Arp2/3 complex and actin depolymerizing factor/cofilin in dendritic organization and treadmilling of actin filament array in lamellipodia

Journal of Cell Biology

Volumn 145, Issue 5, 1999, Pages 1009-1026

  Svitkina, Tatyana M ^a   Borisy, Gary G ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Actin; Actin depolymerizing factor cofilin; Arp2 3 complex; Locomotion; Treadmilling

Indexed keywords

ACTIN DEPOLYMERIZING FACTOR; COFILIN;

ACTIN FILAMENT; ANIMAL CELL; ARTICLE; CELL MOTILITY; CONTROLLED STUDY; CORNEA CELL; DENDRITE; DEPOLYMERIZATION; EMBRYO; FIBROBLAST; HUMAN; HUMAN CELL; LAMELLIPODIUM; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; XENOPUS LAEVIS;

ACTIN DEPOLYMERIZING FACTORS; ACTIN-RELATED PROTEIN 2; ACTIN-RELATED PROTEIN 3; ACTINS; ANIMALS; CELL MOVEMENT; CYTOSKELETAL PROTEINS; DIMERIZATION; KERATINOCYTES; MICROFILAMENT PROTEINS; MICROSCOPY, FLUORESCENCE; ORGANELLES; XENOPUS LAEVIS;

ANIMALIA; XENOPUS LAEVIS;

EID: 0033620689     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.145.5.1009     Document Type: Article

References (71)

