-
2
-
-
11044225555
-
Gastric adenocarcinoma: Review and considerations for future directions
-
Dicken BJ, Bigam DL, Cass C, Mackey JR, Joy AA and Hamilton SM: Gastric adenocarcinoma: review and considerations for future directions. Ann Surg 241: 27-39, 2005.
-
(2005)
Ann Surg
, vol.241
, pp. 27-39
-
-
Dicken, B.J.1
Bigam, D.L.2
Cass, C.3
Mackey, J.R.4
Joy, A.A.5
Hamilton, S.M.6
-
3
-
-
14944385553
-
Global cancer statistics, 2002
-
Parkin DM, Bray F, Ferlay J and Pisani P: Global cancer statistics, 2002. CA Cancer J Clin 55: 74-108, 2005.
-
(2005)
CA Cancer J Clin
, vol.55
, pp. 74-108
-
-
Parkin, D.M.1
Bray, F.2
Ferlay, J.3
Pisani, P.4
-
4
-
-
0001451440
-
The natural history and results of surgical therapy for carcinoma of the stomach. An analysis of 250 cases
-
Clarke JS, Cruze K, El Farra S and Longmire WP Jr: The natural history and results of surgical therapy for carcinoma of the stomach. An analysis of 250 cases. Am J Surg 102: 143-152, 1961.
-
(1961)
Am J Surg
, vol.102
, pp. 143-152
-
-
Clarke, J.S.1
Cruze, K.2
El Farra, S.3
Longmire Jr., W.P.4
-
5
-
-
0034961111
-
A systematic overview of chemotherapy effects in gastric cancer
-
DOI 10.1080/02841860151116385
-
Janunger KG, Hafstrom L, Nygren P and Glimelius B: A systematic overview of chemotherapy effects in gastric cancer. Acta Oncol 40: 309-326, 2001. (Pubitemid 32588125)
-
(2001)
Acta Oncologica
, vol.40
, Issue.2-3
, pp. 309-326
-
-
Janunger, K.G.1
Hafstrom, L.2
Nygren, P.3
Glimelius, B.4
-
6
-
-
1642434133
-
Tobacco carcinogen-induced cellular transformation increases activation of the phosphatidylinositol 3'-kinase/Akt pathway in vitro and in vivo
-
West KA, Linnoila IR, Belinsky SA, Harris CC and Dennis PA: Tobacco carcinogen-induced cellular transformation increases activation of the phosphatidylinositol 3'-kinase/Akt pathway in vitro and in vivo. Cancer Res 64: 446-451, 2004.
-
(2004)
Cancer Res
, vol.64
, pp. 446-451
-
-
West, K.A.1
Linnoila, I.R.2
Belinsky, S.A.3
Harris, C.C.4
Dennis, P.A.5
-
7
-
-
34447623763
-
Deguelin inhibits expression of Ikappa- Balpha protein and induces apoptosis of B-CLL cells in vitro
-
Geeraerts B, Vanhoecke B, Vanden Berghe W, Philippe J, Offner F and Deforce D: Deguelin inhibits expression of Ikappa- Balpha protein and induces apoptosis of B-CLL cells in vitro. Leukemia 21: 1610-1618, 2007.
-
(2007)
Leukemia
, vol.21
, pp. 1610-1618
-
-
Geeraerts, B.1
Vanhoecke, B.2
Vanden Berghe, W.3
Philippe, J.4
Offner, F.5
Deforce, D.6
-
8
-
-
0036892114
-
Deguelin inhibits the growth of colon cancer cells through the induction of apoptosis and cell cycle arrest
-
Murillo G, Salti GI, Kosmeder JW II, Pezzuto JM and Mehta RG: Deguelin inhibits the growth of colon cancer cells through the induction of apoptosis and cell cycle arrest. Eur J Cancer 38: 2446-2454, 2002.
