메뉴 건너뛰기




Volumn 17, Issue 3, 1998, Pages 754-764

Membrane targeting of p21-activated kinase 1 (PAK1) induces neurite outgrowth from PC12 cells

Author keywords

Cytoskeleton; Neurite outgrowth; p21 activated kinases; PC12 cells; Rho GTPases

Indexed keywords

ACTIN; NERVE GROWTH FACTOR; PROTEIN KINASE; PROTEIN P21;

EID: 0032472918     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/17.3.754     Document Type: Article
Times cited : (258)

References (48)
  • 1
    • 0025374393 scopus 로고
    • The product of rab2, a small GTP binding protein, increases neuronal adhesion and neunte outgrowth in vitro
    • Ayala, J., Touchot, N., Zahraoui, A., Tavitian, A. and Prochianyz, A. (1990) The product of rab2, a small GTP binding protein, increases neuronal adhesion and neunte outgrowth in vitro. Neuron, 4, 797-805.
    • (1990) Neuron , vol.4 , pp. 797-805
    • Ayala, J.1    Touchot, N.2    Zahraoui, A.3    Tavitian, A.4    Prochianyz, A.5
  • 2
    • 0022137480 scopus 로고
    • Microinjection of the ras oncogenic protein into PC12 cells induces morphological differentiation
    • Bar-Sagi, D. and Feramisco, J.R. (1985) Microinjection of the ras oncogenic protein into PC12 cells induces morphological differentiation. Cell, 42, 841-848.
    • (1985) Cell , vol.42 , pp. 841-848
    • Bar-Sagi, D.1    Feramisco, J.R.2
  • 3
    • 0028126032 scopus 로고
    • Cytoskeletal events in growth cone steering
    • Bentley, D. and O'Connor, T.P. (1994) Cytoskeletal events in growth cone steering. Curr. Opin. Neurobiol., 4, 43-48.
    • (1994) Curr. Opin. Neurobiol. , vol.4 , pp. 43-48
    • Bentley, D.1    O'Connor, T.P.2
  • 4
    • 0028081350 scopus 로고
    • Guanine nucleotide exchange regulates membrane translocation of rac/rho GTP-binding proteins
    • BokochvG.M., Bohl, B.P. and Chuang, T.-H. (1994) Guanine nucleotide exchange regulates membrane translocation of rac/rho GTP-binding proteins. J. Biol. Chem., 269, 31674-31679.
    • (1994) J. Biol. Chem. , vol.269 , pp. 31674-31679
    • Bokochv, G.M.1    Bohl, B.P.2    Chuang, T.-H.3
  • 6
    • 0031026569 scopus 로고    scopus 로고
    • p21-activated kinase (PAK) has substrate specificity similar to Acanthamoeba myosin I heavy chain kinase and activates Acanthamoeba myosin I
    • Brzeska, H., Knaus, U.G., Wang, Z., Bokoch, G.M. and Korn, E.D. (1997) p21-activated kinase (PAK) has substrate specificity similar to Acanthamoeba myosin I heavy chain kinase and activates Acanthamoeba myosin I. Proc. Natl Acad. Sci. USA, 94, 1092-1095.
    • (1997) Proc. Natl Acad. Sci. USA , vol.94 , pp. 1092-1095
    • Brzeska, H.1    Knaus, U.G.2    Wang, Z.3    Bokoch, G.M.4    Korn, E.D.5
  • 7
    • 0028786020 scopus 로고
    • A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases
    • Burbelo, P.D., Dreschsel, D. and Hall, A. (1995) A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases. J. Biol. Chem., 270, 29071-29074.
    • (1995) J. Biol. Chem. , vol.270 , pp. 29071-29074
    • Burbelo, P.D.1    Dreschsel, D.2    Hall, A.3
  • 8
    • 0028041168 scopus 로고
    • Cell polarity in yeast
    • Chant, J. (1994) Cell polarity in yeast. Trends Genet., 10, 328-333.
    • (1994) Trends Genet. , vol.10 , pp. 328-333
    • Chant, J.1
  • 9
    • 0029979723 scopus 로고    scopus 로고
    • The Caenorhabditis elegans p21-activated kinase (CePAK) colocalizes with CeRac1 and CDC42Ce at hypodermal cell boundaries during embryo elongation
    • Cheh, W., Chen, S., Yap, S.F. and Lim, L. (1996) The Caenorhabditis elegans p21-activated kinase (CePAK) colocalizes with CeRac1 and CDC42Ce at hypodermal cell boundaries during embryo elongation. J. Biol. Chem., 271, 26362-26368.
