메뉴 건너뛰기




Volumn 15, Issue 4, 2011, Pages 873-887

RGSZ2 binds to the neural nitric oxide synthase PDZ domain to regulate mu-opioid receptor-mediated potentiation of the N-methyl-D-aspartate receptor-calmodulin-dependent protein kinase II pathway

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; MORPHINE SULFATE; MU OPIATE RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE; PROTEIN KINASE C; REGULATOR OF G PROTEIN SIGNALING Z2; REGULATOR PROTEIN; UNCLASSIFIED DRUG;

EID: 79960393240     PISSN: 15230864     EISSN: 15577716     Source Type: Journal    
DOI: 10.1089/ars.2010.3767     Document Type: Article
Times cited : (32)

References (50)
  • 1
    • 0032796059 scopus 로고    scopus 로고
    • MAP kinase activation by mu opioid receptor involves phosphatidylinositol 3-kinase but not the cAMP/PKA pathway
    • DOI 10.1016/S0014-5793(99)00949-7, PII S0014579399009497
    • Ai W, Gong J, and Yu L. MAP kinase activation by mu opioid receptor involves phosphatidylinositol 3-kinase but not the cAMP/PKA pathway. FEBS Lett 456: 196-200, 1999. (Pubitemid 29339068)
    • (1999) FEBS Letters , vol.456 , Issue.1 , pp. 196-200
    • Ai, W.1    Gong, J.2    Yu, L.3
  • 2
    • 33847021440 scopus 로고    scopus 로고
    • RGSZ1 interacts with protein kinase C interacting protein PKCI-1 and modulates mu opioid receptor signaling
    • DOI 10.1016/j.cellsig.2006.09.008, PII S0898656806002646
    • Ajit SK, Ramineni S, Edris W, Hunt RA, Hum WT, Hepler JR, and Young KH. RGSZ1 interacts with protein kinase C interacting protein PKCI-1 and modulates mu opioid receptor signaling. Cell Signal 19: 723-730, 2007. (Pubitemid 46275365)
    • (2007) Cellular Signalling , vol.19 , Issue.4 , pp. 723-730
    • Ajit, S.K.1    Ramineni, S.2    Edris, W.3    Hunt, R.A.4    Hum, W.-T.5    Hepler, J.R.6    Young, K.H.7
  • 4
    • 33746366493 scopus 로고    scopus 로고
    • Synaptic plasticity: One STEP at a time
    • DOI 10.1016/j.tins.2006.06.007, PII S0166223606001214
    • Braithwaite SP, Paul S, Nairn AC, and Lombroso PJ. Synaptic plasticity: one STEP at a time. Trends Neurosci 29: 452-458, 2006. (Pubitemid 44118442)
    • (2006) Trends in Neurosciences , vol.29 , Issue.8 , pp. 452-458
    • Braithwaite, S.P.1    Paul, S.2    Nairn, A.C.3    Lombroso, P.J.4
  • 6
    • 3242793203 scopus 로고    scopus 로고
    • Peripheral noxious stimulation induces phosphorylation of the NMDA receptor NR1 subunit at the PKC-dependent site, serine-896, in spinal cord dorsal horn neurons
    • DOI 10.1111/j.1460-9568.2004.03506.x
    • Brenner GJ, Ji RR, Shaffer S, andWoolf CJ. Peripheral noxious stimulation induces phosphorylation of the NMDA receptor NR1 subunit at the PKC-dependent site, serine-896, in spinal cord dorsal horn neurons. Eur J Neurosci 20: 375-384, 2004. (Pubitemid 38969623)
    • (2004) European Journal of Neuroscience , vol.20 , Issue.2 , pp. 375-384
    • Brenner, G.J.1    Ji, R.-R.2    Shaffer, S.3    Woolf, C.J.4
  • 8
    • 0025895334 scopus 로고
    • Sustained potentiation of NMDA receptor-mediated glutamate responses through activation of protein kinase C by a l opioid
    • Chen L and Huang LY. Sustained potentiation of NMDA receptor-mediated glutamate responses through activation of protein kinase C by a l opioid. Neuron 7: 319-326, 1991.
