-
1
-
-
0035923665
-
SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase
-
DOI 10.1073/pnas.251194298
-
B.L. Bennett, D.T. Sasaki, B.W. Murray, E.C. O'Leary, S.T. Sakata, W. Xu, J.C. Leisten, A. Motiwala, S. Pierce, Y. Satoh, S.S. Bhagwat, A.M. Manning, and D.W. Anderson SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase Proc. Natl Acad. Sci. USA 98 2001 13681 13686 (Pubitemid 33115958)
-
(2001)
Proceedings of the National Academy of Sciences of the United States of America
, vol.98
, Issue.24
, pp. 13681-13686
-
-
Bennett, B.L.1
Sasaki, D.T.2
Murray, B.W.3
O'Leary, E.C.4
Sakata, S.T.5
Xu, W.6
Leisten, J.C.7
Motiwala, A.8
Pierce, S.9
Satoh, Y.10
Bhagwat, S.S.11
Manning, A.M.12
Anderson, D.W.13
-
2
-
-
47149113591
-
Antiepileptic drug resistant rats differ from drug responsive rats in GABA A receptor subunit expression in a model of temporal lobe epilepsy
-
K. Bethmann, J.M. Fritschy, C. Brandt, and W. Loscher Antiepileptic drug resistant rats differ from drug responsive rats in GABA A receptor subunit expression in a model of temporal lobe epilepsy Neurobiol. Dis. 31 2008 169 187
-
(2008)
Neurobiol. Dis.
, vol.31
, pp. 169-187
-
-
Bethmann, K.1
Fritschy, J.M.2
Brandt, C.3
Loscher, W.4
-
3
-
-
0033532331
-
Repetitive electroconvulsive seizures induce activity of c-Jun N- terminal kinase and compartment-specific desensitization of c-Jun phosphorylation in the rat brain
-
DOI 10.1016/S0169-328X(99)00069-8, PII S0169328X99000698
-
S. Brecht, S. Simler, M. Vergnes, K. Mielke, C. Marescaux, and T. Herdegen Repetitive electroconvulsive seizures induce activity of c-Jun N-terminal kinase and compartment-specific desensitization of c-Jun phosphorylation in the rat brain Brain Res. Mol. Brain Res. 68 1999 101 108 (Pubitemid 29243998)
-
(1999)
Molecular Brain Research
, vol.68
, Issue.1-2
, pp. 101-108
-
-
Brecht, S.1
Simler, S.2
Vergnes, M.3
Mielke, K.4
Marescaux, C.5
Herdegen, T.6
-
4
-
-
34247114226
-
Induction of the Wnt inhibitor, Dickkopf-1, is associated with neurodegeneration related to temporal lobe epilepsy
-
DOI 10.1111/j.1528-1167.2007.01055.x
-
C.L. Busceti, F. Biagioni, E. Aronica, B. Riozzi, M. Storto, G. Battaglia, F.S. Giorgi, R. Gradini, F. Fornai, A. Caricasole, F. Nicoletti, and V. Bruno Induction of the Wnt inhibitor, Dickkopf-1, is associated with neurodegeneration related to temporal lobe epilepsy Epilepsia 48 2007 694 705 (Pubitemid 46587610)
-
(2007)
Epilepsia
, vol.48
, Issue.4
, pp. 694-705
-
-
Busceti, C.L.1
Biagioni, F.2
Aronica, E.3
Riozzi, B.4
Storto, M.5
Battaglia, G.6
Giorgi, F.S.7
Gradini, R.8
Fornai, F.9
Caricasole, A.10
Nicoletti, F.11
Bruno, V.12
-
5
-
-
0028286992
-
Neuronal loss induced in limbic pathways by kindling: Evidence for induction of hippocampal sclerosis by repeated brief seizures
-
J.E. Cavazos, I. Das, and T.P. Sutula Neuronal loss induced in limbic pathways by kindling: evidence for induction of hippocampal sclerosis by repeated brief seizures J. Neurosci. 14 1994 3106 3121 (Pubitemid 24138997)
-
(1994)
Journal of Neuroscience
, vol.14
, Issue.5
, pp. 3106-3121
-
-
Cavazos, J.E.1
Das, I.2
Sutula, T.P.3
-
6
-
-
33748205569
-
C-Jun N-terminal kinase activation responses induced by hippocampal kindling are mediated by reactive astrocytes
-
K.K. Cole-Edwards, A.E. Musto, and N.G. Bazan c-Jun N-terminal kinase activation responses induced by hippocampal kindling are mediated by reactive astrocytes J. Neurosci. 26 2006 8295 8304
-
(2006)