    • (1996) J. Biol. Chem. , vol.271 , pp. 26362-26368
    • Cheh, W.1    Chen, S.2    Yap, S.F.3    Lim, L.4
  • 10
    • 0028228616 scopus 로고
    • Activation of MAP kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells
    • Cowley, S., Paterson, H., Kemp, P. and Marshall, C.J. (1994) Activation of MAP kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells. Cell, 77, 841-852.
    • (1994) Cell , vol.77 , pp. 841-852
    • Cowley, S.1    Paterson, H.2    Kemp, P.3    Marshall, C.J.4
  • 11
    • 0029091498 scopus 로고
    • Ste20-like protein kinases are required for normal localization of cell growth and for cytokinesis in budding yeast
    • Cvrckova, J., DeVirgilio, C., Manser, E., Pringle, J.R. and Nasmyth, K. (1995) Ste20-like protein kinases are required for normal localization of cell growth and for cytokinesis in budding yeast. Genes Dev., 9, 1817-1830.
    • (1995) Genes Dev. , vol.9 , pp. 1817-1830
    • Cvrckova, J.1    DeVirgilio, C.2    Manser, E.3    Pringle, J.R.4    Nasmyth, K.5
  • 12
    • 0030772657 scopus 로고    scopus 로고
    • Localization of p21-activated kinase 1 (PAK1) to pinocytic vesicles and cortical actin structures in stimulated cells
    • Dharmawhardane, S., Sanders, J.C., Martin., .S., Daniels, R.H. and Bokoch, G.M. (1997) Localization of p21-activated kinase 1 (PAK1) to pinocytic vesicles and cortical actin structures in stimulated cells. J. Cell Biol., 138, 1265-1278.
    • (1997) J. Cell Biol. , vol.138 , pp. 1265-1278
    • Dharmawhardane, S.1    Sanders, J.C.2    Martin, S.3    Daniels, R.H.4    Bokoch, G.M.5
  • 13
    • 0022340978 scopus 로고
    • Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product
    • Evan, G.I., Lewis, G.K., Ramsay, G. and Bishop, J.M. (1985) Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product. Mol. Cell. Biol., 5, 744-756.
    • (1985) Mol. Cell. Biol. , vol.5 , pp. 744-756
    • Evan, G.I.1    Lewis, G.K.2    Ramsay, G.3    Bishop, J.M.4
  • 14
    • 0029830139 scopus 로고    scopus 로고
    • The adaptor protein Nck links receptor tyrosine kinases with the serine-threonine kinase Pak1
    • Galisteo, M.L., Chernoff, J., Su, Y.C., Skolnik, E.Y. and Schlessinger, J. (1996) The adaptor protein Nck links receptor tyrosine kinases with the serine-threonine kinase Pak1. J. Biol. Chem., 271, 20997-21000.
    • (1996) J. Biol. Chem. , vol.271 , pp. 20997-21000
    • Galisteo, M.L.1    Chernoff, J.2    Su, Y.C.3    Skolnik, E.Y.4    Schlessinger, J.5
  • 15
    • 0029943447 scopus 로고    scopus 로고
    • Drosophila photoreceptor axon guidance and targeting requires the dreadlocks SH2/SH3 adapter protein
    • Garrity, P.A., Rao, Y., Salecker, J., McGlade, J., Pawson, T. and Zipursky, S.L. (1996) Drosophila photoreceptor axon guidance and targeting requires the dreadlocks SH2/SH3 adapter protein. Cell, 85, 639-650.
    • (1996) Cell , vol.85 , pp. 639-650
    • Garrity, P.A.1    Rao, Y.2    Salecker, J.3    McGlade, J.4    Pawson, T.5    Zipursky, S.L.6
  • 16
    • 0030929149 scopus 로고    scopus 로고
    • Identification of a novel, putative rho-specific GDP/GTP exchange factor and a rhoA-binding protein: Control of neuronal morphology
    • Gebbink, M.F.B.G., Krannenburg, O., Poland, M., van Horck, F.P.G., Houssa, B. and Moolenaar, W.H. (1997) Identification of a novel, putative rho-specific GDP/GTP exchange factor and a rhoA-binding protein: control of neuronal morphology. J. Cell Biol., 137, 1603-1613.
