Functional bone engineering using ex vivo gene therapy and topology-optimized, biodegradable polymer composite scaffolds

Tissue Engineering

Volumn 11, Issue 9-10, 2005, Pages 1589-1598

  Lin, Chia Ying ^a   Schek, Rachel M ^a   Mistry, Amit S ^b   Shi, Xinfeng ^b   Mikos, Antonios G ^b   Krebsbach, Paul H ^a   Hollister, Scott J ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b Rice University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIODEGRADATION; BIOTECHNOLOGY; BONE; COMPUTERIZED TOMOGRAPHY; GENES; OPTIMIZATION; PATHOLOGY;

CELL DELIVERY; SPINAL FUSION; TISSUE ENGINEERING; TISSUE INVASION;

TISSUE CULTURE;

ADENOVIRUS VECTOR; CALCIUM PHOSPHATE; OSTEOGENIC PROTEIN 1; POLYMER; POLYPROPYLENE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOCOMPATIBILITY; BIODEGRADABILITY; BONE ATROPHY; BONE CONDUCTION; BONE DEVELOPMENT; BONE REGENERATION; BONE TISSUE; COMPOSITE MATERIAL; COMPRESSION; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; EX VIVO STUDY; FIBROBLAST; FRACTURE NONUNION; GENE THERAPY; HISTOLOGY; HUMAN; HUMAN CELL; JOINT PROSTHESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; RIGIDITY; SPINE FUSION; TISSUE ENGINEERING; WEIGHT BEARING;

ADENOVIRIDAE; ANIMALS; BIOCOMPATIBLE MATERIALS; BIODEGRADATION, ENVIRONMENTAL; BONE AND BONES; BONE MORPHOGENETIC PROTEINS; BONE REGENERATION; CALCIUM PHOSPHATES; CELL CULTURE TECHNIQUES; CELLS, CULTURED; COMPRESSIVE STRENGTH; EXTRACELLULAR MATRIX; FIBROBLASTS; FUMARATES; GENE THERAPY; GENETIC VECTORS; GINGIVA; HISTOCYTOCHEMISTRY; HISTOLOGICAL TECHNIQUES; HUMANS; INJECTIONS, SUBCUTANEOUS; MATERIALS TESTING; MICE; POLYMERS; POLYPROPYLENES; TIME FACTORS; TISSUE ENGINEERING; TOMOGRAPHY, X-RAY COMPUTED; TRANSFORMING GROWTH FACTOR BETA; TRANSPLANTATION, HETEROLOGOUS;

ADENOVIRIDAE; ANIMALIA;

EID: 27644595283     PISSN: 10763279     EISSN: None     Source Type: Journal    
DOI: 10.1089/ten.2005.11.1589     Document Type: Article

References (50)