    • (1991) Neuron , vol.7 , pp. 319-326
    • Chen, L.1    Huang, L.Y.2
  • 9
    • 0033553834 scopus 로고    scopus 로고
    • Frequent colocalization of mu opioid and NMDA-type glutamate receptors at postsynaptic sites in periaqueductal gray neurons
    • DOI 10.1002/(SICI)1096-9861(19990614)408:4<549::AID-CNE8>3.0.CO;2-3
    • Commons KG, van Bockstaele EJ, and Pfaff DW. Frequent colocalization of mu opioid and NMDA-type glutamate receptors at postsynaptic sites in periaqueductal gray neurons. J Comp Neurol 408: 549-559, 1999. (Pubitemid 29211181)
    • (1999) Journal of Comparative Neurology , vol.408 , Issue.4 , pp. 549-559
    • Commons, K.G.1    Van Bockstaele, E.J.2    Pfaff, D.W.3
  • 10
    • 77952240774 scopus 로고    scopus 로고
    • NO synthase: Structures and mechanisms
    • Daff S. NO synthase: structures and mechanisms. Nitric Oxide 23: 1-11, 2010.
    • (2010) Nitric Oxide , vol.23 , pp. 1-11
    • Daff, S.1
  • 12
    • 58749107499 scopus 로고    scopus 로고
    • A rapid Percoll gradient procedure for preparation of synaptosomes
    • Dunkley PR, Jarvie PE, and Robinson PJ. A rapid Percoll gradient procedure for preparation of synaptosomes. Nat Protoc 3: 1718-1728, 2008.
    • (2008) Nat Protoc , vol.3 , pp. 1718-1728
    • Dunkley, P.R.1    Jarvie, P.E.2    Robinson, P.J.3
  • 13
    • 0028177985 scopus 로고
    • The NMDA receptor antagonists, LY274614 and MK-801, and the nitric oxide synthase inhibitor, NG-nitro-Larginine, attenuate analgesic tolerance to the mu-opioid morphine but not to kappa opioids
    • Elliott K, Minami N, Kolesnikov YA, Pasternak GW, and Inturrisi CE. The NMDA receptor antagonists, LY274614 and MK-801, and the nitric oxide synthase inhibitor, NG-nitro-Larginine, attenuate analgesic tolerance to the mu-opioid morphine but not to kappa opioids. Pain 56: 69-75, 1994.
    • (1994) Pain , vol.56 , pp. 69-75
    • Elliott, K.1    Minami, N.2    Kolesnikov, Y.A.3    Pasternak, G.W.4    Inturrisi, C.E.5
  • 14
    • 0033794460 scopus 로고    scopus 로고
    • Targeting the N-methyl-D-aspartate receptor for chronic pain management. Preclinical animal studies, recent clinical experience and future research directions
    • Fisher K, Coderre TJ, and Hagen NA. Targeting the N-methyl-D-aspartate receptor for chronic pain management. Preclinical animal studies, recent clinical experience and future research directions. J Pain Symptom Manage 20: 358-373, 2000.
    • (2000) J Pain Symptom Manage , vol.20 , pp. 358-373
    • Fisher, K.1    Coderre, T.J.2    Hagen, N.A.3
  • 15
    • 27744598288 scopus 로고    scopus 로고
    • The RGSZ2 protein exists in a complex with μ-opioid receptors and regulates the desensitizing capacity of Gz proteins
    • DOI 10.1038/sj.npp.1300726, PII 1300726
    • Garzón J, Rodŕguez-Muñ oz M, López-Fando A, and Sánchez-Blázquez P. The RGSZ2 protein exists in a complex with mu-opioid receptors and regulates the desensitizing capacity of Gz proteins. Neuropsychopharmacology 30: 1632-1648, 2005. (Pubitemid 43086021)
    • (2005) Neuropsychopharmacology , vol.30 , Issue.9 , pp. 1632-1648
    • Garzon, J.1    Rodriguez-Munoz, M.2    Lopez-Fando, A.3    Sanchez-Blazquez, P.4
  • 16
    • 49549084688 scopus 로고    scopus 로고
    • Do pharmacological approaches that prevent opioid tolerance target different elements in the same regulatory machinery?
