Strategies for articular cartilage lesion repair and functional restoration

Tissue Engineering - Part B: Reviews

Volumn 16, Issue 3, 2010, Pages 305-329

  Ahmed, Tamer A E ^a   Hincke, Maxwell T ^a  

^a UNIVERSITY OF OTTAWA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICULAR CARTILAGES; AUTOLOGOUS CHONDROCYTE IMPLANTATIONS; AUTOLOGOUS CHONDROCYTE TRANSPLANTATIONS; CHONDROCYTES; CLINICAL OUTCOME; COLLAGEN I; ECONOMIC BURDEN; FIBRIN GLUE; HYALOGRAFT; INNOVATIVE APPROACHES; INTEGRATION CAPABILITY; KNEE INJURY; KNEE JOINT; KNEE REPLACEMENT; MATRIX; MINIMALLY INVASIVE; ORTHOPEDIC COMMUNITY; OSTEOCHONDRAL; PATHOLOGICAL CONDITIONS; POLY GLYCOLIC ACID; SHORT TERM; TISSUE ENGINEERED CARTILAGE;

BIOMECHANICS; BODY FLUIDS; COLLAGEN; GLUES; GLUING; GRAFTS; JOINT PROSTHESES; JOINTS (ANATOMY); LIGAMENTS; RESTORATION; TISSUE ENGINEERING; ULTRASONIC MEASUREMENT;

CARTILAGE;

AGAROSE; ALGINIC ACID; ANALGESIC AGENT; CARBOHYDRATE DERIVATIVE; CHITIN; CHITOSAN; CHONDROITIN SULFATE; COLLAGEN; COLLAGEN TYPE 1; COLLAGEN TYPE 3; FIBRIN; FIBRIN GLUE; GELATIN; GLUCOSAMINE; HYALURONIC ACID; MACROGOL; NONSTEROID ANTIINFLAMMATORY AGENT; OPIATE; PARACETAMOL; PLACEBO; POLYCAPROLACTONE; POLYGLACTIN; POLYGLYCOLIC ACID; RECOMBINANT OSTEOGENIC PROTEIN 1; STEROID; TRAMADOL; TRANSFORMING GROWTH FACTOR BETA1;

ARTICULAR CARTILAGE; BIOMECHANICS; CARTILAGE GRAFT; CARTILAGE TRANSPLANTATION; CHONDROPATHY; CONSERVATIVE TREATMENT; DEBRIDEMENT; HUMAN; KNEE ARTHROPLASTY; KNEE ARTHROSCOPY; KNEE INJURY; KNEE PAIN; KNEE SURGERY; LAVAGE; MICROFRACTURE; MOSAICPLASTY; NONVIRAL GENE THERAPY; OUTCOME ASSESSMENT; PHYSIOTHERAPY; PRIORITY JOURNAL; REVIEW; STEM CELL GENE THERAPY; SURGICAL TECHNIQUE; TIBIA OSTEOTOMY; TISSUE ENGINEERING; VIRAL GENE THERAPY;

ARTHROPLASTY, REPLACEMENT, KNEE; CARTILAGE, ARTICULAR; CHONDROCYTES; HUMANS; KNEE INJURIES; KNEE JOINT; MODELS, BIOLOGICAL; ORTHOPEDIC PROCEDURES; TISSUE ENGINEERING; WOUND HEALING;

EID: 77952898790     PISSN: 19373368     EISSN: None     Source Type: Journal    
DOI: 10.1089/ten.teb.2009.0590     Document Type: Review

References (259)

1. Aigner, T., and Stove, J. Collagens\major component of the physiological cartilage matrix, major target of cartilage degeneration, major tool in cartilage repair. Adv Drug Deliv Rev 55, 1569, 2003.
2. Rosowski, M., Falb, M., Tschirschmann, M., and Lauster, R. Initiation of mesenchymal condensation in alginate hollow spheres\a useful model for understanding cartilage repair? Artif Organs 30, 775, 2006.
3. McCormick, F., Yanke, A., Provencher, M.T., and Cole, B.J. Minced articular cartilage\basic science, surgical technique, and clinical application. Sports Med Arthrosc 16, 17, 2008.
4. Blackburn, T.A., and Craig, E. Knee anatomy: a brief review. Phys Ther 60, 1556, 1980.
5. Richmond, J.C. Surgery for osteoarthritis of the knee. Rheum Dis Clin North Am 34, 815, 2008.
6. Bastiaansen-Jenniskens, Y.M., Koevoet, W., de Bart, A.C., van der Linden, J.C., Zuurmond, A.M., Weinans, H., Ver-haar, J.A., van Osch, G.J., and Degroot, J. Contribution of collagen network features to functional properties of engineered cartilage. Osteoarthritis Cartilage 16, 359, 2008.
7. Temenoff, J.S., and Mikos, A.G. Review: tissue engineering for regeneration of articular cartilage. Biomaterials 21, 431, 2000.
8. Ahmed, T.A., Griffith, M., and Hincke, M. Characterization and inhibition of fibrin hydrogel-degrading enzymes during development of tissue engineering scaffolds. Tissue Eng 13, 1469, 2007.
9. Peretti, G.M., Xu, J.W., Bonassar, L.J., Kirchhoff, C.H., Yaremchuk, M.J., and Randolph, M.A. Review of injectable cartilage engineering using fibrin gel in mice and swine models. Tissue Eng 12, 1151, 2006.
10. Zehbe, R., Libera, J., Gross, U., and Schubert, H. Short-term human chondrocyte culturing on oriented collagen coated gelatine scaffolds for cartilage replacement. Biomed Mater Eng 15, 445, 2005.
11. Beris, A.E., Lykissas, M.G., Papageorgiou, C.D., and Georgoulis, A.D. Advances in articular cartilage repair. Injury 36 Suppl 4, S14, 2005.
12. Badley, E.M., and Wang, P.P. Arthritis and the aging population: projections of arthritis prevalence in Canada 1991 to 2031. J Rheumatol 25, 138, 1998.
13. Wang, P.P., and Badley, E.M. Consistent low prevalence of arthritis in Quebec: findings from a provincial variation study in Canada based on several Canadian population health surveys. J Rheumatol 30, 126, 2003.
14. Mehrotra, C., Remington, P.L., Naimi, T.S., Washington, W., and Miller, R. Trends in total knee replacement surgeries and implications for public health, 1990-2000. Public Health Rep 120, 278, 2005.
15. Detterline, A.J., Goldberg, S., Bach, B.R., Jr., and Cole, B.J. Treatment options for articular cartilage defects of the knee. Orthop Nurs 24, 361, 2005.
16. Rosneck, J., Higuera, C.A., Tadross, N., Krebs, V., and Barsoum, W.K. Managing knee osteoarthritis before and after arthroplasty. Cleve Clin J Med 74, 663, 2007.
17. Li, X., Shah, A., Franklin, P., Merolli, R., Bradley, J., and Busconi, B. Arthroscopic debridement of the osteoarthritic knee combined with hyaluronic acid (Orthovisc(R)) treatment: a case series and review of the literature. J Orthop Surg 3, 43, 2008.
18. Laupattarakasem, W., Laopaiboon, M., Laupattarakasem, P., and Sumananont, C. Arthroscopic debridement for knee osteoarthritis. Cochrane Database of Systematic Reviews 2008, Issue 1. Art No.: CD005118. DOI: 10.1002= 14651858.CD005118.pub2.
19. Siparsky, P., Ryzewicz, M., Peterson, B., and Bartz, R. Ar-throscopic treatment of osteoarthritis of the knee: are there any evidence-based indications? Clin Orthop Relat Res 455, 107, 2007.
20. Clarke, H.D., and Scott, W.N. The role of debridement: through small portals. J Arthroplasty 18, 10, 2003.
21. Stuart, M.J., and Lubowitz, J.H. What, if any, are the indications for arthroscopic debridement of the osteoarthritic knee? Arthroscopy 22, 238, 2006.
22. Altman, R.D., and Gray, R. Diagnostic and therapeutic uses of the arthroscope in rheumatoid arthritis and osteoarthri-tis. Am J Med 75, 50, 1983.
23. Hunziker, E.B., and Quinn, T.M. Surgical removal of articular cartilage leads to loss of chondrocytes from cartilage bordering the wound edge. J Bone Joint Surg Am 85-A Suppl 2, 85, 2003.
24. Day, B. The indications for arthroscopic debridement for osteoarthritis of the knee. Orthop Clin North Am 36, 413, 2005.