1. Boden, S.D., Zdeblick, T., Sandhu, H.S., and Heim, S. The use of rhBMP-2 in interbody fusion cages: Definitive evidence of osteoinduction in humans-a preliminary report. Spine 25, 376, 2000.
2. Steinmann, J.C., and Herkowitz, H.N. Pseudarthrosis of the spine. Clin. Orthop. Relat. Res. 284, 80, 1992.
3. Summers, B.N., and Eisenstein, S.M. Donor site pain from the ilium: A complication of lumbar spine fusion. J. Bone Joint Surg. Br. 71, 677, 1989.
4. Cowley, S.P., and Anderson, L.D. Hernias through donor sites for iliac-bone grafts. J. Bone Joint Surg. Am. 65, 1023, 1983.
5. Banwart, J.C., Asher, M.A., and Hassanein, R.S. Iliac crest bone graft harvest donor site morbidity: A statistical evaluation. Spine 20, 1055, 1995.
6. Friedlaender, G. Immune responses to osteochondral allografts: Current knowledge and future directions. Clin. Orthop. Relat. Res. 174, 58, 1983.
7. Winn, S.R., Uludag, H., and Hollinger, J.O. Carrier systems for bone morphogenetic proteins. Clin. Orthop. Relat. Res. 367(Suppl.), S95, 1999.
8. Hollinger, J.O., and Leong, K. Poly(α-hydroxy acids): Carriers for bone morphogenetic proteins. Biomaterials 17, 187, 1996.
9. Langer, R., and Vacanti, J.P. Tissue engineering. Science 260, 920, 1993.
10. Hutmacher, D.W. Scaffold design and fabrication technologies for engineering tissues: State of the art and future perspectives. J. Biomater. Sci. Polym. Ed. 12, 107, 2001.
11. Simske, S., Ayers, R., and Bateman, T. Porous materials for bone regeneration. Mater. Sci. Forum 250, 151, 1997.
12. Vats, A., Tolley, N.S., Polak, J.M., and Gough, J.E. Scaffolds and biomaterials for tissue engineering: A review of clinical applications. Clin. Otolaryngol. 28, 165, 2003.
13. Hollister, S.J., Maddox, R.D., and Taboas, J.M. Optimal design and fabrication of scaffolds to mimic tissue properties and satisfy biological constraints. Biomaterials 23, 4095, 2002.
14. Mikos, A., Thorsen, A., Czerwonka, L., Bao, Y., and Langer, R. Preparation and characterisation of poly(L-lactic acid) foams. Polymer 35, 1068, 1994.
15. Mooney, D.J., Baldwin, D.F., Suh, N.P., Vacanti, J.P., and Langer, R. Novel approach to fabricate porous sponges of poly(D,L-lactic-co-glycolic acid) without the use of organic solvents. Biomaterials 17, 1417, 1996.
16. Cima, L.G., Vacanti, J.P., Vacanti, C., Ingber, D., Mooney, D., and Langer, R. Tissue engineering by cell transplantation using degradable polymer substrates. J. Biomech. Eng. 113, 143, 1991.
17. Lo, H., Ponticiello, M., and Leong, K. Fabrication of controlled release biodegradable foams by phase separation. Tissue Eng. 1, 15, 1995.
18. Thompson, R., Yaszemski, M., Powers, J., and Mikos, A. Fabrication of biodegradable polymer scaffolds to engineering trabecular bone. J. Biomater. Sci. Polym. Ed. 7, 23, 1995.
19. Whang, K., Thomas, C., Nuber, G., and Healy, K. A novel method to fabricate bioabsorbable scaffolds. Polymer 36, 837, 1995.
20. Hsu, Y.Y., Gresser, J.D., Trantolo, D.J., Lyons, C.M., Gangadharam, P.R., and Wise, D.L. Effect of polymer foam morphology and density on kinetics of in vitro controlled release of isoniazid from compressed foam matrices. J. Biomed. Mater. Res. 35, 107, 1997.
21. Yannas, I., Burke, J., Gordon, P., Huang, C., and Rubenstein, R. Design of an artificial skin. II. Control of chemical composition. Biomaterials 14, 107, 1980.
22. Vunjak-Novakovic, G., and Freed, L.E. Culture of organized cell communities. Adv. Drug Deliv. Rev. 33, 15, 1998.
23. Ishaug-Riley, S.L., Crane, G.M., Gurlek, A., Miller, M.J., Yasko, A.W., Yaszemski, M.J., and Mikos, A.G. Ectopic bone formation by marrow stromal osteoblast transplantation using poly(D,L-lactic-co-glycolic acid) foams implanted into the rat mesentery. J. Biomed. Mater. Res. 36, 1, 1997.
24. Guyton, A., and Hall, J. Textbook of Medical Physiology. Philadelphia: W.B. Saunders, 1996.
25. Martin, I., Padera, R.F., Vunjak-Novakovic, G., and Freed, L.E. In vitro differentiation of chick embryo bone marrow stromal cells into cartilaginous and bone-like tissues. J. Orthop. Res. 16, 181, 1998.
26. Lin, C.Y., Hsiao, C.C., Chen, P.Q., and Hollister, S.J. Interbody fusion cage design using integrated global layout and local microstructure topology optimization. Spine 29, 1747, 2004.
27. Lin, C.Y., Lin, C., and Hollister, S.J. A new approach for designing biodegradable bone tissue augmentation devices by using degradation topology optimization. Presented at the 8th World Multiconference on Systemics, Cybernetics and Informatics, Orlando, FL, July 18-21, 2004.
