Regenerative medicine as applied to general surgery

Annals of Surgery

Volumn 255, Issue 5, 2012, Pages 867-880

  Orlando, Giuseppe ^a,b   Wood, Kathryn J ^d   De Coppi, Paolo ^e   Baptista, Pedro M ^a   Binder, Kyle W ^a   Bitar, Khalil N ^f   Breuer, Christopher ^g   Burnett, Luke ^b,h   Christ, George ^a   Farney, Alan ^b   Figliuzzi, Marina ⁱ   Holmes, James H ^c   Koch, Kenneth ^b   MacChiarini, Paolo ^j   Sani, Sayed Hadi Mirmalek ^a   Opara, Emmanuel ^a   Remuzzi, Andrea ^b   Rogers, Jeffrey ^b   Saul, Justin M ^a,k   Seliktar, Dror ^l   Shapira Schweitzer, Keren ^l   Smith, Tom ^b   Solomon, Daniel ^g   Van Dyke, Mark ^a,h   Yoo, James J ^a   Zhang, Yuanyuan ^a   Atala, Anthony ^a   Stratta, Robert J ^b   Soker, Shay ^a   more..

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b Department of Surgery ^*  (United States)

^c Burn Center   (United States)

^d UNIVERSITY OF OXFORD   (United Kingdom)

^e UNIVERSITY COLLEGE LONDON   (United Kingdom)

^f UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^g YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^h Keranetics   (United States)

ⁱ MARIO NEGRI INST PHARMACOL RES   (Italy)

^j KAROLINSKA INSTITUTE   (Sweden)

^k Medical Center Boulevard   (United States)

^l TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

more..

Author keywords

[No Author keywords available]

Indexed keywords

BIOMATERIAL; CHONDROITIN 6 SULFATE; COLLAGEN; FIBRIN; HYALURONIC ACID; POLYCAPROLACTONE; POLYGLYCOLIC ACID; POLYLACTIC ACID; POLYMER; TISSUE SCAFFOLD;

ADIPOSE DERIVED STEM CELL; ARTIFICIAL SKIN; AUTOGRAFT; BIOCOMPATIBILITY; BIODEGRADABILITY; BIOENGINEERING; BLOOD VESSEL; BLOOD VESSEL GRAFT; BONE; BURN; BYPASS SURGERY; CELL FUNCTION; CELL GROWTH; CELL MATURATION; CELL MIGRATION; CELL PROLIFERATION; CELL SURVIVAL; CELL TRANSPLANTATION; CHRONIC LIVER DISEASE; CULTURED EPITHELIAL AUTOGRAFT; DIABETES MELLITUS; EMBRYONIC STEM CELL; ENGRAFTMENT; EXTRACELLULAR MATRIX; FAMILIAL HYPERCHOLESTEROLEMIA; FOREIGN BODY REACTION; GASTROINTESTINAL TRACT; GENERAL SURGERY; HEART; HEART MUSCLE CELL; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEPATOCYTE TRANSPLANTATION; HUMAN; HYDROGEL; IMMUNE RESPONSE; INSULIN DEPENDENT DIABETES MELLITUS; KERATINOCYTE; KIDNEY FAILURE; LIVER DISEASE; MESENCHYMAL STEM CELL; MESENCHYMAL STEM CELL TRANSPLANTATION; NERVE; NONHUMAN; ORTHOPEDICS; PANCREAS; PANCREAS ISLET BETA CELL; PANCREAS ISLET TRANSPLANTATION; PRIORITY JOURNAL; REGENERATIVE MEDICINE; RESPIRATORY SYSTEM; REVIEW; SKIN; SKIN FIBROBLAST; SKIN GRAFT; STEM CELL; STEM CELL TRANSPLANTATION; STRESS INCONTINENCE; TISSUE ENGINEERING; TISSUE GRAFT; TISSUE REGENERATION; URINARY TRACT; WOUND DRESSING; WOUND HEALING;

ANIMALS; BIOCOMPATIBLE MATERIALS; BLOOD VESSEL PROSTHESIS; CELL TRANSPLANTATION; CHONDROITIN SULFATES; COLLAGEN; GASTROINTESTINAL TRACT; GENERAL SURGERY; HEART FAILURE; HUMANS; KIDNEY FAILURE, CHRONIC; LARYNX; LIVER TRANSPLANTATION; REGENERATIVE MEDICINE; RESPIRATORY TRACT DISEASES; SKIN; SKIN, ARTIFICIAL; TISSUE SCAFFOLDS; WOUND HEALING; WOUNDS AND INJURIES;

EID: 84862777058     PISSN: 00034932     EISSN: 15281140     Source Type: Journal    
DOI: 10.1097/SLA.0b013e318243a4db     Document Type: Review

References (266)