1. Abe, H., T. Obinata, L.S. Minamide, and J.R. Bamburg. 1996. Xenopus laevis actin-depolymerizing factor/cofilin: a phosphorylation-regulated protein essential for development. J. Cell Biol. 132:871-885.
2. Anderson, K.I., Y.-L. Wang, and J.V. Small. 1996. Coordination of protrusion and translocalion of the keratocyte involves rolling of the cell body. J. Cell Biol. 134:1209-1218.
3. Ayscough, K. 1998. Use of latrunculin-A, an actin monomer-binding drug. Methods Enzymol. 298:18-25.
4. Ballestrem, C., B. Wehrle-Haller, and B.A. Imhof. 1998. Actin dynamics in living mammalian cells. J. Cell Sci. 111:1649-1658.
5. Bamburg, J.R., and D. Bray. 1987. Distribution and cellular localization of actin depolymerizing factor. J. Cell Biol. 105:2817-2825.
6. Barkalow, K., W. Witke, D.J. Kwiatkowski, and J.H. Hartwig. 1996. Coordinated regulation of platelet actin filament barbed ends by gelsolin and capping protein. J. Cell Biol. 134:389-399.
7. Bereiter-Hahn, J., and M. Vöth. 1988. Ionic control of locomotion and shape of epithelial cells. II. Role of monovalent cations. Cell Motil. Cytoskel. 10:528-536.
8. Brown, S.S., and J.A. Spudich. 1981. Mechanism of action of cytochalasin: evidence that it binds to actin filament ends. J. Cell Biol. 88:487-491.
9. Cano, M.L., D.A. Lauffenburger, and S.H. Zigmond. 1991. Kinetic analysis of F-actin depolymerization in polymorphonuclear leukocyte lysates indicates that chemoattractant stimulation increases actin filament number without altering the filament length distribution. J. Cell Biol. 115:677-687.
10. Cao, L.G., D.J. Fishkind, and Y.L. Wang. 1993. Localization and dynamics of nonfilamentous actin in cultured cells. J. Cell Biol. 123:173-181.
11. Carlier, M.-F. 1998. Control of actin dynamics. Curr. Opin. Cell. Biol. 10:45-51.
12. Carlier, M.-F., and Pantaloni, D. 1997. Control of actin dynamics in cell motility. J. Mol. Biol. 269:459-467.
13. Carlier, M.-F., V. Laurent, J. Santolini, R. Melki, D. Didry, G.X. Xia, Y. Hong, N.H. Chua, and D. Pantaloni. 1997. Actin depolymerizing factor (ADF/cofilin) enhances the rate of filament turnover: implication in actin-based motility. J. Cell Biol. 136:1307-1322.
14. Chan, A.Y., S. Raft, M. Bailly, J.B. Wyckoff, J.E. Segall, and J.S. Condeelis. 1998. EGF stimulates an increase in actin nucleation and filament number at the leading edge of the lamellipod in mammary adenocarcinoma cells. J. Cell Sci. 111:199-211.
15. Condeelis, J. 1993. Life at the leading edge: the formation of cell protrusions. Annu. Rev. Cell Biol. 9:411-444.
16. Daniolos, A., A.B. Lerner, and M.R. Lerner. 1990. Action of light on frog pigment cells in culture. Pigm. Cell Res. 3:38-43.
17. Eddy, R.J., J. Han, and J.S. Condeelis. 1997. Capping protein terminates but does not initiate chemoattractant-induced actin assembly in Dictyostelium. J. Cell Biol. 139:1243-1253.
18. Goddelte, D.W., and C. Frieden. 1986. Actin polymerization. The mechanism of action of cytochalasin D.J. Biol. Chem. 261:15974-15980.
19. Gorlin, J.B., R. Yamin, S. Egan, M. Stewart, T.P. Stossel, D.J. Kwiatkowski, and J.H. Hartwig. 1990. Human endothelial actin-binding protein (ABP-280, nonmuscle filamin): a molecular leaf spring. J. Cell Biol. 111:1089-1105.
20. Hartwig, J.H. 1992. Mechanisms of actin rearrangements mediating platelet activation. J. Cell Biol. 118:1421-1442.
21. Hartwig, J.H., G.M. Bokoch, C.L. Carpenter, P.A. Janmey, L.A. Taylor, A. Toker, and T.P. Stossel. 1995. Thrombin receptor ligation and activated Rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets. Cell. 82:643-653.
22. Higley, S., and M. Way. 1997. Actin and cell pathogenesis. Curr. Opin. Cell Biol. 9:62-69.
23. Kelleher, J.F., S.J. Atkinson, and T.D. Pollard. 1995. Sequences, structural models, and cellular localization of the actin-related proteins Arp2 and Arp3 from Acanthamoeba. J. Cell Biol. 131:385-397.