28. Bendsoe, M.P. Optimization of Structural Topology, Shape, and Material. New York: Springer-Verlag, 1995.
29. Kikuchi, N., and Suzuki, K. A homogenization method for shape and topology optimization. Comput. Methods Appl. Mech. Eng. 93, 291, 1991.
30. Sachlos, E., and Czernuszka, J.T. Making tissue engineering scaffolds work: The application of solid freeform fabrication technology to the production of tissue engineering scaffolds [review]. Eur. Cell Mater. 5, 29, 2003.
31. Taboas, J.M., Maddox, R.D., Krebsbach, P.H., and Hollister, S.J. Indirect solid free form fabrication of local and global porous, biomimetic and composite 3D polymer-ceramic scaffolds. Biomaterials 24, 181, 2003.
32. Bose, S., Darsell, J., Hosick, H., Yany, L., Sarrkar, D., and Bandyopahhyay, A. Processing and characterization of porous alumina scaffolds. J. Mater. Sci. 13, 23, 2002.
33. Chu, T.M., Hollister, S.J., Halloran, J.W., Feinberg, S.E., and Orton, D.G. Manufacturing and characterization of 3-D hydroxyapatite bone tissue engineering scaffolds. Ann. N.Y. Acad. Sci. 961, 114, 2002.
34. Frazier, D.D., Lathi, V.K., Gerhart, T.N., Altobelli, D.E., and Hayes, W.C. In vivo degradation of a poly(propylene-fumarate) biodegradable particulate composite bone cement. MRS Proc. 349, 5, 1995.
35. Yaszemski, M.J., Payne, R.G., Haynes, W.C., Langer, R., and Mikos, A.G. In vitro degradation of a poly(propylene fumarate)-based composite material. Biomaterials 17, 2127, 1996.
36. Peter, S.J., Miller, S.T., Zhu, G., Yasko, A.W., and Mikos, A.G. In vivo degradation of a poly(propylene fumarate)/β-tricalcium phosphate injectable composite scaffold. J. Biomed. Mater. Res. 41, 1, 1998.
37. Peter, S.J., Lu, L., Kim, D.J., and Mikos, A.G. Marrow stromal osteoblast function on a poly(propylene fumarate)/β-tricalcium phosphate biodegradable orthopaedic composite. Biomaterials 21, 1207, 2000.
38. Krebsbach, P.H., Gu, K., Franceschi, R.T., and Rutherford, R.B. Gene therapy-directed osteogenesis: BMP-7-transduced human fibroblasts form bone in vivo. Hum. Gene Ther. 11, 1201, 2000.
39. Gazit, D., Turgeman, G., Kelley, P., Wang, E., Jalenak, M., Zilberman, Y., and Moutsatsos, I. Engineered pluripotent mesenchymal cells integrate and differentiate in regenerating bone: A novel cell-mediated gene therapy. J. Gene Med. 1, 121, 1999.
40. Lieberman, J.R., Le, L.Q., Wu, L., Finerman, G.A., Berk, A., Witte, O.N., and Stevenson, S. Regional gene therapy with a BMP-2-producing murine stromal cell line induces heterotopic and orthotopic bone formation in rodents. J. Orthop. Res. 16, 330, 1998.
41. Rutherford, R.B., Moalli, M., Franceschi, R.T., Wang, D., Gu, K., and Krebsbach, P.M. Bone morphogenetic protein-transduced human fibroblasts convert to osteoblasts and form bone in vivo. Tissue Eng. 8, 441, 2002.
42. Schek, R.M., Taboas, J.M., Hollister, S.J., and Krebsbach, P.H. Engineered osteochondral grafts using biphasic composite solid free form fabricated scaffolds. Tissue Eng. 10, 1376, 2004.
43. Shung, A.K., Timmer, M.D., Jo, S., Engel, P.S., and Mikos, A.G. Kinetics of poly(propylene fumarate) synthesis by step polymerization of diethyl fumarate and propylene glycol using zinc chloride as a catalyst. J. Biomater. Sci. Polym. Ed. 13, 95, 2002.
44. Rutherford, R.B., TrailSmith, M.D., Ryan, M.E., and Charette, M.F. Synergistic effects of dexamethasone on platelet-derived growth factor mitogenesis in vitro. Arch. Oral Biol. 37, 139, 1992.
45. Franceschi, R.T., Wang, D., Krebsbach, P.M., and Rutherford, R.B. Gene therapy for bone formation: In vitro and in vivo osteogenic activity of an adenovirus expressing BMP7. J. Cell Biochem. 78, 476, 2000.
46. Check, E. A tragic setback. Nature 420, 116, 2002.
47. Raper, S.E., Yudkoff, M., Chirmule, N., Gao, G.P., Nunes, F., Haskal, Z.J., Furth, E.E., Propert, K.J., Robinson, M.B., Magosin, S., Simoes, H., Speicher, L., Hughes, J., Tazelaar, J., Wivel, N.A., Wilson, J.M., and Batshaw, M.L. A pilot study of in vivo liver-directed gene transfer with an adenoviral vector in partial ornithine transcarbamylase deficiency. Hum. Gene Ther. 13, 163, 2002.
48. Dettweiler, U., and Simon, P. Points to consider for ethics committees in human gene therapy trials. Bioethics 15, 491, 2001.
49. Lundstrom, K. Latest development in viral vectors for gene therapy. Trends Biotechnol. 21, 117, 2003.
50. Goulet, R.W., Goldstein, S.A., Ciarelli, M.J., Kuhn, J.L., Brown, M.B., and Feldkamp, L.A. The relationship between the structural and orthogonal compressive properties of trabecular bone. J. Biomech. 27, 375, 1994.