    • Garzón J, Rodŕguez-Muñ oz M, and Sánchez- Blázquez P. Do pharmacological approaches that prevent opioid tolerance target different elements in the same regulatory machinery? Curr Drug Abuse Rev 1: 222-238, 2008.
    • (2008) Curr Drug Abuse Rev , vol.1 , pp. 222-238
    • Garzón, J.1    Rodŕguez-Muñoz, M.2    Sánchez- Blázquez, P.3
  • 17
    • 70149120493 scopus 로고    scopus 로고
    • Ultrastructural relationship between N-methyl-D-aspartate-NR1 receptor subunit and mu-opioid receptor in the mouse central nucleus of the amygdala
    • Glass MJ, Vanyo L, Quimson L, and Pickel VM. Ultrastructural relationship between N-methyl-D-aspartate-NR1 receptor subunit and mu-opioid receptor in the mouse central nucleus of the amygdala. Neuroscience 163: 857-867, 2009.
    • (2009) Neuroscience , vol.163 , pp. 857-867
    • Glass, M.J.1    Vanyo, L.2    Quimson, L.3    Pickel, V.M.4
  • 18
    • 6944233607 scopus 로고    scopus 로고
    • Role of mPKCI, a novel μ-opioid receptor interactive protein, in receptor desensitization, phosphorylation, and morphine-induced analgesia
    • DOI 10.1124/mol.66.5.
    • Guang W, Wang H, Su T, Weinstein IB, and Wang JB. Role of mPKCI, a novel mu-opioid receptor interactive protein, in receptor desensitization, phosphorylation, and morphineinduced analgesia. Mol Pharmacol 66: 1285-1292, 2004. (Pubitemid 39411068)
    • (2004) Molecular Pharmacology , vol.66 , Issue.5 , pp. 1285-1292
    • Guang, W.1    Wang, H.2    Su, T.3    Weinstein, I.B.4    Jia, B.W.5
  • 19
    • 33144488804 scopus 로고    scopus 로고
    • Ras regulation by reactive oxygen and nitrogen species
    • DOI 10.1021/bi051872m
    • Heo J and Campbell SL. Ras regulation by reactive oxygen and nitrogen species. Biochemistry 45: 2200-2210, 2006. (Pubitemid 43271319)
    • (2006) Biochemistry , vol.45 , Issue.7 , pp. 2200-2210
    • Heo, J.1    Campbell, S.L.2
  • 20
    • 0042844731 scopus 로고    scopus 로고
    • Locus-specific rescue of Glurε1 NMDA receptors in mutant mice identifies the brain regions important for morphine tolerance and dependence
    • Inoue M, Mishina M, and Ueda H. Locus-specific rescue of GluRe1 NMDA receptors in mutant mice identifies the brain regions important for morphine tolerance and dependence. J Neurosci 23: 6529-6536, 2003. (Pubitemid 36909879)
    • (2003) Journal of Neuroscience , vol.23 , Issue.16 , pp. 6529-6536
    • Inoue, M.1    Mishina, M.2    Ueda, H.3
  • 21
    • 0033719631 scopus 로고    scopus 로고
    • The effect of ketamine on opioid-induced acute tolerance: Can it explain reduction of opioid consumption with ketamine-opioid analgesic combinations?
    • Kissin I, Bright CA, and Bradley EL Jr. The effect of ketamine on opioid-induced acute tolerance: can it explain reduction of opioid consumption with ketamine-opioid analgesic combinations? Anesth Analg 91: 1483-1488, 2000.