24. Laurent, V., T.P. Loisel, B. Harbeck, A. Wehman, L. Grobe, B.M. Jockusch, J. Wehland, F.B. Gertler, and M.-F. Carlier. 1999. Role of proteins of the Ena/ VASP family in actin-based motility of Listeria monocytogenes. J. Cell Biol. 144:1245-1258.
25. Machesky, L.M. 1997. Cell motility: complex dynamics at the leading edge. Curr. Biol. 7:R164-R167.
26. Machesky, L.M., and M. Way. 1998. Actin branches out. Nature. 394:125-126.
27. Machesky, L.M., and K.L. Gould. 1999. The Arp2/3 complex: a multifunctional actin organizer. Curr. Opin. Cell Biol. 11:117-121.
28. Machesky, L.M., S.J. Atkinson, C. Ampe, J. Vandekerckhove, and T.D. Pollard. 1994. Purification of a cortical complex containing two unconventional actins from Acanthamoeba by affinity chromatography on profilin-agarose. J. Cell Biol. 127:107-115.
29. Machesky, L.M., E. Reeves, F. Wientjes, F.J. Mattheyse, A. Grogan, N.F. Totty, A.L. Burlingame, J.J. Hsuan, and A.W. Segal. 1997. Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of evolutionary conserved proteins. Biochem. J. 328: 105-112.
30. Machesky, L.M., R.D. Mullins, H.N. Higgs, D.A. Kaiser, L. Blanchoin, R.C. May, M.E. Hall, and T.D. Pollard. 1999. Scar, a WASP-related protein, activates dendritic nuclealion of actin filaments by the Arp2/3 complex. Proc. Natl. Acad. Sci. USA. 96:3739-3744.
31. Maciver, S.K. 1998. How ADF/cofilin depolymerizes actin filaments. Curr. Opin. Cell Biol. 10:140-144.
32. Maciver, S.K., and A.G. Weeds. 1994. Actophorin preferentially binds monomeric ADP-actin over ATP-bound actin: consequences for cell locomotion. FEBS Lett. 347:251-256.
33. Maciver, S.K., H.G. Zot, and T.D. Pollard. 1991. Characterization of actin filament severing by actophorin from Acanthamoeba castellanii. J. Cell Biol. 115:1611-1620.
34. Maciver, S.K., B.J. Pope, S. Whytock, and A.G. Weeds. 1998. The effect of two actin depolymerizing factors (ADF/cofilins) on actin filament turnover: pH sensitivity of F-actin binding by human ADF, but not of Acanthamoeba actophorin. Eur. J. Biochem. 256:388-397.
35. Matsudaira. P. 1994. Actin cross-linking proteins at the leading edge. Semin. Cell Biol. 5:165-174.
36. Meberg, P.J., S. Ono, L.S. Minamide, M. Takahashi, and J.R. Bamburg. 1998. Actin depolymerizing factor and cofilin phosphorylation dynamics: response to signals that regulate neurile extension. Cell Motil. Cytoskel. 39:172-190.
37. Mogilner, A., and G. Oster. 1996. Cell motility driven by actin polymerization. Biophys. J. 71:3030-3045.
38. Moon, A., and D.G. Drubin. 1995. The ADF/cofilin proteins: stimulus-responsive modulators of actin dynamics. Mol. Biol. Cell. 6:1423-1431.
39. Mullins, R.D., W.F. Stafford, and T.D. Pollard. 1997. Structure, subunit topology, and actin-binding activity of the Arp2/3 complex from Acanthamoeba. J. Cell Biol. 136:331-343.
40. Mullins, R.D., J.A. Heuser, and T.D. Pollard. 1998. The interaction of Arp2/3 complex with actin: nucleation, high affinity pointed end capping, and formation of branching networks of filaments. Proc. Natl. Acad. Sci. USA. 95: 6181-6186.
41. Nieuwkoop, P.D., and J. Faber. 1956. Normal Tables of Xenopus laevis (Daudin). A Systematical and Chronological Survey of the Development from Fertilized Egg Till the End of Metamorphosis. North Holland Publishing Co., Amsterdam.
42. Podolski, J.L., and T.L. Steck. 1990. Length distribution of F-actin in Dictyostelium discoideum. J. Biol. Chem. 265:1312-1318.
43. Pollard, T.D. 1986. Rate constants for the reactions of ATP-and ADP-actin with the ends of actin filaments. J. Cell Biol. 103:2747-2754.
44. Rohatgi, R., L. Ma, H. Miki, M. Lopez, T. Kirchhausen, T. Takenawa, M. W. Kirschner. 1999. The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly. Cell. 97:221-231.
45. Rosenblatt, J., and T.J. Mitchison. 1998. Actin, cofilin and cognition. Nature. 393:739-740.
46. Rosenblatt, J., B.J. Agnew, H. Abe, J.R. Bamburg, and T.J. Mitchison. 1997. Xenopus actin depolymerizing factor/cofilin (XAC) is responsible for the turnover of actin filaments in Listeria monocytogenes tails. J. Cell Biol. 136: 1323-1332.
