Conformational diversity in a yeast prion dictates its seeding specificity

Nature

Volumn 410, Issue 6825, 2001, Pages 223-227

  Chien, P ^a   Weissman, J S ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID; PRION PROTEIN;

ARTICLE; CANDIDA ALBICANS; DISEASE TRANSMISSION; GENE MUTATION; HERITABILITY; NONHUMAN; PRION DISEASE; PRIORITY JOURNAL; PROTEIN CONFORMATION; SACCHAROMYCES CEREVISIAE; SPECIES DIFFERENCE;

AMINO ACID SEQUENCE; AMYLOID; CANDIDA ALBICANS; CATALYSIS; FUNGAL PROTEINS; PRIONS; PROTEIN CONFORMATION; RECOMBINANT FUSION PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SPECIES SPECIFICITY; STRUCTURE-ACTIVITY RELATIONSHIP;

CANDIDA ALBICANS; CHIMAERA; SACCHAROMYCES CEREVISIAE;

EID: 0035826236     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35065632     Document Type: Article

References (30)

1. Prions
2. Non-genetic propagation of strain-specific properties of scrapie prion protein
3. Genesis and variability of [PSI] prion factors in Saccharomyces cerevisiae
4. +]: An epigenetic modulator of translation termination efficiency
5. Evidence for the conformation of the pathologic isoform of the prion protein enciphering and propagating prion diversity
6. +] determinant is mediated by oligomerization of the SUP35-encoded polypeptide chain release factor
7. Molecular analysis of prion strain variation and the aetiology of 'new variant' CJD
8. Variant Creutzfeldt-Jakob disease
9. The products of the SUP45 (eRF1) and SUP35 genes interact to mediate translation termination in Saccharomyces cerevisiae
10. +]
11. +] in the yeast Saccharomyces cerevisiae
12. A critical role for amino-terminal glutamine/ asparagine repeats in the formation and propagation of a yeast prion
13. Support for the prion hypothesis for inheritance of a phenotypic trait in yeast
14. Prion-inducing domain 2-114 of yeast Sup35 protein transforms in vitro into amyloid-like filaments
15. +], a heritable prion-like factor of S. cerevisiae
16. Prion properties of the Sup35 protein of yeast Pichia methanolica
17. Molecular basis of a yeast prion species barrier
18. Evolutionary conservation of prion-forming abilities of the yeast Sup35 protein
19. Oligopeptide-repeat expansions modulate 'protein-only' inheritance in yeast
20. [URE3] as an altered URE2 protein: Evidence for a prion analog in Saccharomyces cerevisiae
21. Rnq1: An epigenetic modifier of protein function in yeast
22. -] in Saccharomyces cerevisiae
23. +], a prion-like form of release factor eRF3
24. Nucleated conformational conversion and the replication of conformational information by a prion determinant
25. In vitro propagation of the prion-like state of yeast Sup35 protein
26. + priori determinant propagation by a mutation of the N-terminus of the yeast Sup35 protein
27. Prion rods contain an inert polysaccharide scaffold
28. Prion rods contain small amounts of two host sphingolipids as revealed by thin-layer chromatography and mass spectrometry
29. Species specificity in the cell-free conversion of prion protein to protease-resistant forms: A model for the scrapie species barrier
30. Bovine spongiform encephalopathy - Epidemiologic studies on the origin