A reporter for amyloid precursor protein γ-secretase activity in Drosophila

Human Molecular Genetics

Volumn 12, Issue 20, 2003, Pages 2669-2678

  Guo, Ming ^a   Hong, Elizabeth J ^b   Fernandes, Jolene ^b   Zipursky, S Larry ^a   Hay, Bruce A ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PRECURSOR PROTEIN; GAMMA SECRETASE; GENE PRODUCT; NICASTRIN; PRESENILIN 1; PRESENILIN 2;

ALZHEIMER DISEASE; ARTICLE; CHROMOSOME IDENTIFICATION; COMPLEX FORMATION; CONTROLLED STUDY; CORRELATION FUNCTION; DROSOPHILA; ENZYME ACTIVITY; ENZYME REGULATION; EYE; GENE MUTATION; GENETIC SCREENING; NONHUMAN; ORGAN SIZE; PRIORITY JOURNAL; REPORTER GENE; SENSITIVITY ANALYSIS; SENSITIZATION;

AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; DROSOPHILA; ENDOPEPTIDASES; GENES, REPORTER; MICROSCOPY, ELECTRON, SCANNING; MODELS, BIOLOGICAL; MODELS, GENETIC; MUTATION; PHENOTYPE; PHOTORECEPTORS, INVERTEBRATE; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; TRANSGENES;

EID: 0142247476     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: 10.1093/hmg/ddg292     Document Type: Article

References (62)