J. Neurosci.
, vol.26
, pp. 8295-8304
-
-
Cole-Edwards, K.K.1
Musto, A.E.2
Bazan, N.G.3
-
7
-
-
0027289173
-
Is c-Jun involved in nerve cell death following status epilepticus and hypoxic-ischaemic brain injury?
-
DOI 10.1016/0169-328X(93)90101-T
-
M. Dragunow, D. Young, P. Hughes, G. MacGibbon, P. Lawlor, K. Singleton, E. Sirimanne, E. Beilharz, and P. Gluckman Is c-Jun involved in nerve cell death following status epilepticus and hypoxic-ischaemic brain injury? Brain Res. Mol. Brain Res. 18 1993 347 352 (Pubitemid 23160055)
-
(1993)
Molecular Brain Research
, vol.18
, Issue.4
, pp. 347-352
-
-
Dragunow, M.1
Young, D.2
Hughes, P.3
MacGibbon, G.4
Lawlor, P.5
Singleton, K.6
Sirimanne, E.7
Beilharz, E.8
Gluckman, P.9
-
8
-
-
0035976866
-
Lack of robust anticonvulsant effects of muscimol microinfusions in the anterior substantia nigra of kindled rats
-
DOI 10.1016/S0014-2999(01)01458-3, PII S0014299901014583
-
M. Gernert, and W. Loscher Lack of robust anticonvulsant effects of muscimol microinfusions in the anterior substantia nigra of kindled rats Eur. J. Pharmacol. 432 2001 35 41 (Pubitemid 33153130)
-
(2001)
European Journal of Pharmacology
, vol.432
, Issue.1
, pp. 35-41
-
-
Gernert, M.1
Loscher, W.2
-
9
-
-
13844262643
-
The neuroprotective action of SP600125, a new inhibitor of JNK, on transient brain ischemia/reperfusion-induced neuronal death in rat hippocampal CA1 via nuclear and non-nuclear pathways
-
Q.H. Guan, D.S. Pei, Q.G. Zhang, Z.B. Hao, T.L. Xu, and G.Y. Zhang The neuroprotective action of SP600125, a new inhibitor of JNK, on transient brain ischemia/reperfusion-induced neuronal death in rat hippocampal CA1 via nuclear and non-nuclear pathways Brain Res. 1035 2005 51 59
-
(2005)
Brain Res.
