1 and phosphatidylinositol 3,4,5-triphosphate Cellular Signalling 2010 22 3 510 518
105. Chambers A. F., Groom A. C., MacDonald I. C., Dissemination and growth of cancer cells in metastatic sites Nature Reviews Cancer 2002 2 8 563 572 (Pubitemid 37328923)
106. Lansbergen G., Grigoriev I., Mimori-Kiyosue Y., Ohtsuka T., Higa S., Kitajima I., Demmers J., Galjart N., Houtsmuller A. B., Grosveld F., Akhmanova A., CLASPs attach microtubule plus ends to the cell cortex through a complex with LL5 Developmental Cell 2006 11 1 21 32 (Pubitemid 43960805)
107. Vanhaesebroeck B., Leevers S. J., Ahmadi K., Timms J., Katso R., Driscoll P. C., Woscholski R., Parker P. J., Waterfield M. D., Synthesis and function of 3-phosphorylated inositol lipids Annual Review of Biochemistry 2001 70 535 602 (Pubitemid 32662219)
108. Haugh J. M., Codazzi F., Teruel M., Meyer T., Spatial sensing in fibroblasts mediated by 3' phosphoinositides Journal of Cell Biology 2000 151 6 1269 1280
109. Srinivasan S., Wang F., Glavas S., Ott A., Hofmann F., Aktories K., Kalman D., Bourne H. R., Rac and Cdc42 play distinct roles in regulating PI(3,4,5)P 3 and polarity during neutrophil chemotaxis Journal of Cell Biology 2003 160 3 375 385 (Pubitemid 36182728)
110. van Haastert P. J., Devreotes P. N., Chemotaxis: signalling the way forward Nature Reviews Molecular Cell Biology 2004 5 8 626 634 (Pubitemid 39025063)
111. Asano Y., Nagasaki A., Uyeda T. Q., Correlated waves of actin filaments and PIP 3 in Dictyostelium cells Cell Motility and the Cytoskeleton 2008 65 12 923 934
112. Cozier G. E., Carlton J., Bouyoucef D., Cullen P. J., Membrane targeting by pleckstrin homology domains Current Topics in Microbiology and Immunology 2004 282 49 88
113. Park W. S., Heo W. D., Whalen J. H., O'Rourke N. A., Bryan H. M., Meyer T., Teruel M. N., Comprehensive identification of PIP 3 -regulated PH domains from C. elegans to H. sapiens by model prediction and live imaging Molecular Cell 2008 30 3 381 392 (Pubitemid 351615320)
114. Myers S. A., Han J. W., Lee Y., Firtel R. A., Chung C. Y., A dictyostelium homologue of WASP is required for polarized F-actin assembly during chemotaxis Molecular Biology of the Cell 2005 16 5 2191 2206 (Pubitemid 40632205)
115. Suetsugu S., Murayama K., Sakamoto A., Hanawa-Suetsugu K., Seto A., Oikawa T., Mishima C., Shirouzu M., Takenawa T., Yokoyama S., The RAC binding domain/IRSp53-MIM homology domain of IRSp53 induces RAC-dependent membrane deformation Journal of Biological Chemistry 2006 281 46 35347 35358 (Pubitemid 46036573)
116. Mattila P. K., Pyklinen A., Saarikangas J., Paavilainen V. O., Vihinen H., Jokitalo E., Lappalainen P., Missing-in-metastasis and IRSp53 deform PI(4,5)P 2 -rich membranes by an inverse BAR domain-like mechanism Journal of Cell Biology 2007 176 7 953 964 (Pubitemid 46506969)
117. Takahashi K., Suzuki K., WAVE2 targeting to phosphatidylinositol 3,4,5-triphosphate mediated by insulin receptor substrate p53 through a complex with WAVE2 Cellular Signalling 2010 22 11 1708 1716
118. Miki H., Yamaguchi H., Suetsugu S., Takenawa T., IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling Nature 2000 408 6813 732 735 (Pubitemid 32015990)
119. Suetsugu S., Kurisu S., Oikawa T., Yamazaki D., Oda A., Takenawa T., Optimization of WAVE2 complex-induced actin polymerization by membrane-bound IRSp53, PIP 3, and Rac Journal of Cell Biology 2006 173 4 571 585 (Pubitemid 43765203)
120. Abou-Kheir W., Isaac B., Yamaguchi H., Cox D., Membrane targeting of WAVE2 is not sufficient for WAVE2-dependent actin polymerization: a role for IRSp53 in mediating the interaction between Rac and WAVE2 Journal of Cell Science 2008 121 3 379 390 (Pubitemid 351356709)
121. Krugmann S., Jordens I., Gevaert K., Driessens M., Vandekerckhove J., Hall A., Cdc42 induces filopodia by promoting the formation of an IRSp53: mena complex Current Biology 2001 11 21 1645 1655 (Pubitemid 33037775)