1. Hollander A, Macchiarini P, Gordijn B, Birchall M. The first stem cell-based tissue-engineered organ replacement: implications for regenerative medicine and society. Regen Med. 2009;4:147-148.
2. Orlando G, Baptista P, Birchall M, et al. Regenerative medicine as applied to solid organ transplantation: current status and future challenges. Transplant Int. 2011;24:223-232.
3. Orlando G, Wood KJ, Stratta RJ, et al. Regenerative medicine and organ transplantation: past, present, and future. Transplantation. 2011;91: 1310-1317.
4. Mason C, Dunnill P. A brief definition of regenerative medicine. Regen Med. 2008;3:1-5. (Pubitemid 351541190)
5. Kemp P. History of regenerative medicine: looking backwards to move forwards. Regen Med. 2006;1:653-669.
6. Atala A. Engineering organs. Curr Opin Biotechnol. 2009;20:575-592.
7. Badylak SF, Russell AJ, Santin M. Introduction: history of regenerative medicine. In: Santin M, ed. Strategies in Regenerative Medicine. Integrating Biology With Material Design. New York, NY: Springer Science-Business Media, LLC; 2009:1-13.
8. Gomez PF, Morcuende JA. Early attempts at hip arthroplasty-1700s to 1950s. Iowa Orthop J. 2005;25:25-29.
9. Shinoka T, Imai Y, IkadaY. Transplantation of a tissue-engineered pulmonary artery. N Engl J Med. 2001;344:532-533. (Pubitemid 32164912)
10. Matsumura G, Hibino N, Ikada Y, et al. Successful application of tissue engineered vascular autografts: clinical experience. Biomaterials. 2003;24: 2303-2308. (Pubitemid 36434049)
11. Shinoka T, Matsumura G, Hibino N, et al. Midterm clinical result of tissueengineered vascular autografts seeded with autologous bone marrow cells. J Thorac Cardiovasc Surg. 2005;129:1330-1338.
12. Hibino N, McGillicuddy E, Matsumura G, et al. Late-term results of tissue-engineered vascular grafts in humans. J Thorac Cardiovasc Surg. 2010;139:431-6, 436.e1-e2.
13. McAllister TN, Maruszewski M, Garrido SA, et al. Effectiveness of haemodialysis access with an autologous tissue-engineered vascular graft: a multicentre cohort study. Lancet. 2009;373:1440-1446.
14. L'Heureux N, McAllister TN, de la Fuente LM. Tissue-engineered blood vessel for adult arterial revascularization. N Engl J Med. 2007;357:1451-1453. (Pubitemid 47535609)
15. Atala A, Bauer SB, Soker S, et al. Tissue-engineered autologous bladders for patients needing cystoplasty. Lancet. 2006;367:1241-1246.
16. Macchiarini P, Jungebluth P, Go T, et al. Clinical transplantation of a tissueengineered airway. Lancet. 2008;372:2023-2030.
17. Baiguera S, Birchall MA, Macchiarini P. Tissue-engineered tracheal transplantation. Transplantation. 2010;89:485-491.
18. Raya-Rivera A, Esquiliano DR, Yoo JJ, et al. Tissue-engineered autologous urethras for patients who need reconstruction: an observational study. Lancet. 2011;377:1175-1182.
19. Ott HC, Matthiesen TS, Goh SK, et al. Perfusion-decellularized matrix: using nature's platformto engineer a bioartificial heart. NatMed. 2008;14:213-221. (Pubitemid 351214548)
20. Uygun BE, Soto-Gutierrez A, Yagi H, et al. Organ reengineering through development of a transplantable recellularized liver graft using decellularized liver matrix. Nat Med. 2010;16:814-820.
21. Baptista PM, Siddiqui MM, Lozier G, et al. The use of whole organ decellularization for the generation of a vascularized liver organoid. Hepatology. 2011;53:604-617.
22. Baptista PM, Orlando G, Mirmalek-Sani SH, et al. Whole organ decellularization-a tool for bioscaffold fabrication and organ bioengineering. Conf Proc IEEE Eng Med Biol Soc. 2009;2009:6526-6529.
23. Badylak SF, Zhang L, Medberry CJ, et al. A whole organ regenerative medicine approach for liver replacement. Tissue Eng Part C Methods. 2011;17:677-686.
24. Petersen TH, Calle EA, Zhao L, et al. Tissue-engineered lungs for in vivo implantation. Science. 2010;29:538-541.
25. Ott HC, Clippinger B, Conrad C, et al. Regeneration and orthotopic transplantation of a bioartificial lung. Nat Med. 2010;16:927-933.
26. Lineen E, Namias N. Biologic dressing in burns. J Craniofac Surg. 2008;19:923-928.
27. Atiyeh BS, Gunn SW, Hayek SN. State of the art in burn treatment. World J Surg. 2005;29:131-148. (Pubitemid 40576458)
28. Auger FA, Lacroix D, Germain L. Skin substitutes and wound healing. Skin Pharmacol Physiol. 2009;22:94-102.
29. Burke JF, Yannas IV, QuinbyWCJr, et al. Successful use of a physiologically acceptable artificial skin in the treatment of extensive burn injury. Ann Surg. 1981;194:413-428.
30. Boyce ST, Kagan RJ, Meyer NA, et al. The 1999 clinical research award: cultured skin substitutes combined with Integra Artificial Skin to replace native skin autograft and allograft for the closure of excised full-thickness burns. J Burn Care Rehabil. 1999;20:453-461. (Pubitemid 30007823)
31. Branski LK, Herndon DN, Pereira C, et al. Longitudinal assessment of Integra in primary burn management: a randomized pediatric clinical trial. Crit Care Med. 2007;35:2615-2623. (Pubitemid 351339025)
32. Helgeson MD, Potter BK, Evans KN, et al. Bioartificial dermal substitute: a preliminary report on its use for the management of complex combat-related soft tissue wounds. J Orthop Trauma. 2007;21:394-399. (Pubitemid 47051870)
33. Jeng JC, Fidler PE, Sokolich JC, et al. Seven years' experience with Integra as a reconstructive tool. J Burn Care Res. 2007;28:120-126. (Pubitemid 46091511)
34. Pollard RL, Kennedy PJ, Maitz PK. The use of artificial dermis (Integra) and topical negative pressure to achieve limb salvage following soft-tissue loss caused by meningococcal septicaemia. J Plast Reconstr Aesthet Surg. 2008 61:319-322. (Pubitemid 351215143)
35. Pham C, Greenwood J, Cleland H, et al. Bioengineered skin substitutes for the management of burns: a systematic review. Burns. 2007;33:946-957. (Pubitemid 350051194)
36. Lutolf MP, Hubbell JA. Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering. Nat Biotechnol. 2005;23:47-55. (Pubitemid 41724624)
37. Broughton G, Janis JE, Attinger CE. The basic science of wound healing. Plast Reconstr Surg. 2006;117:12S-34S. (Pubitemid 44317769)
38. Souren JM, Ponec M, van WR. Contraction of collagen by human fibroblasts and keratinocytes. In Vitro Cell Dev Biol. 1989;25:1039-1045. (Pubitemid 20013895)
39. Chakrabarty KH, Heaton M, Dalley AJ, et al. Keratinocyte-driven contraction of reconstructed human skin. Wound Repair Regen. 2001;9:95-106. (Pubitemid 32458316)
40. Grinnell F. Fibroblasts, myofibroblasts, and wound contraction. J Cell Biol. 1994;124:401-404. (Pubitemid 24064453)
41. Harrison CA,MacNeil S. The mechanism of skin graft contraction: an update on current research and potential future therapies. Burns. 2008;34:153-163.
