The interplay between polyQ and protein context delays aggregation by forming a reservoir of protofibrils

PLoS ONE

Volumn 1, Issue 1, 2006, Pages

  Bulone, Donatella ^a   Masino, Laura ^b   Thomas, David J ^c   San Biagio, Pier Luigi ^a   Pastore, Annalisa ^b  

^a CNR   (Italy)

^b NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^c Scientific Software Solutions   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; GLUTATHIONE TRANSFERASE; POLYGLUTAMINE; HYBRID PROTEIN; MULTIPROTEIN COMPLEX; PEPTIDE;

ARTICLE; CONTROLLED STUDY; DEGENERATIVE DISEASE; ENZYME KINETICS; NONHUMAN; PROTEIN AGGREGATION; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FOLDING; TEMPERATURE STRESS; BIOLOGICAL MODEL; CHEMISTRY; CIRCULAR DICHROISM; DEMYELINATING DISEASE; GENETICS; HUMAN; IN VITRO STUDY; KINETICS; LIGHT; METABOLISM; PROTEIN MULTIMERIZATION; PROTEIN STABILITY; RADIATION SCATTERING; SOLUBILITY; THERMODYNAMICS; TRANSMISSION ELECTRON MICROSCOPY; TRINUCLEOTIDE REPEAT; ULTRASTRUCTURE;

CARRIER PROTEINS; CIRCULAR DICHROISM; GLUTATHIONE TRANSFERASE; HEREDODEGENERATIVE DISORDERS, NERVOUS SYSTEM; HUMANS; KINETICS; LIGHT; MICROSCOPY, ELECTRON, TRANSMISSION; MODELS, BIOLOGICAL; MULTIPROTEIN COMPLEXES; PEPTIDES; PROTEIN FOLDING; PROTEIN MULTIMERIZATION; PROTEIN STABILITY; RECOMBINANT FUSION PROTEINS; SCATTERING, RADIATION; SOLUBILITY; THERMODYNAMICS; TRINUCLEOTIDE REPEAT EXPANSION;

EID: 35648992125     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0000111     Document Type: Article

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