A structure-based analysis of huntingtin mutant polyglutamine aggregation and toxicity: Evidence for a compact beta-sheet structure

Human Molecular Genetics

Volumn 14, Issue 6, 2005, Pages 765-774

  Poirier, Michelle A ^a   Jiang, Haibing ^a   Ross, Christopher A ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTAMINE; HUNTINGTIN; POLYGLUTAMINE;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BETA SHEET; BRAIN CELL; BRAIN CORTEX; CELL CULTURE; CONTROLLED STUDY; CORPUS STRIATUM; CYTOTOXICITY; EXON; EXPERIMENTAL MODEL; GENE MUTATION; HUMAN; HUMAN CELL; HUNTINGTON CHOREA; MAMMAL CELL; MOUSE; NERVE CELL DEGENERATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN STRUCTURE; STRUCTURE ANALYSIS;

ANIMALS; CELL DEATH; CELL LINE; CELL SURVIVAL; CEREBRAL CORTEX; CORPUS STRIATUM; HUMANS; HUNTINGTON DISEASE; MICE; MUTATION; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; PEPTIDES; STRUCTURE-ACTIVITY RELATIONSHIP;

MAMMALIA;

EID: 15544372340     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: 10.1093/hmg/ddi071     Document Type: Article

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