42. Ralston DR, Layton C, Dalley AJ, et al. Keratinocytes contract human dermal extracellular matrix and reduce soluble fibronectin production by fibroblasts in a skin composite model. Br J Plast Surg. 1997;50:408-415. (Pubitemid 27412275)
43. Brown DM, Barton BR, Young VL, et al. Decreased wound contraction with fibrin glue-treated skin grafts. Arch Surg. 1992;127:404-406.
44. Ahmed TA, Dare EV, Hincke M. Fibrin: a versatile scaffold for tissue engineering applications. Tissue Eng Part B Rev. 2008;14:199-215. (Pubitemid 351839214)
45. Currie LJ, Martin R, Sharpe JR, et al. A comparison of keratinocyte cell sprays with and without fibrin glue. Burns. 2003;29:677-685. (Pubitemid 37230082)
46. Grant I,Warwick K, Marshall J, et al. The co-application of sprayed cultured autologous keratinocytes and autologous fibrin sealant in a porcine wound model. Br J Plast Surg. 2002;55:219-227. (Pubitemid 34591362)
47. Larson BJ, Longaker MT, Lorenz HP. Scarless fetal wound healing: a basic science review. Plast Reconstr Surg. 2010;126:1172-1180.
48. Bourguignon LY, Ramez M, Gilad E, et al. Hyaluronan-CD44 interaction stimulates keratinocyte differentiation, lamellar body formation/secretion, and permeability barrier homeostasis. J Invest Dermatol. 2006;126: 1356-1365. (Pubitemid 43997919)
49. Scuderi N, Onesti MG, Bistoni G, et al. The clinical application of autologous bioengineered skin based on a hyaluronic acid scaffold. Biomaterials. 2008;29:1620-1629.
50. Thivolet J, Faure M, Demidem A, et al. Long-term survival and immunological tolerance of human epidermal allografts produced in culture. Transplantation. 1986;42:274-280. (Pubitemid 16020751)
51. Cuono C, Langdon R, McGuire J. Use of cultured epidermal autografts and dermal allografts as skin replacement after burn injury. Lancet. 1986;1:1123-1124. (Pubitemid 16109962)
52. Gallico GG III, O'Connor NE, Compton CC, et al. Cultured epithelial autografts for giant congenital nevi. Plast Reconstr Surg. 1989;84:1-9. (Pubitemid 19195122)
53. Leigh IM, Purkis PE, Navsaria HA, et al. Treatment of chronic venous ulcers with sheets of cultured allogenic keratinocytes. Br JDermatol. 1987;117:591-597. (Pubitemid 18078445)
54. Sood R, Balledux J, Koumanis DJ, et al. Coverage of large pediatric wounds with cultured epithelial autografts in congenital nevi and burns: results and technique. J Burn Care Res. 2009;30:576-586.
55. Wood FM, Kolybaba ML, Allen P. The use of cultured epithelial autograft in the treatment of major burn injuries: a critical review of the literature. Burns. 2006;32:395-401.
56. Hernon CA, Dawson RA, Freedlander E, et al. Clinical experience using cultured epithelial autografts leads to an alternativemethodology for transferring skin cells from the laboratory to the patient. Regen Med. 2006;1:809-821.
57. Brem H, Young J, Tomic-Canic M, et al. Clinical efficacy and mechanism of bilayered living human skin equivalent (HSE) in treatment of diabetic foot ulcers. Surg Technol Int. 2003;11:23-31.
58. Falanga V, Sabolinski M. A bilayered living skin construct (APLIGRAF) accelerates complete closure of hard-to-heal venous ulcers. Wound Repair Regen. 1999;7:201-207. (Pubitemid 29439206)
59. Falanga V, Margolis D, Alvarez O, et al. Rapid healing of venous ulcers and lack of clinical rejection with an allogeneic cultured human skin equivalent. Human Skin Equivalent Investigators Group. Arch Dermatol. 1998;134:293-300. (Pubitemid 28141616)
60. Streit M, Braathen LR. Apligraf-a living human skin equivalent for the treatment of chronic wounds. Int J Artif Organs. 2000;23:831-833. (Pubitemid 32058536)
61. Zaulyanov L, Kirsner RS. A review of a bi-layered living cell treatment (Apligraf) in the treatment of venous leg ulcers and diabetic foot ulcers. Clin Interv Aging. 2007;2:93-98.
62. Grant I,Warwick K, Marshall J, et al. The co-application of sprayed cultured autologous keratinocytes and autologous fibrin sealant in a porcine wound model. Br J Plast Surg. 2002;55:219-227. (Pubitemid 34591362)
63. Horch RE, Bannasch H, Stark GB. Transplantation of cultured autologous keratinocytes in fibrin sealant biomatrix to resurface chronic wounds. Transplant Proc. 2001;33:642-644. (Pubitemid 32237552)
64. Svensjo T, Yao F, Pomahac B, et al. Autologous keratinocyte suspensions accelerate epidermal wound healing in pigs. J Surg Res. 2001;99: 211-221. (Pubitemid 32703439)
65. Velander P, Theopold C, Bleiziffer O, et al. Cell suspensions of autologous keratinocytes or autologous fibroblasts accelerate the healing of full thickness skin wounds in a diabetic porcine wound healing model. J Surg Res. 2009;157:14-20.
66. Wood FM, Stoner ML, Fowler BV, et al. The use of a non-cultured autologous cell suspension and Integra dermal regeneration template to repair full-thickness skin wounds in a porcine model: a one-step process. Burns. 2007;33:693-700. (Pubitemid 47248084)
67. Blanpain C, LowryWE, Geoghegan A, et al. Self-renewal, multipotency, and the existence of two cell populations within an epithelial stem cell niche. Cell. 2004;118:635-648. (Pubitemid 39179715)
68. Fathke C, Wilson L, Shah K, et al. Wnt signaling induces epithelial differentiation during cutaneous wound healing. BMC Cell Biol. 2006;7:4-12.
69. Ghazizadeh S, Taichman LB. Multiple classes of stem cells in cutaneous epithelium: a lineage analysis of adult mouse skin. EMBO J. 2001;20:1215-1222. (Pubitemid 32233962)
70. Ito M, Cotsarelis G. Is the hair follicle necessary for normal wound healing? J Invest Dermatol. 2008;128:1059-1061. (Pubitemid 351543224)
71. Kamimura J, Lee D, Baden HP, et al. Primary mouse keratinocyte cultures contain hair follicle progenitor cells with multiple differentiation potential. J Invest Dermatol. 1997;109:534-540. (Pubitemid 27433597)
72. Levy V, Lindon C, Harfe BD, et al. Distinct stem cell populations regenerate the follicle and interfollicular epidermis. Dev Cell. 2005;9:855-861. (Pubitemid 41724112)
73. Yan X, Owens DM. The skin: a home to multiple classes of epithelial progenitor cells. Stem Cell Rev. 2008;4:113-118.
74. Ferguson MW, O'Kane S. Scar-free healing: from embryonic mechanisms to adult therapeutic intervention. Philos Trans R Soc Lond B Biol Sci. 2004;359: 839-850. (Pubitemid 38673751)
75. Roh C, Lyle S. Cutaneous stem cells and wound healing. Pediatr Res. 2006;59:100R-103R. (Pubitemid 43740043)
76. Guenou H, NissanX, Larcher F, et al.Human embryonic stem-cell derivatives for full reconstruction of the pluristratified epidermis: a preclinical study. Lancet. 2009;374:1745-1753.
77. Hanson SE, Bentz ML, Hematti P. Mesenchymal stem cell therapy for nonhealing cutaneous wounds. Plast Reconstr Surg. 2010;125:510-516.