-
(2002)
Eur J Cancer
, vol.38
, pp. 2446-2454
-
-
Murillo, G.1
Salti, G.I.2
Kosmeder II, J.W.3
Pezzuto, J.M.4
Mehta, R.G.5
-
9
-
-
0037453909
-
Effects of deguelin on the phosphatidylinositol 3-kinase/Akt pathway and apoptosis in premalignant human bronchial epithelial cells
-
Chun KH, Kosmeder JW III, Sun S, et al: Effects of deguelin on the phosphatidylinositol 3-kinase/Akt pathway and apoptosis in premalignant human bronchial epithelial cells. J Natl Cancer Inst 95: 291-302, 2003.
-
(2003)
J Natl Cancer Inst
, vol.95
, pp. 291-302
-
-
Chun, K.H.1
Kosmeder III, J.W.2
Sun, S.3
-
10
-
-
20444484563
-
Deguelin, a PI3K/AKT inhibitor, enhances chemosensitivity of leukaemia cells with an active PI3K/AKT pathway
-
Bortul R, Tazzari PL, Billi AM, et al: Deguelin, A PI3K/AKT inhibitor, enhances chemosensitivity of leukaemia cells with an active PI3K/AKT pathway. Br J Haematol 129: 677-686, 2005.
-
(2005)
Br J Haematol
, vol.129
, pp. 677-686
-
-
Bortul, R.1
Tazzari, P.L.2
Billi, A.M.3
-
11
-
-
1042278720
-
Deguelin-induced inhibition of cyclooxygenase-2 expression in human bronchial epithelial cells
-
Lee HY, Suh YA, Kosmeder JW, Pezzuto JM, Hong WK and Kurie JM: Deguelin-induced inhibition of cyclooxygenase-2 expression in human bronchial epithelial cells. Clin Cancer Res 10: 1074-1079, 2004.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 1074-1079
-
-
Lee, H.Y.1
Suh, Y.A.2
Kosmeder, J.W.3
Pezzuto, J.M.4
Hong, W.K.5
Kurie, J.M.6
-
12
-
-
4143078350
-
Molecular mechanisms of deguelin-induced apoptosis in transformed human bronchial epithelial cells
-
Lee HY: Molecular mechanisms of deguelin-induced apoptosis in transformed human bronchial epithelial cells. Biochem Pharmacol 68: 1119-1124, 2004.
-
(2004)
Biochem Pharmacol
, vol.68
, pp. 1119-1124
-
-
Lee, H.Y.1
-
13
-
-
32044466838
-
Exploiting the PI3K/AKT pathway for cancer drug discovery
-
Hennessy BT, Smith DL, Ram PT, Lu Y and Mills GB: Exploiting the PI3K/AKT pathway for cancer drug discovery. Nat Rev Drug Discov 4: 988-1004, 2005.
-
(2005)
Nat Rev Drug Discov
, vol.4
, pp. 988-1004
-
-
Hennessy, B.T.1
Smith, D.L.2
Ram, P.T.3
Lu, Y.4
Mills, G.B.5
-
14
-
-
27944452718
-
Chemopreventive effects of deguelin, a novel Akt inhibitor, on tobacco-induced lung tumorigenesis
-
Lee HY, Oh SH, Woo JK, et al: Chemopreventive effects of deguelin, a novel Akt inhibitor, on tobacco-induced lung tumorigenesis. J Natl Cancer Inst 97: 1695-1699, 2005.
-
(2005)
J Natl Cancer Inst
, vol.97
, pp. 1695-1699
-
-
Lee, H.Y.1
Oh, S.H.2
Woo, J.K.3
-
15
-
-
0041859233
-
Regulation of ornithine decarboxylase induction by deguelin, a natural product cancer chemopreventive agent
-
Gerhauser C, Lee SK, Kosmeder JW, et al: Regulation of ornithine decarboxylase induction by deguelin, a natural product cancer chemopreventive agent. Cancer Res 57: 3429-3435, 1997.
