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Volumn 217, Issue 3-4, 2012, Pages 413-421

Analysis of amyloid precursor protein function in Drosophila melanogaster

Author keywords

APP proteins; Drosophila

Indexed keywords

ADAM PROTEIN; ALPHA SECRETASE; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; AMYLOID PROTEIN; BETA SECRETASE; GAMMA SECRETASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; ISOPROTEIN; MESSENGER RNA; MULTIPROTEIN COMPLEX; NICASTRIN; NOTCH RECEPTOR; POTASSIUM CHANNEL; PRESENILIN 1;

EID: 84862836856     PISSN: 00144819     EISSN: 14321106     Source Type: Journal    
DOI: 10.1007/s00221-011-2860-3     Document Type: Review
Times cited : (27)

References (83)
  • 2
    • 21344431624 scopus 로고    scopus 로고
    • Fasciclin II signals new synapse formation through amyloid precursor protein and the scaffolding protein dX11/Mint
    • DOI 10.1523/JNEUROSCI.1144-05.2005
    • Ashley J, Packard M, Ataman B, Budnik V (2005) Fasciclin II signals new synapse formation through amyloid precursor protein and the scaffolding protein dX11/Mint. J Neurosci 25(25):5943-5955 (Pubitemid 40911425)
    • (2005) Journal of Neuroscience , vol.25 , Issue.25 , pp. 5943-5955
    • Ashley, J.1    Packard, M.2    Ataman, B.3    Budnik, V.4
  • 4
    • 0000064419 scopus 로고
    • Behavioral mutants of drosophila isolated by countercurrent distribution
    • Benzer S (1967) Behavioral mutants of Drosophila isolated by countercurrent distribution. Proc Natl Acad Sci USA 58(3): 1112-1119
    • (1967) Proc Natl Acad Sci USA , vol.58 , Issue.3 , pp. 1112-1119
    • Benzer, S.1
  • 5
    • 29444455075 scopus 로고    scopus 로고
    • Drosophila as a model for human neurodegenerative disease
    • DOI 10.1146/annurev.genet.39.110304.095804
    • Bilen J, Bonini NM (2005) Drosophila as a model for human neurodegenerative disease. Annu Rev Genet 39:153-171 (Pubitemid 43011111)
    • (2005) Annual Review of Genetics , vol.39 , pp. 153-171
    • Bilen, J.1    Bonini, N.M.2
  • 8
    • 0035816661 scopus 로고    scopus 로고
    • A transcriptivety active complex of APP with Fe65 and histone acetyltransferase Tip60
    • DOI 10.1126/science.1058783
    • Cao X, Südhof TC (2001) A transcriptionally active complex of APP with Fe65 and histone acetyltransferase Tip60. Science 293(5527):115-120 (Pubitemid 32625507)
    • (2001) Science , vol.293 , Issue.5527 , pp. 115-120
    • Cao, X.1    Sudhof, T.C.2
  • 10
    • 0029115555 scopus 로고
    • The structure of the presenilin 1 (S182) gene and identification of six novel mutations in early onset AD families
    • Alzheimer's disease collaborative group
    • Clark RF, Hutton M, Fuldner M, Froelich S, Karran E, Alzheimer's disease collaborative group et al (1995) The structure of the presenilin 1 (S182) gene and identification of six novel mutations in early onset AD families. Nat Genet 11(2):219-222
    • (1995) Nat Genet , vol.11 , Issue.2 , pp. 219-222
    • Clark, R.F.1    Hutton, M.2    Fuldner, M.3    Froelich, S.4    Karran, E.5
  • 11
    • 0033972608 scopus 로고    scopus 로고
    • What the evolution of the amyloid protein precursor supergene family tells us about its function
    • DOI 10.1016/S0197-0186(99)00125-4, PII S0197018699001254