78. Allen-Hoffmann BL, Schlosser SJ, Ivarie CA, et al. Normal growth and differentiation in a spontaneously immortalized near-diploid human keratinocyte cell line, NIKS. J Invest Dermatol. 2000;114:444-455. (Pubitemid 30415329)
79. Schurr MJ, Foster KN, Centanni JM, et al. Phase I/II clinical evaluation of StrataGraft: a consistent, pathogen-free human skin substitute. J Trauma. 2009;66:866-873.
80. Lloyd-Jones D, Adams RJ, Brown TM, et al. Heart disease and stroke statistics-2010 update: a report from the American Heart Association. Circulation. 2010;121:e46-e215.
81. Goodney PP, Beck AW, Nagle J, et al. National trends in lower extremity bypass surgery, endovascular interventions, and major amputations. J Vasc Surg. 2009;50:54-60.
82. CfDCaP. Incidence of end-stage renal disease attributed to diabetes among persons with diagnosed diabetes-United States and Puerto Rico, 1996-2007. MMWR Morb Mortal Wkly Rep. 2010;59:1361-1366.
83. Weinberg CB, Bell E. A blood vessel model constructed from collagen and cultured vascular cells. Science. 1986;231:397-400. (Pubitemid 16108649)
84. L'Heureux N, P̂aquet S, Labb́e R, et al. A completely biological tissueengineered human blood vessel. FASEB J. 1998;12:47-56. (Pubitemid 28060270)
85. Niklason LE, Abbott W, Gao J, et al. Morphologic and mechanical characteristics of engineered bovine arteries. J Vasc Surg. 2001;33:628-638. (Pubitemid 32215616)
86. Allaire E, Guettier C, Bruneval P, et al. Cell-free arterial grafts: morphologic characteristics of aortic isografts, allografts, and xenografts in rats. J Vasc Surg. 1994;19:446-456. (Pubitemid 24093978)
87. Malone JM, Brendel K, Duhamel RC, et al. Detergent-extracted smalldiameter vascular prostheses. J Vasc Surg. 1984;1:181-191.
88. Dahl SL, Kypson AP, Lawson JH, et al. Readily available tissue-engineered vascular grafts. Sci Transl Med. 2011;3:68-69.
89. Jay SM, Shepherd BR, Andrejecsk JW, et al. Dual delivery of VEGF and MCP-1 to support endothelial cell transplantation for therapeutic vascularization. Biomaterials. 2010;31:3054-3062.
90. Sun Y, Weber KT. Infarct scar: a dynamic tissue. Cardiovasc Res. 2000;46:250-256. (Pubitemid 30204596)
91. Kehat I, Kenyagin-Karsenti D, Snir M, et al. Human embryonic stem cells can differentiate into myocytes with structural and functional properties of cardiomyocytes. J Clin Invest. 2001;108:407-414. (Pubitemid 32730787)
92. Christman KL, Lee RJ. Biomaterials for the treatment of myocardial infarction. J Am Coll Cardiol. 2006;48:907-913. (Pubitemid 44292446)
93. ZimmermannWH, Melnychenko I,WasmeierG, et al. Engineered heart tissue grafts improve systolic and diastolic function in infarcted rat hearts. NatMed. 2006;12:452-458.
94. Fazel S, Tang GH, Angoulvant D, et al. Current status of cellular therapy for ischemic heart disease. Ann Thorac Surg. 2005;79:S2238-S2247. (Pubitemid 40804241)
95. Murry CE, Field LJ, Menasche P. Cell-based cardiac repair: reflections at the 10-year point. Circulation. 2005;112:3174-3183. (Pubitemid 43113446)
96. Britten MB, Abolmaali ND, Assmus B, et al.Infarct remodeling after intracoronary progenitor cell treatment in patientswith acutemyocardial infarction (TOPCARE-AMI): mechanistic insights from serial contrast-enhanced magnetic resonance imaging. Circulation. 2003;108:2212-2218. (Pubitemid 37368893)
97. Schachinger V, Assmus B, Britten MB, et al. Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction: final oneyear results of the TOPCARE-AMI Trial. J Am Coll Cardiol. 2004;44:1690-1699. (Pubitemid 39369805)
98. Hofmann M, Wollert KC, Meyer GP, et al. Monitoring of bone marrow cell homing into the infarcted human myocardium. Circulation. 2005;111:2198-2202. (Pubitemid 40632435)
99. Qian H, Yang Y, Huang J, et al. Intracoronary delivery of autologous bone marrow mononuclear cells radiolabeled by 18F-fluoro-deoxy-glucose: tissue distribution and impact on post-infarct swine hearts. J Cell Biochem. 2007;102:64-74. (Pubitemid 47381281)
100. Caspi O, Huber I, Kehat I, et al. Transplantation of human embryonic stem cell-derived cardiomyocytes improves myocardial performance in infarcted rat hearts. J Am Coll Cardiol. 2007;50:1884-1893. (Pubitemid 350007960)
101. ZimmermannWH, Schneiderbanger K, Schubert P, et al. Tissue engineering of a differentiated cardiac muscle construct. Circ Res. 2002;90:223-230. (Pubitemid 34627092)
102. Leor J, Landa N, Cohen S. Renovation of the injured heart with myocardial tissue engineering. Expert Rev Cardiovasc Ther. 2006;4:239-252.
103. Zimmermann WH, Didie M, Doker S, et al. Heart muscle engineering: an update on cardiac muscle replacement therapy. Cardiovasc Res. 2006;71:419-429. (Pubitemid 44107857)
104. Shapira K, Dikovsky D, Habib M, et al. Hydrogels for cardiac tissue regeneration. Biomed Mater Eng. 2008;18:309-314.
105. Lutolf MP, Hubbell JA. Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering. Nat Biotechnol. 2005;23:47-55. (Pubitemid 41724624)
106. Davis ME, Hsieh PC, Grodzinsky AJ, et al. Custom design of the cardiac microenvironment with biomaterials. Circ Res. 2005;97:8-15. (Pubitemid 40982317)
107. Shapira-Schweitzer K, HabibM, Gepstein L, et al. An injectable hydrogel for 3-D culture of human embryonic stem cell-derived cardiomyocytes and rat neonatal cardiac cells. JMCC. 2009;46:213-224.
108. Kofidis T, Lebl DR, Martinez EC, et al. Novel injectable bioartificial tissue facilitates targeted, less invasive, large-scale tissue restoration on the beating heart after myocardial injury. Circulation. 2005;112:I173-I177. (Pubitemid 41266670)
109. McDevitt TC, Woodhouse KA, Hauschka SD, Murry CE, Stayton PS. Spatially organized layers of cardiomyocytes on biodegradable polyurethane films for myocardial repair. J Biomed Mater Res A. 2003;66:586-595. (Pubitemid 37517204)
110. Shapira-Schweitzer K, Seliktar D. Matrix stiffness affects spontaneous contraction of cardiomyocytes cultured within a PEGylated fibrinogen biomaterial. Acta Biomaterialia. 2007;3:33-41. (Pubitemid 44804303)
111. Saha K, Pollock JF, Schaffer DV, et al. Designing synthetic materials to control stem cell phenotype. Curr Opin Chem Biol. 2007;11:381-387. (Pubitemid 47302843)
112. ChristmanKL,VardanianAJ, Fang Q, et al. Injectable fibrin scaffold improves cell transplant survival, reduces infarct expansion, and induces neovasculature formation in ischemic myocardium. J Am Coll Cardiol. 2004;44:654-660. (Pubitemid 39089073)
113. Zhang G, Hu Q, Braunlin EA, et al. Enhancing efficacy of stem cell transplantation to the heart with a PEGylated fibrin biomatrix. Tissue Eng Part A. 2008;14:1025-1036. (Pubitemid 351862226)