1. Walter, J., Kaether, C., Steiner, H. and Haass, C. (2001) The cell biology of Alzheimer's disease: uncovering the secrets of secretases. Curr. Opin. Neurobiol., 11, 585-590.
2. Sisodia, S.S. and St George-Hyslop, P.H. (2002) γ-Secretase, Notch, Ab and Alzheimer's disease: where do the presenilins fit in? Nat. Rev. Neurosci., 3, 281-290.
3. Selkoe, D.J. (2001) Alzheimer's disease: genes, proteins, and therapy. Physiol. Rev., 81, 741-766.
4. St George-Hyslop, P. (2000) Molecular genetics of Alzheimer's disease. Biol. Psych., 47, 183-199.
5. Tanzi, R.E. and Bertram, L. (2001) New frontiers in Alzheimer's disease genetics. Neuron, 32, 181-184.
6. Fortini, M.E. (2002) γ-Secretase-mediated proteolysis in cell-surface receptor signaling. Nat. Rev. Mol. Cell Biol., 3, 673-684.
7. Artavanis-Tsakonas, S., Rand, M.D. and Lake, R.J. (1999) Notch signaling: cell fate control and signal integration in development. Science, 284, 770-776.
8. Li, Y.M., Lai, M.T., Xu, M., Huang, Q., DiMuzio-Mower, J., Sardana, M.K., Shi, X.P., Yin, K.C., Shafer, J.A. and Gardell, S.J. (2000) Presenilin 1 is linked with γ-secretase activity in the detergent solubilized state. Proc. Natl Acad. Sci. USA, 97, 6138-6143.
9. Annaert, W. and De Strooper, B. (2002) A cell biological perspective on Alzheimer's disease. Annu. Rev. Cell Dev. Biol., 18, 25-51.
10. De Strooper, B. (2003) Aph-1, Pen-2, and Nicastrin with Presenilin generate an active γ-secretase complex. Neuron, 38, 9-12.
11. Wolfe, M.S. (2001) Presenilin and γ-secretase: structure meets function. J. Neurochem., 76, 1615-1620.
12. Checler, F. (2001) The multiple paradoxes of presenilins. J. Neurochem., 76, 1621-1627.
13. Wolfe, M. and Selkoe, D.J. (2002) Intramembrane proteases - mixing oil and water. Science, 296, 2156-2157.
14. Haass, C. and Steiner, H. (2002) Alzheimer disease γ-secretase: a complex story of GxGD-type presenilin proteases. Trends Cell Biol., 12, 556-562.
15. Yu, G., Nishimura, M., Arawaka, S., Levitan, D., Zhang, L., Tandon, A., Song, Y.Q., Rogaeva, E., Chen, F., Kawarai, T. et al. (2000) Nicastrin modulates presenilin-mediated Notch/glp-1 signal transduction and βAPP processing. Nature, 407, 48-54.
16. Goutte, C., Hepler, W., Mickey, K.M. and Priess, JR. (2000) aph-2 encodes a novel extracellular protein required for GLP-1-mediated signaling. Development, 127, 2481-2492.
17. Goutte, C., Tsunozaki, M., Hale, V.A. and Priess, J.R. (2002) APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos. Proc. Natl Acad. Sci. USA, 99, 775-779.
18. Francis, R., McGrath, G., Zhang, J., Ruddy, D., Sym, M., Apfeld, J., Nicoll, M., Maxwell, M., Hai, B., Ellis, M. et al. (2002), aph-1 and pen-2 are required for Notch pathway signaling, γ-secretase cleavage of βAPP, and presenilin protein accumulation. Dev. Cell, 3, 85-97.
19. Lee, S.F., Shah, S., Li, H., Yu, C., Han, W. and Yu, G. (2002) Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-β precursor protein and Notch. J. Biol. Chem., 277, 45013-45019.
20. Gu, Y., Chen, F., Sanjo, N., Kawarai, T., Hasegawa, H., Duthie, M., Li, W., Ruan, X., Luthra, A., Mount, H.T.J. et al. (2003) APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin-nicastrin complexes. J. Biol. Chem., 278, 7374-7380.
21. Takasugi, N., Tomita, T., Hayashi, I., Tsuruoka, M., Nimura, M., Takahashi, Y., Thinakaran, G. and Iwatsubo, T. (2003) The role of presenilin cofactors in the γ-secretase complex. Nature, 422, 438-441.
22. Edbauer, D., Winkler, E., Regula, J.T., Pesold, B., Steiner, H. and Haas, C. (2003) Reconstitution of γ-secretase activity. Nat. Cell Biol., 5, 486-488.
23. Kimberly, W., LaVoie, M., Ostaszewski, B., Ye, W., Wolfe, M. and Selkoe, D.J. (2003) γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2. Proc. Natl Acad. Sci. USA, 100, 6382-6387.
24. Hu, Y. and Fortini, M. (2003) Different cofactor activities in γ-secretase assembly: evidence for a nicastrin-aph-1 subcomplex. J. Cell Biol., 161, 685-690.
25. Luo, W., Wang, H., Li, H., Kim, B., Shah, S., Lee, H., Thinakaran, G., Kim, T.W., Yu, G. and Xu, H. (2003) PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1. J. Biol. Chem., 278, 7850-7854.
26. Steiner, H., Winkler, E., Edbauer, D., Prokop, S., Basset, G., Yamasaki, A., Kostka, M. and Haass, C. (2002) PEN-2 is an integral component of the γ-secretase complex required for coordinated expression of presenilin and nicastrin. J. Biol. Chem., 277, 39062-39065.
27. Fossgreen, A., Bruckner, B., Czech, C., Masters, C.L., Beyreuther, K. and Paro, R. (1998) Transgenic Drosophila expressing human amyloid precursor protein show γ-secretase activity and a blistered-wing phenotype. Proc. Natl Acad. Sci. USA, 95, 13703-13708.
28. Takasugi, N., Takahashi, Y., Morohashi, Y., Tomita, T. and Iwatsubo, T. (2002) The mechanism of γ-secretase activities through high molecular weight complex formation of presenilins is conserved in Drosophila melanogaster and mammals. J. Biol. Chem., 277, 50198-50205.
29. Ye, Y. and Fortini, M.E. (1908) Characterization of Drosophila Presenilin and its colocalization with Notch during development. Mech. Dev., 79, 199-211.
30. Boulianne, G.L., Livne-Bar, I., Humphreys, J.M., Liang, Y., Lin, C., Rogaev, E. and St George-Hyslop, P. (1997) Cloning and characterization of the Drosophila presenilin homologue. Neuroreport, 8(4), 1025-1029.
31. Hong, C.S. and Koo, E.H. (1997) Isolation and characterization of Drosophila presenilin homolog. Neuroreport, 8, 665-668.