    • (2000) Anesth Analg , vol.91 , pp. 1483-1488
    • Kissin, I.1    Bright, C.A.2    Bradley Jr., E.L.3
  • 23
    • 0037052624 scopus 로고    scopus 로고
    • Potentiation of the excitatory action of NMDA in ventrolateral periaqueductal gray by the μ-opioid receptor agonist, DAMGO
    • DOI 10.1016/S0006-8993(02)02532-5, PII S0006899302025325
    • Kow LM, Commons KG, Ogawa S, and Pfaff DW. Potentiation of the excitatory action of NMDA in ventrolateral periaqueductal gray by the mu-opioid receptor agonist, DAMGO. Brain Res 935: 87-102, 2002. (Pubitemid 34327849)
    • (2002) Brain Research , vol.935 , Issue.1-2 , pp. 87-102
    • Kow, L.-M.1    Commons, K.G.2    Ogawa, S.3    Pfaff, D.W.4
  • 24
    • 37549050119 scopus 로고    scopus 로고
    • Activation of mu-opioid receptor selectively potentiates NMDA-induced outward currents in rat locus coeruleus neurons
    • Koyama S and Akaike N. Activation of mu-opioid receptor selectively potentiates NMDA-induced outward currents in rat locus coeruleus neurons. Neurosci Res 60: 22-28, 2008.
    • (2008) Neurosci Res , vol.60 , pp. 22-28
    • Koyama, S.1    Akaike, N.2
  • 25
    • 46949109487 scopus 로고    scopus 로고
    • Evaluation of a SNP map of 6q24-27 confirms diabetic nephropathy loci and identifies novel associations in type 2 diabetes patients with nephropathy from an African-American population
    • Leak TS, Mychaleckyj JC, Smith SG, Keene KL, Gordon CJ, Hicks PJ, Freedman BI, Bowden DW, and Sale MM. Evaluation of a SNP map of 6q24-27 confirms diabetic nephropathy loci and identifies novel associations in type 2 diabetes patients with nephropathy from an African-American population. Hum Genet 124: 63-71, 2008.
    • (2008) Hum Genet , vol.124 , pp. 63-71
    • Leak, T.S.1    Mychaleckyj, J.C.2    Smith, S.G.3    Keene, K.L.4    Gordon, C.J.5    Hicks, P.J.6    Freedman, B.I.7    Bowden, D.W.8    Sale, M.M.9
  • 29
    • 0025883699 scopus 로고
    • Delayed application of MK-801 attenuates development of morphine tolerance in rats
    • Marek P, Ben-Eliyahu S, Vaccarino AL, and Liebeskind JC. Delayed application of MK-801 attenuates development of morphine tolerance in rats. Brain Res 558: 163-165, 1991.
    • (1991) Brain Res , vol.558 , pp. 163-165
    • Marek, P.1    Ben-Eliyahu, S.2    Vaccarino, A.L.3    Liebeskind, J.C.4
  • 30
    • 0029860103 scopus 로고    scopus 로고
    • Opioid μ, δ, and κ receptor-induced activation of phospholipase C- β3 and inhibition of adenylyl cyclase is mediated by G(i2) and G(o) in smooth muscle
    • Murthy KS and Makhlouf GM. Opioid mu, delta, and kappa receptor-induced activation of phospholipase C-beta 3 and inhibition of adenylyl cyclase is mediated by Gi2 and G(o) in smooth muscle. Mol Pharmacol 50: 870-877, 1996. (Pubitemid 26347707)
    • (1996) Molecular Pharmacology , vol.50 , Issue.4 , pp. 870-877
    • Murthy, K.S.1    Makhlouf, G.M.2
  • 31
    • 37349105318 scopus 로고    scopus 로고
    • Post-synaptic action of morphine on glutamatergic neuronal transmission related to the descending antinociceptive pathway in the rat thalamus
    • DOI 10.1111/j.1471-4159.2007.05059.x