114. Habib M, Shapira-Schweitzer K, Caspi O, et al. A combined cell therapy and in-situ tissue-engineering approach for myocardial repair. Biomaterials. 2011;32:7514-7523.
115. Davis ME, Motion JP, Narmoneva DA, et al. Injectable self-assembling peptide nanofibers create intramyocardial microenvironments for endothelial cells. Circulation. 2005;111:442-450. (Pubitemid 40204428)
116. Orens JB, Garrity ER. General overview of lung transplantation and review of organ allocation. Proc Am Thorac Soc. 2009;6:13-19.
117. Grillo HC. Tracheal replacement: a critical review. Ann Thorac Surg. 2002;73:1995-2004. (Pubitemid 34596770)
118. Doss AE, Dunn SS, Kucera KA, et al. Tracheal replacements: part 2. ASAIO J. 2007;53:631-639. (Pubitemid 47462257)
119. Bader A, Macchiarini P. Moving towards in situ tracheal regeneration: the bionic tissue engineered transplantation approach. J Cell Mol Med. 2010;14:1877-1889.
120. Kalathur M, Baiguera S, Macchiarini P. Translating tissue-engineered tracheal replacement from bench to bedside. Cell Mol Life Sci. 2010;67:4185-4196.
121. Delaere P, Goeleven A, Poorten VV, et al. Organ preservation surgery for advanced unilateral glottic and subglottic cancer. Laryngoscope. 2007;117:1764-1769. (Pubitemid 47508707)
122. Omori K, Tada Y, Suzuki T, et al. Clinical application of in situ tissue engineering using a scaffolding technique for reconstruction of the larynx and trachea. Ann Otol Rhinol Laryngol. 2008;117:673-678.
123. Huber JE, Spievack A, Simmons-Byrd A, et al. Extracellular matrix as a scaffold for laryngeal reconstruction. Ann Otol Rhinol Laryngol. 2003;112:428-433. (Pubitemid 36617556)
124. Ringel RL, Kahane JC, Hillsamer PJ, et al. The application of tissue engineering procedures to repair the larynx. J Speech Lang Hear Res. 2006;49:194-208. (Pubitemid 46940124)
125. Lwebuga-Mukasa JS, Ingbar DH, Madri JA. Repopulation of a human alveolar matrix by adult rat type II pneumocytes in vitro: a novel system for type II pneumocyte culture. Exp Cell Res. 1986;162:423-435. (Pubitemid 16131242)
126. Meguid El, Nahas A, Bello AK. Chronic kidney disease: the global challenge. Lancet. 2005;365:331-4.
127. Yen TH, Alison MR, Cook HT, et al. The cellular origin and proliferative status of regenerating renal parenchyma after mercuric chloride damage and erythropoietin treatment. Cell Prolif. 2007;40:143-156. (Pubitemid 46398812)
128. Herrera MB, Bussolati B, Bruno S, et al. Mesenchymal stem cells contribute to the renal repair of acute tubular epithelial injury. Int J Mol Med. 2004;14:1035-1041.
129. Morigi M, Introna M, Imberti B, et al. Human bone marrow mesenchymal stem cells accelerate recovery of acute renal injury and prolong survival in mice. Stem Cells. 2008;26:2075-2082.
130. Morigi M, Rota C, Montemurro T, et al. Life-sparing effect of human cord blood-mesenchymal stem cells in experimental acute kidney injury. Stem Cells. 2010;28:513-522.
131. Ross EA, Williams MJ, Hamazaki T, et al. Embryonic stem cells proliferate and differentiate when seeded into kidney scaffolds. J Am Soc Nephrol. 2009;20:2338-2347.
132. Nakayama KH, Batchelder CA, Lee CI, et al. Decellularized rhesus monkey kidney as a three-dimensional scaffold for renal tissue engineering. Tissue Eng Part A. 2010;16:2207-2216.
133. McDougal WS. Metabolic complications of urinary intestinal diversion. J Urol. 1992;147:1199-1208.
134. Atala A, Bauer SB, Hendren WH, et al. The effect of gastric augmentation on bladder function. J Urol. 1993;149:1099-1102. (Pubitemid 23133782)
135. Kaefer M, Tobin MS, Hendren WH, et al. Continent urinary diversion: the Children's Hospital experience. J Urol. 1997; 157:1394-1399. (Pubitemid 27130832)
136. Badylak SF, Lantz GC, Coffey A, et al. Small intestinal submucosa as a large diameter vascular graft in the dog. J Surg Res. 1989;47:74-80. (Pubitemid 19183414)
137. Kropp BP, Rippy MK, Badylak SF, et al. Regenerative urinary bladder augmentation using small intestinal submucosa: urodynamic and histopathologic assessment in long-term canine bladder augmentations. J Urol. 1996;155:2098-2104. (Pubitemid 26144128)
138. Kropp BP, Sawyer BD, Shannon HE, et al. Characterization of small intestinal submucosa regenerated canine detrusor: assessment of reinnervation, in vitro compliance and contractility. J Urol. 1996;156:599-607. (Pubitemid 126444884)
139. Vaught JD, Kropp BP, Sawyer BD, et al. Detrusor regeneration in the rat using porcine small intestinal submucosal grafts: functional innervation and receptor expression. J Urol. 1996;155:374-378. (Pubitemid 126426497)
140. Wefer J, Sievert KD, Schlote N, et al. Time dependent smooth muscle regeneration and maturation in a bladder acellular matrix graft: histological studies and in vivo functional evaluation. J Urol. 2001;165:1755-1759. (Pubitemid 32410303)
141. Sutherland RS, Baskin LS, Hayward SW, et al. Regeneration of bladder urothelium, smooth muscle, blood vessels and nerves into an acellular tissue matrix. J Urol. 1996;156:571-577. (Pubitemid 126444879)
142. Probst M, Dahiya R, Carrier S, et al. Reproduction of functional smooth muscle tissue and partial bladder replacement. Br J Urol. 1997;79: 505-515. (Pubitemid 28321090)
143. Yoo JJ, Meng J, Oberpenning F, et al. Bladder augmentation using allogenic bladder submucosa seeded with cells. Urology. 1998;51:221-225. (Pubitemid 28093171)
144. Piechota HJ, Dahms SE, Nunes LS, et al. In vitro functional properties of the rat bladder regenerated by the bladder acellular matrix graft. J Urol. 1998;159:1717-1724. (Pubitemid 29117390)
145. Zhang Y, Frimberger D, Cheng EY, et al. Challenges in a larger bladder replacement with cell-seeded and unseeded small intestinal submucosa grafts in a subtotal cystectomy model. BJU Int. 2006;98:1100-1105. (Pubitemid 44536466)
146. Jayo MJ, Jain D, Wagner BJ, et al. Early cellular and stromal responses in regeneration versus repair of a mammalian bladder using autologous cell and biodegradable scaffold technologies. J Urol. 2008;180:392-397.
147. Atala A. Tissue engineering in urologic surgery. Urol Clin N Am. 1998;25: 39-50. (Pubitemid 28125396)
148. AtalaA. Thismonth in investigative urology: commentary on the replacement of urologic associated mucosa [comment]. J Urol. 1996;156:338-339.
149. Mangera A, Chapple CR. Tissue engineering in urethral reconstruction. F1000 Med Rep. 2010;2:65.
150. Chen F, Yoo JJ, Atala A. Acellular collagen matrix as a possible "off the shelf" biomaterial for urethral repair. Urology. 1999;54:407-410. (Pubitemid 29407010)
151. Atala A, Guzman L, Retik AB. A novel inert collagen matrix for hypospadias repair. J Urol. 1999;162:1148-1151. (Pubitemid 29434692)
