Structural basis for proteolytic specificity of the human apoptosis-inducing granzyme M

Journal of Immunology

Volumn 183, Issue 1, 2009, Pages 421-429

  Wu, Lianfeng ^a   Wang, Li ^a   Hua, Guoqiang ^a   Liu, Kan ^a   Yang, Xuan ^a   Zhai, Yujia ^a   Bartlam, Mark ^b   Sun, Fei ^a   Fan, Zusen ^a  

^a INSTITUTE OF BIOPHYSICS   (China)

^b NANKAI UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARAGINE; ASPARTIC ACID; GRANZYME; GRANZYME M; KETONE DERIVATIVE; PEPTIDE; TETRAPEPTIDE CHLOROMETHYLKETONE INHIBITOR; UNCLASSIFIED DRUG; APOPTOSIS REGULATORY PROTEIN; GZMM PROTEIN, HUMAN; PEPTIDE FRAGMENT; RECOMBINANT PROTEIN;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; APOPTOSIS; ARTICLE; BINDING AFFINITY; CATALYSIS; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME SPECIFICITY; HUMAN; HUMAN CELL; MUTANT; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN STABILITY; SITE DIRECTED MUTAGENESIS; WILD TYPE; CHEMISTRY; DRUG ANTAGONISM; ENZYME ACTIVE SITE; ENZYME STABILITY; GENETICS; HYDROLYSIS; IMMUNOLOGY; LEUKEMIA CELL LINE; METABOLISM; PROTEIN TERTIARY STRUCTURE; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

AMINO ACID SUBSTITUTION; APOPTOSIS REGULATORY PROTEINS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; ENZYME STABILITY; GRANZYMES; HUMANS; HYDROLYSIS; JURKAT CELLS; MUTAGENESIS, SITE-DIRECTED; PEPTIDE FRAGMENTS; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 68949090269     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0803088     Document Type: Article

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