    • Coulson EJ, Paliga K, Beyreuther K, Masters CL (2000) What the evolution of the amyloid protein precursor supergene family tells us about its function. Neurochem Int 36(3):175-184 (Pubitemid 30047008)
    • (2000) Neurochemistry International , vol.36 , Issue.3 , pp. 175-184
    • Coulson, E.J.1    Paliga, K.2    Beyreuther, K.3    Masters, C.L.4
  • 12
    • 0027333449 scopus 로고
    • Apl-1, a caenorhabditis elegans gene encoding a protein related to the human beta-amyloid protein precursor
    • Daigle I, Li C (1993) apl-1, a Caenorhabditis elegans gene encoding a protein related to the human beta-amyloid protein precursor. Proc Natl Acad Sci USA 90(24):12045-12049
    • (1993) Proc Natl Acad Sci USA , vol.90 , Issue.24 , pp. 12045-12049
    • Daigle, I.1    Li, C.2
  • 13
    • 78049374467 scopus 로고    scopus 로고
    • Novel research horizons for presenilins and c-secretases in cell biology and disease
    • De Strooper B, Annaert W (2010) Novel research horizons for presenilins and c-secretases in cell biology and disease. Annu Rev Cell Dev Biol 26:235-260
    • (2010) Annu Rev Cell Dev Biol , vol.26 , pp. 235-260
    • De Strooper, B.1    Annaert, W.2
  • 17
    • 0030068094 scopus 로고    scopus 로고
    • + channels and suppression of neuronal activity by secreted β-amyloid-precursor protein
    • DOI 10.1038/379074a0
    • + channels and suppression of neuronal activity by secreted beta-amyloid-precursor protein. Nature 379(6560):74-78 (Pubitemid 26008138)
    • (1996) Nature , vol.379 , Issue.6560 , pp. 74-78
    • Furukawa, K.1    Barger, S.W.2    Blalock, E.M.3    Mattson, M.P.4
  • 18
    • 0021256895 scopus 로고
    • Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein
    • Glenner GG, Wong CW (1984) Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem Biophys Res Commun 120(3): 885-890 (Pubitemid 14104991)
    • (1984) Biochemical and Biophysical Research Communications , vol.120 , Issue.3 , pp. 885-890
    • Glenner, G.G.1    Wong, C.W.2
  • 20
    • 0023132387 scopus 로고
    • Characterization and chromosomal localization of a cDNA encodingbrain amyloid of Alzheimer's disease
    • Goldgaber D, Lerman MI, McBride OW, Saffiotti U, Gajdusek DC (1987) Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease. Science 235(4791):877-880 (Pubitemid 17019124)
    • (1987) Science , vol.235 , Issue.4791 , pp. 877-880
    • Goldgaber, D.1    Lerman, M.I.2    McBride, O.W.3
  • 21
    • 0028169905 scopus 로고
    • Secreted forms of beta-amyloid precursor protein protect hippocampal neurons against amyloid beta-peptide-induced oxidative injury
    • Goodman Y, Mattson MP (1994) Secreted forms of beta-amyloid precursor protein protect hippocampal neurons against amyloid beta-peptide-induced oxidative injury. Exp Neurol 128(1):1-12
    • (1994) Exp Neurol , vol.128 , Issue.1 , pp. 1-12
    • Goodman, Y.1    Mattson, M.P.2
  • 22
    • 0034080403 scopus 로고    scopus 로고
    • Aph-2 encodes a novel extracellular protein required for GLP-1-mediated signaling
    • Goutte C, Hepler W, Mickey KM, Priess JR (2000) aph-2 encodes a novel extracellular protein required for GLP-1-mediated signaling. Development 127(11):2481-2492 (Pubitemid 30386585)
    • (2000) Development , vol.127 , Issue.11 , pp. 2481-2492
    • Goutte, C.1    Hepler, W.2    Mickey, K.M.3    Priess, J.R.4
  • 23
    • 0032608712 scopus 로고    scopus 로고
