Optimising islet engraftment is critical for successful clinical islet transplantation

Diabetologia

Volumn 51, Issue 2, 2008, Pages 227-232

  Korsgren, O ^a   Lundgren, T ^b   Felldin, M ^c   Foss, A ^d   Isaksson, B ^b   Permert, J ^b   Persson, N H ^e   Rafael, E ^b   Ryden M ^b   Salmela, K ^f   Tibell, A ^b   Tufveson, G ^a   Nilsson, B ^a  

^a UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

^c SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

^d OSLO UNIVERSITY HOSPITAL   (Norway)

^e University Hospital   (Sweden)

^f UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Clinical; Engraftment; Innate immunity; Intramuscular; Intraportal; Islet transplantation; Liver morphology; Revascularisation; Thrombosis; Tumour metastasis

Indexed keywords

ENGRAFTMENT; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET TRANSPLANTATION; PORTAL VEIN; PRIMATE; PRIORITY JOURNAL; REVASCULARIZATION; REVIEW;

ANIMALS; DIABETES MELLITUS, TYPE 1; GRAFT SURVIVAL; HUMANS; IMMUNITY, INNATE; ISLETS OF LANGERHANS; ISLETS OF LANGERHANS TRANSPLANTATION; MODELS, BIOLOGICAL;

EID: 37549056921     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-007-0868-9     Document Type: Review

References (49)

