Structural insights into the substrate specificity of human granzyme H: The functional roles of a novel RKR motif

Journal of Immunology

Volumn 188, Issue 2, 2012, Pages 765-773

  Wang, Li ^a   Zhang, Kai ^a   Wu, Lianfeng ^a   Liu, Shengwu ^a   Zhang, Honglian ^a   Zhou, Qiangjun ^a   Tong, Liang ^b   Sun, Fei ^a   Fan, Zusen ^a  

^a INSTITUTE OF BIOPHYSICS   (China)

^b Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL PROLYLTHREONYLSERYLTYROSINE CHLOROMETHYLKETONE; AMINO ACID; ENZYME INHIBITOR; GRANZYME; GRANZYME H; UNCLASSIFIED DRUG;

ALPHA HELIX; AMINO TERMINAL SEQUENCE; ARTICLE; BETA SHEET; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ENZYME SPECIFICITY; ENZYME SUBSTRATE; ENZYME SUBSTRATE COMPLEX; HUMAN; HUMAN CELL; NATURAL KILLER CELL MEDIATED CYTOTOXICITY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN SECONDARY STRUCTURE; RKR MOTIF; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS; STRUCTURE ACTIVITY RELATION;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; CATALYTIC DOMAIN; CATS; CELL LINE; CELL LINE, TRANSFORMED; CRYSTALLOGRAPHY, X-RAY; CYTOTOXICITY, IMMUNOLOGIC; DOGS; GRANZYMES; HUMANS; HYDROGEN-ION CONCENTRATION; K562 CELLS; MOLECULAR SEQUENCE DATA; PAN TROGLODYTES; PROTEIN BINDING; SERINE PROTEINASE INHIBITORS; SUBSTRATE SPECIFICITY;

EID: 84862943610     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1101381     Document Type: Article

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