    • Assembly and maturation of the drosophila larval neuromuscular junction
    • Gramates LS, Budnik V (1999) Assembly and maturation of the Drosophila larval neuromuscular junction. Int Rev Neurobiol 43:93-117
    • (1999) Int Rev Neurobiol , vol.43 , pp. 93-117
    • Gramates, L.S.1    Budnik, V.2
  • 25
    • 0142247476 scopus 로고    scopus 로고
    • A reporter for amyloid precursor protein γ-secretase activity in Drosophila
    • DOI 10.1093/hmg/ddg292
    • Guo M, Hong EJ, Fernandes J, Zipursky SL, Hay BA (2003) A reporter for amyloid precursor protein gamma-secretase activity in Drosophila. Hum Mol Genet 12(20):2669-2678 (Pubitemid 37304689)
    • (2003) Human Molecular Genetics , vol.12 , Issue.20 , pp. 2669-2678
    • Guo, M.1    Hong, E.J.2    Fernandes, J.3    Zipursky, S.L.4    Hay, B.A.5
  • 27
    • 0038439322 scopus 로고    scopus 로고
    • Mushroom body memoir: From maps to models
    • DOI 10.1038/nrn1074
    • Heisenberg M (2003) Mushroom body memoir: from maps to models. Nat Rev Neurosci 4(4):266-275 (Pubitemid 37271372)
    • (2003) Nature Reviews Neuroscience , vol.4 , Issue.4 , pp. 266-275
    • Heisenberg, M.1
  • 28
    • 0030889705 scopus 로고    scopus 로고
    • Isolation and characterization of Drosophila presenilin homolog
    • Hong CS, Koo EH (1997) Isolation and characterization of Drosophila presenilin homolog. Neuroreport 8(3):665-668 (Pubitemid 27128213)
    • (1997) NeuroReport , vol.8 , Issue.3 , pp. 665-668
    • Hong, C.-S.1    Koo, E.H.2
  • 31
    • 67650383731 scopus 로고    scopus 로고
    • Amyloid precursor protein and its homologues: A family of proteolysis-dependent receptors
    • Jacobsen KT, Iverfeldt K (2009) Amyloid precursor protein and its homologues: a family of proteolysis-dependent receptors. Cell Mol Life Sci 66:2299-2318
    • (2009) Cell Mol Life Sci , vol.66 , pp. 2299-2318
    • Jacobsen, K.T.1    Iverfeldt, K.2
  • 32
    • 0023105114 scopus 로고
    • The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
    • DOI 10.1038/325733a0
    • Kang J, Lemaire HG, Unterbeck A, Salbaum JM, Masters CL, Grzeschik KH, Multhaup G, Beyreuther K, Müller-Hill B (1987) The precursor of alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature 325(6106):733-736 (Pubitemid 17054046)
    • (1987) Nature , vol.325 , Issue.6106 , pp. 733-736
    • Kang, J.1    Lemaire, H.-G.2    Unterbeck, A.3
  • 33
    • 34247516099 scopus 로고    scopus 로고
    • Drosophila olfactory memory: Single genes to complex neural circuits
    • DOI 10.1038/nrn2098, PII NRN2098
    • Keene AC, Waddell S (2007) Drosophila olfactory memory: single genes to complex neural circuits. Nat Rev Neurosci 8(5):341-354 (Pubitemid 46652464)
    • (2007) Nature Reviews Neuroscience , vol.8 , Issue.5 , pp. 341-354
    • Keene, A.C.1    Waddell, S.2
  • 35
    • 33845516897 scopus 로고    scopus 로고
    • Drosophila homolog of APP-BP1 (dAPP-BP1) interacts antagonistically with APPL during Drosophila development
    • DOI 10.1038/sj.cdd.4401935, PII 4401935
    • Kim HJ, Kim SH, Shim SO, Park E, Kim C, Kim K, Tanouye MA, Yim J (2007) Drosophila homolog of APP-BP1 (dAPP-BP1) interacts antagonistically with APPL during Drosophila development. Cell Death Differ 14(1):103-115 (Pubitemid 44920023)
    • (2007) Cell Death and Differentiation , vol.14 , Issue.1 , pp. 103-115