152. El-Kassaby AW, Retik AB, Yoo JJ, et al. Urethral stricture repair with an off-the-shelf collagen matrix. J Urol. 2003;169:170-173; discussion 173. (Pubitemid 35461579)
153. El-Kassaby A, AbouShwareb T, Atala A. Randomized comparative study between buccal mucosal and acellular bladder matrix grafts in complex anterior urethral strictures. J Urol. 2008;179:1432-1436.
154. De Filippo RE, Yoo JJ, Atala A. Urethral replacement using cell seeded tubularized collagen matrices. J Urol. 2002; 168:1789-1792; discussion 1792-1783. (Pubitemid 35034086)
155. Kim BS, Atala A, Yoo JJ. A collagen matrix derived from bladder can be used to engineer smooth muscle tissue. World J Urol. 2008;26:307-314.
156. Dorin RP, Pohl HG, De Filippo RE, et al. Tubularized urethral replacement with unseeded matrices: what is the maximum distance for normal tissue regeneration? World J Urol. 2008;26:323-326.
157. Le Roux PJ. Endoscopic urethroplasty with unseeded small intestinal submucosa collagen matrix grafts: a pilot study. J Urol. 2005;173:140-143. (Pubitemid 39627695)
158. Farhat WA, Yeger H. Does mechanical stimulation have any role in urinary bladder tissue engineering? World J Urol. 2008;26:301-305.
159. Devarapalli M, Lawrence BJ, Madihally SV. Modeling nutrient consumptions in large flow-through bioreactors for tissue engineering. Biotechnol Bioeng. 2009;103:1003-1015.
160. Fioretto P, Sutherland DE, Najafian B, Mauer M. Remodeling of renal interstitial and tubular lesions in pancreas transplant recipients. Kidney Int. 2006;69:907-912.
161. Sutherland DE, Gruessner AC. Long-term results after pancreas transplantation. Transplant Proc. 2007;39:2323-2325. (Pubitemid 47418188)
162. Korsgren O, Lundgren T, Felldin M, et al.Optimising islet engraftment is critical for successful clinical islet transplantation. Diabetologia. 2008;51:227-232.
163. Mahmoud IM, Gabr MM, Refaie AF, et al. Purified murine islet allografts: islet engraftment as influenced by implantation site and glucotoxicity. Transplant Proc. 1998:30:369-372. (Pubitemid 28207207)
164. Watt PC, Mullen Y, Nomura Y, et al. Successful engraftment of autologous and allogeneic islets into the porcine thymus. J Surg Res. 1994;56:367-371. (Pubitemid 24129879)
165. Farney AC, Hering BJ, Nelson L, et al. No late failures of intraportal human islet autografts beyond 2 years. Transplant Proc. 1998;30:420. (Pubitemid 28207231)
166. Shapiro AM, Lakey JR, Ryan EA, et al. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med. 2000;343:230-238. (Pubitemid 30490390)
167. Shapiro AM, Ricordi C, Hering BJ, et al. International trial of the Edmonton protocol for islet transplantation. N Engl J Med. 2006;355:1318-1330. (Pubitemid 44465460)
168. Aguayo-Mazzucato C, Bonner-Weir S. Stem cell therapy for type 1 diabetes mellitus. Nat Rev Endocrinol. 2010;6:139-148.
169. D'Amour KA, Bang AG, Eliazer S, et al. Production of pancreatic hormoneexpressing endocrine cells from human embryonic stem cells. Nat Biotechnol. 2006;24:1392-1401. (Pubitemid 44722103)
170. Shi Y. Generation of functional insulin-producing cells from human embryonic stem cells in vitro. Methods Mol Biol. 2010;636:79-85.
171. Chandra VGS, Phadnis S, et al. Generation of pancreatic hormone-expressing islet-like cell aggregates from murine adipose tissue-derived stem cells. Stem Cells. 2009;27:1941-1953.
172. Ezquer FE, EzquerME, Parrau DB, et al. Systemic administration ofmultipotent mesenchymal stromal cells reverts hyperglycemia and prevents nephropathy in type 1 diabetic mice. Biol Blood Marrow Transplant. 2008;14:631-640.
173. Gabr MM, Sobh MM, Zakaria MM, et al. Transplantation of insulinproducing clusters derived from adult bone marrowstem cells to treat diabetes in rats. Exp Clin Transplant. 2008;6:236-243.
174. Kroon E, Martinson LA, Kadoya K, et al. Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo. Nat Biotechnol. 2008;26:443-452. (Pubitemid 351501814)
175. Couri CE, Oliveira MC, Stracieri AB, et al. C-peptide levels and insulin independence following autologous nonmyeloablative hematopoietic stem cell transplantation in newly diagnosed type 1 diabetes mellitus. JAMA. 2009;301:1573-1579.
176. Chiou SH, Chen SJ, Chang YL, et al. MafA promotes the reprogramming of placenta-derived multipotent stem cells into pancreatic islets-like and insulinpositive cells. J Cell MolMed. 2011;15:612-662.
177. Bernardo AS, Cho CH, Mason S, et al. Biphasic induction of Pdx1 in mouse and human embryonic stem cells can mimic development of pancreatic betacells. Stem CellS. 2009;27:341-351.
178. Shimizu H, Ohashi K, Utoh R, et al. Bioengineering of a functional sheet of islet cells for the treatment of diabetes mellitus. Biomaterials. 2009;30:5943-5949.
179. Mao GH, Chen GA, Bai HY, et al. The reversal of hyperglycaemia in diabetic mice using PLGA scaffolds seeded with islet-like cells derived from human embryonic stem cells. Biomaterials. 2009;30:1706-1714.
180. Wang X,Ye K. Three-dimensional differentiation of embryonic stem cells into islet-like insulin-producing clusters. Tissue Eng Part A. 2009;15:1941-1952.
181. Badylak SF, Taylor D, Uygun K. Whole-organ tissue engineering: decellularization and recellularization of three-dimensional matrix scaffolds. Annu Rev Biomed Eng. 2010 Jul 21. 2011;13:27-53.
182. De Carlo E, Baiguera S, Conconi MT, et al. Pancreatic acellular matrix supports islet survival and function in a synthetic tubular device: in vitro and in vivo studies. Int J Mol Med. 2010;25:195-202.
183. Cooper DK, Dorling A, Pierson RN III, et al. Alpha1,3- galactosyltransferase gene-knockout pigs for xenotransplantation: where do we go from here? Transplantation. 2007;84:1-7. (Pubitemid 47094631)
184. Posselt AM, Szot GL, Frassetto LA, et al. Islet transplantation in type 1 diabetic patients using calcineurin inhibitor-free immunosuppressive protocols based on T-cell adhesion or costimulation blockade. Transplantation. 2010;90:1595-601.
185. Hoesli CA, Lu M, Piret JM. A novel alginate hollow fiber bioreactor process for cellular therapy applications. Biotechnol Prog. 2009;25:1740-1751.
186. Jain K, Yang H, Cai BR, et al. Retrievable, replaceable, macroencapsulated pancreatic islet xenografts: long-term engraftment without immunosuppression. Transplantation. 1995;59:319-324.
187. Cornolti R, Figliuzzi M, Remuzzi A. Effect of micro-andmacroencapsulation on oxygen consumption by pancreatic islets. Cell Transplant. 2009;18:195-201.
188. Gimi B, Kwon J, Kuznetsov A, et al. A nanoporous, transparent microcontainer for encapsulated islet therapy. J Diabetes Sci Technol. 2009;3:297-303.
