Intraperitoneal injection of JNK-specific inhibitor SP600125 inhibits the expression of presenilin-1 and Notch signaling in mouse brain without induction of apoptosis

Brain Research

Volumn 1448, Issue , 2012, Pages 117-128

  Rahman, Moshiur ^a   Zhang, Zhijie ^a   Mody, Avani A ^a   Su, Dong Ming ^a   Das, Hriday K ^a  

^a UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER   (United States)

Author keywords

Hes1; JNK; Notch 1; Notch signaling; p53; Presenilin 1

Indexed keywords

ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; GAMMA SECRETASE; NOTCH RECEPTOR; PRESENILIN 1; PROTEIN P53; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR HES 1;

ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN SLICE; CONTROLLED STUDY; ENZYME ACTIVITY; GENE TARGETING; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; SIGNAL TRANSDUCTION;

AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ANTHRACENES; APOPTOSIS; BLOTTING, WESTERN; BRAIN; BRAIN CHEMISTRY; ENZYME INHIBITORS; FLUORESCENT ANTIBODY TECHNIQUE; GENES, P53; IN SITU NICK-END LABELING; INJECTIONS, INTRAPERITONEAL; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MALE; MICE; MICE, INBRED C57BL; PHOSPHORYLATION; PRESENILIN-1; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTOR, NOTCH1; RNA, MESSENGER; SIGNAL TRANSDUCTION;

EID: 84862786880     PISSN: 00068993     EISSN: 18726240     Source Type: Journal    
DOI: 10.1016/j.brainres.2012.01.066     Document Type: Article

References (42)

