Cucurbitacin IIa: A novel class of anti-cancer drug inducing non-reversible actin aggregation and inhibiting survivin independent of JAK2/STAT3 phosphorylation

British Journal of Cancer

Volumn 104, Issue 5, 2011, Pages 781-789

  Boykin, C ^a   Zhang, G ^a   Chen, Y H ^a   Zhang, R W ^b   Fan, X E ^b   Yang, W M ^c   Lu, Q ^a  

^a EAST CAROLINA UNIVERSITY   (United States)

^b Longjin Pharmaceuticals   (China)

^c KUNMING MEDICAL UNIVERSITY   (China)

Author keywords

actin cytoskeleton; apoptosis; cucurbitacin IIa; JAK2 STAT3; RhoA; survivin

Indexed keywords

CASPASE; CUCURBITACIN; F ACTIN; MITOGEN ACTIVATED PROTEIN KINASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; STAT3 PROTEIN; SURVIVIN;

ANIMAL CELL; ARTICLE; CANCER CELL; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL DEATH; CELL SURVIVAL; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFICACY; DRUG STRUCTURE; GROWTH INHIBITION; LIVER CELL CARCINOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; TUMOR GROWTH; TUMOR VOLUME;

ACTINS; ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CUCURBITACINS; HUMANS; INHIBITOR OF APOPTOSIS PROTEINS; JANUS KINASE 2; MICE; MICROTUBULE-ASSOCIATED PROTEINS; PHOSPHORYLATION; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR;

EID: 79952281492     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/bjc.2011.10     Document Type: Article

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