189. Opara EC, Mirmalek-Sani SH, Khanna O, Moya ML, Brey EM. Design of a bioartificial pancreas(+). J Investig Med. 2010;58:831-837.
190. Lechler RI, Sykes M, Thomson AW, Turka LA. Organ transplantation-how much of the promise has been realized? Nat Med. 2005;11:605-613. (Pubitemid 40868300)
191. Grossman M, Raper SE, Kozarsky K, et al. Successful ex vivo gene therapy directed to liver in a patient with familial hypercholesterolaemia. Nat Genet. 1994;6:335-341. (Pubitemid 24190015)
192. Grossman M, Rader DJ, Muller DW, et al. A pilot study of ex vivo gene therapy for homozygous familial hypercholesterolaemia. NatMed. 1995;1:1148-1154.
193. Fox IJ, Chowdhury JR, Kaufman SS, et al.Treatment of theCrigler-Najjar syndrome type I with hepatocyte transplantation. N Engl JMed. 1998;338:1422-1426. (Pubitemid 28221983)
194. Horslen SP, McCowan TC, Goertzen TC, et al. Isolated hepatocyte transplantation in an infant with a severe urea cycle disorder. Pediatrics. 2003; 111:1262-1267. (Pubitemid 36682258)
195. Ambrosino G, Varotto S, Strom SC, et al. Isolated hepatocyte transplantation for Crigler-Najjar syndrome type 1. Cell Transplant. 2005;14:151-157. (Pubitemid 40604958)
196. Muraca M, Gerunda G, Neri D, et al.Hepatocyte transplantation as a treatment for glycogen storage disease type 1a. Lancet. 2002;359:317-318. (Pubitemid 34119297)
197. Sokal EM, Smets F, Bourgois A, et al. Hepatocyte transplantation in a 4-yearold girl with peroxisomal biogenesis disease: technique, safety, andmetabolic follow-up. Transplantation. 2003;76:735-738. (Pubitemid 37072014)
198. Strom SC, Fisher RA, Thompson MT, et al. Hepatocyte transplantation as a bridge to orthotopic liver transplantation in terminal liver failure. Transplantation. 1997;63:559-569. (Pubitemid 27102626)
199. Strom SC, Chowdhury JR, Fox IJ. Hepatocyte transplantation for the treatment of human disease. Semin Liver Dis. 1999;19:39-48. (Pubitemid 29220830)
200. Strom SC, Fisher RA, Rubinstein WS, et al. Transplantation of human hepatocytes. Transplant Proc. 1997;29:2103-2106. (Pubitemid 27265252)
201. Combs C, Brunt EM, Solomon H, et al. Rapid development of hepatic alpha1-antitrypsin globules after liver transplantation for chronic hepatitis C. Gastroenterology. 1997;112:1372-1375. (Pubitemid 27157552)
202. Mito M, Kusano M, Kawaura Y. Hepatocyte transplantation in man. Transplant Proc. 1992;24:3052-3053. (Pubitemid 23011826)
203. Fisher RA, Strom SC. Human hepatocyte transplantation: worldwide results. Transplantation. 2006;82:441-449. (Pubitemid 44290247)
204. Kharaziha P, Hellstrom PM, Noorinayer B, et al. Improvement of liver function in liver cirrhosis patients after autologous mesenchymal stem cell injection: a phase I-II clinical trial. Eur J Gastroenterol Hepatol. 2009;21:1199-1205.
205. SalamaH, Zekri AR, ZernM, et al. Autologous hematopoietic stem cell transplantation in 48 patientswith end-stage chronic liver diseases. Cell Transplant. 2010;19:1475-1486.
206. Zacharoulis D, Milicevic MN, Helmy S, et al. Autologous infusion of expanded mobilized adult bone marrow-derived CD34+ cells into patients with alcoholic liver cirrhosis. Am J Gastroenterol. 2008;103:1952-1958.
207. Khan AA, Shaik MV, Parveen N, et al. Human fetal liver derived stem cell transplantation as supportive modality in the management of end-stage decompensated liver cirrhosis. Cell Transplant. 2010;19:409-418.
208. Schmelzer E, Zhang L, Bruce A, et al. Human hepatic stem cells from fetal and postnatal donors. J ExpMed. 2007;204:1973-1987. (Pubitemid 47236331)
209. Gouon-Evans V, Boussemart L, Gadue P, et al. BMP-4 is required for hepatic specification of mouse embryonic stem cell-derived definitive endoderm. Nat Biotechnol. 2006;24:1402-1411. (Pubitemid 44722104)
210. Gadue P, Huber TL, Paddison PJ,KellerGM. Wnt and TGF-beta signaling are required for the induction of an in vitro model of primitive streak formation using embryonic stem cells. Proc Natl Acad SciUSA. 2006;103:16806-16811. (Pubitemid 44737334)
211. Basma H, Soto-Gutierrez A, Yannam GR, et al. Differentiation and transplantation of human embryonic stem cell-derived hepatocytes. Gastroenterology. 2009;136:990-999.
212. Yang J, Yamato M, Shimizu T, et al. Reconstruction of functional tissues with cell sheet engineering. Biomaterials. 2007;28:5033-5043. (Pubitemid 47488500)
213. Ohashi K, Yokoyama T, Yamato M, et al. Engineering functional two-and three-dimensional liver systems in vivo using hepatic tissue sheets. Nat Med. 2007;13:880-885. (Pubitemid 47038184)
214. Hecker L, Baar K, Dennis RG, et al. Development of a three-dimensional physiological model of the internal anal sphincter bioengineered in vitro from isolated smooth muscle cells. Am J Physiol Gastrointest Liver Physiol. 2005;289: G188-G196. (Pubitemid 41022743)
215. Somara S, Gilmont RR, Dennis RG, et al. Bioengineered internal anal sphincter derived from isolated human internal anal sphincter smooth muscle cells. Gastroenterology. 2009;137:53-61.
216. Raghavan S, Miyasaka EA, Hashish M, et al. Successful implantation of physiologically functional bioengineered mouse internal anal sphincter. Am J Physiol Gastrointest Liver Physiol. 2010;299:G430-G439.
217. LeeM,Wu BM, Stelzner M, et al. Intestinal smooth muscle cell maintenance by basic fibroblast growth factor. Tissue Eng Part A. 2008;14:1395-1402.
218. Miyasaka EA, Raghavan S, Gilmont RR, et al. In vivo growth of a bioengineered internal anal sphincter: comparison of growth factors for optimization of growth and survival. Pediatr Surg Int. 2011;27:137-143.
219. Freud E, Efrati I, Kidron D, et al. Comparative experimental study of esophageal wall regeneration after prosthetic replacement. J Biomed Mater Res. 1999;45:84-91. (Pubitemid 29114155)
220. Nakase Y, Nakamura T, Kin S, et al. Intrathoracic esophageal replacement by in situ tissue-engineered esophagus. J Thorac Cardiovasc Surg. 2008;136: 850-859.
221. Hori Y, Nakamura T, Kimura D, et al. Functional analysis of the tissueengineered stomach wall. Artif Organs. 2002;26:868-872. (Pubitemid 36005547)
222. Grikscheit TC, Siddique A, Ochoa ER, et al. Tissue-engineered small intestine improves recovery after massive small bowel resection. Ann Surg. 2004;240:748-754. (Pubitemid 39425765)
223. Chen MK, Badylak SF. Small bowel tissue engineering using small intestinal submucosa as a scaffold. J Surg Res. 2001;99:352-358. (Pubitemid 32703459)
224. Gilmont RR, Somara S, Srinivasan S, Raghavan S, Bitar KN. IAS smooth muscle cells direct the differentiation of neuronal progenitor cells into mature neurons. Gastroenterology. 2010;138:S110.