1. Ables, J.L., Breunig, J.J., Eisch, A.J., Rakic, P., 2011. Not(ch) just development: Notch signalling in the adult brain. Nat. Rev. Neurosci. 12, 269-283.
2. Artavanis-Tsakonas, S., Rand,M.D., Lake, R.J., 1999. Notch signaling: cell fate control and signal integration in development. Science 284, 770-776. (Pubitemid 29291335)
3. Bennett, B.L., Sasaki, D.T., Murray, B.W., O'Leary, E.C., Sakata, S.T., Xu, W., Leisten, J.C., Motiwala, A., Pierce, S., Satoh, Y., Bhagwat, S.S., Manning, A.M., Anderson, D.W., 2001. SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase. Proc. Natl. Acad. Sci. U. S. A. 98, 13681-13686. (Pubitemid 33115958)
4. Berezovska, O., Xia, M.Q., Hyman, B.T., 1998. Notch is expressed in adult brain, is coexpressed with presenilin-1, and is altered in Alzheimer disease. J. Neuropathol. Exp. Neurol. 57, 738-745. (Pubitemid 28378151)
5. Bogoyevitch, M.A., Ngoei, K.R., Zhao, T.T., Yeap, Y.Y., Ng, D.C., 2010. c-Jun N-terminal kinase (JNK) signaling: recent advances and challenges. Biochim. Biophys. Acta 1804, 463-475.
6. Borchelt, D.R., Thinakaran, G., Eckman, C.B., Lee, M.K., Davenport, F., Ratovitsky, T., Prada, C.M., Kim, G., Seekins, S., Yager, D., Slunt, H.H., Wang, R., Seeger, M., Levey, A.I., Gandy, S.E., Copeland, N.G., Jenkins, N.A., Price, D.L., Younkin, S.G., Sisodia, S.S., 1996. Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo. Neuron 17, 1005-1013. (Pubitemid 26424026)
7. Borghi, R., Piccini, A., Barini, E., Cirmena, G., Guglielmotto, M., Tamagno, E., Fornaro, M., Perry, G., Smith, M.A., Garuti, A., Tabaton, M., 2010. Upregulation of presenilin 1 in brains of sporadic, late-onset Alzheimer's disease. J. Alzheimers Dis. 22, 771-775.
8. Chen, X., Wu, J., Hua, D., Shu, K., Wang, J.Z., Li, L., Lei, T., 2010. The c-jun N-terminal kinase inhibitor SP600125 is neuroprotective in amygdala kindled rats. Brain Res. 1357, 104-14.
9. Chyung, J.H., Raper, D.M., Selkoe, D.J., 2005. Gamma-secretase exists on the plasma membrane as an intact complex that accepts substrates and effects intramembrane cleavage. J. Biol. Chem. 280, 4383-4392. (Pubitemid 40288602)
10. De Strooper, B., 2003. Aph-1, Pen-2, and nicastrin with presenilin generate an active gamma-secretase complex. Neuron 38, 9-12. (Pubitemid 36423348)
11. De Strooper, B., Saftig, P., Craessaerts, K., Vanderstichele, H., Guhde, G., Annaert, W., Von Figura, K., Van Leuven, F., 1998. Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein. Nature 391, 387-390. (Pubitemid 28093512)
12. Dewji, N.N., Valdez, D., Singer, S.J., 2004. The presenilins turned inside out: implications for their structures and functions. Proc. Natl. Acad. Sci. U. S. A. 101, 1057-1062. (Pubitemid 38160583)
13. Fuchs, S.Y., Adler, V., Buschmann, T., Yin, Z., Wu, X., Jones, S.N., Ronai, Z., 1998a. JNK targets p53 ubiquitination and degradation in nonstressed cells. Genes Dev. 12, 2658-2663. (Pubitemid 28420646)
14. Fuchs, S.Y., Adler, V., Pincus, M.R., Ronai, Z., 1998b. MEKK1/JNK signaling stabilizes and activates p53. Proc. Natl. Acad. Sci. U. S. A. 95, 10541-10546. (Pubitemid 28413103)
15. Gao, Y., Signore, A.P., Yin, W., Cao, G., Yin, X.M., Sun, F., Luo, Y., Graham, S.H., Chen, J., 2005. Neuroprotection against focal ischemic brain injury by inhibition of c-jun N-terminal kinase and attenuation of the mitochondrial apoptosis-signaling pathway. J. Cereb. Blood Flow Metab. 25, 694-712. (Pubitemid 40705605)
16. Kimberly, W.T., Wolfe, M.S., 2003. Identity and function of gamma-secretase. J. Neurosci. Res. 74, 353-360.
17. Koo, E.H., Kopan, R., 2004. Potential role of presenilin-regulated signaling pathways in sporadic neurodegeneration. Nat. Med. 10 (Suppl.), S26-S33. (Pubitemid 38901864)
18. Kopan, R., Goate, A., 2000. A common enzyme connects notch signaling and Alzheimer's disease. Genes Dev. 14, 2799-2806.
19. Lee, S., Das, H.K., 2008. Inhibition of basal activity of c-jun-NH2-terminal kinase (JNK) represses the expression of presenilin-1 by a p53-dependent mechanism. Brain Res. 1207, 19-31.
20. Lee, S., Das, H.K., 2010. Transcriptional regulation of the presenilin-1 gene controls gamma-secretase activity. Front. Biosci. (Elite Ed) 2, 22-35.
21. Levine, A.J., 1997. p53, the cellular gatekeeper for growthand division. Cell 88, 323-331. (Pubitemid 27131374)
22. Li, Y.M., Xu, M., Lai, M.T., Huang, Q., Castro, J.L., DiMuzio-Mower, J., Harrison, T., Lellis, C., Nadin, A., Neduvelil, J.G., Register, R.B., Sardana, M.K., Shearman, M.S., Smith, A.L., Shi, X.P., Yin, K.C., Shafer, J.A., Gardell, S.J., 2000. Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1. Nature 405, 689-694. (Pubitemid 30428655)