, vol.1035
, pp. 51-59
-
-
Guan, Q.H.1
Pei, D.S.2
Zhang, Q.G.3
Hao, Z.B.4
Xu, T.L.5
Zhang, G.Y.6
-
10
-
-
0034931503
-
c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis
-
DOI 10.1172/JCI200112466
-
Z. Han, D.L. Boyle, L. Chang, B. Bennett, M. Karin, L. Yang, A.M. Manning, and G.S. Firestein c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis J. Clin. Invest. 108 2001 73 81 (Pubitemid 32634924)
-
(2001)
Journal of Clinical Investigation
, vol.108
, Issue.1
, pp. 73-81
-
-
Han, Z.1
Boyle, D.L.2
Chang, L.3
Bennett, B.4
Karin, M.5
Yang, L.6
Manning, A.M.7
Firestein, G.S.8
-
11
-
-
1642576083
-
Stress-specific activation mechanisms for the "cell integrity" MAPK pathway
-
J.C. Harrison, T.R. Zyla, E.S. Bardes, and D.J. Lew Stress-specific activation mechanisms for the "cell integrity" MAPK pathway J. Biol. Chem. 279 2004 2616 2622
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 2616-2622
-
-
Harrison, J.C.1
Zyla, T.R.2
Bardes, E.S.3
Lew, D.J.4
-
12
-
-
0032527879
-
Lasting N-terminal phosphorylation of c-Jun and activation of c-Jun N- terminal kinases after neuronal injury
-
T. Herdegen, F.X. Claret, T. Kallunki, A. Martin-Villalba, C. Winter, T. Hunter, and M. Karin Lasting N-terminal phosphorylation of c-Jun and activation of c-Jun N-terminal kinases after neuronal injury J. Neurosci. 18 1998 5124 5135 (Pubitemid 28311930)
-
(1998)
Journal of Neuroscience
, vol.18
, Issue.14
, pp. 5124-5135
-
-
Herdegen, T.1
Claret, F.-X.2
Kallunki, T.3
Martin-Villalba, A.4
Winter, C.5
Hunter, T.6
Karin, M.7
-
13
-
-
0034739826
-
Activation of JNK and p38 in rat hippocampus after kainic acid induced seizure
-
S.H. Jeon, Y.S. Kim, C.D. Bae, and J.B. Park Activation of JNK and p38 in rat hippocampus after kainic acid induced seizure Exp. Mol. Med. 32 2000 227 230
-
(2000)
Exp. Mol. Med.
, vol.32
, pp. 227-230
-
-
Jeon, S.H.1
Kim, Y.S.2
Bae, C.D.3
Park, J.B.4
-
14
-
-
0037032817
-
Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases
-
DOI 10.1126/science.1072682
-
G.L. Johnson, and R. Lapadat Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases Science 298 2002 1911 1912 (Pubitemid 35425238)
-
(2002)
Science
, vol.298
, Issue.5600
, pp. 1911-1912
-
-
Johnson, G.L.1
Lapadat, R.2
-
15
-
-
0030739416
-
Temporal pattern of AP-1 DNA-binding activity in the rat hippocampus following a kindled seizure
-
DOI 10.1016/S0306-4522(97)00133-4, PII S0306452297001334
-
K. Kashihara, K. Sato, K. Akiyama, S. Okada, T. Ishihara, T. Hayabara, and T. Shomori Temporal pattern of AP-1 DNA-binding activity in the rat hippocampus following a kindled seizure Neuroscience 80 1997 753 761 (Pubitemid 27334619)
-
(1997)
Neuroscience
, vol.80
, Issue.3
, pp. 753-761
-
-
Kashihara, K.1
Sato, K.2
Akiyama, K.3
Okada, S.4
Ishihara, T.5
Hayabara, T.6
Shomori, T.7
-
16
-
-
0030550364
-
Astrocytes in kindling: Relevance to epileptogenesis
-
DOI 10.1016/S0920-1211(96)00051-4, PII S0920121196000514
-
M. Khurgel, and G.O. Ivy Astrocytes in kindling: relevance to epileptogenesis Epilepsy Res. 26 1996 163 175 (Pubitemid 26420740)
-
(1996)
Epilepsy Research
, vol.26
, Issue.1
, pp. 163-175
-
-
Khurgel, M.1
Ivy, G.O.2
-
17
-
-
67649311410
-
Partial kindling induces neurogenesis, activates astrocytes and alters synaptic morphology in the dentate gyrus of freely moving adult rats
-
I.V. Kraev, O.V. Godukhin, I.V. Patrushev, H.A. Davies, V.I. Popov, and M.G. Stewart Partial kindling induces neurogenesis, activates astrocytes and alters synaptic morphology in the dentate gyrus of freely moving adult rats Neuroscience 162 2009 254 267
-
(2009)
Neuroscience
, vol.162
, pp. 254-267
-
-
Kraev, I.V.1
Godukhin, O.V.2
Patrushev, I.V.3
Davies, H.A.4
Popov, V.I.5
Stewart, M.G.6
-
18
-
-
33645985197
-
Distribution of GABAergic neurons in the striatum of amygdala-kindled rats: An immunohistochemical and in situ hybridization study
-
W. Loscher, M. Schirmer, C. Freichel, and M. Gernert Distribution of GABAergic neurons in the striatum of amygdala-kindled rats: an immunohistochemical and in situ hybridization study Brain Res. 1083 2006 50 60
-
(2006)
Brain Res.