47. Sampath, P., and T.D. Pollard. 1991. Effects of cytochalasin, phalloidin, and pH on the elongation of actin filaments. Biochemistry. 30:1973-1980.
48. Schafer, D.A., P.B. Jennings, and J.A. Cooper. 1996. Dynamics of capping protein and actin assembly in vitro: uncapping barbed ends by polyphosphoinositides. J. Cell Biol. 135:169-179.
49. Schafer, D.A., M.D. Welch, L.M. Machesky, P.C. Bridgman, S.M. Meyer, and J.A. Cooper. 1998. Visualization and molecular analysis of actin assembly in living cells. J. Cell Biol. 143:1919-1930.
50. Small, J.V. 1988. The actin cytoskeleton. Electron Microsc. Rev. 1:155-174.
51. Small, J.V. 1994. Lamellipodia architecture: actin filament turnover and the lateral flow of actin filaments during motility. Semin. Cell. Biol. 5:157-163.
52. Small, J.V. 1995. Getting the actin filaments straight: nucleation-release or treadmilling? Trends Cell Biol. 5:52-55.
53. Small, J.V., M. Herzog, and K. Anderson. 1995. Actin filament organization in the fish keratocyte lamellipodium. J. Cell Biol. 129:1275-1286.
54. Svitkina, T.M., and G.G. Borisy. 1998. Correlative light and electron microscopy of the cytoskeleton of cultured cells. Methods Enzymol 298:570-592.
55. Svitkina, T.M., A.B. Verkhovsky, and G.G. Borisy. 1995. Improved procedures for electron microscopic visualization of the cytoskeleton of cultured cells. J. Struct. Biol. 115:290-303.
56. Svitkina, T.M., A.B. Verkhovsky, G.G. Borisy. 1996. Plectin sidearms mediate interaction of intermediate filaments with microtubules and other components of the cytoskeleton. J. Cell Biol. 135:991-1007.
57. Svitkina, T.M., A.B. Verkhovsky, K.M. McQuade, and G.G. Borisy. 1997. Analysis of the actin-myosin II system in fish epidermal keratocytes: mechanism of cell body translocation. J. Cell Biol. 139:397-415.
58. Symons, M.H., and T.J. Mitchison. 1991. Control of actin polymerization in live and permeabilized fibroblasts. J. Cell Biol. 114:503-513.
59. Theriot, J.A. 1997. Accelerating on a treadmill: ADF/cofilin promotes rapid actin filament turnover in the dynamic cytoskeleton. J. Cell Biol. 136:1165-1168.
60. Theriot, J.A., and T.J. Mitchison. 1991. Actin microfilament dynamics in locomoting cells. Nature. 352:126-131.
61. Theriot, J.A., and T.J. Mitchison. 1992. Comparison of actin and cell surface dynamics in motile fibroblasts. J. Cell Biol. 119:367-377.
62. Verkhovsky, A.B., T.M. Svitkina, and G.G. Borisy. 1995. Myosin II filament assemblies in the active lamella of fibroblasts: their morphogenesis and role in the formation of actin filament bundles. J. Cell Biol. 131:989-1002.
63. Wegner, A. 1976. A head to tail polymerization of actin. J. Mol. Biol. 108:139-150.
64. Welch, M.D., A. Iwamatsu, and T.J. Mitchison. 1997a. Actin polymerization is induced by Arp2/3 protein complex at the surface of Listeria monocytogenes. Nature. 385:265-269.
65. Welch, M.D., A. Mallavarapu, J. Rosenblatt, and T.J. Mitchison. 1997b. Actin dynamics in vivo. Curr. Opin. Cell. Biol. 9:54-61.
66. Welch, M.D., A.H. DePace, S. Verma, A. Iwamatsu, and T.J. Mitchison. 1997c. The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly. J. Cell Biol. 138:375-384.
67. Welch, M.D., J. Rosenblatt, J. Skoble, D.A. Portnoy, and T.J. Mitchison. 1998. Interaction of human Arp2/3 complex and the Listeria monocytogenes ActA protein in actin filament nucleation. Science. 281:105-108.
68. Yonezawa, N., E. Nishida, S. Koyasu, S. Maekawa, Y. Ohta, I. Yahara, and H. Sakai. 1987. Distribution among tissues and intracellular localization of cofilin, a 21 kDa actin-binding protein. Cell Struct. Funct. 12:443-452.
69. Zigmond, S.H. 1996. Signal transduction and actin filament organization. Curr. Opin. Cell Biol. 8:66-73.
70. Zigmond, S.H. 1998. Actin cytoskelelon: the Arp2/3 complex gets to the point. Curr. Biol. 8:R654-R657.
71. Zigmond, S.H., M. Joyce, C. Yang, K. Brown, M. Huang, and M. Pring. 1998. Mechanism of Cdc42-induced actin polymerization in neutrophil extracts. J. Cell Biol. 142:1001-1012.