Loss of yata, a novel gene regulating the subcellular localization of APPL, induces deterioration of neural tissues and lifespan shortening

PLoS ONE

Volumn 4, Issue 2, 2009, Pages

  Sone, Masaki ^a,b,c   Uchida, Atsuko ^b,e   Komatsu, Ayumi ^b,f   Suzuki, Emiko ^d   Ibuki, Ikue ^b   Asada, Megumi ^b   Shiwaku, Hiroki ^a   Tamura, Takuya ^a   Hoshino, Mikio ^b,g   Okazawa, Hitoshi ^a   Nabeshima, Yo Ichi ^b  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^d NATIONAL INSTITUTE OF GENETICS   (Japan)

^e MIE UNIVERSITY   (Japan)

^f Osaka Prefecture University   (Japan)

^g NATIONAL INSTITUTE OF NEUROSCIENCE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PRECURSOR PROTEIN; AMYLOID PRECURSOR PROTEIN LIKE; HIKARU GENKI PROTEIN; PROTEIN SEC23P; REGULATOR PROTEIN; SECRETORY PROTEIN; UNCLASSIFIED DRUG; YATA PROTEIN;

ANIMAL TISSUE; ARTICLE; BRAIN SIZE; CELL VACUOLE; CONTROLLED STUDY; EMBRYO; ENDOPLASMIC RETICULUM; FEMALE; GENE CONTROL; GENE MUTATION; GOLGI COMPLEX; IMMUNOHISTOCHEMISTRY; INSECT; LARVA; LIFESPAN; NERVE DEGENERATION; NERVOUS TISSUE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN ISOLATION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION;

EID: 84887212473     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0004466     Document Type: Article

References (38)