225. Raghavan S, Gilmont RRS, Sita Srinivasan S, Bitar KN. Physiology of intrinsically innervated bioengineered construct from human internal anal sphincter smooth muscle cells. Gastroenterology. 2010;138:S31.
226. Mertsching H, Schanz J, Steger V, et al. Generation and transplantation of an autologous vascularized bioartificial human tissue. Transplantation. 2009;88:203-210.
227. Soucacos PN, Johnson EO, Babis G. An update on recent advances in bone regeneration. Injury. 2008;39:S1-S4.
228. Gates CB, Karthikeyan T, Fu F, Huard J. Regenerative medicine for the musculoskeletal system based on muscle-derived stem cells. J Am Acad Orthop Surg. 2008;16:68-76.
229. Lu HH, Subramony SD, Boushell MK, Zhang X. Tissue engineering strategies for the regeneration of orthopedic interfaces. Ann Biomed Eng. 2010;38:2142-2154.
230. Ahmed TA, Hincke MT. Strategies for articular cartilage lesion repair and functional restoration. Tissue Eng Part B Rev. 2010;16:305-329.
231. Battiston B, Raimondo S, Tos P, et al. Tissue engineering of peripheral nerves. Int Rev Neurobiol. 2009;87:227-249.
232. Peng H, Huard J.Muscle-derived stem cells for musculoskeletal tissue regeneration and repair. Transpl Immunol. 2004;12:311-319. (Pubitemid 38639726)
233. Barry FP, Murphy JM. Mesenchymal stem cells: clinical applications and biological characterization. Int J Biochem Cell Biol. 2004;36:568-584. (Pubitemid 38324589)
234. Holzer N, Hogendoorn S, Z̈urcher L, et al. Autologous transplantation of porcine myogenic precursor cells in skeletal muscle. Neuromuscul Disord. 2005;15:237-244. (Pubitemid 40255779)
235. Burt RK, Loh Y, Pearce W, et al. Clinical applications of blood-derived and marrow-derived stem cells for nonmalignant diseases. JAMA. 2008;299:925-936. (Pubitemid 351397068)
236. Poehling GG, Curl WW, Lee CA, et al. Analysis of outcomes of anterior cruciate ligament repair with 5-year follow-up: allograft versus autograft. Arthroscopy. 2005;21:774-785. (Pubitemid 40984666)
237. Meek MF, Coert JH. US Food and Drug Administration/Conformit Europeapproved absorbable nerve conduits for clinical repair of peripheral and cranial nerves. Ann Plast Surg. 2008;60:466-472.
238. McKay WF, Peckham SM, Badura JM. A comprehensive clinical review of recombinant human bone morphogenetic protein-2 (INFUSE Bone Graft). Int Orthop. 2007;31:729-734. (Pubitemid 350160311)
239. Langer R, Vacanti JP. Tissue engineering. Science. 1993; 260:920-926. (Pubitemid 23209960)
240. Furth ME, Atala A, Van Dyke ME. Smart biomaterials design for tissue engineering and regenerative medicine. Biomaterials. 2007;28: 5068-5073. (Pubitemid 47488490)
241. CooperML, Spielvogel RL. Artificial skin for wound healing. Clin Dermatol. 1994;12:183-191.
242. Anderson JM,RodriguezA,Chang DT. Foreign body reaction to biomaterials. Semin Immunol. 2008;20:86-100.
243. Mieszawska AJ, Kaplan DL. Smart biomaterials-regulating cell behavior through signaling molecules. BMC Biol. 2010;8:59.
244. Lutolf MP, Gilbert PM, Blau HM. Designing materials to direct stem-cell fate. Nature. 2009;462:433-441.
245. Biondi M, Ungaro F, Quaglia F, et al. Controlled drug delivery in tissue engineering. Adv Drug Deliv Rev. 2008;60:229-242. (Pubitemid 350236401)
246. Hollister SJ. Porous scaffold design for tissue engineering. Nat Mater. 2005;4:518-524. (Pubitemid 40952745)
247. Hoffman-Kim D, Mitchel JA, Bellamkonda RV. Topography, cell response, and nerve regeneration. Annu Rev Biomed Eng. 2010;12:203-231.
248. Nakayama K, Takakuda K,Koyama Y, et al. Enhancement of peripheral nerve regeneration using bioabsorbable polymer tubes packed with fibrin gel. Artif Organs. 2007;31:500-508. (Pubitemid 46961707)
249. Sierpinski P, Garrett J, Ma J, et al. The use of keratin biomaterials derived from human hair for the promotion of rapid regeneration of peripheral nerves. Biomaterials. 2008;29:118-128. (Pubitemid 47599650)
250. Suri S, Schmidt CE. Cell-laden hydrogel constructs of hyaluronic acid, collagen, and laminin for neural tissue engineering. Tissue Eng Part A. 2010;16:1703-1716.
251. Yoshii S, Oka M. Collagen filaments as a scaffold for nerve regeneration. J Biomed Mater Res. 2001;56:400-405. (Pubitemid 32611891)
252. Dodla MC, Bellamkonda RV. Differences between the effect of anisotropic and isotropic laminin and nerve growth factor presenting scaffolds on nerve regeneration across long peripheral nerve gaps. Biomaterials. 2008;29:33-46. (Pubitemid 47599652)
253. Taylor SJ, Sakiyama-Elbert SE. Effect of controlled delivery of neurotrophin-3 from fibrin on spinal cord injury in a long term model. J Control Release. 2006;116:204-210. (Pubitemid 44854282)
254. Ju YM, Choi JS, Atala A, et al. Bilayered scaffold for engineering cellularized blood vessels. Biomaterials. 2010;31:4313-4321.
255. Grasl C, Bergmeister H, Stoiber M, et al. Electrospun polyurethane vascular grafts: in vitro mechanical behavior and endothelial adhesion molecule expression. J Biomed Mater Res A. 2010;93:716-723.
256. Soletti L, Nieponice A, Hong Y, et al. In vivo performance of a phospholipidcoated bioerodable elastomeric graft for small-diameter vascular applications. J Biomed Mater Res A. 2011;96:436-448.
257. Hollister SJ, Lin CY, Saito E, et al. Engineering craniofacial scaffolds. Orthod Craniofac Res. 2005;8:162-173.
258. Lin CY, Schek RM, Mistry AS, et al. Functional bone engineering using ex vivo gene therapy and topology-optimized, biodegradable polymer composite scaffolds. Tissue Eng. 2005;11:1589-1598. (Pubitemid 41636443)
259. Badylak SF, Gilbert TW. Immune response to biologic scaffold materials. Semin Immunol. 2008;20:109-116.
260. Babensee JE, Anderson JM, McIntire LV, et al. Host response to tissue engineered devices. Adv Drug Deliv Rev. 1998;33:111-139. (Pubitemid 28403539)
261. Bayrak A, Tyralla M, Ladhoff J, et al. Human immune responses to porcine xenogeneic matrices and their extracellular matrix constituents in vitro. Biomaterials. 2010;31:3793-3803.
262. Daly KA, Stewart-Akers AM, Hara H, et al. Effect of the alpha-Gal epitope on the response to small intestinal submucosa extracellularmatrix in a nonhuman primate model. Tissue Eng Part A. 2009;15:3877-3888.
263. Nilsson B, Ekdahl KN, Mollnes TE, Lambris JD. The role of complement in biomaterial-induced inflammation. Molecular Immunol. 2007;44:82-94. (Pubitemid 44647107)
264. Anderson JM. Biological responses to biomaterials. Annu Rev Mater Res. 2001;31:81-110.
265. Rock KL, Latz E, Ontiveros F, et al. The sterile inflammatory response. Annu Rev Immunol. 2010;28:321-342.
266. Chen GY, Nuñez G. Sterile inflammation: sensing and reacting to damage. Nat Rev Immunol. 2010;10:826-837.