Phosphorylation of the β1 integrin cytoplasmic domain: Toward an understanding of function and mechanism

Experimental Cell Research

Volumn 258, Issue 2, 2000, Pages 332-341

  Mulrooney, James ^a   Foley, Kate ^a   Vineberg, Sabrina ^a   Barreuther, Mark ^b   Grabel, Laura ^a  

^a WESLEYAN UNIVERSITY   (United States)

^b Albertus Magnus College New Haven   (United States)

Author keywords

F9 teratocarcinoma cells; Integrin linked kinase.; Parietal endoderm; Protein phosphatase 2A

Indexed keywords

BETA1 INTEGRIN; FIBRONECTIN RECEPTOR; INTEGRIN; INTEGRIN LINKED KINASE; INTEGRIN-LINKED KINASE; OKADAIC ACID; PHOSPHOPROTEIN PHOSPHATASE; PROTEIN SERINE THREONINE KINASE; VERY LATE ACTIVATION ANTIGEN 6;

ARTICLE; CANCER CELL CULTURE; CELL DIFFERENTIATION; CONTROLLED STUDY; CROSS LINKING; IMMUNOCYTOCHEMISTRY; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN DOMAIN; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; TERATOCARCINOMA; ANIMAL; CELL CULTURE; CYTOPLASM; HUMAN; METABOLISM; MOUSE; PHOSPHORYLATION; PROTEIN TERTIARY STRUCTURE; RAT;

ANIMALS; ANTIGENS, CD29; CYTOPLASM; HUMANS; INTEGRIN ALPHA6BETA1; INTEGRINS; MICE; OKADAIC ACID; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHORYLATION; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; RATS; RECEPTORS, FIBRONECTIN; TUMOR CELLS, CULTURED;

EID: 0034238109     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.2000.4964     Document Type: Article

References (39)

