Atrophin-1, the dentato-rubral and pallido-luysian atrophy gene product, interacts with ETO/MTG8 in the nuclear matrix and represses transcription

Journal of Cell Biology

Volumn 150, Issue 5, 2000, Pages 939-948

  Wood, Jonathan D ^a   Nucifora Jr , Frederick C ^a   Duan, Kui ^a   Zhang, Chuanyi ^a   Wang, Jianxiang ^b   Kim, Yujin ^a   Schilling, Gabriele ^a   Sacchi, Nicoletta ^c   Liu, Johnson M ^b   Ross, Christopher A ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^c UNIVERSITY OF MILAN   (Italy)

Author keywords

Cerebellar nuclei; Myeloid leukemia; Neurodegenerative diseases; Nuclear matrix; Trinucleotide repeats

Indexed keywords

ATROPHIN 1; GENE PRODUCT; HISTONE DEACETYLASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL NUCLEUS MATRIX; CONTROLLED STUDY; DEGENERATIVE DISEASE; DENTATORUBROPALLIDOLUYSIAN ATROPHY; DISEASE ASSOCIATION; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; TRANSCRIPTION REGULATION;

ANIMALS; ATROPHY; CLONING, MOLECULAR; DNA-BINDING PROTEINS; GLOBUS PALLIDUS; HISTONE DEACETYLASES; HUMANS; MICE; MICE, TRANSGENIC; NERVE TISSUE PROTEINS; NUCLEAR MATRIX; PEPTIDE FRAGMENTS; PROTO-ONCOGENE PROTEINS; RECOMBINANT PROTEINS; REPRESSOR PROTEINS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION; TUMOR CELLS, CULTURED;

ANIMALIA; MUS MUSCULUS;

EID: 0034605071     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.150.5.939     Document Type: Article

References (44)

1. Aberrant interactions of transcriptional repressor proteins with the Huntington's disease gene product, huntingtin
2. Altered brain neurotransmitter receptors in transgenic mice expressing a portion of an abnormal human huntington disease gene
3. Evidence for proteasome involvement in polyglutamine disease: Localization to nuclear inclusions in SCA3/MJD and suppression of polyglutamine aggregation in vitro
4. The capacity of polyomavirus enhancer binding protein 2alphaB (AML1/Cbfa2) to stimulate polyomavirus DNA replication is related to its affinity for the nuclear matrix
5. Protein interaction cloning in yeast: Identification of mammalian proteins that react with the leucine zipper of Jun
6. Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1
7. ETO-2, a new member of the ETO-family of nuclear proteins
8. Identification of break-points in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt
9. The partner gene of AML1 in t(16;21) myeloid malignancies is a novel member of the MTG8(ETO) family
10. Aberrant recruitment of the nuclear receptor corepressor-histone deacetylase complex by the acute myeloid leukemia fusion partner ETO
11. Trinucleotide instability: A repeating theme in human inherited disorders
12. A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration
13. Insoluble detergent-resistant aggregates form between pathological and nonpathological lengths of polyglutamine in mammalian cells
14. The AML1-MTG8 leukemic fusion protein forms a complex with a novel member of the MTG8(ETO/CDR) family, MTGR1
15. Ataxin-1 nuclear localization and aggregation: Role in polyglutamine-induced disease in SCA1 transgenic mice
16. A neurological disease caused by an expanded CAG trinucleotide repeat in the TATA-binding protein gene: A new polyglutamine disease?
17. Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy
18. Structure and function in the nucleus
19. Characterization of the ETO and AML1-ETO proteins involved in 8;21 translocation in acute myelogenous leukemia
20. Polyglutamine expansion down-regulates specific neuronal genes before pathologic changes in SCA1
21. Decreased expression of striatal signaling genes in a mouse model of Huntington's disease
22. The MYND motif is required for repression of basal transcription from the multidrug resistance 1 promoter by the t(8;21) fusion protein
23. ETO, a target of t(8;21) in acute leukemia, interacts with the N-CoR and mSin3 corepressors
24. The cerebellar leucine-rich acidic nuclear protein interacts with ataxin-1
25. The t(8;21) chromosomal translocation in acute myelogenous leukemia modifies intranuclear targeting of the AML1/ CBFalpha2 transcription factor
26. The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcript
27. Structure and expression of the gene responsible for the triplet repeat disorder, dentatorubral and pallidoluysian atrophy (DRPLA)
28. Transcriptionally active chimeric gene derived from the fusion of the AML1 gene and a novel gene on chromosome 8 in t(8;21) leukemic ceils
29. Trinucleotide repeats in neurogenetic disorders
30. Recruitment and the role of nuclear localization in polyglutamine-mediated aggregation
31. PML induces a novel caspase-independent death process
32. PEST sequences and regulation by proteolysis
33. When more is less: Pathogenesis of glutamine repeat neurodegenerative diseases
34. Intranuclear neuronal inclusions: A common pathogenic mechanism for glutamine-repeat neurodegenerative diseases?
35. Subcellular localization of the oncoprotein MTG8 (CDR/ ETO) in neural cells
36. Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions
37. Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo
38. Nuclear accumulation of truncated atrophin-1 fragments in a transgenic mouse model of DRPLA
39. Ataxin-1 with an expanded glutamine tract alters nuclear matrix-associated structures
40. Ataxin-3 is transported into the nucleus and associates with the nuclear matrix
41. ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex
42. PML is essential for multiple apoptotic pathways
43. Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins
44. Abnormal gene product identified in hereditary dentatorubral-pallidoluysian atrophy (DRPLA) brain