    • Kim, H.-J.1    Kim, S.-H.2    Shim, S.-O.3    Park, E.4    Kim, C.5    Kim, K.6    Tanouye, M.A.7    Yim, J.8
  • 36
    • 0035955693 scopus 로고    scopus 로고
    • The intracellular domain of the beta-amyloid precursor protein is stabilized by fe65 and translocates to the nucleus in a notch-like manner
    • Kimberly WT, Zheng JB, Guénette SY, Selkoe DJ (2001) The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner. J Biol Chem 276(43):40288-40292
    • (2001) J Biol Chem , vol.276 , Issue.43 , pp. 40288-40292
    • Kimberly, W.T.1    Zheng, J.B.2    Guénette, S.Y.3    Selkoe, D.J.4
  • 37
    • 18244384720 scopus 로고    scopus 로고
    • Characterization of Drosophila aspartic proteases that induce the secretion of a golgi-resident transferase, heparan sulfate 6-O-sulfotransferase
    • DOI 10.1093/jb/mvi034
    • Kotani N, Kitazume S, Kamimura K, Takeo S, Aigaki T, Nakato H, Hashimoto Y (2005) Characterization of Drosophila aspartic proteases that induce the secretion of a Golgi-resident transfer-ase, heparan sulfate 6-O- sulfotransferase. J Biochem 137(3): 315-322 (Pubitemid 40628437)
    • (2005) Journal of Biochemistry , vol.137 , Issue.3 , pp. 315-322
    • Kotani, N.1    Kitazume, S.2    Kamimura, K.3    Takeo, S.4    Aigaki, T.5    Nakato, H.6    Hashimoto, Y.7
  • 38
    • 33845880917 scopus 로고    scopus 로고
    • Sequential use of mushroom body neuron subsets during drosophila odor memory processing
    • DOI 10.1016/j.neuron.2006.11.021, PII S089662730600941X
    • Krashes MJ, Keene AC, Leung B, Armstrong JD, Waddell S (2007) Sequential use of mushroom body neuron subsets during Drosophila odor memory processing. Neuron 53(1):103-115 (Pubitemid 46017024)
    • (2007) Neuron , vol.53 , Issue.1 , pp. 103-115
    • Krashes, M.J.1    Keene, A.C.2    Leung, B.3    Armstrong, J.D.4    Waddell, S.5
  • 39
    • 1842715781 scopus 로고    scopus 로고
    • A hidden program in Drosophila peripheral neurogenesis revealed: Fundamental principles underlying sensory organ diversity
    • DOI 10.1016/j.ydbio.2004.01.032, PII S001216060400082X
    • Lai EC, Orgogozo V (2004) A hidden program in Drosophila peripheral neurogenesis revealed: fundamental principles underlying sensory organ diversity. Dev Biol 269(1):1-17 (Pubitemid 38471819)
    • (2004) Developmental Biology , vol.269 , Issue.1 , pp. 1-17
    • Lai, E.C.1    Orgogozo, V.2
  • 41
    • 28644449284 scopus 로고    scopus 로고
    • Amyloid precursor protein promotes post-developmental neurite arborization in the Drosophila brain
    • DOI 10.1038/sj.emboj.7600757, PII 7600757
    • Leyssen M, Ayaz D, Hebert SS, Reeve S, De Strooper B, Hassan BA (2005) Amyloid precursor protein promotes post-developmental neurite arborization in the Drosophila brain. EMBO J 24(16):2944-2955 (Pubitemid 43079897)
    • (2005) EMBO Journal , vol.24 , Issue.16 , pp. 2944-2955
    • Leyssen, M.1    Ayaz, D.2    Hebert, S.S.3    Reeve, S.4    De Strooper, B.5    Hassan, B.A.6
  • 42
    • 9144248022 scopus 로고    scopus 로고
    • Specific functions of Drosophila amyloid precursor-like protein in the development of nervous system and nonneural tissues
    • DOI 10.1002/neu.20048
    • Li Y, Liu T, Peng Y, Yuan C, Guo A (2004) Specific functions of Drosophila amyloid precursor-like protein in the development of nervous system and non-neural tissues. J Neurobiol 61(3):343-358 (Pubitemid 39546360)
