NMDA receptors are involved in upstream of the spinal JNK activation in morphine antinociceptive tolerance

Neuroscience Letters

Volumn 467, Issue 2, 2009, Pages 95-99

  Guo, Rui xian ^a   Zhang, Mei ^a,b   Liu, Wei ^a,c   Zhao, Chun mei ^a   Cui, Yu ^a   Wang, Chu huai ^d   Feng, Jian qiang ^a   Chen, Pei xi ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b GUANGZHOU MEDICAL UNIVERSITY   (China)

^c GUANGZHOU UNIVERSITY OF CHINESE MEDICINE   (China)

^d SUN YAT SEN UNIVERSITY   (China)

Author keywords

JNK; MK 801; Morphine tolerance; NMDA receptors; Spinal cord

Indexed keywords

DIZOCILPINE; MORPHINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL EXPERIMENT; ANTINOCICEPTION; ARTICLE; ASTROCYTE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; MALE; MORPHINE TOLERANCE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL CORD DORSAL HORN; UPREGULATION;

ANALGESICS, OPIOID; ANIMALS; ANTHRACENES; DIZOCILPINE MALEATE; DRUG TOLERANCE; ENZYME ACTIVATION; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MALE; MORPHINE; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE; SPINAL CORD;

EID: 70350571696     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2009.10.013     Document Type: Article

References (31)