-
(1997)
Cancer Res
, vol.57
, pp. 3429-3435
-
-
Gerhauser, C.1
Lee, S.K.2
Kosmeder, J.W.3
-
16
-
-
2442669734
-
Apoptosis induction by the natural product cancer chemopreventive agent deguelin is mediated through the inhibition of mitochondrial bioenergetics
-
Hail N Jr and Lotan R: Apoptosis induction by the natural product cancer chemopreventive agent deguelin is mediated through the inhibition of mitochondrial bioenergetics. Apoptosis 9: 437-447, 2004.
-
(2004)
Apoptosis
, vol.9
, pp. 437-447
-
-
Hail Jr., N.1
Lotan, R.2
-
17
-
-
0030878978
-
Cancer chemopreventive activity mediated by deguelin, a naturally occurring rotenoid
-
Udeani GO, Gerhauser C, Thomas CF, et al: Cancer chemopreventive activity mediated by deguelin, a naturally occurring rotenoid. Cancer Res 57: 3424-3428, 1997.
-
(1997)
Cancer Res
, vol.57
, pp. 3424-3428
-
-
Udeani, G.O.1
Gerhauser, C.2
Thomas, C.F.3
-
18
-
-
0142166332
-
Targeting HIF-1 for cancer therapy
-
Semenza GL: Targeting HIF-1 for cancer therapy. Nat Rev Cancer 3: 721-732, 2003.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 721-732
-
-
Semenza, G.L.1
-
19
-
-
33745307617
-
Ras, PI(3)K and mTOR signalling controls tumour cell growth
-
Shaw RJ and Cantley LC: Ras, PI(3)K and mTOR signalling controls tumour cell growth. Nature 441: 424-430, 2006.
-
(2006)
Nature
, vol.441
, pp. 424-430
-
-
Shaw, R.J.1
Cantley, L.C.2
-
20
-
-
0001582482
-
Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: Amplification of AKT1 in a primary human gastric adenocarcinoma
-
Staal SP: Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma. Proc Natl Acad Sci USA 84: 5034-5037, 1987.
-
(1987)
Proc Natl Acad Sci USA
, vol.84
, pp. 5034-5037
-
-
Staal, S.P.1
-
21
-
-
11144358645
-
High Frequency of Mutations of the PIK3CA Gene in Human Cancers
-
DOI 10.1126/science.1096502
-
Samuels Y, Wang Z, Bardelli A, et al: High frequency of mutations of the PIK3CA gene in human cancers. Science 304: 554, 2004. (Pubitemid 38541907)
-
(2004)
Science
, vol.304
, Issue.5670
, pp. 554
-
-
Samuels, Y.1
Wang, Z.2
Bardelli, A.3
Silliman, N.4
Ptak, J.5
Szabo, S.6
Yan, H.7
Gazdar, A.8
Powell, S.M.9
Riggins, G.J.10
Willson, J.K.V.11
Markowitz, S.12
Kinzler, K.W.13
Vogelstein, B.14
Velculescu, V.E.15
-
22
-
-
18244406326
-
Analysis of genetic and epigenetic alterations of the PTEN gene in gastric cancer
-
DOI 10.1007/s004280100499
-
Sato K, Tamura G, Tsuchiya T, et al: Analysis of genetic and epigenetic alterations of the PTEN gene in gastric cancer. Virchows Arch 440: 160-165, 2002. (Pubitemid 34169853)
-
(2002)
Virchows Archiv
, vol.440
, Issue.2
, pp. 160-165
-
-
Sato, K.1
Tamura, G.2
Tsuchiya, T.3
Endoh, Y.4
Sakata, K.5
Motoyama, T.6
Usuba, O.7
Kimura, W.8
Terashima, M.9
Nishizuka, S.10
Zou, T.11
Meltzer, S.J.12
-
23
-
-
26444503696
-
Akt phosphorylation associates with LOH of PTEN and leads to chemoresistance for gastric cancer
-
Oki E, Baba H, Tokunaga E, et al: Akt phosphorylation associates with LOH of PTEN and leads to chemoresistance for gastric cancer. Int J Cancer 117: 376-380, 2005.