    • (2004) Journal of Neurobiology , vol.61 , Issue.3 , pp. 343-358
    • Li, V.1    Liu, T.2    Peng, Y.3    Yuan, C.4    Guo, A.5
  • 43
    • 78650166808 scopus 로고    scopus 로고
    • Alpha-secretase in alzheimer's disease: Molecular identity, regulation and therapeutic potential
    • Lichtenthaler SF (2011) Alpha-secretase in alzheimer's disease: molecular identity, regulation and therapeutic potential. J Neurochem 116(1):10-21
    • (2011) J Neurochem , vol.116 , Issue.1 , pp. 10-21
    • Lichtenthaler, S.F.1
  • 44
    • 17644382712 scopus 로고    scopus 로고
    • Invertebrate models of Alzheimer's disease
    • DOI 10.1111/j.1601-183X.2004.00105.x
    • Link CD (2005) Invertebrate models of alzheimer's disease. Genes Brain Behav 4(3):147-156 (Pubitemid 40559141)
    • (2005) Genes, Brain and Behavior , vol.4 , Issue.3 , pp. 147-156
    • Link, C.D.1
  • 45
    • 0028914672 scopus 로고
    • Expression in mouse embryos and in adult mouse brain of three members of the amyloid precursor protein family, of the alpha-2-macroglobulin receptor/low density lipoprotein receptor-related protein and of its ligands apolipoprotein E, lipoprotein lipase, alpha-2-macroglobulin and the 40,000 molecular weight receptor-associated protein
    • Lorent K, Overbergh L, Moechars D, De Strooper B, Van Leuven F, Van den Berghe H (1995) Expression in mouse embryos and in adult mouse brain of three members of the amyloid precursor protein family, of the alpha-2-macroglobulin receptor/low density lipoprotein receptor-related protein and of its ligands apolipoprotein E, lipoprotein lipase, alpha-2-macroglobulin and the 40,000 molecular weight receptor-associated protein. Neuroscience 65(4):1009-1025
    • (1995) Neuroscience , vol.65 , Issue.4 , pp. 1009-1025
    • Lorent, K.1    Overbergh, L.2    Moechars, D.3    De Strooper, B.4    Van Leuven, F.5    Van Den Berghe, H.6
  • 46
    • 0025664016 scopus 로고
    • Identification, secretion, and neural expression of APPL, a drosophila protein similar to human amyloid protein precursor
    • Luo LQ, Martin-Morris L, White K (1990) Identification, secretion, and neural expression of APPL, a Drosophila protein similar to human amyloid protein precursor. J Neurosci 10(12):3849-3861
    • (1990) J Neurosci , vol.10 , Issue.12 , pp. 3849-3861
    • Luo, L.Q.1    Martin-Morris, L.2    White, K.3
  • 47
    • 0026783241 scopus 로고
    • Human amyloid precursor protein ameliorates behavioral deficit of flies deleted for appl gene
    • Luo L, Tully T, White K (1992) Human amyloid precursor protein ameliorates behavioral deficit of flies deleted for Appl gene. Neuron 9:595-605
    • (1992) Neuron , vol.9 , pp. 595-605
    • Luo, L.1    Tully, T.2    White, K.3
  • 48
    • 0025125432 scopus 로고
    • The drosophila transcript encoded by the β-amyloid protein precursor-like gene is restricted to the nervous system
    • Martin-Morris L, White K (1990) The Drosophila transcript encoded by the β-amyloid protein precursor-like gene is restricted to the nervous system. Development 110(1):185-195
    • (1990) Development , vol.110 , Issue.1 , pp. 185-195
    • Martin-Morris, L.1    White, K.2
  • 50
    • 0027478347 scopus 로고
    • Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the β-amyloid precursor protein
