Ignition of p53 bomb sensitizes tumor cells to granzyme K-mediated cytolysis

Journal of Immunology

Volumn 182, Issue 4, 2009, Pages 2152-2159

  Hua, Guoqiang ^a   Wang, Shuo ^a   Zhong, Chao ^a   Xue, Peng ^a   Fan, Zusen ^a  

^a INSTITUTE OF BIOPHYSICS   (China)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; GLUTATHIONE TRANSFERASE; GRANZYME; GRANZYME K; PROTEIN P53; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ADENOVIRUS; ARTICLE; CELL CYCLE; CELL MEDIATED CYTOTOXICITY; CELL STRAIN HCT116; CELLULAR DISTRIBUTION; CYTOLYSIS; ENZYME ACTIVITY; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR CELL; TUMOR SUPPRESSOR GENE; APOPTOSIS; CONFOCAL MICROSCOPY; CYTOTOXICITY; GENETIC TRANSFECTION; GENETICS; HELA CELL; IMMUNOBLOTTING; IMMUNOLOGY; IMMUNOPRECIPITATION; METABOLISM; NATURAL KILLER CELL; NEOPLASM; NICK END LABELING; PATHOLOGY; PHYSIOLOGY;

APOPTOSIS; CYTOTOXICITY, IMMUNOLOGIC; GRANZYMES; HELA CELLS; HUMANS; IMMUNOBLOTTING; IMMUNOPRECIPITATION; IN SITU NICK-END LABELING; KILLER CELLS, NATURAL; MICROSCOPY, CONFOCAL; NEOPLASMS; TRANSFECTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 61449210797     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0802307     Document Type: Article

References (30)