25. McLaren, A.C., Blokker, C.P., Fowler, P.J., Roth, J.N., and Rock, M.G. Arthroscopic debridement of the knee for os-teoarthrosis. Can J Surg 34, 595, 1991.
26. Burkart, A.C., Schoettle, P.B., and Imhoff, A.B. [Surgical therapeutic possibilities of cartilage damage]. Unfallchirurg 104, 798, 2001.
27. Fithian, D.C. A historical perspective of anterior knee pain. Sports Med Arthrosc Rev 9, 273, 2001.
28. Kim, H.K., Moran, M.E., and Salter, R.B. The potential for regeneration of articular cartilage in defects created by chondral shaving and subchondral abrasion. An experimental investigation in rabbits. J Bone Joint Surg Am 73, 1301, 1991.
29. Spahn, G., Frober, R., and Linss, W. Treatment of chondral defects by hydro jet. Results of a preliminary scanning electron microscopic evaluation. Arch Orthop Trauma Surg 126, 223, 2006.
30. Uribe, J.W. The use of radiofrequency devices for chondral debridement. Sports Med Arthrosc Rev 11, 214, 2003.
31. David, T.S., and Shields, C.L. Radiofrequency and articular cartilage. Tech Knee Surg 3, 193, 2004.
32. Vangsness, C.T. Radiofrequency use on articular cartilage lesions. Orthop Clin North Am 36, 427, 2005.
33. Hempfling, H. Intra-articular hyaluronic acid after knee arthroscopy: a two-year study. Knee Surg Sports Traumatol Arthrosc 15, 537, 2007.
34. Nehrer, S., and Minas, T. Treatment of articular cartilage defects. Invest Radiol 35, 639, 2000.
35. Jackson, R.W., and Dieterichs, C. The results of arthro-scopic lavage and debridement of osteoarthritic knees based on the severity of degeneration: a 4-to 6-year symptomatic follow-up. Arthroscopy 19, 13, 2003.
36. Tanaka, N., Sakahashi, H., Sato, E., Hirose, K., and Ishii, S. Effects of needle-arthroscopic lavage with different volumes of fluid on knee synovitis in rheumatoid arthritis. Clin Rheumatol 21, 4, 2002.
37. Fu, X., Lin, L., Zhang, J., and Yu, C. Assessment of the efficacy of joint lavage in rabbits with osteoarthritis of the knee. J Orthop Res 27, 91, 2009.
38. Lutzner, J., Kasten, P., Gunther, K.P., and Kirschner, S. Surgical options for patients with osteoarthritis of the knee. Nat Rev Rheumatol 5, 309, 2009.
39. Steinwachs, M.R., Guggi, T., and Kreuz, P.C. Marrow stimulation techniques. Injury 39 Suppl 1, S26, 2008.
40. Johnson, L.L. Arthroscopic abrasion arthroplasty: a review. Clin Orthop Relat Res 391 Suppl, S306, 2001.
41. Johnson, L.L. Arthroscopic abrasion arthroplasty historical and pathologic perspective: present status. Arthroscopy 2, 54, 1986.
42. Kocheta, A., and Toms, A. Isolated chondral injuries of the knee (diagnosis and treatment). Curr Orthop 18, 154, 2004.
43. Kessler, M.W., Ackerman, G., Dines, J.S., and Grande, D. Emerging technologies and fourth generation issues in cartilage repair. Sports Med Arthrosc 16, 246, 2008.
44. Anderson, A.F., Richards, D.B., Pagnani, M.J., and Hovis, W.D. Antegrade drilling for osteochondritis dissecans of the knee. Arthroscopy 13, 319, 1997.
45. Mitchell, N., and Shepard, N. The resurfacing of adult rabbit articular cartilage by multiple perforations through the subchondral bone. J Bone Joint Surg Am 58, 230, 1976.
46. Bhosale, A.M., and Richardson, J.B. Articular cartilage: structure, injuries and review of management. Br Med Bull 87, 77, 2008.
47. Galois, L., Freyria, A.M., Grossin, L., Hubert, P., Mainard, D., Herbage, D., Stoltz, J.F., Netter, P., Dellacherie, E., and Payan, E. Cartilage repair: surgical techniques and tissue engineering using polysaccharide-and collagen-based biomaterials. Biorheology 41, 433, 2004.
48. Ficat, R.P., Ficat, C., Gedeon, P., and Toussaint, J.B. Spon-gialization: a new treatment for diseased patellae. Clin Orthop Relat Res 144, 74, 1979.
49. Hunziker, E.B. Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects. Osteoarthritis Cartilage 10, 432, 2002.
50. Grelsamer, R.P., and Stein, D.A. Patellofemoral arthritis. J Bone Joint Surg Am 88, 1849, 2006.
51. Mina, C., Garrett, W.E., Jr., Pietrobon, R., Glisson, R., and Higgins, L. High tibial osteotomy for unloading os-teochondral defects in the medial compartment of the knee. Am J Sports Med 36, 949, 2008.
52. Tang, W.C., and Henderson, I.J. High tibial osteotomy: long term survival analysis and patients' perspective. Knee 12, 410, 2005.
53. Wright, J.M., Crockett, H.C., Slawski, D.P., Madsen, M.W., and Windsor, R.E. High tibial osteotomy. J Am Acad Orthop Surg 13, 279, 2005.
54. Miller, T.T. Imaging of knee arthroplasty. Eur J Radiol 54, 164, 2005.
55. Bert, J.M. Unicompartmental knee replacement. Orthop Clin North Am 36, 513, 2005.
56. Antoniou, J., Hadjipavlou, A., Enker, P., and Antoniou, A. Unicompartmental knee arthroplasty with patelloplasty. Int Orthop 20, 94, 1996.
57. Bert, J.M. Unicompartmental arthroplasty for unicompart-mental knee arthritis. Tech Knee Surg 7, 51, 2007.
58. Meek, R.M., Masri, B.A., and Duncan, C.P. Minimally invasive unicompartmental knee replacement: rationale and correct indications. Orthop Clin North Am 35, 191, 2004.
59. Rees, J.L., Price, A.J., Lynskey, T.G., Svard, U.C., Dodd, C.A., and Murray, D.W. Medial unicompartmental ar-throplasty after failed high tibial osteotomy. J Bone Joint Surg Br 83, 1034, 2001.
60. Berger, R.A., Meneghini, R.M., Jacobs, J.J., Sheinkop, M.B., Della Valle, C.J., Rosenberg, A.G., and Galante, J.O. Results of unicompartmental knee arthroplasty at a minimum of ten years of follow-up. J Bone Joint Surg Am 87, 999, 2005.
61. O'Neill, T., Jinks, C., and Ong, B.N. Decision-making regarding total knee replacement surgery: a qualitative meta-synthesis. BMC Health Serv Res 7, 52, 2007.
62. Buly, R.L., and Sculco, T.P. Recent advances in total knee replacement surgery. Curr Opin Rheumatol 7, 107, 1995.
63. Pavone, V., Boettner, F., Fickert, S., and Sculco, T.P. Total condylar knee arthroplasty: a long-term followup. Clin Orthop Relat Res 18, 2001.
64. Rorabeck, C.H., Bourne, R.B., and Nott, L. The cemented kinematic-II and the non-cemented porous-coated anatomic prostheses for total knee replacement. A prospective evaluation. J Bone Joint Surg Am 70, 483, 1988.
65. Sharkey, P.F., Hozack, W.J., Rothman, R.H., Shastri, S., and Jacoby, S.M. Insall Award paper. Why are total knee arthroplasties failing today? Clin Orthop Relat Res 404, 7, 2002.
66. Gonzalez Della Valle, A., Leali, A., and Haas, S. Etiology and surgical interventions for stiff total knee replacements. HSS J 3, 182, 2007.
67. Mahomed, N.N., Barrett, J., Katz, J.N., Baron, J.A., Wright, J., and Losina, E. Epidemiology of total knee replacement in the United States Medicare population. J Bone Joint Surg Am 87, 1222, 2005.
68. Kerker, J.T., Leo, A.J., and Sgaglione, N.A. Cartilage repair: synthetics and scaffolds: basic science, surgical techniques, and clinical outcomes. Sports Med Arthrosc 16, 208, 2008.
69. Hangody, L., Vasarhelyi, G., Hangody, L.R., Sukosd, Z., Tibay, G., Bartha, L., and Bodo, G. Autologous os-teochondral grafting\technique and long-term results. Injury 39 Suppl 1, S32, 2008.