, vol.1083
, pp. 50-60
-
-
Loscher, W.1
Schirmer, M.2
Freichel, C.3
Gernert, M.4
-
19
-
-
0001182421
-
Protein kinase inhibitors: Structural determinants for target specificity
-
G. McMahon, L. Sun, C. Liang, and C. Tang Protein kinase inhibitors: structural determinants for target specificity Curr. Opin. Drug Discov. Dev. 1 1998 131 146
-
(1998)
Curr. Opin. Drug Discov. Dev.
, vol.1
, pp. 131-146
-
-
McMahon, G.1
Sun, L.2
Liang, C.3
Tang, C.4
-
20
-
-
0032909368
-
Activity and expression of JNK1, p38 and ERK kinases, c-Jun N-terminal phosphorylation, and c-Jun promoter binding in the adult rat brain following kainate-induced seizures
-
DOI 10.1016/S0306-4522(98)00667-8, PII S0306452298006678
-
K. Mielke, S. Brecht, A. Dorst, and T. Herdegen Activity and expression of JNK1, p38 and ERK kinases, c-Jun N-terminal phosphorylation, and c-jun promoter binding in the adult rat brain following kainate-induced seizures Neuroscience 91 1999 471 483 (Pubitemid 29193256)
-
(1999)
Neuroscience
, vol.91
, Issue.2
, pp. 471-483
-
-
Mielke, K.1
Brecht, S.2
Dorst, A.3
Herdegen, T.4
-
21
-
-
0025959674
-
Stimulus-transcription coupling in the nervous system: Involvement of the inducible proto-oncogenes fos and jun
-
J.I. Morgan, and T. Curran Stimulus-transcription coupling in the nervous system: involvement of the inducible proto-oncogenes fos and jun Annu. Rev. Neurosci. 14 1991 421 451
-
(1991)
Annu. Rev. Neurosci.
, vol.14
, pp. 421-451
-
-
Morgan, J.I.1
Curran, T.2
-
22
-
-
49549091329
-
Benefits and risks of intranigral transplantation of GABA-producing cells subsequent to the establishment of kindling-induced seizures
-
M.W. Nolte, W. Loscher, C. Herden, W.J. Freed, and M. Gernert Benefits and risks of intranigral transplantation of GABA-producing cells subsequent to the establishment of kindling-induced seizures Neurobiol. Dis. 31 2008 342 354
-
(2008)
Neurobiol. Dis.
, vol.31
, pp. 342-354
-
-
Nolte, M.W.1
Loscher, W.2
Herden, C.3
Freed, W.J.4
Gernert, M.5
-
23
-
-
70450231826
-
Inhibition of c-Jun N-terminal kinase enhances temozolomide-induced cytotoxicity in human glioma cells
-
S. Ohba, Y. Hirose, T. Kawase, and H. Sano Inhibition of c-Jun N-terminal kinase enhances temozolomide-induced cytotoxicity in human glioma cells J. Neurooncol. 95 2009 307 316
-
(2009)
J. Neurooncol.
, vol.95
, pp. 307-316
-
-
Ohba, S.1
Hirose, Y.2
Kawase, T.3
Sano, H.4
-
25
-
-
0015309163
-
Modification of seizure activity by electrical stimulation. II. Motor seizure
-
R.J. Racine Modification of seizure activity by electrical stimulation. II. Motor seizure Electroencephalogr. Clin. Neurophysiol. 32 1972 281 294
-
(1972)
Electroencephalogr. Clin. Neurophysiol.