    • (1997) J. Cell Biol. , vol.137 , pp. 1603-1613
    • Gebbink, M.F.B.G.1    Krannenburg, O.2    Poland, M.3    Van Horck, F.P.G.4    Houssa, B.5    Moolenaar, W.H.6
  • 17
    • 0026166253 scopus 로고
    • Growth cones: The mechanism of neurite advance
    • Gordon-Weeks, P.R. (1991) Growth cones: the mechanism of neurite advance. BioEssays, 13, 235-239.
    • (1991) BioEssays , vol.13 , pp. 235-239
    • Gordon-Weeks, P.R.1
  • 18
    • 0023885305 scopus 로고
    • The protein kinase family: Conserved features and deduced phylogeny of the catalytic domains
    • Hanks, S.K., Quinn, A.M. and Hunter, T. (1988) The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. Science, 241, 42-52.
    • (1988) Science , vol.241 , pp. 42-52
    • Hanks, S.K.1    Quinn, A.M.2    Hunter, T.3
  • 19
    • 0029963547 scopus 로고    scopus 로고
    • A Drosophila homolog of the Rac- And Cdc42-activated serine/threonine kinase PAK is a potential focal adhesion and focal complex protein that colocalizes with dynamic actin structures
    • Harden, N., Lee, J., Loh, H.-Y., Ong, Y.-M., Tan, I., Leung, T., Manser, E. and Lim, L. (1996) A Drosophila homolog of the Rac-and Cdc42-activated serine/threonine kinase PAK is a potential focal adhesion and focal complex protein that colocalizes with dynamic actin structures. Mol. Cell. Biol., 16, 1896-1908.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 1896-1908
    • Harden, N.1    Lee, J.2    Loh, H.-Y.3    Ong, Y.-M.4    Tan, I.5    Leung, T.6    Manser, E.7    Lim, L.8
  • 20
    • 0030479324 scopus 로고    scopus 로고
    • Suppression of nerve growth factor-induced neuronal differentiation of PC12 cells
    • Kamata, H., Tanaka, C., Yagisawa, H., Matsuda, S., Gotoh, Y., Nishida, E. and Hirata, H. (1996) Suppression of nerve growth factor-induced neuronal differentiation of PC12 cells. J. Biol. Chem., 271, 33018-33025.
    • (1996) J. Biol. Chem. , vol.271 , pp. 33018-33025
    • Kamata, H.1    Tanaka, C.2    Yagisawa, H.3    Matsuda, S.4    Gotoh, Y.5    Nishida, E.6    Hirata, H.7
  • 21
    • 0028998794 scopus 로고
    • Regulation of human leukocyte p21-activated kinases through G protein-coupled receptors
    • Knaus, U.G., Morris, S., Dong, H.-J., Chernoff, J. and Bokoch, G.M. (1995) Regulation of human leukocyte p21-activated kinases through G protein-coupled receptors. Science, 269, 221-223.
    • (1995) Science , vol.269 , pp. 221-223
    • Knaus, U.G.1    Morris, S.2    Dong, H.-J.3    Chernoff, J.4    Bokoch, G.M.5
  • 22
    • 0030917921 scopus 로고    scopus 로고
    • Expression of a constitutively active phosphatidylinositol 3-kinase induces process formation in rat PC12 cells
    • Kobayashi, M. et al. (1997) Expression of a constitutively active phosphatidylinositol 3-kinase induces process formation in rat PC12 cells. J. Biol. Chem., 272, 16089-16092.
    • (1997) J. Biol. Chem. , vol.272 , pp. 16089-16092
    • Kobayashi, M.1
  • 23
    • 0031027205 scopus 로고    scopus 로고
    • Rho family GTPases and neuronal growth cone remodeling: Relationship between increased complexity induced by Cdc42Hs, Rac1, and acetylcholine and collapse induced by RhoA and lysophosphatidic acid
    • Kozma, R., Sarner, S., Ahmed, S. and Lim, L. (1997) Rho family GTPases and neuronal growth cone remodeling: relationship between increased complexity induced by Cdc42Hs, Rac1, and acetylcholine and collapse induced by RhoA and lysophosphatidic acid. Mol. Cell. Biol., 17, 1201-1211.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 1201-1211
    • Kozma, R.1    Sarner, S.2    Ahmed, S.3    Lim, L.4
  • 24
    • 0031015562 scopus 로고    scopus 로고
    • Functional characterization of the Cdc42p binding domain of yeast Ste20p protein kinase
    • Leberer, E., Wu, C., Leeuw, T., Fourest-Lieuvin, A., Segall, J.E. and Thomas, D.Y. (1997a) Functional characterization of the Cdc42p binding domain of yeast Ste20p protein kinase. EMBO J., 16, 83-97.