1. Hynes R. O. Integrins: Versatility, modulation, and signaling in cell adhesion. Cell. 69:1992;11-25.
2. Howe A., Aplin A. E., Alahari S. K., Juliano R. L. Integrin signaling and cell growth control. Curr. Opin. Cell Biol. 10:1998;220-231.
3. Otey C. A., Pavalko F. M., Burridge K. An interaction between alpha-actinin and the beta 1 integrin subunit in vitro. J. Cell Biol. 111:1990;721-729.
4. Otey C. A., Vasquez G. B., Burridge K., Erickson B. W. Mapping of the alpha-actinin binding site within the beta 1 integrin cytoplasmic domain. J. Biol. Chem. 268:1993;21193-21197.
5. Burn P., Kupfer A., Singer S. J. Dynamic membrane-cytoskeletal interactions: Specific association of integrin and talin arises in vivo after phorbol ester treatment of peripheral blood lymphocytes. Proc. Natl. Acad. Sci. USA. 85:1988;497-501.
6. Keely P., Parise L., Juliano R. Integrins and GTPases in tumour cell growth, motility and invasion. Trends Cell Biol. 8:1998;101-106.
7. Yamada K. M. Integrin signaling. Matrix Biol. 16:1997;137-141.
8. LaFlamme S. E., Homan S. M., Bodeau A. L., Mastrangelo A. M. Integrin cytoplasmic domains as connectors to the cell's signal transduction apparatus. Matrix Biol. 16:1997;153-163.
9. Burridge K., Chrzanowska-Wodnicka M. Focal adhesions, contractility, and signaling. Annu. Rev. Cell Dev. Biol. 12:1996;463-518.
10. Lewis J. M., Schwartz M. A. Mapping in vivo associations of cytoplasmic proteins with integrin beta 1 cytoplasmic domain mutants. Mol. Biol. Cell. 6:1995;151-160.
11. Johansson M. W., Larsson E., Luning B., Pasquale E. B., Ruoslahti E. Altered localization and cytoplasmic domain-binding properties of tyrosine-phosphorylated beta 1 integrin. J. Cell Biol. 126:1994;1299-1309.
12. Barreuther M. F., Grabel L. B. The role of phosphorylation in modulating beta 1 integrin localization. Exp. Cell Res. 222:1996;10-15.
13. Reszka A. A., Hayashi Y., Horwitz A. F. Identification of amino acid sequences in the integrin beta 1 cytoplasmic domain implicated in cytoskeletal association. J. Cell Biol. 117:1992;1321-1330.
14. Sakai T., Zhang Q., Fassler R., Mosher D. F. Modulation of beta1A integrin functions by tyrosine residues in the beta1 cytoplasmic domain. J. Cell Biol. 141:1998;527-538.
15. Wennerberg K., Fassler R., Warmegard B., Johansson S. Mutational analysis of the potential phosphorylation sites in the cytoplasmic domain of integrin beta1A. J. Cell Sci. 111:1998;1117-1126.
16. Dahl S. C., Grabel L. B. Altered accumulations of fibronectin are not dependent on fibronectin modifications during the differentiation of F-9 teratocarcinoma stem cells. Exp. Cell Res. 176:1988;234-247.
17. Dahl S. C., Grabel L. B. Integrin phosphorylation is modulated during the differentiation of F-9 teratocarcinoma stem cells. J. Cell Biol. 108:1989;183-190.
18. Jiang R., Grabel L. B. Function and differential regulation of the alpha 6 integrin isoforms during parietal endoderm differentiation. Exp. Cell Res. 217:1995;195-204.
19. Mumby M. C., Walter G. Protein serine/threonine phosphatases: Structure, regulation, and functions in cell growth. Physiol. Rev. 73:1993;673-699.
20. Hannigan G. E. Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinase. Nature. 379:1996;91-96.
21. Cohen P., Holmes C. F., Tsukitani Y. Okadaic acid: A new probe for the study of cellular regulation. Trends Biochem. Sci. 15:1990;98-102.
22. Hardie D. G. Protein Phosphorylation: A Practical Approach. The Practical Approach Series. 1993;Oxford Univ. Press, New York.
23. Miyamoto S., Akiyama S. K., Yamada K. M. Synergistic roles for receptor occupancy and aggregation in integrin transmembrane function. Science. 267:1995;883-885.
24. Belkin A. M. Muscle beta1D integrin reinforces the cytoskeleton-matrix link: modulation of integrin adhesive function by alternative splicing. J. Cell Biol. 139:1997;1583-1595.
25. Felsenfeld D. P., Choquet D., Sheetz M. P. Ligand binding regulates the directed movement of beta1 integrins on fibroblasts. Nature. 383:1996;438-440.
26. Dedhar S., Williams B., Hannigan G. Integrin-linked kinase (ILK): A regulator of integrin and growth-factor signalling. Trends Cell Biol. 9:1999;319-323.
27. Chajry N., Martin P. M., Cochet C., Berthois Y. Regulation of p42 mitogen-activated-protein kinase activity by protein phosphatase 2A under conditions of growth inhibition by epidermal growth factor in A431 cells. Eur. J. Biochem. 235:1996;97-102.
28. Kawada M., Amemiya M., Ishizuka M., Takeuchi T. Cytostatin, an inhibitor of cell adhesion to extracellular matrix, selectively inhibits protein phosphatase 2A. Biochim. Biophys. Acta. 1452:1999;209-217.
29. Delcommenne M., Tan C., Gray V., Rue L., Woodgett J., Dedhar S. Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase. Proc. Natl. Acad. Sci. USA. 95:1998;11211-11216.
30. Wu C. Integrin-linked protein kinase regulates fibronectin matrix assembly, E-cadherin expression, and tumorigenicity. J. Biol. Chem. 273:1998;528-536.
31. Radeva G., Petrocelli T., Behrend E., Leung-Hagesteijn C., Filmus J., Slingerland J., Dedhar S. Overexpression of the integrin-linked kinase promotes anchorage-independent cell cycle progression. J. Biol. Chem. 272:1997;13937-13944.
32. Li F., Zhang Y., Wu C. Integrin-linked kinase is localized to cell-matrix focal adhesions but not cell-cell adhesion sites and the focal adhesion localization of integrin-linked kinase is regulated by the PINCH-binding ANK repeats. J. Cell Sci. 112:1999;4589-4599.
33. Sheetz M. P., Felsenfeld D. P., Galbraith C. G. Cell migration: Regulation of force on extracellular matrix-integrin complexes. Trends Cell Biol. 8:1998;51-54.
34. Schmidt C. E., Horwitz A. F., Lauffenburger D. A., Sheetz M. P. Integrin-cytoskeletal interactions in migrating fibroblasts are dynamic, asymmetric, and regulated. J. Cell Biol. 123:1993;977-991.
35. Regen C. M., Horwitz A. F. Dynamics of beta 1 integrin-mediated adhesive contacts in motile fibroblasts. J. Cell Biol. 119:1992;1347-1359.
36. Palecek S. P., Schmidt C. E., Lauffenburger D. A., Horwitz A. F. Integrin dynamics on the tail region of migrating fibroblasts. J. Cell Sci. 109:1996;941-952.
37. Palecek S., Huttenlocher A., Horwitz A., Lauffenburger D. Physical and biochemical regulation of integrin release during rear detachment of migrating cells. J. Cell Sci. 111:1998;929-940.
38. Filardo E. J., Brooks P. C., Deming S. L., Damsky C., Cheresh D. A. Requirement of the NPXY motif in the integrin beta 3 subunit cytoplasmic tail for melanoma cell migration in vitro and in vivo. J. Cell Biol. 130:1995;441-450.
39. Haas T. A., Plow E. F. Development of a structural model for the cytoplasmic domain of an integrin. Protein Eng. 10:1997;1395-1405.