    • DOI 10.1016/0896-6273(93)90315-I
    • Mattson MP, Cheng B, Culwell AR, Esch FS, Lieberburg I, Rydel RE (1993) Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the beta-amyloid precursor protein. Neuron 10(2):243-254 (Pubitemid 23079546)
    • (1993) Neuron , vol.10 , Issue.2 , pp. 243-254
    • Mattson, M.P.1    Cheng, B.2    Culwell, A.R.3    Esch, F.S.4    Lieberburg, I.5    Rydel, R.E.6
  • 51
    • 8144229817 scopus 로고    scopus 로고
    • Interference of human and Drosophila APP and APP-like proteins with PNS development in Drosophila
    • DOI 10.1038/sj.emboj.7600413
    • Merdes G, Soba P, Loewer A, Bilic MV, Beyreuther K, Paro R (2004) Interference of human and Drosophila APP and APP-like proteins with PNS development in Drosophila. EMBO J 23(20):4082-4095 (Pubitemid 39472429)
    • (2004) EMBO Journal , vol.23 , Issue.20 , pp. 4082-4095
    • Merdes, G.1    Soba, P.2    Loewer, A.3    Bilic, M.V.4    Beyreuther, K.5    Paro, R.6
  • 55
    • 60549089207 scopus 로고    scopus 로고
    • APP binds DR6 to trigger axon pruning and neuron death via distinct caspases
    • Nikolaev A, McLaughlin T, O'Leary DD, Tessier-Lavigne M (2009) APP binds DR6 to trigger axon pruning and neuron death via distinct caspases. Nature 457(7232):981-989
    • (2009) Nature , vol.457 , Issue.7232 , pp. 981-989
    • Nikolaev, A.1    McLaughlin, T.2    O'Leary, D.D.3    Tessier-Lavigne, M.4
  • 56
    • 0343196671 scopus 로고    scopus 로고
    • Kuzbanian controls proteolytic processing of Notch and mediates lateral inhibition during Drosophila and vertebrate neurogenesis
    • DOI 10.1016/S0092-8674(00)80335-9
    • Pan D, Rubin GM (1997) Kuzbanian controls proteolytic processing of Notch and mediates lateral inhibition during Drosophila and vertebrate neurogenesis. Cell 90(2):271-280 (Pubitemid 27329712)
    • (1997) Cell , vol.90 , Issue.2 , pp. 271-280
    • Duojia, P.1    Rubin, G.M.2
  • 57
    • 34547315810 scopus 로고    scopus 로고
    • Alzheimer's disease: Cholesterol, membrane rafts, isoprenoids and statins
    • DOI 10.1111/j.1582-4934.2007.00054.x
    • Reid PC, Urano Y, Kodama T, Hamakubo T (2007) Alzheimer's disease: cholesterol, membrane rafts, isoprenoids and statins. J Cell Mol Med 11(3):383-392 (Pubitemid 47153452)
    • (2007) Journal of Cellular and Molecular Medicine , vol.11 , Issue.3 , pp. 383-392
    • Reid, P.C.1    Urano, Y.2    Kodama, T.3    Hamakubo, T.4
  • 59
    • 0028169266 scopus 로고
    • Non-amyloidogenic cleavage of the beta-amyloid precursor protein by an integral membrane metalloendopeptidase
    • Roberts SB, Ripellino JA, Ingalls KM, Robakis NK, Felsenstein KM (1994) Non-amyloidogenic cleavage of the beta-amyloid precursor protein by an integral membrane metalloendopeptidase. J Biol Chem 269(4):3111-3116
    • (1994) J Biol Chem , vol.269 , Issue.4 , pp. 3111-3116
    • Roberts, S.B.1    Ripellino, J.A.2    Ingalls, K.M.3    Robakis, N.K.4    Felsenstein, K.M.5
  • 60
    • 0029788321 scopus 로고    scopus 로고
    • KUZ, a conserved metalloprotease-disintegrin protein with two roles in Drosophila neurogenesis
    • Rooke J, Pan D, Xu T, Rubin GM (1996) KUZ, a conserved metalloprotease-disintegrin protein with two roles in Drosophila neurogenesis. Science 273(5279):1227-1231 (Pubitemid 26293213)