70. Recht, M., White, L.M., Winalski, C.S., Miniaci, A., Minas, T., and Parker, R.D. MR imaging of cartilage repair procedures. Skeletal Radiol 32, 185, 2003.
71. Marcacci, M., Kon, E., Delcogliano, M., Filardo, G., Busacca, M., and Zaffagnini, S. Arthroscopic autologous osteo-chondral grafting for cartilage defects of the knee: prospective study results at a minimum 7-year follow-up. Am J Sports Med 35, 2014, 2007.
72. Gudas, R., Stankevicius, E., Monastyreckiene, E., Pranys, D., and Kalesinskas, R.J. Osteochondral autologous transplantation versus microfracture for the treatment of articular cartilage defects in the knee joint in athletes. Knee Surg Sports Traumatol Arthrosc 14, 834, 2006.
73. Williams, R.J., 3rd, Ranawat, A.S., Potter, H.G., Carter, T., and Warren, R.F. Fresh stored allografts for the treatment of osteochondral defects of the knee. J Bone Joint Surg Am 89, 718, 2007.
74. Aubin, P.P., Cheah, H.K., Davis, A.M., and Gross, A.E. Long-term followup of fresh femoral osteochondral allo-grafts for posttraumatic knee defects. Clin Orthop Relat Res 391 Suppl, S318, 2001.
75. Morag, G., Kulidjian, A., Zalzal, P., Shasha, N., Gross, A.E., and Backstein, D. Total knee replacement in previous recipients of fresh osteochondral allograft transplants. J Bone Joint Surg Am 88, 541, 2006.
76. Hettrich, C.M., Crawford, D., and Rodeo, S.A. Cartilage repair: third-generation cell-based technologies\basic science, surgical techniques, clinical outcomes. Sports Med Arthrosc 16, 230, 2008.
77. Iwasa, J., Engebretsen, L., Shima, Y., and Ochi, M. Clinical application of scaffolds for cartilage tissue engineering. Knee Surg Sports Traumatol Arthrosc 17, 561, 2009.
78. Jobanputra, P., Parry, D., Fry-Smith, A., and Burls, A. Effectiveness of autologous chondrocyte transplantation for hyaline cartilage defects in knees: a rapid and systematic review. Health Technol Assess 5, 1, 2001.
79. Ferruzzi, A., Buda, R., Faldini, C., Vannini, F., Di Caprio, F., Luciani, D., and Giannini, S. Autologous chondrocyte implantation in the knee joint: open compared with arthro-scopic technique. Comparison at a minimum follow-up of five years. J Bone Joint Surg Am 90 Suppl 4, 90, 2008.
80. McNickle, A.G., L'Heureux, D.R., Yanke, A.B., and Cole, B.J. Outcomes of autologous chondrocyte implantation in a diverse patient population. Am J Sports Med 37, 1344, 2009.
81. Peterson, L., Minas, T., Brittberg, M., Nilsson, A., Sjogren-Jansson, E., and Lindahl, A. Two-to 9-year outcome after autologous chondrocyte transplantation of the knee. Clin Orthop Relat Res 374, 212, 2000.
82. McNickle, A.G., Provencher, M.T., and Cole, B.J. Overview of existing cartilage repair technology. Sports Med Arthrosc 16, 196, 2008.
83. Clair, B.L., Johnson, A.R., and Howard, T. Cartilage repair: current and emerging options in treatment. Foot Ankle Spec 2, 179, 2009.
84. Cascio, B.M., and Sharma, B. The future of cartilage repair. Oper Tech Sports Med 16, 221, 2008.
85. Ahmed, T.A., Dare, E.V., and Hincke, M. Fibrin: a versatile scaffold for tissue engineering applications. Tissue Eng B 14, 199, 2008.
86. Lien, S.M., Ko, L.Y., and Huang, T.J. Effect of pore size on ECM secretion and cell growth in gelatin scaffold for articular cartilage tissue engineering. Acta Biomater 5, 670, 2009.
87. Gerard, C., Catuogno, C., Amargier-Huin, C., Grossin, L., Hubert, P., Gillet, P., Netter, P., Dellacherie, E., and Payan, E. The effect of alginate, hyaluronate and hyaluronate derivatives biomaterials on synthesis of non-articular chon-drocyte extracellular matrix. J Mater Sci Mater Med 16, 541, 2005.
88. Iwasaki, N., Yamane, S.T., Majima, T., Kasahara, Y., Min-ami, A., Harada, K., Nonaka, S., Maekawa, N., Tamura, H., Tokura, S., Shiono, M., Monde, K., and Nishimura, S. Feasibility of polysaccharide hybrid materials for scaffolds in cartilage tissue engineering: evaluation of chondrocyte adhesion to polyion complex fibers prepared from alginate and chitosan. Biomacromolecules 5, 828, 2004.
89. Quinn, T.M., Schmid, P., Hunziker, E.B., and Grodzinsky, A.J. Proteoglycan deposition around chondrocytes in aga-rose culture: construction of a physical and biological interface for mechanotransduction in cartilage. Biorheology 39, 27, 2002.
90. Ng, K.W., Wang, C.C., Mauck, R.L., Kelly, T.A., Chahine, N.O., Costa, K.D., Ateshian, G.A., and Hung, C.T. A layered agarose approach to fabricate depth-dependent inho-mogeneity in chondrocyte-seeded constructs. J Orthop Res 23, 134, 2005.
91. Chowdhury, T.T., Bader, D.L., Shelton, J.C., and Lee, D.A. Temporal regulation of chondrocyte metabolism in agarose constructs subjected to dynamic compression. Arch Bio-chem Biophys 417, 105, 2003.
92. Mauck, R.L., Soltz, M.A., Wang, C.C., Wong, D.D., Chao, P.H., Valhmu, W.B., Hung, C.T., and Ateshian, G.A. Functional tissue engineering of articular cartilage through dynamic loading of chondrocyte-seeded agarose gels. J Biomech Eng 122, 252, 2000.
93. Wu, M.H., Urban, J.P., Cui, Z.F., Cui, Z., and Xu, X. Effect of extracellular pH on matrix synthesis by chondrocytes in 3D agarose gel. Biotechnol Prog 23, 430, 2007.
94. Ng, K.W., Saliman, J.D., Lin, E.Y., Statman, L.Y., Kugler, L.E., Lo, S.B., Ateshian, G.A., and Hung, C.T. Culture duration modulates collagen hydrolysate-induced tissue remodeling in chondrocyte-seeded agarose hydrogels. Ann Biomed Eng 35, 1914, 2007.
95. Mauck, R.L., Seyhan, S.L., Ateshian, G.A., and Hung, C.T. Influence of seeding density and dynamic deformational loading on the developing structure=function relationships of chondrocyte-seeded agarose hydrogels. Ann Biomed Eng 30, 1046, 2002.
96. Kuo, S.M., Wang, Y.J., Weng, C.L., Lu, H.E., and Chang, S.J. Influence of alginate on type II collagen fibrillogenesis. J Mater Sci Mater Med 16, 525, 2005.
97. Lee, D.A., Reisler, T., and Bader, D.L. Expansion of chon-drocytes for tissue engineering in alginate beads enhances chondrocytic phenotype compared to conventional mono-layer techniques. Acta Orthop Scand 74, 6, 2003.
98. Stevens, M.M., Qanadilo, H.F., Langer, R., and Prasad Shastri, V. A rapid-curing alginate gel system: utility in periosteum-derived cartilage tissue engineering. Biomater-ials 25, 887, 2004.
99. Grunder, T., Gaissmaier, C., Fritz, J., Stoop, R., Hort-schansky, P., Mollenhauer, J., and Aicher, W.K. Bone morphogenetic protein (BMP)-2 enhances the expression of type II collagen and aggrecan in chondrocytes embedded in alginate beads. Osteoarthritis Cartilage 12, 559, 2004.
100. Yoon, D.M., and Fisher, J.P. Effects of exogenous IGF-1 delivery on the early expression of IGF-1 signaling molecules by alginate embedded chondrocytes. Tissue Eng A 14, 1263, 2008.
101. Gaissmaier, C., Fritz, J., Krackhardt, T., Flesch, I., Aicher, W.K., and Ashammakhi, N. Effect of human platelet supernatant on proliferation and matrix synthesis of human articular chondrocytes in monolayer and three-dimensional alginate cultures. Biomaterials 26, 1953, 2005.
102. Masuda, K., Pfister, B.E., Sah, R.L., and Thonar, E.J. Osteogenic protein-1 promotes the formation of tissue-engineered cartilage using the alginate-recovered-chondrocyte method. Osteoarthritis Cartilage 14, 384, 2006.