    • (1997) EMBO J. , vol.16 , pp. 83-97
    • Leberer, E.1    Wu, C.2    Leeuw, T.3    Fourest-Lieuvin, A.4    Segall, J.E.5    Thomas, D.Y.6
  • 25
    • 0031058930 scopus 로고    scopus 로고
    • Pheromone signaling and polarized morphogenesis in yeast
    • Leberer, E., Thomas, D.Y. and Whiteway, M. (1997b) Pheromone signaling and polarized morphogenesis in yeast. Curr. Opin. Genet. Dev., 7, 59-66.
    • (1997) Curr. Opin. Genet. Dev. , vol.7 , pp. 59-66
    • Leberer, E.1    Thomas, D.Y.2    Whiteway, M.3
  • 26
    • 0028884447 scopus 로고
    • Pheromone response in yeast: Association of Bem1p with proteins of the MAP kinase cascade and actin
    • Leeuw, T., Fourest, A., Wu, C., Chenevert, J., Clark, K., Whiteway, M., Thomas, D.Y. and Leberer, E. (1995) Pheromone response in yeast: association of Bem1p with proteins of the MAP kinase cascade and actin. Science, 270, 1210-1213.
    • (1995) Science , vol.270 , pp. 1210-1213
    • Leeuw, T.1    Fourest, A.2    Wu, C.3    Chenevert, J.4    Clark, K.5    Whiteway, M.6    Thomas, D.Y.7    Leberer, E.8
  • 27
    • 0031080595 scopus 로고    scopus 로고
    • Activation of Pak by membrane localization mediated by an SH3 domain from the adaptor protein Nek
    • Lu, W., Katz, S., Gupta, R. and Mayer, B.J. (1997) Activation of Pak by membrane localization mediated by an SH3 domain from the adaptor protein Nek. Curr. Biol., 1, 85-94.
    • (1997) Curr. Biol. , vol.1 , pp. 85-94
    • Lu, W.1    Katz, S.2    Gupta, R.3    Mayer, B.J.4
  • 28
    • 0028086441 scopus 로고
    • Distinct morphogenetic functions of similar small GTPases: Drosophila Drac1 is involved in axonal outgrowth and myoblast fusion
    • Luo, L., Liao, Y.J., Jan, L.Y and Jan, Y.N. (1994) Distinct morphogenetic functions of similar small GTPases: Drosophila Drac1 is involved in axonal outgrowth and myoblast fusion. Genes Dev., 8, 1787-1802.
    • (1994) Genes Dev. , vol.8 , pp. 1787-1802
    • Luo, L.1    Liao, Y.J.2    Jan, L.Y.3    Jan, Y.N.4
  • 29
    • 0030026182 scopus 로고    scopus 로고
    • Differential effects of the Rac GTPase on purkinje cell axons and dendritic trunks and spines
    • Luo, L., Hensch, T.K., Ackerman, L., Barbel, S., Jan, L.Y. and Jan, Y.N. (1996) Differential effects of the Rac GTPase on purkinje cell axons and dendritic trunks and spines. Nature, 379, 837-840.
    • (1996) Nature , vol.379 , pp. 837-840
    • Luo, L.1    Hensch, T.K.2    Ackerman, L.3    Barbel, S.4    Jan, L.Y.5    Jan, Y.N.6
  • 30
    • 0028078824 scopus 로고
    • A brain serine/threonine protein kinase activated by Cdc42 and Rac1
    • Manser, E., Leung, T. Salihuddin, H., Tan, L. and Lim, L. (1994) A brain serine/threonine protein kinase activated by Cdc42 and Rac1. Nature, 367, 40-46.