    • (1996) Science , vol.273 , Issue.5279 , pp. 1227-1231
    • Rooke, J.1    Pan, D.2    Xu, T.3    Rubin, G.M.4
  • 62
    • 0035066332 scopus 로고    scopus 로고
    • Alzheimer's disease: Genes, proteins, and therapy
    • Selkoe DJ (2001) Alzheimer's disease: genes, proteins, and therapy. Physiol Rev 81(2):741-766 (Pubitemid 32267077)
    • (2001) Physiological Reviews , vol.81 , Issue.2 , pp. 741-766
    • Selkoe, D.J.1
  • 63
    • 33748426487 scopus 로고    scopus 로고
    • Unraveling in vivo functions of amyloid precursor protein: Insights from knockout and knockdown studies
    • DOI 10.1159/000094772
    • Senechal Y, Larmet Y, Dev KK (2006) Unraveling in vivo functions of amyloid precursor protein: insights from knockout and knockdown studies. Neurodegener Dis 3(3):134-147 (Pubitemid 44343885)
    • (2006) Neurodegenerative Diseases , vol.3 , Issue.3 , pp. 134-147
    • Senechal, Y.1    Larmet, Y.2    Dev, K.K.3
  • 66
    • 0033819772 scopus 로고    scopus 로고
    • A new aspartyl protease on 21q22.3, BACE2, is highly similar to alzheimer's amyloid precursor protein beta-secretase
    • Solans A, Estivill X, de La Luna S (2001) A new aspartyl protease on 21q22.3, BACE2, is highly similar to Alzheimer's amyloid precursor protein beta-secretase. Cytogenet Cell Genet 89(3-4): 177-184
    • (2001) Cytogenet Cell Genet , vol.89 , Issue.3-4 , pp. 177-184
    • Solans, A.1    Estivill, X.2    De La Luna, S.3
  • 68
    • 77953435020 scopus 로고    scopus 로고
    • In vivo reconstitution of gamma-secretase in drosophila results in substrate specificity
    • Stempfle D, Kanwar R, Loewer A, Fortini ME, Merdes G (2010) In vivo reconstitution of gamma-secretase in Drosophila results in substrate specificity. Mol Cell Biol 30(13):3165-3175
    • (2010) Mol Cell Biol , vol.30 , Issue.13 , pp. 3165-3175
    • Stempfle, D.1    Kanwar, R.2    Loewer, A.3    Fortini, M.E.4    Merdes, G.5
  • 69
    • 0033535508 scopus 로고    scopus 로고
    • Presenilin is required for activity and nuclear access of notch in drosophila
    • Struhl G, Greenwald I (1999) Presenilin is required for activity and nuclear access of Notch in Drosophila. Nature 398(6727): 522-525
    • (1999) Nature , vol.398 , Issue.6727 , pp. 522-525
    • Struhl, G.1    Greenwald, I.2
  • 71
    • 0023109592 scopus 로고
    • Amyloid β protein gene: CDNA, mRNA distribution, and genetic linkage near the Alzheimer locus
    • Tanzi RE, Gusella JF, Watkins PC, Bruns GA, St George-Hyslop P, Van Keuren ML, Patterson D, Pagan S, Kurnit DM, Neve RL (1987) Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the alzheimer locus. Science 235(4791): 880-884 (Pubitemid 17019125)
    • (1987) Science , vol.235 , Issue.4791 , pp. 880-884
    • Tanzi, R.E.1    Gusella, J.F.2    Watkins, P.C.3
  • 72
    • 0029929779 scopus 로고    scopus 로고
    • APPL, the Drosophila member of the APP-family, exhibits differential trafficking and processing in CNS neurons
    • Torroja L, Luo L, White K (1996) APPL, the Drosophila member of the APP-family, exhibits differential trafficking and processing in CNS neurons. J Neurosci 16(15):4638-4650 (Pubitemid 26251060)
    • (1996) Journal of Neuroscience , vol.16 , Issue.15 , pp. 4638-4650
    • Torroja, L.1    Luo, L.2    White, K.3
  • 73
    • 0033568874 scopus 로고    scopus 로고
