Modeling nutrient consumptions in large flow-through bioreactors for tissue engineering

Biotechnology and Bioengineering

Volumn 103, Issue 5, 2009, Pages 1003-1015

  Devarapalli, Mamatha ^a   Lawrence, Benjamin J ^a   Madihally, Sundararajan V ^a  

^a Oklahoma State University   (United States)

Author keywords

Bioreactor; Glucose; Nutrient consumption; Oxygen; Pore number; Pore size; Shear stress; Tissue regeneration

Indexed keywords

BRINKMAN EQUATION; CELL NUMBER; CELL TYPES; CHONDROCYTES; CONVECTIVE DIFFUSION EQUATIONS; DYNAMIC PROCESS; FLOWTHROUGH; FLUID FLOW; FUNDAMENTAL CONCEPTS; HEPATOCYTES; HIGH ASPECT RATIO; HIGH-FLOW RATE; HYDRODYNAMIC STRESS; IN-CELL; LARGE SURFACE AREA; MATRIX; MATRIX COMPONENTS; MICHAELIS-MENTEN; MINIMUM FLOW; NEW DESIGN; NONUNIFORM; NONUNIFORMITY; NUTRIENT CONSUMPTION; NUTRIENT DISTRIBUTIONS; PORE CHARACTERISTICS; PORE NUMBER; POROUS ARCHITECTURES; POROUS STRUCTURES; RATE LAWS; SHEAR STRESS DISTRIBUTION; TISSUE REGENERATION; TRANSPORT CHARACTERISTICS;

ASPECT RATIO; BIOCONVERSION; BIOREACTORS; CELL MEMBRANES; COMPUTATIONAL FLUID DYNAMICS; FLOW RATE; FLUID DYNAMICS; GLUCOSE; HYDRODYNAMICS; INDUSTRIAL CHEMICALS; NUTRIENTS; ORGANIC POLYMERS; OXYGEN; PHOTORESISTS; PORE SIZE; PRESSURE DROP; RATE CONSTANTS; SHEAR STRESS; STRENGTH OF MATERIALS; STRESS CONCENTRATION; TISSUE;

TISSUE ENGINEERING;

GLUCOSE; OXYGEN;

ARTICLE; BIOREACTOR; CARTILAGE CELL; CELL DENSITY; COMPUTATIONAL FLUID DYNAMICS; CONCENTRATION RESPONSE; CONTROLLED STUDY; FLOW RATE; FLUID FLOW; GLUCOSE TRANSPORT; LIVER CELL; MICHAELIS CONSTANT; MICHAELIS MENTEN KINETICS; NUTRIENT UPTAKE; OXYGEN CONSUMPTION; PRESSURE GRADIENT; SHEAR STRESS; SIMULATION; SMOOTH MUSCLE FIBER; STEADY STATE; TIME; TISSUE ENGINEERING; TISSUE REGENERATION;

BIOREACTORS; CULTURE MEDIA; FOOD; OXYGEN CONSUMPTION; STRESS, MECHANICAL; TISSUE ENGINEERING;

EID: 67650796913     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.22333     Document Type: Article

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