Polyglutamine expansion alters the dynamics and molecular architecture of aggregates in dentatorubropallidoluysian atrophy

Journal of Biological Chemistry

Volumn 287, Issue 3, 2012, Pages 2068-2078

  Hinz, Justyna ^a   Lehnhardt, Lothar ^a   Zakrzewski, Silke ^a,b   Zhang, Gong ^a,c   Ignatova, Zoya ^a  

^a UNIVERSITY OF POTSDAM   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c JINAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CELLULAR TOXICITIES; CLINICAL FEATURES; COMPOSITION ANALYSIS; CYTOPLASMIC INCLUSION; DYNAMIC IMAGING; MOLECULAR ARCHITECTURE; MOLECULAR SPECIES; MUTANT PROTEINS; NEURODEGENERATION; NEURODEGENERATIVE DISORDERS; POLYGLUTAMINE; POLYGLUTAMINE (POLYQ); SLOW DYNAMICS;

AGGREGATES; NEURODEGENERATIVE DISEASES; TOXICITY;

DYNAMICS;

ATROPHIN 1; BRAIN PROTEIN; CASPASE; POLYGLUTAMINE; UNCLASSIFIED DRUG;

ARTICLE; CAG REPEAT; CELL NUCLEUS MEMBRANE; COMPLEX FORMATION; CONTROLLED STUDY; DENTATORUBROPALLIDOLUYSIAN ATROPHY; FLUORESCENCE RECOVERY AFTER PHOTOBLEACHING; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MOLECULAR DYNAMICS; NERVE DEGENERATION; NUCLEAR LOCALIZATION SIGNAL; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN ASSEMBLY; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; WESTERN BLOTTING;

ANIMALS; ATROPHY; CELL LINE; CYTOPLASM; HEREDODEGENERATIVE DISORDERS, NERVOUS SYSTEM; HUMANS; MICE; MULTIPROTEIN COMPLEXES; NERVE TISSUE PROTEINS; PEPTIDES;

EID: 84862968848     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.318915     Document Type: Article

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