    • The Drosophila β-amyloid precursor protein homolog promotes synapse differentiation at the neuromuscular junction
    • Torroja L, Packard M, Gorczyca M, White K, Budnik V (1999a) The Drosophila beta-amyloid precursor protein homolog promotes synapse differentiation at the neuromuscular junction. J Neurosci 19(18):7793-7803 (Pubitemid 30225778)
    • (1999) Journal of Neuroscience , vol.19 , Issue.18 , pp. 7793-7803
    • Torroja, L.1    Packard, M.2    Gorczyca, M.3    White, K.4    Budnik, V.5
  • 74
    • 0033529031 scopus 로고    scopus 로고
    • Neuronal overexpression of APPL, the Drosophila homologue of the amyloid precursor protein (APP), disrupts axonal transport
    • DOI 10.1016/S0960-9822(99)80215-2
    • Torroja L, Chu H, Kotovsky I, White K (1999b) Neuronal overex-pression of APPL, the Drosophila homologue of the amyloid precursor protein (APP), disrupts axonal transport. Curr Biol 9(9):489-492 (Pubitemid 29228622)
    • (1999) Current Biology , vol.9 , Issue.9 , pp. 489-492
    • Torroja, L.1    Chu, H.2    Kotovsky, I.3    White, K.4
  • 75
    • 0037011118 scopus 로고    scopus 로고
    • The neurodegeneration mutant löchrig interferes with cholesterol homeostasis and Appl processing
    • DOI 10.1093/emboj/cdf636
    • Tschäpe JA, Hammerschmied C, Mühlig-Versen M, Athenstaedt K, Daum G, Kretzschmar D (2002) The neurodegeneration mutant löchrig interferes with cholesterol homeostasis and APPL processing. EMBO J 21(23):6367-6376 (Pubitemid 35448415)
    • (2002) EMBO Journal , vol.21 , Issue.23 , pp. 6367-6376
    • Tschape, J.-A.1    Hammerschmied, C.2    Muhlig-Versen, M.3    Athenstaedt, K.4    Daum, G.5    Kretzschmar, D.6
  • 76
    • 0022119763 scopus 로고
    • Classical conditioning and retention in normal and mutant drosophila melanogaster
    • Tully T, Quinn WG (1985) Classical conditioning and retention in normal and mutant Drosophila melanogaster. J Comp Physiol A 157(2):263-277
    • (1985) J Comp Physiol A , vol.157 , Issue.2 , pp. 263-277
    • Tully, T.1    Quinn, W.G.2
  • 77
    • 0042634362 scopus 로고    scopus 로고
    • Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory
    • DOI 10.1016/S0301-0082(03)00089-3
    • Turner PR, O'Connor K, Tate WP, Abraham WC (2003) Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory. Prog Neurobiol 70(1):1-32 (Pubitemid 36966639)
    • (2003) Progress in Neurobiology , vol.70 , Issue.1 , pp. 1-32
    • Turner, P.R.1    O'Connor, K.2    Tate, W.P.3    Abraham, W.C.4
  • 79
    • 0033535553 scopus 로고    scopus 로고
    • Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity
    • Wolfe MS, Xia W, Ostaszewski BL, Diehl TS, Kimberly WT, Selkoe DJ (1999) Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity. Nature 398(6727):513-517
    • (1999) Nature , vol.398 , Issue.6727 , pp. 513-517
    • Wolfe, M.S.1    Xia, W.2    Ostaszewski, B.L.3    Diehl, T.S.4    Kimberly, W.T.5    Selkoe, D.J.6
  • 81
    • 0033535555 scopus 로고    scopus 로고
    • Neurogenic phenotypes and altered notch processing in drosophila presenilin mutants
    • Ye Y, Lukinova N, Fortini ME (1999) Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants. Nature 398(6727):525-529
    • (1999) Nature , vol.398 , Issue.6727 , pp. 525-529
    • Ye, Y.1    Lukinova, N.2    Fortini, M.E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.