Amitriptyline preserves morphine's antinociceptive effect by regulating the glutamate transporter GLAST and GLT-1 trafficking and excitatory amino acids concentration in morphine-tolerant rats

Pain

Volumn 129, Issue 3, 2007, Pages 343-354

  Tai, Yueh Hua ^a   Wang, Yu Hsueh ^b   Tsai, Ru Yin ^a   Wang, Jhi Joung ^c   Tao, Pao Luh ^a   Liu, Tso Mei ^b   Wang, Ya Chin ^b   Wong, Chih Shung ^b  

^a NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^b TRI SERVICE GENERAL HOSPITAL   (Taiwan)

^c CHI MEI MEDICAL CENTER   (Taiwan)

Author keywords

Amitriptyline; Glutamate transporter; Morphine tolerance; Protein kinase A; Protein kinase C; Trafficking

Indexed keywords

AMITRIPTYLINE; CYCLIC AMP DEPENDENT PROTEIN KINASE; EXCITATORY AMINO ACID; GLUTAMATE ASPARTATE TRANSPORTER; GLUTAMATE TRANSPORTER; MORPHINE; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; PROTEIN KINASE C; PROTEIN KINASE C ALPHA; PROTEIN KINASE C BETA; PROTEIN KINASE C BETA II; PROTEIN KINASE C GAMMA; PROTEIN KINASE C INHIBITOR; UNCLASSIFIED DRUG; VESICULAR GLUTAMATE TRANSPORTER 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; CELL SURFACE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; DRUG POTENTIATION; GLIA CELL; MALE; MORPHINE TOLERANCE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TRANSPORT; PROVOCATION TEST; RAT; REGULATORY MECHANISM; SPINAL CORD DORSAL HORN; UPREGULATION;

AMITRIPTYLINE; ANALGESICS; ANALGESICS, NON-NARCOTIC; ANALGESICS, OPIOID; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG COMBINATIONS; DRUG TOLERANCE; EXCITATORY AMINO ACID TRANSPORTER 1; EXCITATORY AMINO ACID TRANSPORTER 2; EXCITATORY AMINO ACID TRANSPORTER 3; INJECTIONS, SPINAL; MALE; MORPHINE; PAIN MEASUREMENT; PAIN THRESHOLD; POSTERIOR HORN CELLS; PROTEIN TRANSPORT; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION;

EID: 34248573304     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pain.2007.01.031     Document Type: Article

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