    • (1994) Nature , vol.367 , pp. 40-46
    • Manser, E.1    Leung, T.2    Salihuddin, H.3    Tan, L.4    Lim, L.5
  • 31
    • 0031036626 scopus 로고    scopus 로고
    • Expression of constitutively active α-PAK reveals effects of the kinase on actin and focal complexes
    • Manser, E., Huang, H.-Y., Loo, T.-H., Chen, X.-Q., Dong, J.-M., Leung, T. and Lim, L. (1997) Expression of constitutively active α-PAK reveals effects of the kinase on actin and focal complexes. Mol. Cell. Biol., 17, 1129-1143.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 1129-1143
    • Manser, E.1    Huang, H.-Y.2    Loo, T.-H.3    Chen, X.-Q.4    Dong, J.-M.5    Leung, T.6    Lim, L.7
  • 33
    • 0028961293 scopus 로고
    • Rho, Rac and Cdc42 GTPases regulate the assembly of multi-molecular focal complexes associated with actin stress fibers, lamellipodia and filopodia
    • Nobes, C.D. and Hall, A. (1995) Rho, Rac and Cdc42 GTPases regulate the assembly of multi-molecular focal complexes associated with actin stress fibers, lamellipodia and filopodia. Cell, 81, 53-62.
    • (1995) Cell , vol.81 , pp. 53-62
    • Nobes, C.D.1    Hall, A.2
  • 34
    • 0022347122 scopus 로고
    • Sarcoma viruses carrying ras oncogenes induce differentiation-associated properties in a neuronal cell line
    • Noda, M., Ko, M., Ogura, A., Lim, D.G., Amano, T., Takano, T. and Ikawa, Y. (1985) Sarcoma viruses carrying ras oncogenes induce differentiation-associated properties in a neuronal cell line. Nature, 318, 73-75.
    • (1985) Nature , vol.318 , pp. 73-75
    • Noda, M.1    Ko, M.2    Ogura, A.3    Lim, D.G.4    Amano, T.5    Takano, T.6    Ikawa, Y.7
  • 35
    • 0030465534 scopus 로고    scopus 로고
    • Functional analysis of the interaction between the small GTP binding protein Cdc42 and the Ste20 protein kinase in yeast
    • Peter, M., Neiman, A.M., Park, H.-O., van Lohuizen, M. and Herskowitz, I. (1996) Functional analysis of the interaction between the small GTP binding protein Cdc42 and the Ste20 protein kinase in yeast. EMBO J., 15, 7046-7059.
    • (1996) EMBO J. , vol.15 , pp. 7046-7059
    • Peter, M.1    Neiman, A.M.2    Park, H.-O.3    Van Lohuizen, M.4    Herskowitz, I.5
  • 36
    • 0026778133 scopus 로고
    • The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibres in response to growth factors
    • Ridley, A.J. and Hall, A. (1992) The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibres in response to growth factors. Cell, 70, 389-399.
    • (1992) Cell , vol.70 , pp. 389-399
    • Ridley, A.J.1    Hall, A.2
  • 37
    • 0026654125 scopus 로고
    • The small GTP-binding protein rac regulates growth factor-induced membrane ruffling
    • Ridley, A.J., Paterson, H.F., Johnson, C., Diekmann, D. and Hall, A. (1992) The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. Cell, 70, 401-410.
    • (1992) Cell , vol.70 , pp. 401-410
    • Ridley, A.J.1    Paterson, H.F.2    Johnson, C.3    Diekmann, D.4    Hall, A.5
  • 38
    • 0028933716 scopus 로고
    • Ultrastructural localization of ras-related proteins using epitope-tagged plasmids
    • Robertson, D., Paterson, H.F., Adamson, P., Hall, A. and Monaghan, P. (1995) Ultrastructural localization of ras-related proteins using epitope-tagged plasmids. J. Histochem. Cytochem., 43, 471-480.
    • (1995) J. Histochem. Cytochem. , vol.43 , pp. 471-480
    • Robertson, D.1    Paterson, H.F.2    Adamson, P.3    Hall, A.4    Monaghan, P.5
  • 39
    • 0030918572 scopus 로고    scopus 로고
    • Membrane and morphological changes in apoptotic cells regulated by caspase-mediated activation of PAK2
    • Rudel, T. and Bokoch, G.M. (1997) Membrane and morphological changes in apoptotic cells regulated by caspase-mediated activation of PAK2. Science, 276, 1571-1574.