    • Narita M, Hashimoto K, Amano T, Narita M, Niikura K, Nakamura A, and Suzuki T. Post-synaptic action of morphine on glutamatergic neuronal transmission related to the descending antinociceptive pathway in the rat thalamus. J Neurochem 104: 469-478, 2008. (Pubitemid 350293886)
    • (2008) Journal of Neurochemistry , vol.104 , Issue.2 , pp. 469-478
    • Narita, M.1    Hashimoto, K.2    Amano, T.3    Narita, M.4    Niikura, K.5    Nakamura, A.6    Suzuki, T.7
  • 32
    • 0029618055 scopus 로고
    • Perspectives on the N-methyl-D-aspartate/nitric oxide cascade and opioid tolerance
    • DOI 10.1016/0893-133X(95)00084-Q
    • Pasternak GW, Kolesnikov YA, and Babey AM. Perspectives on the N-methyl-D-aspartate/nitric oxide cascade and opioid tolerance. Neuropsychopharmacology 13: 309-313, 1995. (Pubitemid 26008850)
    • (1995) Neuropsychopharmacology , vol.13 , Issue.4 , pp. 309-313
    • Pasternak, G.W.1    Kolesnikov, Y.A.2    Babey, A.-M.3
  • 33
    • 34047148363 scopus 로고    scopus 로고
    • Biphasic coupling of neuronal nitric oxide synthase phosphorylation to the NMDA receptor regulates AMPA receptor trafficking and neuronal cell death
    • DOI 10.1523/JNEUROSCI.4799-06.2007
    • Rameau GA, Tukey DS, Garcin-Hosfield ED, Titcombe RF, Misra C, Khatri L, Getzoff ED, and Ziff EB. Biphasic coupling of neuronal nitric oxide synthase phosphorylation to the NMDA receptor regulates AMPA receptor trafficking and neuronal cell death. J Neurosci 27: 3445-3455, 2007. (Pubitemid 46515122)
    • (2007) Journal of Neuroscience , vol.27 , Issue.13 , pp. 3445-3455
    • Rameau, G.A.1    Tukey, D.S.2    Garcin-Hosfield, E.D.3    Titcombe, R.F.4    Misra, C.5    Khatri, L.6    Getzoff, E.D.7    Ziff, E.B.8
  • 34
    • 33947275782 scopus 로고    scopus 로고
    • Sumoylated RGS-Rz proteins act as scaffolds for Mu-opioid receptors and G-protein complexes in mouse brain
    • DOI 10.1038/sj.npp.1301184, PII 1301184
    • Rodŕguez-Muñ oz M, Bermúdez D, Sánchez- Blázquez P, and Garzón J. Sumoylated RGS-Rz proteins act as scaffolds for Mu-opioid receptors and G-protein complexes in mouse brain. Neuropsychopharmacology 32: 842-850, 2007. (Pubitemid 46426183)
    • (2007) Neuropsychopharmacology , vol.32 , Issue.4 , pp. 842-850
    • Rodriguez-Munoz, M.1    Bermudez, D.2    Sanchez-Blazquez, P.3    Garzon, J.4
  • 35
    • 34548040700 scopus 로고    scopus 로고
    • Morphine induces endocytosis of neuronal mu-opioid receptors through the sustained transfer of Galpha subunits to RGSZ2 proteins
    • Rodŕguez-Muñ oz M, de la Torre-Madrid E, Sánchez-Blázquez P, and Garzón J. Morphine induces endocytosis of neuronal mu-opioid receptors through the sustained transfer of Galpha subunits to RGSZ2 proteins. Mol Pain 3: 19, 2007.
    • (2007) Mol Pain , vol.3 , pp. 19
    • Rodŕguez-Muñoz, M.1    De La Torre-Madrid, E.2    Sánchez- Blázquez, P.3    Garzón, J.4
  • 36
    • 49549108443 scopus 로고    scopus 로고
    • NMDAR-nNOS generated zinc recruits PKCgamma to the HINT1-RGS17 complex bound to the C terminus of Mu-opioid receptors
    • Rodŕguez-Muñ oz M, de la Torre-Madrid E, Sánchez-Blázquez P, Wang JB, and Garzón J. NMDAR-nNOS generated zinc recruits PKCgamma to the HINT1-RGS17 complex bound to the C terminus of Mu-opioid receptors. Cell Signal 20: 1855-1864, 2008.
