A conditional deletion of the NR1 subunit of the NMDA receptor in adult spinal cord dorsal horn reduces NMDA currents and injury-induced pain

Journal of Neuroscience

Volumn 23, Issue 12, 2003, Pages 5031-5040

  South, Samantha M ^a   Kohno, Tatsuro ^b   Kaspar, Brian K ^c   Hegarty, Deborah ^a   Vissel, Bryce ^c   Drake, Carrie T ^a   Ohata, Megumi ^a   Jenab, Shirzad ^a   Sailer, Andreas W ^c   Malkmus, Shelle ^d   Masuyama, Takashi ^d   Horner, Philip ^c   Bogulavsky, Johanna ^a   Gage, Fred H ^c   Yaksh, Tony L ^d   Woolf, Clifford J ^b   Heinemann, Stephen F ^c   Inturrisi, Charles E ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^d University of California   (United States)

Author keywords

Central sensitization; Conditional knock out; Cre loxP; Formalin pain; NMDA receptor; Spinal cord dorsal horn; Synaptic transmission

Indexed keywords

ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; CRE RECOMBINASE; MESSENGER RNA; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 1; RECEPTOR SUBUNIT; UNCLASSIFIED DRUG;

ADENO ASSOCIATED VIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INJURY; COLD STRESS; CONTROLLED STUDY; FACILITATION; GENE DELETION; HEAT STRESS; INJURY; KNOCKOUT GENE; LATENT PERIOD; LUMBAR SPINE; MECHANICAL STIMULATION; MOTOR PERFORMANCE; MOUSE; NONHUMAN; PAIN; PAIN ASSESSMENT; POSTSYNAPTIC POTENTIAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENSITIZATION; SPINAL CORD DORSAL HORN; WITHDRAWAL REFLEX;

EID: 0038113357     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.23-12-05031.2003     Document Type: Article

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