Amitriptyline attenuates astrocyte activation and morphine tolerance in rats: Role of the PSD-95/NR1/nNOS/PKCγ signaling pathway

Behavioural Brain Research

Volumn 229, Issue 2, 2012, Pages 401-411

  Huang, Ya Ni ^a,b   Tsai, Ru Yin ^b   Lin, Shinn Long ^c   Chien, Chih Cheng ^d   Cherng, Chen Hwan ^c   Wu, Ching Tang ^c   Yeh, Chun Chang ^c   Wong, Chih Shung ^b,c,e  

^a HSIN SHENG COLLEGE OF MEDICAL CARE AND MANAGEMENT   (Taiwan)

^b CATHAY GENERAL HOSPITAL   (Taiwan)

^c TRI SERVICE GENERAL HOSPITAL   (Taiwan)

^d FU JEN CATHOLIC UNIVERSITY   (Taiwan)

^e NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

Author keywords

Amitriptyline; Astrocyte activation; Morphine tolerance; NMDA receptors; NNOS; NR1 subunit; PKC ; PSD 95

Indexed keywords

AMITRIPTYLINE; MORPHINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 1; NEURONAL NITRIC OXIDE SYNTHASE; POSTSYNAPTIC DENSITY PROTEIN 95; PROTEIN KINASE C GAMMA; SODIUM CHLORIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; ASTROCYTE; CONTROLLED STUDY; CYTOSOL; DRUG INFUSION; ENZYME INHIBITION; MALE; MORPHINE TOLERANCE; NERVE CELL MEMBRANE; NERVE CELL STIMULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RAT; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; SPINAL CORD DORSAL HORN; SPINAL CORD NERVE CELL; SYNAPTOSOME; TREATMENT DURATION;

AMITRIPTYLINE; ANALGESICS, OPIOID; ANIMALS; ANTIDEPRESSIVE AGENTS, TRICYCLIC; ASTROCYTES; DIZOCILPINE MALEATE; DOWN-REGULATION; DRUG INTERACTIONS; DRUG TOLERANCE; INJECTIONS, SPINAL; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MEMBRANE PROTEINS; MORPHINE; NITRIC OXIDE SYNTHASE TYPE I; PROTEIN KINASE C; RATS; RATS, WISTAR; RECEPTORS, N-METHYL-D-ASPARTATE; SIGNAL TRANSDUCTION; SPINAL CORD; UP-REGULATION;

EID: 84862831460     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2012.01.044     Document Type: Article

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