    • (1997) Science , vol.276 , pp. 1571-1574
    • Rudel, T.1    Bokoch, G.M.2
  • 40
  • 41
    • 0030811528 scopus 로고    scopus 로고
    • Kinase deficient Pak1 mutants inhibit Ras transformation of rat-1 fibroblasts
    • Tang, Y., Chen, Z., Ambrose, D., Liu, J., Gibbs, J.B., Chernoff, J. and Field, J. (1997) Kinase deficient Pak1 mutants inhibit Ras transformation of rat-1 fibroblasts. Mol. Cell. Biol., 17, 4454-4464.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 4454-4464
    • Tang, Y.1    Chen, Z.2    Ambrose, D.3    Liu, J.4    Gibbs, J.B.5    Chernoff, J.6    Field, J.7
  • 42
    • 0021348015 scopus 로고
    • Activation of actin-activated ATPase in smooth muscle by phosphorylation of myosin light chain with protease-activated kinase I
    • Tauzon, P.T. and Traugh, J.A. (1984) Activation of actin-activated ATPase in smooth muscle by phosphorylation of myosin light chain with protease-activated kinase I. J. Biol. Chem., 259, 541-546.
    • (1984) J. Biol. Chem. , vol.259 , pp. 541-546
    • Tauzon, P.T.1    Traugh, J.A.2
  • 43
    • 0026534571 scopus 로고
    • Ras is essential for nerve growth factor- and phorbol ester-induced tyrosine phosphorylation of MAP kinases
    • Thomas, S.M., DeMarco, M., D'Arcangelo, G., Halegona, S. and Brugge, J.S. (1992) Ras is essential for nerve growth factor- and phorbol ester-induced tyrosine phosphorylation of MAP kinases. Cell, 68, 1031-1040.
    • (1992) Cell , vol.68 , pp. 1031-1040
    • Thomas, S.M.1    DeMarco, M.2    D'Arcangelo, G.3    Halegona, S.4    Brugge, J.S.5
  • 44
    • 0030043989 scopus 로고    scopus 로고
    • Lysophosphatidic acid-induced neurite retraction in PC12 cells: Control by phosphoinositide signaling and rho
    • Tigyi, G., Fischer, D.J., Sebok, A., Yang, C., Dyer, D.L. and Miledi, R. (1996a) Lysophosphatidic acid-induced neurite retraction in PC12 cells: control by phosphoinositide signaling and rho. J. Neurochem., 66, 537-548.
    • (1996) J. Neurochem. , vol.66 , pp. 537-548
    • Tigyi, G.1    Fischer, D.J.2    Sebok, A.3    Yang, C.4    Dyer, D.L.5    Miledi, R.6
  • 45
    • 0030049359 scopus 로고    scopus 로고
    • Lysophosphatidic acid-induced neurite retraction in PC12 cells: Neurite-protective effects of cyclic AMP signaling
    • Tigyi, G., Fischer, D.J., Sebök, A., Marshall, F., Dyer, D.L. and Miledi, R. (1996b) Lysophosphatidic acid-induced neurite retraction in PC12 cells: neurite-protective effects of cyclic AMP signaling. J. Neurochem., 66, 549-558.
    • (1996) J. Neurochem. , vol.66 , pp. 549-558
    • Tigyi, G.1    Fischer, D.J.2    Sebök, A.3    Marshall, F.4    Dyer, D.L.5    Miledi, R.6
  • 46
    • 0026523559 scopus 로고
    • Ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1 and RSK
    • Wood, K.W., Sarnecki, C., Roberts, T.M. and Blenis, J. (1992) Ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1 and RSK. Cell, 68, 1041-1050.
    • (1992) Cell , vol.68 , pp. 1041-1050
    • Wood, K.W.1    Sarnecki, C.2    Roberts, T.M.3    Blenis, J.4
  • 48
    • 0030835893 scopus 로고    scopus 로고
    • 2-terminal kinase isoform and induction of neurite outgrowth in PC12 cells by staurosporine
    • 2-terminal kinase isoform and induction of neurite outgrowth in PC12 cells by staurosporine. J. Biol. Chem., 272, 18261-18266.
    • (1997) J. Biol. Chem. , vol.272 , pp. 18261-18266
    • Yao, R.1    Yoshihara, M.2    Osada, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.