103. Heywood, H.K., Bader, D.L., and Lee, D.A. Glucose concentration and medium volume influence cell viability and glycosaminoglycan synthesis in chondrocyte-seeded algi-nate constructs. Tissue Eng 12, 3487, 2006.
104. Choi, B.H., Woo, J.I., Min, B.H., and Park, S.R. Low-intensity ultrasound stimulates the viability and matrix gene expression of human articular chondrocytes in algi-nate bead culture. J Biomed Mater Res A 79, 858, 2006.
105. Lee, H.J., Choi, B.H., Min, B.H., Son, Y.S., and Park, S.R. Low-intensity ultrasound stimulation enhances chondro-genic differentiation in alginate culture of mesenchymal stem cells. Artif Organs 30, 707, 2006.
106. Williams, G.M., Klein, T.J., and Sah, R.L. Cell density alters matrix accumulation in two distinct fractions and the mechanical integrity of alginate-chondrocyte constructs. Acta Biomater 1, 625, 2005.
107. Heywood, H.K., Sembi, P.K., Lee, D.A., and Bader, D.L. Cellular utilization determines viability and matrix distribution profiles in chondrocyte-seeded alginate constructs. Tissue Eng 10, 1467, 2004.
108. Lindenhayn, K., Perka, C., Spitzer, R., Heilmann, H., Pommerening, K., Mennicke, J., and Sittinger, M. Retention of hyaluronic acid in alginate beads: aspects for in vitro cartilage engineering. J Biomed Mater Res 44, 149, 1999.
109. Xu, J., Wang, W., Ludeman, M., Cheng, K., Hayami, T., Lotz, J.C., and Kapila, S. Chondrogenic differentiation of human mesenchymal stem cells in three-dimensional algi-nate gels. Tissue Eng A 14, 667, 2008.
110. Park, Y., Sugimoto, M., Watrin, A., Chiquet, M., and Hunziker, E.B. BMP-2 induces the expression of chondrocyte-specific genes in bovine synovium-derived progenitor cells cultured in three-dimensional alginate hy-drogel. Osteoarthritis Cartilage 13, 527, 2005.
111. Lee, K.Y., Jeong, L., Kang, Y.O., Lee, S.J., and Park, W.H. Electrospinning of polysaccharides for regenerative medicine. Adv Drug Deliv Rev 61, 1020, 2009.
112. Di Martino, A., Sittinger, M., and Risbud, M.V. Chitosan: a versatile biopolymer for orthopaedic tissue-engineering. Biomaterials 26, 5983, 2005.
113. Lahiji, A., Sohrabi, A., Hungerford, D.S., and Frondoza, C.G. Chitosan supports the expression of extracellular matrix proteins in human osteoblasts and chondrocytes. J Biomed Mater Res 51, 586, 2000.
114. Hoemann, C.D., Sun, J., Legare, A., McKee, M.D., and Buschmann, M.D. Tissue engineering of cartilage using an injectable and adhesive chitosan-based cell-delivery vehicle. Osteoarthritis Cartilage 13, 318, 2005.
115. Li, Z., and Zhang, M. Chitosan-alginate as scaffolding material for cartilage tissue engineering. J Biomed Mater Res A 75, 485, 2005.
116. Yamane, S., Iwasaki, N., Majima, T., Funakoshi, T., Masu-ko, T., Harada, K., Minami, A., Monde, K., and Nishimura, S. Feasibility of chitosan-based hyaluronic acid hybrid biomaterial for a novel scaffold in cartilage tissue engineering. Biomaterials 26, 611, 2005.
117. Hsu, S.H., Whu, S.W., Hsieh, S.C., Tsai, C.L., Chen, D.C., and Tan, T.S. Evaluation of chitosan-alginate-hyaluronate complexes modified by an RGD-containing protein as tissue-engineering scaffolds for cartilage regeneration. Artif Organs 28, 693, 2004.
118. Donati, I., Stredanska, S., Silvestrini, G., Vetere, A., Marcon, P., Marsich, E., Mozetic, P., Gamini, A., Paoletti, S., and Vittur, F. The aggregation of pig articular chondrocyte and synthesis of extracellular matrix by a lactose-modified chitosan. Biomaterials 26, 987, 2005.
119. Yan, J., Qi, N., and Zhang, Q. Rabbit articular chondrocytes seeded on collagen-chitosan-GAG scaffold for cartilage tissue engineering in vivo. Artif Cells Blood Substit Immobil Biotechnol 35, 333, 2007.
120. Lee, J.E., Kim, K.E., Kwon, I.C., Ahn, H.J., Lee, S.H., Cho, H., Kim, H.J., Seong, S.C., and Lee, M.C. Effects of the controlled-released TGF-beta 1 from chitosan micro-spheres on chondrocytes cultured in a collagen=chitosan= glycosaminoglycan scaffold. Biomaterials 25, 4163, 2004.
121. Chen, Y.L., Lee, H.P., Chan, H.Y., Sung, L.Y., Chen, H.C., and Hu, Y.C. Composite chondroitin-6-sulfate=dermatan sulfate=chitosan scaffolds for cartilage tissue engineering. Biomaterials 28, 2294, 2007.
122. Kuo, Y.C., and Lin, C.Y. Effect of genipin-crosslinked chitin-chitosan scaffolds with hydroxyapatite modifications on the cultivation of bovine knee chondrocytes. Biotechnol Bioeng 95, 132, 2006.
123. Abe, M., Takahashi, M., Tokura, S., Tamura, H., and Nagano, A. Cartilage-scaffold composites produced by bioresorbable beta-chitin sponge with cultured rabbit chondrocytes. Tissue Eng 10, 585, 2004.
124. Cho, J.H., Kim, S.H., Park, K.D., Jung, M.C., Yang, W.I., Han, S.W., Noh, J.Y., and Lee, J.W. Chondrogenic differentiation of human mesenchymal stem cells using a thermo-sensitive poly(N-isopropylacrylamide) and water-soluble chitosan copolymer. Biomaterials 25, 5743, 2004.
125. Marcacci, M., Berruto, M., Brocchetta, D., Delcogliano, A., Ghinelli, D., Gobbi, A., Kon, E., Pederzini, L., Rosa, D., Sacchetti, G.L., Stefani, G., and Zanasi, S. Articular cartilage engineering with Hyalograft C: 3-year clinical results. Clin Orthop Relat Res 435, 96, 2005.
126. Banu, N., and Tsuchiya, T. Markedly different effects of hyaluronic acid and chondroitin sulfate-A on the differentiation of human articular chondrocytes in micromass and 3-D honeycomb rotation cultures. J Biomed Mater Res A 80, 257, 2007.
127. Nettles, D.L., Vail, T.P., Morgan, M.T., Grinstaff, M.W., and Setton, L.A. Photocrosslinkable hyaluronan as a scaffold for articular cartilage repair. Ann Biomed Eng 32, 391, 2004.
128. Chung, C., Erickson, I.E., Mauck, R.L., and Burdick, J.A. Differential behavior of auricular and articular chon-drocytes in hyaluronic acid hydrogels. Tissue Eng A 14, 1121, 2008.
129. Kayakabe, M., Tsutsumi, S., Watanabe, H., Kato, Y., and Takagishi, K. Transplantation of autologous rabbit BM-derived mesenchymal stromal cells embedded in hya-luronic acid gel sponge into osteochondral defects of the knee. Cytotherapy 8, 343, 2006.
130. Solchaga, L.A., Gao, J., Dennis, J.E., Awadallah, A., Lund-berg, M., Caplan, A.I., and Goldberg, V.M. Treatment of osteochondral defects with autologous bone marrow in a hyaluronan-based delivery vehicle. Tissue Eng 8, 333, 2002.
131. Allison, D.D., and Grande-Allen, K.J. Review. Hyaluronan: a powerful tissue engineering tool. Tissue Eng 12, 2131, 2006.
132. Almond, A. Hyaluronan. Cell Mol Life Sci 64, 1591, 2007.
133. Grigolo, B., Roseti, L., Fiorini, M., Fini, M., Giavaresi, G., Aldini, N.N., Giardino, R., and Facchini, A. Transplantation of chondrocytes seeded on a hyaluronan derivative (hyaff-11) into cartilage defects in rabbits. Biomaterials 22, 2417, 2001.
134. Trattnig, S., Pinker, K., Krestan, C., Plank, C., Millington, S., and Marlovits, S. Matrix-based autologous chondrocyte implantation for cartilage repair with HyalograftC: two-year follow-up by magnetic resonance imaging. Eur J Radiol 57, 9, 2006.