1. Torroja L, Luo L, White K (1996) APPL, the Drosophila member of the APP-family, exhibits differential trafficking and processing in CNS neurons. J Neurosci 16: 4638-4650.
2. Luo L, Tully T, White K (1992) Human amyloid precursor protein ameliorates behavioral deficit of flies deleted for Appl gene. Neuron 9: 595-605.
3. Hardy J (2006) A hundred years of Alzheimer's disease research. Neuron 52: 3-13.
4. Luo L, Martin-Morris LE, White K (1990) Identification, secretion, and neural expression of APPL, a Drosophila protein similar to human Amyloid protein precursor. J Neurosci 10: 3849-3861.
5. Torroja L, Packard M, Gorczyca M, White K, Budnik V (1999) The Drosophila beta-amyloid precursor protein homolog promotes synapse differentiation at the neuromuscular junction. J Neurosci 19: 7793-7803.
6. Ashley J, Packard M, Ataman B, Budnik V (2005) Fasciclin II signals new synapse formation through amyloid precursor protein and the scaffolding protein dX11/Mint. J Neurosci 25: 5943-5955.
7. Torroja L, Chu H, Kotovsky I, White K (1999) Neuronal overexpression of APPL, the Drosophila homologue of the amyloid precursor protein (APP), disrupts axonal transport. Curr Biol 9: 489-92.
8. Gunawardena S, Goldstein LS (2001) Disruption of axonal transport and neuronal viability by amyloid precursor protein mutations in Drosophila. Neuron 32: 389-401.
9. Merdes G, Soba P, Loewer A, Bilic MV, Beyreuther K, Paro R (2004) Interference of human and Drosophila APP and APP-like proteins with PNS development in Drosophila. EMBO J 23: 4082-4095.
10. Leyssen M, Ayaz D, Hébert SS, Reeve S, De Strooper B, et al. (2005) Amyloid precursor protein promotes post-developmental neurite arborization in the Drosophila brain. EMBO J 24: 2944-2955.
11. Hoshino M, Suzuki E, Nabeshima Y, Hama C (1996) Hikaru genki protein is secreted into synaptic clefts from an early stage of synapse formation in Drosophila. Development 122: 589-597.
12. Hoshino M, Matsuzaki F, Nabeshima Y, Hama C (1993) hikaru genki, a CNS-specific gene identified by abnormal locomotion in Drosophila, encodes a novel type of protein. Neuron 10: 395-407.
13. Hoshino M, Suzuki E, Miyake T, Sone M, Komatsu A, et al. (1999) Neural expression of hikaru genki protein during embryonic and larval development of Drosophila melanogaster. Dev Genes Evol 209: 1-9.
14. McMahon HT, Mills IG (2004) COP and clathrin-coated vesicle budding: different pathways,common approaches. Curr Opin Cell Biol 16: 379-391.
15. Sato K, Nakano A (2007) Mechanisms of COPII vesicle formation and protein sorting. FEBS Lett 581: 2076-2082.
16. Fromme JC, Orci L, Schekman R (2008) Coordination of COPII vesicle trafficking by Sec23. Trends Cell Biol 18: 330-336.
17. Boyadjiev SA, Fromme JC, Ben J, Chong SS, Nauta C, et al. (2006) Cranio-lenticulo-sutural dysplasia is caused by a SEC23A mutation leading to abnormal endoplasmic-reticulum-to-Golgi trafficking. Nat Genet 38: 1192-1197.
18. Lang MR, Lapierre LA, Frotscher M, Goldenring JR, Knapik EW (2006) Secretory COPII coat component Sec23a is essential for craniofacial chondrocyte maturation. Nat Genet 38: 1198-1203.
19. McGuire AT, Mangroo D (2007) Cex1p is a novel cytoplasmic component of the Saccharomyces cerevisiae nuclear tRNA export machinery. EMBO J 26: 288-300.
20. Kato M, Yano K, Morotomi-Yano K, Saito H, Miki Y (2002) Identification and characterization of the human protein kinase-like gene NTKL: mitosis-specific centrosomal localization of an alternatively spliced isoform. Genomics 79: 760-767.
21. Liu SCH, Lane WS, Lienhard GE (2000) Cloning and preliminary characterization of a 105 kDa protein with an N-terminal kinase-like domain. Biochem Biophys Acta 1517: 148-152.
22. Manning G, Whyte DB, Martinez R, Hunter T, Sudarsanam S (2002) The protein kinase complement of the human genome. Science 298: 1912-1934.
23. Schmidt WM, Kraus C, Höger H, Hochmeister S, Oberndorfer F, et al. (2007) Mutation in the Scyl1 gene encoding amino-terminal kinase-like protein causes a recessive form of spinocerebellar ataxia. EMBO Rep 8: 691-697.
24. Schmid EM, Ford MGJ, Burtey A, Praefcke GJK, Peak-Chew S-Y, et al. (2006) Role of the AP2 β-appendage hub in recruiting partners for Clathrin-coated vesicle assembly. PLoS Biol 4: e262.
25. Fischbach K-F, Dittrich APM (1989) The optic lobe of Drosophila melanogaster. I. A Golgi analysis of wild-type structure. Cell Tissue Res 258: 441-475.
26. Littleton JT, Bellen HJ, Perin MS (1993) Expression of Synaptotagmin in Drosophila reveals transport and localization of synaptic vesicles to the synapse. Development 118: 1077-1088.
27. Xu T, Rubin GM (1993) Analysis of genetic mosaics in developing and adult Drosophila tissues. Development 117: 1223-1237.
28. Johansen J, Halpern ME, Johansen KM, Keshishian H (1989) Stereotypic morphology of glutamatergic synapses on identified muscle cells of Drosophila larvae. J Neurosci 9: 710-725.
29. Kondylis V, Rabouille C (2003) A novel role for dp115 in the organization of tER sites in Drosophila. J Cell Biol 162: 185-198.
30. Kondylis V, Spoorendonk KM, Rabouille C (2005) dGRASP localization and function in the early exocytic pathway in Drosophila S2 cells. Mol Biol Cell 16: 4061-4072.
31. Burman JL, Bourbonniere L, Philie J, Stroh T, Dejgaard SY, et al. (2008) Scyl1, mutated in a recessive form of spinocerebellar neurodegeneration, regulates COPI-mediated retrograde traffic. J Biol Chem 283: 22774-22786.
32. Knust E (2007) Photoreceptor morphogenesis and retinal degeneration: lessons from Drosophila. Curr Opin Neurobiol 17: 541-547.
33. Li Y, Liu T, Peng Y, Yuan C, Guo A (2004) Specific functions of Drosophila Amyloid precursor-like protein in the development of nervous system and nonneural tissues. J Neurobiol 61: 343-358.
34. Tschäpe J-A, Hammerschmied C, Mühlig-Versen M, Athenstaedt K, Daum G, et al. (2002) The neurodegeneration mutant löchrig interferes with cholesterol homeostasis and Appl processing. EMBO J 21: 6367-6376.
35. Lim J, Hao T, Shaw C, Patel AJ, Szabó G, et al. (2006) A protein-protein interaction network for human inherited ataxias and disorders of purkinje cell degeneration. Cell 125: 801-814.
36. Chu H, Parras C, White K, Jiménez F (1998) Formation and specification of ventral neuroblasts is controlled by vnd in Drosophila neurogenesis. Genes Dev 12: 3613-3624.
37. Masai I, Suzuki E, Yoon C-S, Kohyama A, Hotta Y (1997) Immunolocalization of Drosophila eye-Specific diacylgylcerol kinase, rdgA, which is essential for the maintenance of the photoreceptor. J Neurobiol 32: 695-706.
38. Sone M, Suzuki E, Hoshino M, Hou D, Kuromi H, et al. (2000) Synaptic development is controlled in the periactive zones of Drosophila synapses. Development 127: 4157-4168.