    • (2008) Cell Signal , vol.20 , pp. 1855-1864
    • Rodŕguez-Muñoz, M.1    De La Torre-Madrid, E.2    Sánchez- Blázquez, P.3    Wang, J.B.4    Garzón, J.5
  • 38
    • 67349153367 scopus 로고    scopus 로고
    • Brain-specific Gaz interacts with Src tyrosine kinase to regulate Mu-opioid receptor-NMDAR signaling pathway
    • Sánchez-Blázquez P, Rodŕguez-Muñ oz M, de la Torre-Madrid E, and Garzón J. Brain-specific Gaz interacts with Src tyrosine kinase to regulate Mu-opioid receptor-NMDAR signaling pathway. Cell Signal 21: 1444-1454, 2009.
    • (2009) Cell Signal , vol.21 , pp. 1444-1454
    • Sánchez-Blázquez, P.1    Rodŕguez-Muñoz, M.2    De La Torre-Madrid, E.3    Garzón, J.4
  • 39
    • 77955356174 scopus 로고    scopus 로고
    • Mu-opioid receptors transiently activate the Akt-nNOS pathway to produce sustained potentiation of PKC-mediated NMDAR-CaMKII signaling
    • Sánchez-Blázquez P, Rodŕguez-Muñ oz M, and Garzón J. Mu-opioid receptors transiently activate the Akt-nNOS pathway to produce sustained potentiation of PKC-mediated NMDAR-CaMKII signaling. PLoS ONE 5: e11278, 2010.
    • (2010) PLoS ONE , vol.5
    • Sánchez-Blázquez, P.1    Rodŕguez-Muñoz, M.2    Garzón, J.3
  • 40
    • 38149077089 scopus 로고    scopus 로고
    • Calcium/calmodulindependent protein kinase II supports morphine antinociceptive tolerance by phosphorylation of glycosylated phosducin-like protein
    • Sánchez-Blázquez P, Rodŕguez-Muñ oz M, Montero C, de la Torre-Madrid E, and Garzón J. Calcium/calmodulindependent protein kinase II supports morphine antinociceptive tolerance by phosphorylation of glycosylated phosducin-like protein. Neuropharmacology 54: 319-330, 2008.
    • (2008) Neuropharmacology , vol.54 , pp. 319-330
    • Sánchez-Blázquez, P.1    Rodŕguez-Muñoz, M.2    Montero, C.3    De La Torre-Madrid, E.4    Garzón, J.5
  • 41
    • 0041412768 scopus 로고    scopus 로고
    • Magic peptides, magic antibodies: Guidelines for appropriate controls for immunohistochemistry
    • DOI 10.1002/cne.10858
    • Saper CB and Sawchenko PE. Magic peptides, magic antibodies: guidelines for appropriate controls for immunohistochemistry. J Comp Neurol 465: 161-163, 2003. (Pubitemid 37100126)
    • (2003) Journal of Comparative Neurology , vol.465 , Issue.2 , pp. 161-163
    • Saper, C.B.1    Sawchenko, P.E.2
  • 42
    • 4444311166 scopus 로고    scopus 로고
    • Morphine induces terminal μ-opioid receptor desensitization by sustained phosphorylation of serine-375
    • DOI 10.1038/sj.emboj.7600334
    • Schulz S, Mayer D, Pfeiffer M, Stumm R, Koch T, and Hö llt V. Morphine induces terminal micro-opioid receptor desensitization by sustained phosphorylation of serine-375. EMBO J 23: 3282-3289, 2004. (Pubitemid 39209152)
    • (2004) EMBO Journal , vol.23 , Issue.16 , pp. 3282-3289
    • Schulz, S.1    Mayer, D.2    Pfeiffer, M.3    Stumm, R.4    Koch, T.5    Hollt, V.6
  • 43
    • 44649126027 scopus 로고    scopus 로고
    • Adrenomedullin expression is up-regulated by acute hypobaric hypoxia in the cerebral cortex of the adult rat
    • DOI 10.1111/j.1750-3639.2008.00142.x