135. Nehrer, S., Domayer, S., Dorotka, R., Schatz, K., Bindreiter, U., and Kotz, R. Three-year clinical outcome after chon-drocyte transplantation using a hyaluronan matrix for cartilage repair. Eur J Radiol 57, 3, 2006.
136. Radice, M., Brun, P., Cortivo, R., Scapinelli, R., Battaliard, C., and Abatangelo, G. Hyaluronan-based biopolymers as delivery vehicles for bone-marrow-derived mesenchymal progenitors. J Biomed Mater Res 50, 101, 2000.
137. Gao, J., Dennis, J.E., Solchaga, L.A., Goldberg, V.M., and Caplan, A.I. Repair of osteochondral defect with tissue-engineered two-phase composite material of injectable calcium phosphate and hyaluronan sponge. Tissue Eng 8, 827, 2002.
138. Tognana, E., Borrione, A., De Luca, C., and Pavesio, A. Hyalograft C: hyaluronan-based scaffolds in tissue-engineered cartilage. Cells Tissues Organs 186, 97, 2007.
139. Stark, Y., Suck, K., Kasper, C., Wieland, M., van Griensven, M., and Scheper, T. Application of collagen matrices for cartilage tissue engineering. Exp Toxicol Pathol 57, 305, 2006.
140. Chen, G., Sato, T., Ushida, T., Hirochika, R., Shirasaki, Y., Ochiai, N., and Tateishi, T. The use of a novel PLGA fiber=collagen composite web as a scaffold for engineering of articular cartilage tissue with adjustable thickness. J Biomed Mater Res A 67, 1170, 2003.
141. Chen, G., Sato, T., Ushida, T., Ochiai, N., and Tateishi, T. Tissue engineering of cartilage using a hybrid scaffold of synthetic polymer and collagen. Tissue Eng 10, 323, 2004.
142. Yates, K.E., Allemann, F., and Glowacki, J. Phenotypic analysis of bovine chondrocytes cultured in 3D collagen sponges: effect of serum substitutes. Cell Tissue Bank 6, 45, 2005.
143. Freyria, A.M., Cortial, D., Ronziere, M.C., Guerret, S., and Herbage, D. Influence of medium composition, static and stirred conditions on the proliferation of and matrix protein expression of bovine articular chondrocytes cultured in a 3-D collagen scaffold. Biomaterials 25, 687, 2004.
144. Wakitani, S., Goto, T., Young, R.G., Mansour, J.M., Goldberg, V.M., and Caplan, A.I. Repair of large full-thickness articular cartilage defects with allograft articular chon-drocytes embedded in a collagen gel. Tissue Eng 4, 429, 1998.
145. Willers, C., Chen, J., Wood, D., Xu, J., and Zheng, M.H. Autologous chondrocyte implantation with collagen bios-caffold for the treatment of osteochondral defects in rabbits. Tissue Eng 11, 1065, 2005.
146. Dorotka, R., Bindreiter, U., Macfelda, K., Windberger, U., and Nehrer, S. Marrow stimulation and chondrocyte transplantation using a collagen matrix for cartilage repair. Osteoarthritis Cartilage 13, 655, 2005.
147. Malicev, E., Radosavljevic, D., and Velikonja, N.K. Fibrin gel improved the spatial uniformity and phenotype of human chondrocytes seeded on collagen scaffolds. Bio-technol Bioeng 96, 364, 2007.
148. Fujisato, T., Sajiki, T., Liu, Q., and Ikada, Y. Effect of basic fibroblast growth factor on cartilage regeneration in chondrocyte-seeded collagen sponge scaffold. Biomaterials 17, 155, 1996.
149. Sato, M., Ishihara, M., Ishihara, M., Kaneshiro, N., Mitani, G., Nagai, T., Kutsuna, T., Asazuma, T., Kikuchi, M., and Mochida, J. Effects of growth factors on heparin-carrying polystyrene-coated atelocollagen scaffold for articular cartilage tissue engineering. J Biomed Mater Res B Appl Bio-mater 83, 181, 2007.
150. Weiser, L., Bhargava, M., Attia, E., and Torzilli, P.A. Effect of serum and platelet-derived growth factor on chon-drocytes grown in collagen gels. Tissue Eng 5, 533, 1999.
151. Hunter, C.J., Imler, S.M., Malaviya, P., Nerem, R.M., and Levenston, M.E. Mechanical compression alters gene expression and extracellular matrix synthesis by chon-drocytes cultured in collagen I gels. Biomaterials 23, 1249, 2002.
152. Schulz, R.M., Zscharnack, M., Hanisch, I., Geiling, M., Hepp, P., and Bader, A. Cartilage tissue engineering by collagen matrix associated bone marrow derived mesen-chymal stem cells. Biomed Mater Eng 18, S55, 2008.
153. Dorotka, R., Windberger, U., Macfelda, K., Bindreiter, U., Toma, C., and Nehrer, S. Repair of articular cartilage defects treated by microfracture and a three-dimensional collagen matrix. Biomaterials 26, 3617, 2005.
154. Cen, L., Liu, W., Cui, L., Zhang, W., and Cao, Y. Collagen tissue engineering: development of novel biomaterials and applications. Pediatr Res 63, 492, 2008.
155. Glowacki, J., and Mizuno, S. Collagen scaffolds for tissue engineering. Biopolymers 89, 338, 2008.
156. Chajra, H., Rousseau, C.F., Cortial, D., Ronziere, M.C., Herbage, D., Mallein-Gerin, F., and Freyria, A.M. Collagen-based biomaterials and cartilage engineering. Application to osteochondral defects. Biomed Mater Eng 18, S33, 2008.
157. Freyria, A.M., Ronziere, M.C., Cortial, D., Galois, L., Hartmann, D., Herbage, D., and Mallein-Gerin, F. Comparative phenotypic analysis of articular chondrocytes cultured within type I or type II collagen scaffolds. Tissue Eng A 15, 1233, 2009.
158. Buma, P., Pieper, J.S., van Tienen, T., van Susante, J.L., van der Kraan, P.M., Veerkamp, J.H., van den Berg, W.B., Veth, R.P., and van Kuppevelt, T.H. Cross-linked type I and type II collagenous matrices for the repair of full-thickness articular cartilage defects\a study in rabbits. Biomaterials 24, 3255, 2003.
159. Lee, C.R., Grodzinsky, A.J., Hsu, H.P., and Spector, M. Effects of a cultured autologous chondrocyte-seeded type II collagen scaffold on the healing of a chondral defect in a canine model. J Orthop Res 21, 272, 2003.
160. Lee, C.R., Grodzinsky, A.J., and Spector, M. Biosynthetic response of passaged chondrocytes in a type II collagen scaffold to mechanical compression. J Biomed Mater Res A 64, 560, 2003.
161. Shields, K.J., Beckman, M.J., Bowlin, G.L., and Wayne, J.S. Mechanical properties and cellular proliferation of electro-spun collagen type II. Tissue Eng 10, 1510, 2004.
162. Vickers, S.M., Squitieri, L.S., and Spector, M. Effects of cross-linking type II collagen-GAG scaffolds on chon-drogenesis in vitro: dynamic pore reduction promotes cartilage formation. Tissue Eng 12, 1345, 2006.
163. Veilleux, N., and Spector, M. Effects of FGF-2 and IGF-1 on adult canine articular chondrocytes in type II collagen-glycosaminoglycan scaffolds in vitro. Osteoarthritis Cartilage 13, 278, 2005.
164. Ko, C.S., Huang, J.P., Huang, C.W., and Chu, I.M. Type II collagen-chondroitin sulfate-hyaluronan scaffold cross-linked by genipin for cartilage tissue engineering. J Biosci Bioeng 107, 177, 2009.
165. Pieper, J.S., van der Kraan, P.M., Hafmans, T., Kamp, J., Buma, P., van Susante, J.L., van den Berg, W.B., Veerkamp, J.H., and van Kuppevelt, T.H. Crosslinked type II collagen matrices: preparation, characterization, and potential for cartilage engineering. Biomaterials 23, 3183, 2002.
166. Vinatier, C., Gauthier, O., Masson, M., Malard, O., Moreau, A., Fellah, B.H., Bilban, M., Spaethe, R., Daculsi, G., and Guicheux, J. Nasal chondrocytes and fibrin sealant for cartilage tissue engineering. J Biomed Mater Res A 89, 176, 2009.
167. Hunter, C.J., Mouw, J.K., and Levenston, M.E. Dynamic compression of chondrocyte-seeded fibrin gels: effects on matrix accumulation and mechanical stiffness. Osteoar-thritis Cartilage 12, 117, 2004.