-
(2005)
Int J Cancer
, vol.117
, pp. 376-380
-
-
Oki, E.1
Baba, H.2
Tokunaga, E.3
-
24
-
-
36849015047
-
Phosphoinositide 3-kinase/Akt pathway plays an important role in chemoresistance of gastric cancer cells against etoposide and doxorubicin induced cell death
-
Yu HG, Ai YW, Yu LL, et al: Phosphoinositide 3-kinase/Akt pathway plays an important role in chemoresistance of gastric cancer cells against etoposide and doxorubicin induced cell death. Int J Cancer 122: 433-443, 2008.
-
(2008)
Int J Cancer
, vol.122
, pp. 433-443
-
-
Yu, H.G.1
Ai, Y.W.2
Yu, L.L.3
-
25
-
-
0028589101
-
A role for Hsp90 in cell cycle control: Wee1 tyrosine kinase activity requires interaction with Hsp90
-
Aligue R, Akhavan-Niak H and Russell P: A role for Hsp90 in cell cycle control: wee1 tyrosine kinase activity requires interaction with Hsp90. EMBO J 13: 6099-6106, 1994.
-
(1994)
EMBO J
, vol.13
, pp. 6099-6106
-
-
Aligue, R.1
Akhavan-Niak, H.2
Russell, P.3
-
26
-
-
17144377442
-
Hsp90 activation and cell cycle regulation
-
Burrows F, Zhang H and Kamal A: Hsp90 activation and cell cycle regulation. Cell Cycle 3: 1530-1536, 2004.
-
(2004)
Cell Cycle
, vol.3
, pp. 1530-1536
-
-
Burrows, F.1
Zhang, H.2
Kamal, A.3
-
27
-
-
34347256360
-
Structural basis for depletion of heat shock protein 90 client proteins by deguelin
-
Oh SH, Woo JK, Yazici YD, et al: Structural basis for depletion of heat shock protein 90 client proteins by deguelin. J Natl Cancer Inst 99: 949-961, 2007.
-
(2007)
J Natl Cancer Inst
, vol.99
, pp. 949-961
-
-
Oh, S.H.1
Woo, J.K.2
Yazici, Y.D.3
-
28
-
-
49849099406
-
Deguelin inhibits human hepatocellular carcinoma by antiangiogenesis and apoptosis
-
Lee JH, Lee DH, Lee HS, Choi JS, Kim KW and Hong SS: Deguelin inhibits human hepatocellular carcinoma by antiangiogenesis and apoptosis. Oncol Rep 20: 129-134, 2008.
-
(2008)
Oncol Rep
, vol.20
, pp. 129-134
-
-
Lee, J.H.1
Lee, D.H.2
Lee, H.S.3
Choi, J.S.4
Kim, K.W.5
Hong, S.S.6
-
29
-
-
0036782278
-
VEGF and the quest for tumour angiogenesis factors
-
Ferrara N: VEGF and the quest for tumour angiogenesis factors. Nat Rev Cancer 2: 795-803, 2002.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 795-803
-
-
Ferrara, N.1
-
30
-
-
14644440555
-
Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis
-
Hicklin DJ and Ellis LM: Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J Clin Oncol 23: 1011-1027, 2005.
-
(2005)
J Clin Oncol
, vol.23
, pp. 1011-1027
-
-
Hicklin, D.J.1
Ellis, L.M.2
-
31
-
-
62349092784
-
A novel derivative of the natural agent deguelin for cancer chemoprevention and therapy
-
Kim WY, Chang DJ, Hennessy B, et al: A novel derivative of the natural agent deguelin for cancer chemoprevention and therapy. Cancer Prev Res 1: 577-587, 2008.