23. Milne, D.M., Campbell, L.E., Campbell, D.G., Meek, D.W., 1995. p53 is phosphorylated in vitro and in vivo by an ultraviolet radiation-induced protein kinase characteristic of the c-jun kinase, JNK1. J. Biol. Chem. 270, 5511-5518.
24. Miyamoto-Yamasaki, Y., Yamasaki, M., Tachibana, H., Yamada, K., 2007. Induction of endoreduplication by a JNK inhibitor SP600125 in human lung carcinoma A 549 cells. Cell Biol. Int. 31, 1501-1506. (Pubitemid 47610738)
25. Morrison, R.S., Kinoshita, Y., 2000. The role of p53 in neuronal cell death. Cell Death Differ. 7, 868-879.
26. Nakamizo, A., Amano, T., Zhang, W., Zhang, X.Q., Ramdas, L., Liu, T.J., Bekele, B.N., Shono, T., Sasaki, T., Benedict, W.F., Sawaya, R., Lang, F.F., 2008. Phosphorylation of Thr18 and Ser20 of p53 in Ad-p53-induced apoptosis. Neuro Oncol. 10, 275-291.
27. Pastorcic, M., Das, H.K., 1999. An upstream element containing an ETS binding site is crucial for transcription of the human presenilin-1 gene. J. Biol. Chem. 274, 24297-24307.
28. Pastorcic, M., Das, H.K., 2000. Regulation of transcription of the human presenilin-1 gene by ets transcription factors and the p53 protooncogene. J. Biol. Chem. 275, 34938-34945.
29. Roperch, J.P., Alvaro, V., Prieur, S., Tuynder, M., Nemani, M., Lethrosne, F., Piouffre, L., Gendron, M.C., Israeli, D., Dausset, J., Oren,M.,Amson, R., Telerman, A., 1998. Inhibition of presenilin 1 expression is promoted by p53 and p21WAF-1 and results in apoptosis and tumor suppression. Nat. Med. 4, 835-838. (Pubitemid 28331027)
30. Shen, J., Bronson, R.T., Chen, D.F., Xia, W., Selkoe, D.J., Tonegawa, S., 1997. Skeletal and CNS defects in presenilin-1-deficient mice. Cell 89, 629-639. (Pubitemid 27511773)
31. Sherrington, R., Rogaev, E.I., Liang, Y., Rogaeva, E.A., Levesque, G., Ikeda, M., Chi, H., Lin, C., Li, G., Holman, K., Tsuda, T., Mar, L., Foncin, J.F., Bruni, A.C., Montesi, M.P., Sorbi, S., Rainero, I., Pinessi, L., Nee, L., Chumakov, I., Pollen, D., Brookes, A., Sanseau, P., Polinsky, R.J., Wasco, W., Da Silva, H.A., Haines, J.L., Perkicak-Vance, M.A., Tanzi, R.E., Roses, A.D., Fraser, P.E., Rommens, J.M., St George-Hyslop, P.H., 1995. Cloning of a gene bearing missensemutations in early-onset familial Alzheimer's disease. Nature 375, 754-760.
32. Shieh, S.Y., Ikeda,M., Taya, Y., Prives, C., 1997. DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2. Cell 91, 325-334. (Pubitemid 27467963)
33. Sisodia, S.S., Koo, E.H., Beyreuther, K., Unterbeck, A., Price,D.L., 1990. Evidence that beta-amyloid protein in Alzheimer's disease is not derived by normal processing. Science 248, 492-495.
34. Tafolla, E., Wang, S., Wong, B., Leong, J., Kapila, Y.L., 2005. JNK1 and JNK2 oppositely regulate p53 in signaling linked to apoptosis triggered by an altered fibronectinmatrix: JNKlinks FAK and p53. J. Biol. Chem. 280, 19992-19999. (Pubitemid 41379528)
35. Takasugi, N., Tomita, T., Hayashi, I., Tsuruoka, M., Niimura, M., Takahashi, Y., Thinakaran, G., Iwatsubo, T., 2003. The role of presenilin cofactors in the gamma-secretase complex. Nature 422, 438-441. (Pubitemid 36411397)
36. Tanzi, R.E., Kovacs, D.M., Kim, T.W., Moir, R.D., Guenette, S.Y., Wasco, W., 1996. The gene defects responsible for familial Alzheimer's disease. Neurobiol. Dis. 3, 159-168. (Pubitemid 26391319)
37. Thinakaran, G., Parent, A.T., 2004. Identification of the role of presenilins beyond Alzheimer's disease. Pharmacol. Res. 50, 411-418. (Pubitemid 39078532)
38. Wang, J., Friedman, E., 2000. Downregulation of p53 by sustained JNK activation during apoptosis. Mol. Carcinog. 29, 179-188.
39. Wang, W., Shi, L., Xie, Y., Ma, C., Li, W., Su, X., Huang, S., Chen, R., Zhu, Z.,Mao, Z., Han, Y., Li, M., 2004. SP600125, a newJNK inhibitor, protects dopaminergic neurons in theMPTP model of Parkinson's disease. Neurosci. Res. 48, 195-202. (Pubitemid 38096401)
40. Wolfe, M.S., Xia, W., Ostaszewski, B.L., Diehl, T.S., Kimberly, W.T., Selkoe, D.J., 1999. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity. Nature 398, 513-517.
41. Wong, P.C., Zheng, H., Chen, H., Becher, M.W., Sirinathsinghji, D.J., Trumbauer, M.E., Chen, H.Y., Price, D.L., Van der Ploeg, L.H., Sisodia, S.S., 1997. Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm. Nature 387, 288-292. (Pubitemid 27220764)
42. Zhu, X., Raina, A.K., Rottkamp, C.A., Aliev, G., Perry, G., Boux, H., Smith, M.A., 2001. Activation and redistribution of c-jun N-terminal kinase/stress activated protein kinase in degenerating neurons in Alzheimer's disease. J. Neurochem. 76, 435-441. (Pubitemid 32097021)