1. Lu, X. 2005. p53: a heavily dictated dictator of life and death. Curr. Opin. Genet. Dev. 15: 27-33.
2. Donehower, L. A., M. Harvey, B. L. Slagle, M. J. McArthur, C. A. Montgomery, Jr., J. S. Butel, and A. Bradley. 1992. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature 356: 215-221.
3. Brown, J. M., and B. G. Wouters. 1999. Apoptosis, p53, and tumor cell sensitivity to anticancer agents. Cancer Res. 59: 1391-1399.
4. Pipkin, M. E., and J. Lieberman. 2007. Delivering the kiss of death: progress on understanding how perforin works. Curr. Opin. Immunol. 19: 301-308.
5. Trapani, J. A., and M. J. Smyth. 2002. Functional significance of the perforin/ granzyme cell death pathway. Nat. Rev. Immunol 2: 735-747.
6. Russell, J. H., and T. J. Ley. 2002. Lymphocyte-mediated cytotoxicity. Annu. Rev. Immunol. 20: 323-370.
7. Thiery, J., G. Dorothee, H. Haddada, H. Echchakir, C. Richon, R. Stancou, I. Vergnon, J. Benard, F. Mami-Chouaib, and S. Chouaib. 2003. Potentiation of a tumor cell susceptibility to autologous CTL killing by restoration of wild-type p53 function. J. Immunol 170: 5919-5926.
8. Thiery, J., S. Abouzahr, G. Dorothee, A. Jalil, C. Richon, I. Vergnon, F. Mami-Chouaib, and S. Chouaib. 2005. p53 potentiation of tumor cell susceptibility to CTL involves Fas and mitochondrial pathways. J. Immunol. 174: 871-878.
9. Meslin, F., J. Thiery, C. Richon, A. Jalil, and S. Chouaib. 2007. Granzyme Binduced cell death involves induction of p53 tumor suppressor gene and its activation in tumor target cells. J. Biol. Chem. 282: 32991-32999.
10. + T cell differentiation in peripheral blood. Eur. J. Immunol. 35: 2608-2616.
11. Guo, Y., J. Chen, T. Zhao, and Z. Fan. 2008. Granzyme K degrades the redox/ DNA repair enzyme Ape1 to trigger oxidative stress of target cells leading to cytotoxicity. Mol. Immunol. 45: 2225-2235.
12. Zhao, T., H. Zhang, Y. Guo, Q. Zhang, G. Hua, H. Lu, Q. Hou, H. Liu, and Z. Fan. 2007. Granzyme K cleaves the nucleosome assembly protein SET to induce singlestranded DNA nicks of target cells. Cell. Death Differ. 14: 489-499.
13. Zhao, T., H. Zhang, Y. Guo, and Z. Fan. 2007. Granzyme K directly processes bid to release cytochrome c and endonuclease G leading to mitochondria-dependent cell death. J. Biol. Chem. 282: 12104-12111.
14. Lohrum, M., and K. H. Scheidtmann. 1996. Differential effects of phosphorylation of rat p53 on transactivation of promoters derived from different p53 responsive genes. Oncogene 13: 2527-2539.
15. Lowe, S. W., H. E. Ruley, T. Jacks, and D. E. Housman. 1993. p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell 74: 957-967.
16. Chan, C. W., and F. Housseau. 2008. The 'kiss of death' by dendritic cells to cancer cells. Cell. Death Differ. 15: 58-69.
17. + T-cell immunity to reject established tumors. Blood 107: 1342-1351.
18. MacDonald, G., L. Shi, C. Vande Velde, J. Lieberman, and A. H. Greenberg. 1999. Mitochondria-dependent and -independent regulation of granzyme B-induced apoptosis. J. Exp. Med. 189: 131-144.
19. Barry, M., J. A. Heibein, M. J. Pinkoski, S. F. Lee, R. W. Moyer, D. R. Green, and R. C. Bleackley. 2000. Granzyme B short-circuits the need for caspase 8 activity during granule-mediated cytotoxic T-lymphocyte killing by directly cleaving Bid. Mol. Cell. Biol. 20: 3781-3794.
20. Heibein, J. A., I. S. Goping, M. Barry, M. J. Pinkoski, G. C. Shore, D. R. Green, and R. C. Bleackley. 2000. Granzyme B-mediated cytochrome c release is regulated by the Bcl-2 family members bid and Bax. J. Exp. Med. 192: 1391-1402.
21. Martinvalet, D., P. Zhu, and J. Lieberman. 2005. Granzyme A induces caspaseindependent mitochondrial damage, a required first step for apoptosis. Immunity 22: 355-370.
22. Hua, G., Q. Zhang, and Z. Fan. 2007. Heat shock protein 75 (TRAP1) antagonizes reactive oxygen species generation and protects cells from granzyme Mmediated apoptosis. J. Biol. Chem. 282: 20553-20560.
23. Karawajew, L., P. Rhein, G. Czerwony, and W. D. Ludwig. 2005. Stress-induced activation of the p53 tumor suppressor in leukemia cells and normal lymphocytes requires mitochondrial activity and reactive oxygen species. Blood 105: 4767-4775.
24. Okorokov, A. L., F. Ponchel, and J. Milner. 1997. Induced N- and C-terminal cleavage of p53: a core fragment of p53, generated by interaction with damaged DNA, promotes cleavage of the N terminus of full-length p53, whereas ssDNA induces C-terminal cleavage of p53. EMBO J. 16: 6008-6017.
25. Chen, X., L. J. Ko, L. Jayaraman, and C. Prives. 1996. p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells. Genes Dev. 10: 2438-2451.
26. Halazonetis, T. D., and A. N. Kandil. 1993. Conformational shifts propagate from the oligomerization domain of p53 to its tetrameric DNA binding domain and restore DNA binding to select p53 mutants. EMBO J. 12: 5057-5064.
27. Sayan, B. S., A. E. Sayan, R. A. Knight, G. Melino, and G. M. Cohen. 2006. p53 is cleaved by caspases generating fragments localizing to mitochondria. J. Biol. Chem. 281: 13566-13573.
28. Dinnen, R. D., L. Drew, D. P. Petrylak, Y. Mao, N. Cassai, J. Szmulewicz, P. Brandt-Rauf, and R. L. Fine. 2007. Activation of targeted necrosis by a p53 peptide: a novel death pathway that circumvents apoptotic resistance. J. Biol. Chem. 282: 26675-26686.
29. Sayan, B. S., A. E. Sayan, A. L. Yang, R. I. Aqeilan, E. Candi, G. M. Cohen, R. A. Knight, C. M. Croce, and G. Melino. 2007. Cleavage of the transactivationinhibitory domain of p63 by caspases enhances apoptosis. Proc. Natl. Acad. Sci. USA 104: 10871-10876.
30. Sayan, A. E., B. S. Sayan, V. Gogvadze, D. Dinsdale, U. Nyman, T. M. Hansen, B. Zhivotovsky, G. M. Cohen, R. A. Knight, and G. Melino. 2008. P73 and caspase-cleaved p73 fragments localize to mitochondria and augment TRAILinduced apoptosis. Oncogene 27: 4363-4372.