-
(2008)
Cancer Prev Res
, vol.1
, pp. 577-587
-
-
Kim, W.Y.1
Chang, D.J.2
Hennessy, B.3
-
32
-
-
60549083336
-
Targeting heat shock protein 90 overrides the resistance of lung cancer cells by blocking radiation-induced stabilization of hypoxiainducible factor-1alpha
-
Kim WY, Oh SH, Woo JK, Hong WK and Lee HY: Targeting heat shock protein 90 overrides the resistance of lung cancer cells by blocking radiation-induced stabilization of hypoxiainducible factor-1alpha. Cancer Res 69: 1624-1632, 2009.
-
(2009)
Cancer Res
, vol.69
, pp. 1624-1632
-
-
Kim, W.Y.1
Oh, S.H.2
Woo, J.K.3
Hong, W.K.4
Lee, H.Y.5
-
33
-
-
36749072578
-
Identification of novel antiangiogenic anticancer activities of deguelin targeting hypoxiainducible factor-1 alpha
-
Oh SH, Woo JK, Jin Q, et al: Identification of novel antiangiogenic anticancer activities of deguelin targeting hypoxiainducible factor-1 alpha. Int J Cancer 122: 5-14, 2008.
-
(2008)
Int J Cancer
, vol.122
, pp. 5-14
-
-
Oh, S.H.1
Woo, J.K.2
Jin, Q.3
-
34
-
-
67549093924
-
Liposomal encapsulation of deguelin: Evidence for enhanced antitumor activity in tobacco carcinogen-induced and oncogenic K-ras-induced lung tumorigenesis
-
Woo JK, Choi DS, Tran HT, Gilbert BE, Hong WK and Lee HY: Liposomal encapsulation of deguelin: evidence for enhanced antitumor activity in tobacco carcinogen-induced and oncogenic K-ras-induced lung tumorigenesis. Cancer Prev Res 2: 361-369, 2009.
-
(2009)
Cancer Prev Res
, vol.2
, pp. 361-369
-
-
Woo, J.K.1
Choi, D.S.2
Tran, H.T.3
Gilbert, B.E.4
Hong, W.K.5
Lee, H.Y.6
-
35
-
-
34548102391
-
Nicotine induces hypoxia-inducible factor-1alpha expression in human lung cancer cells via nicotinic acetylcholine receptor-mediated signaling pathways
-
Zhang Q, Tang X, Zhang ZF, Velikina R, Shi S and Le AD: Nicotine induces hypoxia-inducible factor-1alpha expression in human lung cancer cells via nicotinic acetylcholine receptor-mediated signaling pathways. Clin Cancer Res 13: 4686-4694, 2007.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 4686-4694
-
-
Zhang, Q.1
Tang, X.2
Zhang, Z.F.3
Velikina, R.4
Shi, S.5
Le, A.D.6
-
36
-
-
33747488399
-
PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR
-
Bernardi R, Guernah I, Jin D, et al: PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR. Nature 442: 779-785, 2006.
-
(2006)
Nature
, vol.442
, pp. 779-785
-
-
Bernardi, R.1
Guernah, I.2
Jin, D.3
-
37
-
-
33746899015
-
Akt1 activation can augment hypoxia-inducible factor-1alpha expression by increasing protein translation through a mammalian target of rapamycin-independent pathway
-
Pore N, Jiang Z, Shu HK, Bernhard E, Kao GD and Maity A: Akt1 activation can augment hypoxia-inducible factor-1alpha expression by increasing protein translation through a mammalian target of rapamycin-independent pathway. Mol Cancer Res 4: 471-479, 2006.
-
(2006)
Mol Cancer Res
, vol.4
, pp. 471-479
-
-
Pore, N.1
Jiang, Z.2
Shu, H.K.3
Bernhard, E.4
Kao, G.D.5
Maity, A.6
|