α1,3-galactosyltransferase gene-knockout pigs for xenotransplantation: Where do we go from here?

Transplantation

Volumn 84, Issue 1, 2007, Pages 1-7

  Cooper, David K C ^a   Dorling, Anthony ^b   Pierson III, Richard N ^c   Rees, Michael ^d   Seebach, Jorg ^e   Yazer, Mark ^f   Ohdan, Hideki ^g   Awwad, Michel ^h   Ayares, David ^h  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^d MEDICAL COLLEGE OF OHIO   (United States)

^e UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^f UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^g HIROSHIMA UNIVERSITY   (Japan)

^h REVIVICOR INC   (United States)

Author keywords

1,3 Galactosyltransferase gene knockout; Antibody mediated rejection; Coagulation; Genetic engineering; Pancreatic islets; Pig; Xenotransplantation

Indexed keywords

ALPHA 1,3 GALACTOSYLTRANSFERASE; BLOOD CLOTTING FACTOR 10A; CD39 ANTIGEN; CD40 LIGAND MONOCLONAL ANTIBODY; CORTICOSTEROID; FIBRINOGEN; HIRUDIN; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; TISSUE FACTOR PATHWAY INHIBITOR; GALACTOSYLTRANSFERASE; HETEROPHILE ANTIBODY; HETEROPHILE ANTIGEN; UDP GALACTOSE LACTOSYLCERAMIDE ALPHA 1 4 GALACTOSYLTRANSFERASE; UDP-GALACTOSE-LACTOSYLCERAMIDE ALPHA 1-4-GALACTOSYLTRANSFERASE; UNCLASSIFIED DRUG;

ANTIGEN DETECTION; BLOOD CLOTTING; BLOOD CLOTTING DISORDER; BREEDING; CARDIAC GRAFT REJECTION; CELL ACTIVITY; DRUG DOSE REDUCTION; GENETIC ENGINEERING; GRAFT FAILURE; GRAFT SURVIVAL; IMMUNOLOGICAL TOLERANCE; IMMUNOSUPPRESSIVE TREATMENT; INNATE IMMUNITY; KNOCKOUT GENE; MACROPHAGE; NATURAL KILLER CELL; NONHUMAN; ORGAN TRANSPLANTATION; PRIMATE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; SWINE; T LYMPHOCYTE; THROMBOTIC THROMBOCYTOPENIC PURPURA; TRANSGENIC ANIMAL; XENOTRANSPLANTATION; ANIMAL; BLOOD; GENETICS; HUMAN; IMMUNOLOGY; THROMBOSIS; TRANSPLANTATION TOLERANCE; XENOGRAFT;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; ANTIBODIES, HETEROPHILE; ANTIGENS, HETEROPHILE; BLOOD COAGULATION; GALACTOSYLTRANSFERASES; HUMANS; IMMUNOSUPPRESSION; ORGAN TRANSPLANTATION; PRIMATES; SWINE; THROMBOSIS; TRANSPLANTATION TOLERANCE; TRANSPLANTATION, HETEROLOGOUS;

EID: 34447642540     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.tp.0000260427.75804.f2     Document Type: Review

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