    • Serrano J, Fernandez AP, Sánchez J, Rodrigo J, and Mart́nez A. Adrenomedullin expression is up-regulated by acute hypobaric hypoxia in the cerebral cortex of the adult rat. Brain Pathol 18: 434-442, 2008. (Pubitemid 351782852)
    • (2008) Brain Pathology , vol.18 , Issue.3 , pp. 434-442
    • Serrano, J.1    Fernandez, A.P.2    Sanchez, J.3    Rodrigo, J.4    Martinez, A.5
  • 45
    • 0032916127 scopus 로고    scopus 로고
    • Solution structure of the extended neuronal nitric oxide synthase PDZ domain complexed with an associated peptide
    • DOI 10.1038/8216
    • Tochio H, Zhang Q, Mandal P, Li M, and Zhang M. Solution structure of the extended neuronal nitric oxide synthase PDZ domain complexed with an associated peptide. Nat Struct Biol 6: 417-421, 1999. (Pubitemid 29218008)
    • (1999) Nature Structural Biology , vol.6 , Issue.5 , pp. 417-421
    • Tochio, H.1    Zhang, Q.2    Mandal, P.3    Li, M.4    Zhang, M.5
  • 46
    • 0025971938 scopus 로고
    • Inhibition of morphine tolerance and dependence by the NMDA receptor antagonist MK-801
    • Trujillo KA and Akil H. Inhibition of morphine tolerance and dependence by the NMDA receptor antagonist MK-801. Science 251: 85-87, 1991. (Pubitemid 21916858)
    • (1991) Science , vol.251 , Issue.4989 , pp. 85-87
    • Trujillo, K.A.1    Akil, H.2
  • 47
    • 0017089254 scopus 로고
    • Systematic examination in the rat of brain sites sensitive to the direct application of morphine: Observation of differential effects within the periaqueductal gray
    • Yaksh TL, Yeung JC, and Rudy TA. Systematic examination in the rat of brain sites sensitive to the direct application of morphine: observation of differential effects within the periaqueductal gray. Brain Res 114: 83-103, 1976.
    • (1976) Brain Res , vol.114 , pp. 83-103
    • Yaksh, T.L.1    Yeung, J.C.2    Rudy, T.A.3
  • 48
    • 0032510787 scopus 로고    scopus 로고
    • Nitric oxide mediates N-methyl-D-aspartate receptorinduced activation of p21ras
    • Yun HY, Gonzalez-Zulueta M, Dawson VL, and Dawson TM. Nitric oxide mediates N-methyl-D-aspartate receptorinduced activation of p21ras. Proc Natl Acad Sci USA 95: 5773-5778, 1998.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 5773-5778
    • Yun, H.Y.1    Gonzalez-Zulueta, M.2    Dawson, V.L.3    Dawson, T.M.4
  • 49
    • 67349230279 scopus 로고    scopus 로고
    • Neuronal nitric oxide synthase: Structure, subcellular localization, regulation, and clinical implications
    • Zhou L and Zhu DY. Neuronal nitric oxide synthase: structure, subcellular localization, regulation, and clinical implications. Nitric Oxide 20: 223-230, 2009.
    • (2009) Nitric Oxide , vol.20 , pp. 223-230
    • Zhou, L.1    Zhu, D.Y.2
  • 50
    • 0037162696 scopus 로고    scopus 로고
    • Ras and Rap control AMPA receptor trafficking during synaptic plasticity
    • DOI 10.1016/S0092-8674(02)00897-8
    • Zhu JJ, Qin Y, Zhao M, Van AL, and Malinow R. Ras and Rap control AMPA receptor trafficking during synaptic plasticity. Cell 110: 443-455, 2002. (Pubitemid 35232288)
    • (2002) Cell , vol.110 , Issue.4 , pp. 443-455
    • Zhu J.Julius1    Qin, Y.2    Zhao, M.3    Van Aelst, L.4    Malinow, R.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.