122. Saez C. G., Myers J. C., Shows T. B., Leinwand L. A., Human nonmuscle myosin heavy chain mRNA: generation of diversity through alternative polyadenylylation Proceedings of the National Academy of Sciences of the United States of America 1990 87 3 1164 1168
123. Simons M., Wang M., McBride O. W., Kawamoto S., Yamakawa K., Gdula D., Adelstein R. S., Weir L., Human nonmuscle myosin heavy chains are encoded by two genes located on different chromosomes Circulation Research 1991 69 2 530 539
124. Leal A., Endele S., Stengel C., Huehne K., Loetterle J., Barrantes R., Winterpacht A., Rautenstrauss B., A novel myosin heavy chain gene in human chromosome 19q13.3 Gene 2003 312 1-2 165 171 (Pubitemid 37338121)
125. Morimura S., Suzuki K., Takahashi K., Nonmuscle myosin IIA is required for lamellipodia formation through binding to WAVE2 and phosphatidylinositol 3,4,5-triphosphate Biochemical and Biophysical Research Communications 2011 404 3 834 840
126. Komaba S., Coluccio L. M., Localization of myosin 1b to actin protrusions requires phosphoinositide binding Journal of Biological Chemistry 2010 285 36 27686 27693
127. Plantard L., Arjonen A., Lock J. G., Nurani G., Ivaska J., Strmblad S., PtdIns(3,4,5)P 3 is a regulator of myosin-X localization and filopodia formation Journal of Cell Science 2010 123 20 3525 3534
128. Liang W., Licate L., Warrick H., Spudich J., Egelhoff T., Differential localization in cells of myosin II heavy chain kinases during cytokinesis and polarized migration BMC Cell Biology 2002 3 1, article 19
129. Guha M., Zhou M., Wang Y. L., Cortical actin turnover during cytokinesis requires myosin II Current Biology 2005 15 8 732 736 (Pubitemid 40599927)
130. Lord M., Laves E., Pollard T. D., Cytokinesis depends on the motor domains of myosin-II in fission yeast but not in budding yeast Molecular Biology of the Cell 2005 16 11 5346 5355 (Pubitemid 41566844)
131. Medeiros N. A., Burnette D. T., Forscher P., Myosin II functions in actin-bundle turnover in neuronal growth cones Nature Cell Biology 2006 8 3 215 226 (Pubitemid 43336063)
132. Koestler S. A., Auinger S., Vinzenz M., Rottner K., Small J. V., Differentially oriented populations of actin filaments generated in lamellipodia collaborate in pushing and pausing at the cell front Nature Cell Biology 2008 10 3 306 313 (Pubitemid 351331017)
133. Urban E., Jacob S., Nemethova M., Resch G. P., Small J. V., Electron tomography reveals unbranched networks of actin filaments in lamellipodia Nature Cell Biology 2010 12 5 429 435
134. Yamagishi A., Masuda M., Ohki T., Onishi H., Mochizuki N., A novel actin bundling/filopodium-forming domain conserved in insulin receptor tyrosine kinase substrate p53 and missing in metastasis protein Journal of Biological Chemistry 2004 279 15 14929 14936 (Pubitemid 38618884)
135. Millard T. H., Bompard G., Heung M. Y., Dafforn T. R., Scott D. J., Machesky L. M., Ftterer K., Structural basis of filopodia formation induced by the IRSp53/MIM homology domain of human IRSp53 EMBO Journal 2005 24 2 240 250 (Pubitemid 40216129)
136. Chan A. Y., Coniglio S. J., Chuang Y. Y., Michaelson D., Knaus U. G., Philips M. R., Symons M., Roles of the Rac1 and Rac3 GTPases in human tumor cell invasion Oncogene 2005 24 53 7821 7829 (Pubitemid 41715188)
137. Kikuchi K., Takahashi K., WAVE2- and microtubule-dependent formation of long protrusions and invasion of cancer cells cultured on three-dimensional extracellular matrices Cancer Science 2008 99 11 2252 2259
138. Takahashi K., Suzuki K., WAVE2, N-WASP, and Mena facilitate cell invasion via phosphatidylinositol 3-kinase-dependent local accumulation of actin filaments Journal of Cellular Biochemistry 2011 112 11 3421 3429
139. Morimura S., Takahashi K., Rac1 and stathmin but not EB1 are required for invasion of breast cancer cells in response to IGF-I International Journal of Cell Biology 2011 2011 9