1. Allen R.M., and Dykstra L.A. The competitive NMDA receptor antagonist LY235959 modulates the progression of morphine tolerance in rats. Psychopharmacology 142 (1999) 209-214
2. Cao J.L., He J.H., Ding H.L., and Zeng Y.M. Activation of the spinal ERK signaling pathway contributes naloxone-precipitated withdrawal in morphine-dependent rats. Pain 118 (2005) 336-349
3. Cao F.L., Liu M.G., Hao J., Li Z., Lu Z.M., and Chen J. Different roles of spinal p38 and c-Jun N-terminal kinase pathways in bee venom-induced multiple pain-related behaviors. Neurosci. Lett. 427 (2007) 50-54
4. Centeno C., Repicl M., Chatton J.Y., Riederer B.M., Bonny C., Nicod P., Price M., Clarke P.G., Papa S., Franzoso G., and Borsello T. Role of the JNK pathway in NMDA-mediated excitotoxicity of cortical neurons. Cell Differ. 14 (2007) 240-253
5. Chen R.W., Qin Z.H., Ren M., Kanai H., Chalecka-Franaszek E., Leeds P., and Chuang D.M. Regulation of c-Jun N-terminal kinase, p38 kinase and AP-1 DNA binding in cultured brain neurons: roles in glutamate excitotoxicity and lithium neuroprotection. J. Neurochem. 84 (2003) 566-575
6. Chen Y., Geis C., and Sommer C. Activation of TRPV1 contributes to morphine tolerance: involvement of the mitogen-activated protein kinase signaling pathway. J. Neurosci. 28 (2008) 5836-5845
7. Cui Y., Chen Y., Zhi J.L., Guo R.X., Feng J.Q., and Chen P.X. Activation of p38 mitogen-activated protein kinase in spinal microglia mediates morphine antinociceptive tolerance. Brain Res. 1069 (2006) 235-243
8. Cui Y., Liao X.X., Liu W., Guo R.X., Wu Z.Z., Zhao C.M., Chen P.X., and Feng J.Q. A novel role of minocycline: attenuating morphine antinociceptive tolerance by inhibition of p38 MAPK in the activated spinal microglia. Brain Behav. Immun. 22 (2008) 114-123
9. Daulhac L., Mallet C., Courteix C., Etienne M., Duroux E., Privat A.M., Eschalier A., and Fialip J. Diabetes-induced mechanical hyperalgesia involves spinal mitogen-activated protein kinase activation in neurons and microglia via N-methyl-d-aspartate-dependent mechanisms. Mol. Pharmacol. 70 (2006) 1246-1254
10. Doya H., Ohtori S., Fujitani M., Saito T., Hata K., Ino H., Takahashi K., Moriya H., and Yamashita T. c-Jun N-terminal kinase activation in dorsal root ganglion contributes to pain hypersensitivity. Biochem. Biophys. Res. Commun. 335 (2005) 132-138
11. Fan X.L., Zhang J.S., Zhang X.Q., and Ma L. Chronic morphine treatment and withdrawal induce upregulation of c-Jun N-terminal kinase 3 gene expression in rat brain. Neuroscience 122 (2003) 997-1002
12. Harris J., Joules C., Stanley C., Thomas P., and Clarke R.W. Glutamate and tachykinin receptors in central sensitization of withdrawal reflexes in the decerebrated rabbit. Exp. Physiol. 89 (2004) 187-198
13. Houghton A.K., Parsons C.G., and Headley P.M. Mrz 2/579, a fast kinetic NMDA channel blocker, reduces the development of morphine tolerance in awake rats. Pain 91 (2001) 201-207
14. Inoue M., Mishina M., and Ueda H. Locus-specific rescue of GluRepsilon1 NMDA receptors in mutant mice identifies the brain regions important for morphine tolerance and dependence. J. Neurosci. 23 (2003) 6529-6536
15. Johnson G.L., and Lapadat R. Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science 298 (2002) 1911-1912
16. Kovács G., Kocsis P., Tarnawa I., Horváth C., Szombathelyi Z., and Farkas S. NR2B containing NMDA receptor dependent windup of single spinal neurons. Neuropharmacology 46 (2004) 23-30
17. Kozela E., and Popik P. A complete analysis of NMDA receptor subunits in periaqueductal grey and ventromedial medulla of morphine tolerant mice. Drug Alcohol Depen. 86 (2007) 290-293
18. Lim G., Wang S., Zeng Q., Sung B., Yang L., and Mao J. Expression of spinal NMDA receptor and PKCγ after chronic morphine is regulated by spinal glucocorticoid receptor. J. Neurosci. 25 (2005) 11145-11154
19. Liu W., Wang C.H., Cui Y., Mo L.Q., Zhi J.L., Sun S.N., Wang Y.L., Yu H.M., Zhao C.M., Feng J.Q., and Chen P.X. Inhibition of neuronal nitric oxide synthase antagonizes morphine antinociceptive tolerance by decreasing activation of p38 MAPK in the spinal microglia. Neurosci. Lett. 410 (2006) 174-177
20. Ma W., Zheng W.H., Powell K., Jhamandas K., and Quirion R. Chronic morphine exposure increases the phosphorylation of MAP kinases and the transcription factor CREB in dorsal root ganglion neurons: an in vitro and in vivo study. Eur. J. Neurosci. 14 (2001) 1091-1104
21. Mayer D.J., Mao J., Holt J., and Price D.D. Cellular mechanisms of neuropathic pain, morphine tolerance, and their interactions. Proc. Natl. Acad. Sci. U.S.A. 96 (1999) 7731-7736
22. Mori H., and Mishina M. Structure and function of the NMDA receptor channel. Neuropharmacology 34 (1995) 1219-1237
23. Narita M., Aoki T., and Suzuki T. Molecular evidence for the involvement of NR2B subunit containing N-methyl-d-aspartate receptors in the development of morphine-induced place preference. Neuroscience 101 (2000) 601-606
24. Popik P., and Kozela E. Clinically available NMDA antagonist, memantine, attenuates tolerance to analgesic effects of morphine in a mouse tail flick test. Pol. J. Pharmacol. 51 (1999) 223-231
25. Schwarzschild M.A., Cole R.L., and Hyman S.E. Glutamate, but not dopamine, stimulates stress-activated protein kinase and AP-1-mediated transcription in striatal neurons. J. Neurosci. 17 (1997) 3455-3466
26. Siggins G.R., Martin G., Roberto M., Nie Z., Madamba S., and De Lecea L. Glutamatergic transmission in opiate and alcohol dependence. Ann. N. Y. Acad. Sci. 1003 (2003) 196-211
27. Sucher N.J., Brose N., Deitche R.D.L., Awobuluyi M., Gasic G.P., Bading H., Cepko C.L., Greenberg M.E., Jahn R., and Heinemann S.F. Expression of endogenous NMDAR1 transcripts without receptor protein suggests post-transcriptional control in PC12 cells. J. Biol. Chem. 268 (1993) 22299-22304
28. Trujillo K.A., and Akil H. Inhibition of morphine tolerance and dependence by the NMDA receptor antagonist MK-801. Science 251 (1991) 85-87
29. Tso P.H., and Wong Y.H. Role of extracellular signal-regulated kinases in opioid-induced adenylyl cyclase superactivation in human embryonic kidney 293 cells. Neurosci. Lett. 316 (2001) 13-16
30. Zhu H., Jang C.G., Ma T., Oh S., Rockhold R.W., and Ho I.K. Region specific expression of NMDA receptor NR1 subunit mRNA in hypothalamus and pons following chronic morphine treatment. Eur. J. Pharmacol. 365 (1999) 47-54
31. Zhuang Z.Y., Wen Y.R., Zhang D.R., Borsello T., Bonny C., Strichartz G.R., Decosterd I., and Ji R.R. A peptide c-Jun N-terminal kinase (JNK) inhibitor blocks mechanical allodynia after spinal nerve ligation: respective roles of JNK activation in primary sensory neurons and spinal astrocytes for neuropathic pain development and maintenance. J. Neurosci. 26 (2006) 3551-3560