p-41-Arc subunit of human Arp2/3 complex is a p21-activated kinase-1-interacting substrate

EMBO Reports

Volumn 5, Issue 2, 2004, Pages 154-160

  Vadlamudi, Ratna K ^a   Li, Feng ^a   Barnes, Christopher J ^a   Bagheri Yarmand, Rozita ^a   Kumar, Rakesh ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN RELATED PROTEIN 2; ACTIN RELATED PROTEIN 3; ASPARTIC ACID; GROWTH FACTOR; PROTEIN KINASE; PROTEIN P21; PROTEIN SUBUNIT; THREONINE; TRYPTOPHAN; ACTIN; ACTIN RELATED PROTEIN 2-3 COMPLEX; ARPC1B PROTEIN, HUMAN; EPIDERMAL GROWTH FACTOR; GLUTATHIONE TRANSFERASE; PAK1 PROTEIN, HUMAN; PHALLOIDIN; PROTEIN SERINE THREONINE KINASE; SMALL INTERFERING RNA;

ACTIN FILAMENT; APICAL MEMBRANE; ARTICLE; BINDING SITE; CELL MIGRATION; CELL MOTILITY; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME SUBSTRATE; GENE FUNCTION; GENE MUTATION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SIMPLE SEQUENCE REPEAT; CELL MOTION; CHEMISTRY; DRUG EFFECT; GENE LIBRARY; GENETICS; IMMUNOPRECIPITATION; METABOLISM; MICROFILAMENT; MUTATION; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN BINDING; WOUND HEALING;

MAMMALIA;

ACTIN-RELATED PROTEIN 2-3 COMPLEX; ACTINS; CELL MOVEMENT; EPIDERMAL GROWTH FACTOR; GENE LIBRARY; GLUTATHIONE TRANSFERASE; HUMANS; IMMUNOPRECIPITATION; MICROFILAMENTS; MUTATION; PHALLOIDINE; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN SUBUNITS; PROTEIN-SERINE-THREONINE KINASES; RNA, SMALL INTERFERING; THREONINE; WOUND HEALING;

EID: 1642446043     PISSN: 1469221X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.embor.7400079     Document Type: Article

References (17)

1. Albini A, Iwamoto Y, Kleinman HK, Martin GR, Aaronson AS, Kozlowski JM, Mcewan RN (1987) A rapid in vitro assay for quantitating the invasive potential of tumor cells. Cancer Res 47: 3239-3245
2. Bishop AL, Hall A (2000) Rho GTPases and their effector proteins. Biochem J 348: 241-255
3. Edwards DC, Sanders LC, Bokoch GM, Gill GN (1999) Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signaling to actin cytoskeletal dynamics. Nat Cell Biol 1: 253-259
4. Gournier H, Goley ED, Niederstrasser H, Trinh T, Welch MD (2001) Reconstitution of human Arp2/3 complex reveals critical roles of individual subunits in complex structure and activity. Mol Cell 8: 1041-1052
5. Hall A (1998) Rho GTPases and the actin cytoskeleton. Science 279: 509-514
6. Kumar R, Vadlamudi R (2002) Emerging functions of p21-activated kinases in human cancer cells. J Cell Physiol 193: 133-144
7. Li F, Adam L, Vadlamudi RK, Zhou H, Sen S, Chernoff J, Kumar R (2002) p21 activating kinase 1, a new chromosomal passenger, phosphorylates histone H3 in eukaryotic cells. EMBO Rep 3: 767-773
8. Mullins RD, Pollard TD (1999) Structure and function of the Arp2/3 complex. Curr Opin Struct Biol 9: 244-249
9. Mullins RD, Heuser JA, Pollard TD (1998) The interaction of Arp2/3 complex with actin: Nucleation, high affinity pointed end capping, and formation of branching networks of filaments. Proc Natl Acad Sci USA 95: 6181-6186
10. Robinson RC, Turbedsky K, Kaiser DA, Marchand J, Higgs HN, Choe S, Pollard TD (2001) Crystal structure of Arp2/3 complex. Science 294: 1679-1684
11. Sells MA, Pfaff A, Chernoff J (2002) Temporal and spatial distribution of activated Pak1 in fibroblasts. J Cell Biol 151: 1449-1458
12. Wang R, Mazumdar A, Vadlamudi RK, Kumar R (2002) P21-activated kinase-1 phosphorylates and transactivates estrogen receptor-α and promotes hyperplasia in mammary epithelium. EMBO J 21: 5437-5447
13. Weaver AM, Heuser JE, Karginov AV, Lee WL, Parsons JT, Cooper JA (2002) Interaction of cortactin and N-WASp with Arp2/3 complex. Curr Biol 12: 1270-1278
14. Weaver AM, Young ME, Lee W, Cooper JA (2003) Integration of signals to the ARP2/3 complex. Curr Opin Cell Biol 15: 23-30
15. Welch MD (1999) The world according to Arp: Regulation of actin nucleation by the Arp2/3 complex. Trends Cell Biol 9: 423-427
16. Welch MD, DePace AH, Verma S, Iwamatsu A, Mitchison TJ (1997) The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly. J Cell Biol 138: 375-384
17. Winter DC, Elizabeth YC, Li R (1999) Genetic dissection of the budding yeast Arp2/3 complex: A comparison of the in vivo and structural roles of individual subunits. Proc Natl Acad Sci USA 96: 7288-7293