32. Chung, H.M. and Struhl, G. (2002) Nicastrin is required for Presenilin-mediated transmembrane cleavage in Drosophila. Dev. Cell, 2(1), 79-89.
33. Hu, Y., Ye, Y. and Fortini, M.E. (2002) Nicastrin is required for γ-secretase cleavage of the Drosophila Notch receptor. Dev. Cell, 289(3), 678-680.
34. Lopez-Schier, H. and St Johnston, D. (2002) Drosophila nicastrin is essential for the intramembranous cleavage of Notch. Dev. Cell, 2(1), 69-78.
35. Struhl, G. and Greenwald, I. (1999) Presenilin is required for activity and nuclear access of Notch in Drosophila. Nature, 398, 522-525.
36. Ye, Y., Lukinova, N. and Fortini, M.E. (1999) Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants. Nature, 398, 525-529.
37. Guo, Y., Livne-Bar, I., Zhou, L. and Boulianne, G.L. (1999) Drosophila presenilin is required for neuronal differentiation and affects notch subcellular localization and signaling. J Neurosci., 19(19), 8435-8442.
38. Hay, B.A., Wolff, T. and Rubin, G.M. (1994) Expression of baculovirus P35 prevents cell death in Drosophila. Development, 120, 2121-2129.
39. Chen, P., Nordstrom, W., Gish, B. and Abrams, J.M. (1996) Grim, a novel cell death gene in Drosophila. Genes Dev., 10, 1773-1782.
40. Hawkins, C.J., Wang, S.L. and Hay, B.A. (1999) A cloning method to identify caspases and their regulators in yeast: identification of Drosophila IAP1 as an inhibitor of the Drosophila caspase DCP-1. Proc. Natl Acad. Sci. USA, 96, 2885-2890.
41. Struhl, G. and Adachi, A. (1998) Nuclear access and action of Notch in vivo. Cell, 93, 649-660.
42. Lecourtois, M. and Schweisguth, F. (1998) Indirect evidence for Delta-dependent intracellular processing of notch in Drosophila embryos. Curr. Biol., 8, 771-774.
43. Karlstrom, H., Bergman, A., Lendahl, U., Naslund, J. and Lundkvist, J. (2002) A sensitive and quantitative assay for measuring cleavage of presenilin substrates. J. Biol. Chem., 277, 6763-6766.
44. Hay, B.A., Wassarman, D.A. and Rubin, G.M. (1995) Drosophila homologs of baculovirus inhibitor of apoptosis proteins function to block cell death. Cell, 83, 1253-1262.
45. Wing, J.P., Schwartz, L.M. and Nambu, J.R. (2001) The RHG motifs of Drosophila Reaper and Grim are important for their distinct cell death-inducing abilities. Mech. Dev., 102, 193-203.
46. White, K., Grether, M.E., Abrams, J.M., Young, L., Farrell, K. and H.S. (1994) Genetic control of programmed cell death in Drosophila. Science, 264, 677-683.
47. Moses, K., Ellis, M.C. and Rubin, G.M. (1989) The glass gene encodes a zinc-finger protein required by Drosophila photoreceptor cells. Nature, 340, 531-536.
48. Koo, E.H. (2002) The β-amyloid precursor protein (APP) and Alzheimer's disease: does the tail wag the dog? Traffic, 3, 763-770.
49. Brand, A.H. and Perrimon, N. (1993) Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development, 118, 401-415.
50. Rutherford, S. (2003) Between genotype and phenotype: protein chaperones and evolvability. Nat. Rev. Genet., 4, 263-274.
51. Weidemann, A., Eggert, S., Reinhard, F., Vogel, M., Paliga, K., Baier, G., Masters, C., Beyreuther, K. and Evin, G. (2002) A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing. Biochemistry, 41, 2825-2835.
52. Sastre, M., Steiner, H., Fuchs, K., Capell, A., Multhaup, G., Condron, M., Teplow, D. and Haass, C. (2001) Presenilin-dependent γ-secretase processing of β-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch. EMBO reports, 2, 835-841.
53. Yu, C., Kim, S., Ikeuchi, T., Xu, H., Gasparini, L., Wang, R. and Sisodia, S. (2001) Characterization of a presenilin-mediated amyloid precursor protein carboxyl-terminal fragment γ. Evidence for distinct mechanisms involved in γ-secretase processing of the APP and Notch1 transmembrane domains. J. Biol. Chem., 276, 43756-43760.
54. Gu, Y., Misonou, H., Sato, T., Dohmae, N., Takio, K. and Ihara, Y. (2001) Distinct intramembrane cleavage of the β-amyloid precursor protein family resembling γ-secretase-like cleavage of Notch. J. Biol. Chem., 276, 35235-35238.
55. Thomas, B.J. and Wassarman, D.A. (1999) A fly's eye view of biology. Trends Genet., 15, 184-190.
56. Kang, J., Lemaire, H.G., Unterbeck, A., Salbaum, J.M., Masters, C.L., Grzeschik, K.H., Multhaup, G., Beyreuther, K. and Muller-Hill, B. (1987) The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature, 325, 733-736.
57. Laughon, A. and Gesteland, R.F. (1984) Primary structure of the Saccharomyces cerevisiae GAL4 gene. Mol. Cell Biol., 4, 260-267.
58. Wolfe, M.S., Xia, W., Ostaszewski, B.L., Diehl, T.S., Kimberly, W.T. and Selkoe, D.J. (1999) Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity. Nature, 398, 513-517.
59. Vernooy, S.Y., Chow, V., Su, J., Verbrugghe, K., Yang, J., Cole, S., Olson, M.R. and Hay, B.A. (2002) Drosophila Bruce can potently suppress Rpr- and Grim-dependent but not Hid-dependent cell death. Curr. Biol., 12, 1164-1168.
60. Giordano, E., Rendina, R., Peluso, I. and Furia, M. (2002) RNAi Triggered by Symmetrically Transcribed Transgenes in Drosophila melanogaster. Genetics, 160, 637-648.
61. Hawkins, C.J., Yoo, S.J., Peterson, E.P., Wang, S.L., Vernooy, S.Y. and Hay, B.A. (2000) The Drosophila caspase DRONC cleaves following glutamate or aspartate and is regulated by DIAP1, HID, and GRIM. J. Biol. Chem., 275, 27084 27093.
62. Rubin, G. and Spradling, A.C. (1982) Genetic transformation of Drosophila with transposable element vectors. Science, 218, 348-353.