The induction of G2/M cell-cycle arrest and apoptosis by cucurbitacin e is associated with increased phosphorylation of eIF2α in leukemia cells

Anti-Cancer Drugs

Volumn 21, Issue 4, 2010, Pages 389-400

  Li, Yanchun ^a   Wang, Rui ^b   Ma, Enlong ^a   Deng, Yihui ^a   Wang, Xiaolong ^a   Xiao, Jinfang ^a   Jing, Yongkui ^b  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Caspase; Cell cycle; Cucurbitacin E; EIF2

Indexed keywords

ACETYLCYSTEINE; ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 8; CASPASE 9; CATALASE; CUCURBITACIN E; CYCLIN DEPENDENT KINASE 1; CYCLIN DEPENDENT KINASE INHIBITOR 1; INITIATION FACTOR 2ALPHA; PROTEIN BAX; PROTEIN MCL 1; REACTIVE OXYGEN METABOLITE; SURVIVIN; UNCLASSIFIED DRUG; X LINKED INHIBITOR OF APOPTOSIS; BIRC5 PROTEIN, HUMAN; CFLAR PROTEIN, HUMAN; FLICE INHIBITORY PROTEIN; GROWTH INHIBITOR; INITIATION FACTOR 2; MICROTUBULE ASSOCIATED PROTEIN; MYELOID CELL LEUKEMIA SEQUENCE 1 PROTEIN; PROTEIN BCL 2; TRITERPENE;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL STRAIN HL 60; CONTROLLED STUDY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; LEUKEMIA CELL; LEUKEMIA CELL LINE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; CELL CYCLE; CELL DIVISION; DRUG EFFECT; LEUKEMIA; METABOLISM; PHOSPHORYLATION;

ACETYLCYSTEINE; ANTINEOPLASTIC AGENTS; APOPTOSIS; CASP8 AND FADD-LIKE APOPTOSIS REGULATING PROTEIN; CASPASE 3; CASPASE 8; CASPASE 9; CATALASE; CELL CYCLE; CELL DIVISION; EUKARYOTIC INITIATION FACTOR-2; G2 PHASE; GROWTH INHIBITORS; HUMANS; JURKAT CELLS; LEUKEMIA; MICROTUBULE-ASSOCIATED PROTEINS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; TRITERPENES; X-LINKED INHIBITOR OF APOPTOSIS PROTEIN;

EID: 77949356144     PISSN: 09594973     EISSN: None     Source Type: Journal    
DOI: 10.1097/CAD.0b013e328336b383     Document Type: Article

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