168. Perka, C., Spitzer, R.S., Lindenhayn, K., Sittinger, M., and Schultz, O. Matrix-mixed culture: new methodology for chondrocyte culture and preparation of cartilage transplants. J Biomed Mater Res 49, 305, 2000.
169. Almqvist, K.F., Wang, L., Wang, J., Baeten, D., Cornelissen, M., Verdonk, R., Veys, E.M., and Verbruggen, G. Culture of chondrocytes in alginate surrounded by fibrin gel: characteristics of the cells over a period of eight weeks. Ann Rheum Dis 60, 781, 2001.
170. Chou, C.H., Cheng, W.T., Kuo, T.F., Sun, J.S., Lin, F.H., and Tsai, J.C. Fibrin glue mixed with gelatin=hyaluronic acid= chondroitin-6-sulfate tri-copolymer for articular cartilage tissue engineering: the results of real-time polymerase chain reaction. J Biomed Mater Res A 82, 757, 2007.
171. Lee, C.R., Grad, S., Gorna, K., Gogolewski, S., Goessl, A., and Alini, M. Fibrin-polyurethane composites for articular cartilage tissue engineering: a preliminary analysis. Tissue Eng 11, 1562, 2005.
172. Eyrich, D., Wiese, H., Maier, G., Skodacek, D., Appel, B., Sarhan, H., Tessmar, J., Staudenmaier, R., Wenzel, M.M., Goepferich, A., and Blunk, T. In vitro and in vivo cartilage engineering using a combination of chondrocyte-seeded long-term stable fibrin gels and polycaprolactone-based polyurethane scaffolds. Tissue Eng 13, 2207, 2007.
173. Park, S.H., Park, S.R., Chung, S.I., Pai, K.S., and Min, B.H. Tissue-engineered cartilage using fibrin=hyaluronan composite gel and its in vivo implantation. Artif Organs 29, 838, 2005.
174. Handl, M., Trc, T., Hanus, M., Stastny, E., Fricova-Poulova, M., Neuwirth, J., Adler, J., Havranova, D., and Varga, F. [Therapy of severe chondral defects of the patella by au-tologous chondrocyte implantation]. Acta Chir Orthop Traumatol Cech 73, 373, 2006.
175. Visna, P., Pasa, L., Hart, R., Kocis, J., Cizmar, I., and Adler, J. [Treatment of deep chondral defects of the knee using autologous chondrocytes cultured on a support\results after one year]. Acta Chir Orthop Traumatol Cech 70, 356, 2003.
176. Visna, P., Pasa, L., Cizmar, I., Hart, R., and Hoch, J. Treatment of deep cartilage defects of the knee using au-tologous chondrograft transplantation and by abrasive techniques\a randomized controlled study. Acta Chir Belg 104, 709, 2004.
177. Barker, T.H., Fuller, G.M., Klinger, M.M., Feldman, D.S., and Hagood, J.S. Modification of fibrinogen with poly(ethylene glycol) and its effects on fibrin clot characteristics. J Biomed Mater Res 56, 529, 2001.
178. Temenoff, J.S., Athanasiou, K.A., LeBaron, R.G., and Mikos, A.G. Effect of poly(ethylene glycol) molecular weight on tensile and swelling properties of oligo(poly(ethylene gly-col) fumarate) hydrogels for cartilage tissue engineering. J Biomed Mater Res 59, 429, 2002.
179. Redwan el, R.M. Animal-derived pharmaceutical proteins. J Immunoassay Immunochem 30, 262, 2009.
180. Goodstone, N.J., Cartwright, A., and Ashton, B. Effects of high molecular weight hyaluronan on chondrocytes cultured within a resorbable gelatin sponge. Tissue Eng 10, 621, 2004.
181. Ibusuki, S., Fujii, Y., Iwamoto, Y., and Matsuda, T. Tissue-engineered cartilage using an injectable and in situ gelable thermoresponsive gelatin: fabrication and in vitro performance. Tissue Eng 9, 371, 2003.
182. Ibusuki, S., Iwamoto, Y., and Matsuda, T. System-engineered cartilage using poly(N-isopropylacrylamide)-grafted gelatin as in situ-formable scaffold: in vivo performance. Tissue Eng 9, 1133, 2003.
183. Hoshikawa, A., Nakayama, Y., Matsuda, T., Oda, H., Na-kamura, K., and Mabuchi, K. Encapsulation of chon-drocytes in photopolymerizable styrenated gelatin for cartilage tissue engineering. Tissue Eng 12, 2333, 2006.
184. Chang, C.H., Lin, F.H., Lin, C.C., Chou, C.H., and Liu, H.C. Cartilage tissue engineering on the surface of a novel gelatin-calcium-phosphate biphasic scaffold in a double-chamber bioreactor. J Biomed Mater Res B Appl Biomater 71, 313, 2004.
185. Chang, C.H., Liu, H.C., Lin, C.C., Chou, C.H., and Lin, F.H. Gelatin-chondroitin-hyaluronan tri-copolymer scaffold for cartilage tissue engineering. Biomaterials 24, 4853, 2003.
186. Chang, C.H., Kuo, T.F., Lin, C.C., Chou, C.H., Chen, K.H., Lin, F.H., and Liu, H.C. Tissue engineering-based cartilage repair with allogenous chondrocytes and gelatin-chondroitin-hyaluronan tri-copolymer scaffold: a porcine model assessed at 18, 24, and 36 weeks. Biomaterials 27, 1876, 2006.
187. Young, S., Wong, M., Tabata, Y., and Mikos, A.G. Gelatin as a delivery vehicle for the controlled release of bioactive molecules. J Control Release 109, 256, 2005.
188. Munirah, S., Kim, S.H., Ruszymah, B.H., and Khang, G. The use of fibrin and poly(lactic-co-glycolic acid) hybrid scaffold for articular cartilage tissue engineering: an in vivo analysis. Eur Cell Mater 15, 41, 2008.
189. Zwingmann, J., Mehlhorn, A.T., Sudkamp, N., Stark, B., Dauner, M., and Schmal, H. Chondrogenic differentiation of human articular chondrocytes differs in biodegradable PGA=PLA scaffolds. Tissue Eng 13, 2335, 2007.
190. Lu, L., Zhu, X., Pederson, L.G., Jabbari, E., Currier, B., O'Driscoll, S., and Yaszemski, M. Effects of dynamic fluid pressure on chondrocytes cultured in biodegradable poly (glycolic acid) fibrous scaffolds. Tissue Eng 11, 1852, 2005.
191. Kon, E., Delcogliano, M., Filardo, G., Montaperto, C., and Marcacci, M. Second generation issues in cartilage repair. Sports Med Arthrosc 16, 221, 2008.
192. Erggelet, C., Kreuz, P.C., Mrosek, E.H., Schagemann, J.C., Lahm, A., Ducommun, P.P., and Ossendorf, C. Autologous chondrocyte implantation versus ACI using 3D-bioresorbable graft for the treatment of large full-thickness cartilage lesions of the knee. Arch Orthop Trauma Surg 2009. [Epub ahead of print].
193. Kreuz, P.C., Muller, S., Ossendorf, C., Kaps, C., and Erg-gelet, C. Treatment of focal degenerative cartilage defects with polymer-based autologous chondrocyte grafts: four-year clinical results. Arthritis Res Ther 11, R33, 2009.
194. Chu, C.R., Coutts, R.D., Yoshioka, M., Harwood, F.L., Monosov, A.Z., and Amiel, D. Articular cartilage repair using allogeneic perichondrocyte-seeded biodegradable porous polylactic acid (PLA): a tissue-engineering study. J Biomed Mater Res 29, 1147, 1995.
195. Pulliainen, O., Vasara, A.I., Hyttinen, M.M., Tiitu, V., Va-lonen, P., Kellomaki, M., Jurvelin, J.S., Peterson, L., Lindahl, A., Kiviranta, I., and Lammi, M.J. Poly-L-D-lactic acid scaffold in the repair of porcine knee cartilage lesions. Tissue Eng 13, 1347, 2007.
196. Gong, Y., Zhou, Q., Gao, C., and Shen, J. In vitro and in vivo degradability and cytocompatibility of poly(l-lactic acid) scaffold fabricated by a gelatin particle leaching method. Acta Biomater 3, 531, 2007.