1. Shapiro AM, Ricordi C, Hering BJ et al (2006) International trial of the Edmonton protocol for islet transplantation. N Engl J Med 355:1318-1330
2. Keymeulen B, Gillard P, Mathieu C et al (2006) Correlation between beta cell mass and glycemic control in type 1 diabetic recipients of islet cell graft. Proc Natl Acad Sci USA 103:17444-17449
3. Ryan EA, Paty BW, Senior PA et al (2005) Five-year follow-up after clinical islet transplantation. Diabetes 54:2060-2069
4. Shapiro AM, Lakey JR, Ryan EA et al (2000) Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med 343:230-238
5. Keymeulen B, Ling Z, Gorus FK et al (1998) Implantation of standardized beta-cell grafts in a liver segment of IDDM patients: graft and recipients characteristics in two cases of insulin-independence under maintenance immunosuppression for prior kidney graft. Diabetologia 41:452-459
6. van Kampen CA, van de Linde P, Duinkerken G et al (2005) Alloreactivity against repeated HLA mismatches of sequential islet grafts transplanted in non-uremic type 1 diabetes patients. Transplantation 80:118-126
7. Desai NM, Goss JA, Deng S et al (2003) Elevated portal vein drug levels of sirolimus and tacrolimus in islet transplant recipients: local immunosuppression or islet toxicity. Transplantation 76:1623-1625
8. Shapiro AM, Gallant HL, Hao EG et al (2005) The portal immunosuppressive storm: relevance to islet transplantation. Ther Drug Monit 27:35-37
9. Unger RH (1991) Diabetic hyperglycemia: link to impaired glucose transport in pancreatic beta cells. Science 251:1200-1205
10. Unger RH, Orci L (2002) Lipoapoptosis: its mechanism and its diseases. Biochim Biophys Acta 1585:202-212
11. Lee Y, Ravazzola M, Park B, Bashmakov Y, Orci L, Unger R (2007) Metabolic mechanisms of failure of intraportally transplanted pancreatic beta-cells in rats: role of lipotoxicity and prevention by leptin. Diabetes 56:2295-2301
12. MacDonald IC, Groom AC, Chambers AF (2002) Cancer spread and micrometastasis development: quantitative approaches for in vivo models. Bioessays 24:885-893
13. Gonda T, Ishida H, Yoshinaga K, Sugihara K (2000) Microvasculature of small liver metastases in rats. J Surg Res 94:43-48
14. Graf W, Sundin A, Glimelius B, Ahlstrom H, Carlsson J (1992) Induction and quantification of hepatic metastases from a human colonic cancer in the nude rat. Eur J Surg Oncol 18:608-614
15. Lehmann R, Zuellig RA, Kugelmeier P et al (2007) Superiority of small islets in human islet transplantation. Diabetes 56:594-603
16. Dunger A, Korsgren O, Andersson A (1990) DNA replication in mouse pancreatic islets transplanted subcapsularly into the kidney or intraportally into the liver. Influence of unilateral nephrectomy or partial hepatectomy. Transplantation 49:686-689
17. Nakano M, Yasunami Y, Maki T et al (2000) Hepatocyte growth factor is essential for amelioration of hyperglycemia in streptozotocin-induced diabetic mice receiving a marginal mass of intrahepatic islet grafts. Transplantation 69:214-221
18. Andersson A, Korsgren O, Jansson L (1989) Intraportally transplanted pancreatic islets revascularized from hepatic arterial system. Diabetes 1(38 Suppl):192-195
19. Lau J, Jansson L, Carlsson PO (2006) Islets transplanted intraportally into the liver are stimulated to insulin and glucagon release exclusively through the hepatic artery. Am J Transplant 6:967-975
20. Davalli AM, Maffi P, Socci C et al (2000) Insights from a successful case of intrahepatic islet transplantation into a type 1 diabetic patient. J Clin Endocrinol Metab 85:3847-3852
21. Oberholzer J, Mathe Z, Bucher P et al (2003) Islet autotransplantation after left pancreatectomy for non-enucleable insulinoma. Am J Transplant 3:1302-1307
22. Adams AB, Shirasugi N, Durham MM et al (2002) Calcineurin inhibitor-free CD28 blockade-based protocol protects allogeneic islets in nonhuman primates. Diabetes 51:265-270
23. Adams AB, Shirasugi N, Jones TR et al (2005) Development of a chimeric anti-CD40 monoclonal antibody that synergizes with LEA29Y to prolong islet allograft survival. J Immunol 174:542-550
24. Hirshberg B, Mog S, Patterson N, Leconte J, Harlan DM (2002) Histopathological study of intrahepatic islets transplanted in the nonhuman primate model using Edmonton protocol immunosuppression. J Clin Endocrinol Metab 87:5424-5429
25. Hirshberg B, Montgomery S, Wysoki MG et al (2002) Pancreatic islet transplantation using the nonhuman primate (rhesus) model predicts that the portal vein is superior to the celiac artery as the islet infusion site. Diabetes 51:2135-2140
26. Kawai T, Sogawa H, Koulmanda M et al (2001) Long-term islet allograft function in the absence of chronic immunosuppression: a case report of a nonhuman primate previously made tolerant to a renal allograft from the same donor. Transplantation 72:351-354
27. Kenyon NS, Fernandez LA, Lehmann R et al (1999) Long-term survival and function of intrahepatic islet allografts in baboons treated with humanized anti-CD154. Diabetes 48:1473-1481
28. Koulmanda M, Smith RN, Qipo A, Weir G, Auchincloss H, Strom TB (2006) Prolonged survival of allogeneic islets in cynomolgus monkeys after short-term anti-CD154-based therapy: nonimmunologic graft failure. Am J Transplant 6:687-696
29. Levisetti MG, Padrid PA, Szot GL et al (1997) Immunosuppressive effects of human CTLA4Ig in a non-human primate model of allogeneic pancreatic islet transplantation. J Immunol 159:5187-5191
30. Wijkstrom M, Kenyon NS, Kirchhof N et al (2004) Islet allograft survival in nonhuman primates immunosuppressed with basiliximab, RAD, and FTY720. Transplantation 77:827-835
31. Moberg L, Johansson H, Lukinius A et al (2002) Production of tissue factor by pancreatic islet cells as a trigger of detrimental thrombotic reactions in clinical islet transplantation. Lancet 360:2039-2045
32. Kemp CB, Knight MJ, Scharp DW, Ballinger WF, Lacy PE (1973) Effect of transplantation site on the results of pancreatic islet isografts in diabetic rats. Diabetologia 9:486-491
33. Hiller WF, Klempnauer J, Luck R, Steiniger B (1991) Progressive deterioration of endocrine function after intraportal but not kidney subcapsular rat islet transplantation. Diabetes 40:134-140
34. Evans MG, Warnock GL, Rajotte RV (1989) Comparison of sites for transplantation of canine pancreatic microfragments. Diabetes Res 10:35-41
35. Warnock GL, Dabbs KD, Evans MG, Cattral MS, Kneteman NM, Rajotte RV (1990) Critical mass of islets that function after implantation in a large mammalian. Horm Metab Res Suppl 25:156-161
36. Dombrowski F, Mathieu C, Evert M (2006) Hepatocellular neoplasms induced by low-number pancreatic islet transplants in autoimmune diabetic BB/Pfd rats. Cancer Res 66:1833-1843
37. Bhargava R, Senior PA, Ackerman TE et al (2004) Prevalence of hepatic steatosis after islet transplantation and its relation to graft function. Diabetes 53:1311-1317
38. Markmann JF, Rosen M, Siegelman ES et al (2003) Magnetic resonance-defined periportal steatosis following intraportal islet transplantation: a functional footprint of islet graft survival. Diabetes 52:1591-1594
39. Yasunami Y, Lacy PE, Finke EH (1983) A new site for islet transplantation-a peritoneal-omental pouch. Transplantation 36:181-182
40. Kenyon N, Berman D, O'Neil J et al (2007) Long-term survival of cynomolgus monkey islets implanted in an omental pouch site on tissue engineered scaffolds. Am J Transplant 7 Abstr 1653:572
41. Wells SA Jr, Gunnells JC, Shelburne JD, Schneider AB, Sherwood LM (1975) Transplantation of the parathyroid glands in man: clinical indications and results. Surgery 78:34-44
42. Tominaga Y, Uchida K, Haba T et al (2001) More than 1,000 cases of total parathyroidectomy with forearm autograft for renal hyperparathyroidism. Am J Kidney Dis 38:S168-171
43. Axen KV, Pi-Sunyer FX (1981) Long-term reversal of streptozotocin-induced diabetes in rats by intramuscular islet implantation. Transplantation 31:439-441
44. Dafoe DC, Wang X, Tafra L, Berezniak R, Lloyd RV (1992) Studies of composite grafts of fetal pancreas (FP) and fetal liver (FL) in the streptozotocin-induced diabetic rat. Adv Exp Med Biol 321:171-177
45. Weber CJ, Hardy MA, Pi-Sunyer F, Zimmerman E, Reemtsma K (1978) Tissue culture preservation and intramuscular transplantation of pancreatic islets. Surgery 84:166-174
46. Jovanovic-Peterson L, Williams K, Brennan M, Rashbaum W, Peterson CM (1989) Studies of human fetal pancreatic allografts in diabetic recipients without immunosuppression. J Diabet Complications 3:107-112
47. Tuch BE, Sheil AG, Ng AB, Turtle JR (1986) Long-term survival of human fetal pancreatic tissue transplanted into an insulin-dependent diabetic patient. Diabet Med 3:24-28
48. Johansson U, Elgue G, Nilsson B, Korsgren O (2005) Composite islet-endothelial cell grafts: a novel approach to counteract innate immunity in islet transplantation. Am J Transplant 5:2632-2639
49. Rafael E, Tibell A, Ryden M et al (2007) Intramuscular autotransplantation of pancreatic islets in a 7-year old child: a two year follow up. Am J Transplant DOI 10.1111/j.1600-6143.2007.02060.x