, vol.32
, pp. 281-294
-
-
Racine, R.J.1
-
26
-
-
16644381829
-
Wnt signaling through Dishevelled, Rac and JNK regulates dendritic development
-
DOI 10.1038/nn1374
-
S.B. Rosso, D. Sussman, A. Wynshaw-Boris, and P.C. Salinas Wnt signaling through Dishevelled, Rac and JNK regulates dendritic development Nat. Neurosci. 8 2005 34 42 (Pubitemid 41236729)
-
(2005)
Nature Neuroscience
, vol.8
, Issue.1
, pp. 34-42
-
-
Rosso, S.B.1
Sussman, D.2
Wynshaw-Boris, A.3
Salinas, P.C.4
-
27
-
-
0033545386
-
JNK2 is required for efficient T-cell activation and apoptosis but not for normal lymphocyte development
-
DOI 10.1016/S0960-9822(99)80065-7
-
K. Sabapathy, Y. Hu, T. Kallunki, M. Schreiber, J.P. David, W. Jochum, E.F. Wagner, and M. Karin JNK2 is required for efficient T-cell activation and apoptosis but not for normal lymphocyte development Curr. Biol. 9 1999 116 125 (Pubitemid 29087541)
-
(1999)
Current Biology
, vol.9
, Issue.3
, pp. 116-125
-
-
Sabapathy, K.1
Hu, Y.2
Kallunki, T.3
Schreiber, M.4
David, J.-P.5
Jochum, W.6
Wagner, E.F.7
Karin, M.8
-
28
-
-
0037042382
-
An inhibitor of c-jun aminoterminal kinase (SP600125) represses c-Jun activation, DNA-binding and PMA-inducible 92-kDa type IV collagenase expression
-
DOI 10.1016/S0167-4889(02)00195-7, PII S0167488902001957
-
M. Shin, C. Yan, and D. Boyd An inhibitor of c-jun aminoterminal kinase (SP600125) represses c-Jun activation, DNA-binding and PMA-inducible 92-kDa type IV collagenase expression Biochim. Biophys. Acta 1589 2002 311 316 (Pubitemid 34603302)
-
(2002)
Biochimica et Biophysica Acta - Molecular Cell Research
, vol.1589
, Issue.3
, pp. 311-316
-
-
Shin, M.1
Yan, C.2
Boyd, D.3
-
29
-
-
0025850714
-
Differential expression of immediate early genes in the hippocampus in the kindling model of epilepsy
-
M. Simonato, D.A. Hosford, D.M. Labiner, C. Shin, H.H. Mansbach, and J.O. McNamara Differential expression of immediate early genes in the hippocampus in the kindling model of epilepsy Brain Res. Mol. Brain Res. 11 1991 115 124
-
(1991)
Brain Res. Mol. Brain Res.
, vol.11
, pp. 115-124
-
-
Simonato, M.1
Hosford, D.A.2
Labiner, D.M.3
Shin, C.4
Mansbach, H.H.5
McNamara, J.O.6
-
30
-
-
77950450579
-
C-Jun N-terminal kinase signaling pathway in excitotoxic cell death following kainic acid-induced status epilepticus
-
G. Spigolon, C. Veronesi, C. Bonny, and A. Vercelli c-Jun N-terminal kinase signaling pathway in excitotoxic cell death following kainic acid-induced status epilepticus Eur. J. Neurosci. 31 2010 1261 1272
-
(2010)
Eur. J. Neurosci.
, vol.31
, pp. 1261-1272
-
-
Spigolon, G.1
Veronesi, C.2
Bonny, C.3
Vercelli, A.4
-
31
-
-
0030780804
-
Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene
-
DOI 10.1038/39899
-
D.D. Yang, C.Y. Kuan, A.J. Whitmarsh, M. Rincon, T.S. Zheng, R.J. Davis, P. Rakic, and R.A. Flavell Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene Nature 389 1997 865 870 (Pubitemid 27462982)
-
(1997)
Nature
, vol.389
, Issue.6653
, pp. 865-870
-
-
Yang, D.D.1
Kuan, C.-Y.2
Whitmarsh, A.J.3
Rincon, M.4
Zheng, T.S.5
Davis, R.J.6
Rakic, P.7
Flavell, R.A.8
|