197. Tamai, N., Myoui, A., Hirao, M., Kaito, T., Ochi, T., Tanaka, J., Takaoka, K., and Yoshikawa, H. A new biotechnology for articular cartilage repair: subchondral implantation of a composite of interconnected porous hydroxyapatite, synthetic polymer (PLA-PEG), and bone morphogenetic protein-2 (rhBMP-2). Osteoarthritis Cartilage 13, 405, 2005.
198. Shin, H.J., Lee, C.H., Cho, I.H., Kim, Y.J., Lee, Y.J., Kim, I.A., Park, K.D., Yui, N., and Shin, J.W. Electrospun PLGA nanofiber scaffolds for articular cartilage reconstruction: mechanical stability, degradation and cellular responses under mechanical stimulation in vitro. J Biomater Sci Polym Ed 17, 103, 2006.
199. Mercier, N.R., Costantino, H.R., Tracy, M.A., and Bonassar, L.J. Poly(lactide-co-glycolide) microspheres as a moldable scaffold for cartilage tissue engineering. Biomaterials 26, 1945, 2005.
200. Kang, S.W., Jeon, O., and Kim, B.S. Poly(lactic-co-glycolic acid) microspheres as an injectable scaffold for cartilage tissue engineering. Tissue Eng 11, 438, 2005.
201. Kang, S.W., Yoon, J.R., Lee, J.S., Kim, H.J., Lim, H.W., Lim, H.C., Park, J.H., and Kim, B.S. The use of poly(lactic-co-glycolic acid) microspheres as injectable cell carriers for cartilage regeneration in rabbit knees. J Biomater Sci Polym Ed 17, 925, 2006.
202. Han, S.H., Kim, Y.H., Park, M.S., Kim, I.A., Shin, J.W., Yang, W.I., Jee, K.S., Park, K.D., Ryu, G.H., and Lee, J.W. Histological and biomechanical properties of regenerated articular cartilage using chondrogenic bone marrow stro-mal cells with a PLGA scaffold in vivo. J Biomed Mater Res A 87, 850, 2008.
203. Park, G.E., Pattison, M.A., Park, K., and Webster, T.J. Accelerated chondrocyte functions on NaOH-treated PLGA scaffolds. Biomaterials 26, 3075, 2005.
204. Savaiano, J.K., and Webster, T.J. Altered responses of chondrocytes to nanophase PLGA=nanophase titania composites. Biomaterials 25, 1205, 2004.
205. Sha'ban, M., Kim, S.H., Idrus, R.B., and Khang, G. Fibrin and poly(lactic-co-glycolic acid) hybrid scaffold promotes early chondrogenesis of articular chondrocytes: an in vitro study. J Orthop Surg 3, 17, 2008.
206. Yoo, H.S., Lee, E.A., Yoon, J.J., and Park, T.G. Hyaluronic acid modified biodegradable scaffolds for cartilage tissue engineering. Biomaterials 26, 1925, 2005.
207. Lind, M., Larsen, A., Clausen, C., Osther, K., and Everland, H. Cartilage repair with chondrocytes in fibrin hydrogel and MPEG polylactide scaffold: an in vivo study in goats. Knee Surg Sports Traumatol Arthrosc 16, 690, 2008.
208. Hsu, S.H., Chang, S.H., Yen, H.J., Whu, S.W., Tsai, C.L., and Chen, D.C. Evaluation of biodegradable polyesters modified by type II collagen and Arg-Gly-Asp as tissue engineering scaffolding materials for cartilage regeneration. Artif Organs 30, 42, 2006.
209. Smith, R.C., Spalding, T., and Masri, B.A. Trufit polymer scaffolds for the management of cartilage defects of the knee. Tech Knee Surg 8, 136, 2009.
210. Lu, J.M., Wang, X., Marin-Muller, C., Wang, H., Lin, P.H., Yao, Q., and Chen, C. Current advances in research and clinical applications of PLGA-based nanotechnology. Expert Rev Mol Diagn 9, 325, 2009.
211. Bryant, S.J., Arthur, J.A., and Anseth, K.S. Incorporation of tissue-specific molecules alters chondrocyte metabolism and gene expression in photocrosslinked hydrogels. Acta Biomater 1, 243, 2005.
212. Bryant, S.J., Chowdhury, T.T., Lee, D.A., Bader, D.L., and Anseth, K.S. Crosslinking density influences chondrocyte metabolism in dynamically loaded photocrosslinked poly(ethylene glycol) hydrogels. Ann Biomed Eng 32, 407, 2004.
213. Bryant, S.J., Bender, R.J., Durand, K.L., and Anseth, K.S. Encapsulating chondrocytes in degrading PEG hydrogels with high modulus: engineering gel structural changes to facilitate cartilaginous tissue production. Biotechnol Bioeng 86, 747, 2004.
214. Bryant, S.J., Anseth, K.S., Lee, D.A., and Bader, D.L. Crosslinking density influences the morphology of chon-drocytes photoencapsulated in PEG hydrogels during the application of compressive strain. J Orthop Res 22, 1143, 2004.
215. Nguyen, K.T., and West, J.L. Photopolymerizable hydro-gels for tissue engineering applications. Biomaterials 23, 4307, 2002.
216. Elisseeff, J., McIntosh, W., Anseth, K., Riley, S., Ragan, P., and Langer, R. Photoencapsulation of chondrocytes in poly(ethylene oxide)-based semi-interpenetrating networks. J Biomed Mater Res 51, 164, 2000.
217. Buxton, A.N., Zhu, J., Marchant, R., West, J.L., Yoo, J.U., and Johnstone, B. Design and characterization of poly (ethylene glycol) photopolymerizable semi-interpenetrating networks for chondrogenesis of human mesenchymal stem cells. Tissue Eng 13, 2549, 2007.
218. Bryant, S.J., Durand, K.L., and Anseth, K.S. Manipulations in hydrogel chemistry control photoencapsulated chon-drocyte behavior and their extracellular matrix production. J Biomed Mater Res A 67, 1430, 2003.
219. Malda, J., Woodfield, T.B., van der Vloodt, F., Wilson, C., Martens, D.E., Tramper, J., van Blitterswijk, C.A., and Riesle, J. The effect of PEGT=PBT scaffold architecture on the composition of tissue engineered cartilage. Biomaterials 26, 63, 2005.
220. Holland, T.A., Bodde, E.W., Baggett, L.S., Tabata, Y., Mi-kos, A.G., and Jansen, J.A. Osteochondral repair in the rabbit model utilizing bilayered, degradable oligo(poly(ethylene glycol) fumarate) hydrogel scaffolds. J Biomed Mater Res A 75, 156, 2005.
221. Taguchi, T., Xu, L., Kobayashi, H., Taniguchi, A., Kataoka, K., and Tanaka, J. Encapsulation of chondrocytes in in-jectable alkali-treated collagen gels prepared using poly(ethylene glycol)-based 4-armed star polymer. Bioma-terials 26, 1247, 2005.
222. Ifkovits, J.L., and Burdick, J.A. Review: photopolymeriz-able and degradable biomaterials for tissue engineering applications. Tissue Eng 13, 2369, 2007.
223. Song, L., Baksh, D., and Tuan, R.S. Mesenchymal stem cell-based cartilage tissue engineering: cells, scaffold and biology. Cytotherapy 6, 596, 2004.
224. Kessler, M.W., and Grande, D.A. Tissue engineering and cartilage. Organogenesis 4, 28, 2008.
225. Isogai, N., Kusuhara, H., Ikada, Y., Ohtani, H., Jacquet, R., Hillyer, J., Lowder, E., and Landis, W.J. Comparison of different chondrocytes for use in tissue engineering of cartilage model structures. Tissue Eng 12, 691, 2006.
226. Tuan, R.S., Boland, G., and Tuli, R. Adult mesenchymal stem cells and cell-based tissue engineering. Arthritis Res Ther 5, 32, 2003.
227. Leo, A.J., and Grande, D.A. Mesenchymal stem cells in tissue engineering. Cells Tissues Organs 183, 112, 2006.
228. Kim, H.J., and Im, G.I. Combination of transforming growth factor-beta2 and bone morphogenetic protein 7 enhances chondrogenesis from adipose tissue-derived mesenchymal stem cells. Tissue Eng Part A 15, 1543, 2009.
229. Xiang, Y., Zheng, Q., Jia, B.B., Huang, G.P., Xu, Y.L., Wang, J.F., and Pan, Z.J. Ex vivo expansion and pluripotential differentiation of cryopreserved human bone marrow mesenchymal stem cells. J Zhejiang Univ Sci B 8, 136, 2007.
230. Kurth, T., Hedbom, E., Shintani, N., Sugimoto, M., Chen, F.H., Haspl, M., Martinovic, S., and Hunziker, E.B. Chon-drogenic potential of human synovial mesenchymal stem cells in alginate. Osteoarthritis Cartilage 15, 1178, 2007.
231. Yasuda, A., Kojima, K., Tinsley, K.W., Yoshioka, H., Mori, Y., and Vacanti, C.A. In vitro culture of chondrocytes in a novel thermoreversible gelation polymer scaffold containing growth factors. Tissue Eng 12, 1237, 2006.
232. Im, G.I., Jung, N.H., and Tae, S.K. Chondrogenic differentiation of mesenchymal stem cells isolated from patients in late adulthood: the optimal conditions of growth factors. Tissue Eng 12, 527, 2006.
233. Takagi, M., Umetsu, Y., Fujiwara, M., and Wakitani, S. High inoculation cell density could accelerate the differentiation of human bone marrow mesenchymal stem cells to chondrocyte cells. J Biosci Bioeng 103, 98, 2007.
234. Kafienah, W., Mistry, S., Dickinson, S.C., Sims, T.J., Lear-month, I., and Hollander, A.P. Three-dimensional cartilage tissue engineering using adult stem cells from osteoarthritis patients. Arthritis Rheum 56, 177, 2007.
235. Hennig, T., Lorenz, H., Thiel, A., Goetzke, K., Dickhut, A., Geiger, F., and Richter, W. Reduced chondrogenic potential of adipose tissue derived stromal cells correlates with an altered TGFbeta receptor and BMP profile and is overcome by BMP-6. J Cell Physiol 211, 682, 2007.
236. Sekiya, I., Larson, B.L., Vuoristo, J.T., Reger, R.L., and Prockop, D.J. Comparison of effect of BMP-2,-4, and-6 on in vitro cartilage formation of human adult stem cells from bone marrow stroma. Cell Tissue Res 320, 269, 2005.
237. Schmitt, B., Ringe, J., Haupl, T., Notter, M., Manz, R., Burmester, G.R., Sittinger, M., and Kaps, C. BMP2 initiates chondrogenic lineage development of adult human mes-enchymal stem cells in high-density culture. Differentiation 71, 567, 2003.
238. Indrawattana, N., Chen, G., Tadokoro, M., Shann, L.H., Ohgushi, H., Tateishi, T., Tanaka, J., and Bunyaratvej, A. Growth factor combination for chondrogenic induction from human mesenchymal stem cell. Biochem Biophys Res Commun 320, 914, 2004.
239. Kafienah, W., Mistry, S., Perry, M.J., Politopoulou, G., and Hollander, A.P. Pharmacological regulation of adult stem cells: chondrogenesis can be induced using a synthetic inhibitor of the retinoic acid receptor. Stem Cells 25, 2460, 2007.
240. Kim, H.T., Zaffagnini, S., Mizuno, S., Abelow, S., and Sa-fran, M.R. A peek into the possible future of management of articular cartilage injuries: gene therapy and scaffolds for cartilage repair. J Orthop Sports Phys Ther 36, 765, 2006.
241. Steinert, A.F., Noth, U., and Tuan, R.S. Concepts in gene therapy for cartilage repair. Injury 39 Suppl 1, S97, 2008.
242. Saraf, A., and Mikos, A.G. Gene delivery strategies for cartilage tissue engineering. Adv Drug Deliv Rev 58, 592, 2006.
243. Grande, D.A., Mason, J., Light, E., and Dines, D. Stem cells as platforms for delivery of genes to enhance cartilage repair. J Bone Joint Surg Am 85-A Suppl 2, 111, 2003.
244. Guo, X., Zheng, Q., Yang, S., Shao, Z., Yuan, Q., Pan, Z., Tang, S., Liu, K., and Quan, D. Repair of full-thickness articular cartilage defects by cultured mesenchymal stem cells transfected with the transforming growth factor beta1 gene. Biomed Mater 1, 206, 2006.
245. Hao, J., Yao, Y., Varshney, R.R., Wang, L., Prakash, C., Li, H., and Wang, D.A. Gene transfer and living release of transforming growth factor-beta3 for cartilage tissue engineering applications. Tissue Eng C 14, 273, 2008.
246. Palmer, G.D., Steinert, A., Pascher, A., Gouze, E., Gouze, J.N., Betz, O., Johnstone, B., Evans, C.H., and Ghivizzani, S.C. Gene-induced chondrogenesis of primary mesenchy-mal stem cells in vitro. Mol Ther 12, 219, 2005.
247. Babister, J.C., Tare, R.S., Green, D.W., Inglis, S., Mann, S., and Oreffo, R.O. Genetic manipulation of human mesen-chymal progenitors to promote chondrogenesis using "bead-in-bead'' polysaccharide capsules. Biomaterials 29, 58, 2008.
248. Sun, X.D., Jeng, L., Bolliet, C., Olsen, B.R., and Spector, M. Non-viral endostatin plasmid transfection of mesenchymal stem cells via collagen scaffolds. Biomaterials 30, 1222, 2009.
249. Song, S.U., Cha, Y.D., Han, J.U., Oh, I.S., Choi, K.B., Yi, Y., Hyun, J.P., Lee, H.Y., Chi, G.F., Lim, C.L., Ganjei, J.K., Noh, M.J., Kim, S.J., Lee, D.K., and Lee, K.H. Hyaline cartilage regeneration using mixed human chondrocytes and transforming growth factor-beta1-producing chondrocytes. Tissue Eng 11, 1516, 2005.
250. Goomer, R.S., Deftos, L.J., Terkeltaub, R., Maris, T., Lee, M.C., Harwood, F.L., and Amiel, D. High-efficiency non-viral transfection of primary chondrocytes and peri-chondrial cells for ex-vivo gene therapy to repair articular cartilage defects. Osteoarthritis Cartilage 9, 248, 2001.
251. Chen, H.C., Sung, L.Y., Lo, W.H., Chuang, C.K., Wang, Y.H., Lin, J.L., and Hu, Y.C. Combination of baculovirus-expressed BMP-2 and rotating-shaft bioreactor culture synergistically enhances cartilage formation. Gene Ther 15, 309, 2008.
252. Kaps, C., Bramlage, C., Smolian, H., Haisch, A., Ungethum, U., Burmester, G.R., Sittinger, M., Gross, G., and Haupl, T. Bone morphogenetic proteins promote cartilage differentiation and protect engineered artificial cartilage from fibroblast invasion and destruction. Arthritis Rheum 46, 149, 2002.
253. Madry, H., Padera, R., Seidel, J., Langer, R., Freed, L.E., Trippel, S.B., and Vunjak-Novakovic, G. Gene transfer of a human insulin-like growth factor I cDNA enhances tissue engineering of cartilage. Hum Gene Ther 13, 1621, 2002.
254. Thibault, M., Poole, A.R., and Buschmann, M.D. Cyclic compression of cartilage=bone explants in vitro leads to physical weakening, mechanical breakdown of collagen and release of matrix fragments. J Orthop Res 20, 1265, 2002.
255. Quinn, T.M., Maung, A.A., Grodzinsky, A.J., Hunziker, E.B., and Sandy, J.D. Physical and biological regulation of proteoglycan turnover around chondrocytes in cartilage explants. Implications for tissue degradation and repair. Ann N Y Acad Sci 878, 420, 1999.
256. Miyanishi, K., Trindade, M.C., Lindsey, D.P., Beaupre, G.S., Carter, D.R., Goodman, S.B., Schurman, D.J., and Smith, R.L. Effects of hydrostatic pressure and transforming growth factor-beta 3 on adult human mesenchymal stem cell chondrogenesis in vitro. Tissue Eng 12, 1419, 2006.
257. McMahon, L.A., Reid, A.J., Campbell, V.A., and Pre-ndergast, P.J. Regulatory effects of mechanical strain on the chondrogenic differentiation of MSCs in a collagen-GAG scaffold: experimental and computational analysis. Ann Biomed Eng 36, 185, 2008.
258. Ebisawa, K., Hata, K., Okada, K., Kimata, K., Ueda, M., Torii, S., and Watanabe, H. Ultrasound enhances transforming growth factor beta-mediated chondrocyte differentiation of human mesenchymal stem cells. Tissue Eng 10, 921, 2004.
259. Lee, H.J., Choi, B.H., Min, B.H., and Park, S.R. Low-intensity ultrasound inhibits apoptosis and enhances viability of human mesenchymal stem cells in three-dimensional algi-nate culture during chondrogenic differentiation. Tissue Eng 13, 1049, 2007.